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2020-10-24 06:14:47, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001137668            6649 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript
            variant 3, mRNA.
ACCESSION   NM_001137668
VERSION     NM_001137668.1  GI:212549531
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6649)
  AUTHORS   Yang,X.C., Sabath,I., Debski,J., Kaus-Drobek,M., Dadlez,M.,
            Marzluff,W.F. and Dominski,Z.
  TITLE     A complex containing the CPSF73 endonuclease and other
            polyadenylation factors associates with U7 snRNP and is recruited
            to histone pre-mRNA for 3'-end processing
  JOURNAL   Mol. Cell. Biol. 33 (1), 28-37 (2013)
   PUBMED   23071092
  REMARK    GeneRIF: FLASH/Lsm11 complex bind a unique combination of
            polyadenylation factors
REFERENCE   2  (bases 1 to 6649)
  AUTHORS   Lee,K.D., Pai,M.Y., Hsu,C.C., Chen,C.C., Chen,Y.L., Chu,P.Y.,
            Lee,C.H., Chen,L.T., Chang,J.Y., Huang,T.H., Hsiao,S.H. and
            Leu,Y.W.
  TITLE     Targeted Casp8AP2 methylation increases drug resistance in
            mesenchymal stem cells and cancer cells
  JOURNAL   Biochem. Biophys. Res. Commun. 422 (4), 578-585 (2012)
   PUBMED   22595458
  REMARK    GeneRIF: These data demonstrate that methylation within the
            Casp8AP2 promoter correlates with the development of drug
            resistance and might serve as a biomarker and treatment target for
            drug resistance in cancer cells.
REFERENCE   3  (bases 1 to 6649)
  AUTHORS   De Cola,A., Bongiorno-Borbone,L., Bianchi,E., Barcaroli,D.,
            Carletti,E., Knight,R.A., Di Ilio,C., Melino,G., Sette,C. and De
            Laurenzi,V.
  TITLE     FLASH is essential during early embryogenesis and cooperates with
            p73 to regulate histone gene transcription
  JOURNAL   Oncogene 31 (5), 573-582 (2012)
   PUBMED   21725362
  REMARK    GeneRIF: Data show that show that the transcription factor p73
            binds to Flice-Associated Huge Protein (FLASH) and is part of the
            complex that regulates histone gene transcription.
REFERENCE   4  (bases 1 to 6649)
  AUTHORS   Chen,S., Evans,H.G. and Evans,D.R.
  TITLE     FLASH knockdown sensitizes cells to Fas-mediated apoptosis via
            down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip
            short
  JOURNAL   PLoS ONE 7 (3), E32971 (2012)
   PUBMED   22427918
  REMARK    GeneRIF: FLASH knockdown in HT1080 mutant cells defective in p53
            did not significantly accelerate Fas mediated apoptosis indicating
            that the effect was dependent on functional p53.
REFERENCE   5  (bases 1 to 6649)
  AUTHORS   Hummon,A.B., Pitt,J.J., Camps,J., Emons,G., Skube,S.B., Huppi,K.,
            Jones,T.L., Beissbarth,T., Kramer,F., Grade,M.,
            Difilippantonio,M.J., Ried,T. and Caplen,N.J.
  TITLE     Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional
            deregulation of the replication-dependent histone genes and
            extensive effects on the transcriptome of colorectal cancer cells
  JOURNAL   Mol. Cancer 11, 1 (2012)
   PUBMED   22216762
  REMARK    GeneRIF: This study further defines the role CASP8AP2/FLASH plays
            in the regulating expression of the replication-dependent histones
            and shows that its LOF results in broad and reproducible effects on
            the transcriptome of colorectal cancer cells
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6649)
  AUTHORS   Jun,J.I., Chung,C.W., Lee,H.J., Pyo,J.O., Lee,K.N., Kim,N.S.,
            Kim,Y.S., Yoo,H.S., Lee,T.H., Kim,E. and Jung,Y.K.
  TITLE     Role of FLASH in caspase-8-mediated activation of NF-kappaB:
            dominant-negative function of FLASH mutant in NF-kappaB signaling
            pathway
  JOURNAL   Oncogene 24 (4), 688-696 (2005)
   PUBMED   15592525
  REMARK    GeneRIF: endogenous caspase-8 mediates tumor necrosis
            factor-alpha-induced activation of NF-kappaB via FLASH
REFERENCE   7  (bases 1 to 6649)
  AUTHORS   Kino,T. and Chrousos,G.P.
  TITLE     Tumor necrosis factor alpha receptor- and Fas-associated FLASH
            inhibit transcriptional activity of the glucocorticoid receptor by
            binding to and interfering with its interaction with p160 type
            nuclear receptor coactivators
  JOURNAL   J. Biol. Chem. 278 (5), 3023-3029 (2003)
   PUBMED   12477726
REFERENCE   8  (bases 1 to 6649)
  AUTHORS   Choi,Y.H., Kim,K.B., Kim,H.H., Hong,G.S., Kwon,Y.K., Chung,C.W.,
            Park,Y.M., Shen,Z.J., Kim,B.J., Lee,S.Y. and Jung,Y.K.
  TITLE     FLASH coordinates NF-kappa B activity via TRAF2
  JOURNAL   J. Biol. Chem. 276 (27), 25073-25077 (2001)
   PUBMED   11340079
REFERENCE   9  (bases 1 to 6649)
  AUTHORS   Koonin,E.V., Aravind,L., Hofmann,K., Tschopp,J. and Dixit,V.M.
  TITLE     Apoptosis. Searching for FLASH domains
  JOURNAL   Nature 401 (6754), 662 (1999)
   PUBMED   10537104
REFERENCE   10 (bases 1 to 6649)
  AUTHORS   Imai,Y., Kimura,T., Murakami,A., Yajima,N., Sakamaki,K. and
            Yonehara,S.
  TITLE     The CED-4-homologous protein FLASH is involved in Fas-mediated
            activation of caspase-8 during apoptosis
  JOURNAL   Nature 398 (6730), 777-785 (1999)
   PUBMED   10235259
  REMARK    Erratum:[Nature 1999 Jul 1;400(6739):89]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP192859.1, BC132828.1 and
            AF154415.1.
            
            Summary: This protein is highly similar to FLASH, a mouse apoptotic
            protein identified by its interaction with the death-effector
            domain (DED) of caspase 8. Studies of FLASH protein suggested that
            this protein may be a component of the death-inducing signaling
            complex that includes Fas receptor, Fas-binding adapter FADD, and
            caspase 8, and plays a regulatory role in Fas-mediated apoptosis.
            Alternative splicing results in multiple transcript variants
            encoding the same protein.[provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF154415.1, AF164678.2 [ECO:0000331]
            RNAseq introns       :: mixed/partial sample support ERS025084,
                                    ERS025086 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BP192859.1         1-35
            36-6539             BC132828.1         16-6519
            6540-6649           AF154415.1         6673-6782
FEATURES             Location/Qualifiers
     source          1..6649
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..6649
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="caspase 8 associated protein 2"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:1510"
                     /db_xref="MIM:606880"
     variation       4
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375731771"
     variation       10
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368340936"
     variation       24
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:183190155"
     misc_feature    40..42
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="upstream in-frame stop codon"
     variation       55
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371341158"
     CDS             64..6012
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="FLICE associated huge; CASP8 associated protein 2;
                     FLICE-associated huge protein; human FLASH; FLASH homolog
                     RIP25"
                     /codon_start=1
                     /product="CASP8-associated protein 2"
                     /protein_id="NP_001131140.1"
                     /db_xref="GI:212549532"
                     /db_xref="GeneID:9994"
                     /db_xref="HGNC:1510"
                     /db_xref="MIM:606880"
                     /translation="
MAADDDNGDGTSLFDVFSASPLKNNDEGSLDIYAGLDSAVSDSASKSCVPSRNCLDLYEEILTEEGTAKEATYNDLQVEYGKCQLQMKELMKKFKEIQTQNFSLINENQSLKKNISALIKTARVEINRKDEEISNLHQRLSEFPHFRNNHKTARTFDTVKTKDLKSRSPHLDDCSKTDHRAKSDVSKDVHHSTSLPNLEKEGKPHSDKRSTSHLPTSVEKHCTNGVWSRSHYQVGEGSSNEDSRRGRKDIRHSQFNRGTERVRKDLSTGCGDGEPRILEASQRLQGHPEKYGKGEPKTESKSSKFKSNSDSDYKGERINSSWEKETPGERSHSRVDSQSDKKLERQSERSQNINRKEVKSQDKEERKVDQKPKSVVKDQDHWRRSERASLPHSKNEITFSHNSSKYHLEERRGWEDCKRDKSVNSHSFQDGRCPSSLSNSRTHKNIDSKEVDAMHQWENTPLKAERHRTEDKRKREQESKEENRHIRNEKRVPTEHLQKTNKETKKTTTDLKKQNEPKTDKGEVLDNGVSEGADNKELAMKAESGPNETKNKDLKLSFMKKLNLTLSPAKKQPVSQDNQHKITDIPKSSGVCDSESSMQVKTVAYVPSISEHILGEAAVSEHTMGETKSTLLEPKVALLAVTEPRIGISETNKEDENSLLVRSVDNTMHCEEPICGTETSFPSPMEIQQTESLFPSTGMKQTINNGRAAAPVVMDVLQTDVSQNFGLELDTKRNDNSDYCGISEGMEMKVALSTTVSETTESILQPSIEEADILPIMLSEDNNPKFEPSVIVTPLVESKSCHLEPCLPKETLDSSLQQTELMDHRMATGETNSVYHDDDNSVLSIDLNHLRPIPEAISPLNSPVRPVAKVLRNESPPQVPVYNNSHKDVFLPNSAHSTSKSQSDLNKENQKPIYKSDKCTEADTCKNSPLDELEEGEIRSDSETSKPQESFEKNSKRRVSADVRKSKTIPRRGKSTVCLDKDSRKTHVRIHQTNNKWNKRPDKSSRSSKTEKKDKVMSTSSLEKIVPIIAVPSSEQEIMHMLRMIRKHVRKNYMKFKAKFSLIQFHRIIESAILSFTSLIKHLNLHKISKSVTTLQKNLCDIIESKLKQVKKNGIVDRLFEQQLPDMKKKLWKFVDDQLDYLFAKLKKILVCDSKSFGRDSDEGKLEKTSKQNAQYSNSQKRSVDNSNRELLKEKLSKSEDPVHYKSLVGCKKSEENYQDQNNSSINTVKHDIKKNFNICFDNIKNSQSEERSLEVHCPSTPKSEKNEGSSIEDAQTSQHATLKPERSFEILTEQQASSLTFNLVSDAQMGEIFKSLLQGSDLLDSSVNCTEKSEWELKTPEKQLLETLKCESIPACTTEELVSGVASPCPKMISDDNWSLLSSEKGPSLSSGLSLPVHPDVLDESCMFEVSTNLPLSKDNVCSVEKSKPCVSSILLEDLAVSLTVPSPLKSDGHLSFLKPDMSSSSTPEEVISAHFSEDALLEEEDASEQDIHLALESDNSSSKSSCSSSWTSRSVAPGFQYHPNLPMHAVIMEKSNDHFIVKIRRATPSTSSGLKQSMMPDELLTSLPRHGKEADEGPEKEYISCQNTVFKSVEELENSNKNVDGSKSTHEEQSSMIQTQVPDIYEFLKDASDKMGHSDEVADECFKLHQVWETKVPESIEELPSMEEISHSVGEHLPNTYVDLTKDPVTETKNLGEFIEVTVLHIDQLGCSGGNLNQSAQILDNSLQADTVGAFIDLTQDASSEAKSEGNHPALAVEDLGCGVIQVDEDNCKEEKAQVANRPLKCIVEETYIDLTTESPSSCEVKKDELKSEPGSNCDNSELPGTLHNSHKKRRNISDLNHPHKKQRKETDLTNKEKTKKPTQDSCENTEAHQKKASKKKAPPVTKDPSSLKATPGIKDSSAALATSTSLSAKNVIKKKGEIIILWTRNDDREILLECQKRGPSFKTFAYLAAKLDKNPNQVSERFQQLMKLFEKSKCR
"
     misc_feature    67..69
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N-acetylalanine; propagated from
                     UniProtKB/Swiss-Prot (Q9UKL3.1); acetylation site"
     misc_feature    121..123
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9UKL3.1); phosphorylation site"
     misc_feature    5110..5124
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 1 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5188..6009
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: NCOA2-binding"
     misc_feature    5272..5286
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 2 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5443..5457
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UKL3.1);
                     Region: SUMO interaction motif 3 (SIM), mediates the
                     binding to polysumoylated substrates (By similarity)"
     misc_feature    5809..6003
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /note="Caspase 8-associated protein 2 myb-like domain;
                     Region: CASP8AP2; cd12202"
                     /db_xref="CDD:213401"
     variation       72
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371635635"
     variation       111
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:35891026"
     variation       114
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376288172"
     variation       139
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377117590"
     variation       208
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:138471825"
     variation       225
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374871939"
     variation       237
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369309364"
     variation       342
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369328"
     variation       411
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375845338"
     variation       414
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370454326"
     variation       558
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191794738"
     variation       574
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375746744"
     variation       580
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371046529"
     variation       655
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:79485882"
     variation       695
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199979891"
     variation       716
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:115337779"
     variation       718
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374867724"
     variation       726
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182729426"
     variation       735
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372111972"
     variation       749
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377049861"
     variation       772
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:368353175"
     variation       773
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202238236"
     variation       791
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376835324"
     variation       808
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369918159"
     variation       833
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371653827"
     variation       834
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:116832209"
     variation       851
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200917530"
     variation       873
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201596073"
     variation       875
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369118984"
     variation       933
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3734656"
     variation       934
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376169756"
     variation       935
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369927994"
     variation       957
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373400557"
     variation       972
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377422956"
     variation       1042
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200248550"
     variation       1064
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374722055"
     variation       1092
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:9444715"
     variation       1110
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370574439"
     variation       1120
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375447849"
     variation       1168
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368346657"
     variation       1179
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372317117"
     variation       1227
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374277382"
     variation       1323
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75673851"
     variation       1367
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74395498"
     variation       1400
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:187658864"
     variation       1405
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372268202"
     variation       1406
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374708182"
     variation       1415
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202104748"
     variation       1419
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34701151"
     variation       1435
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201785439"
     variation       1494
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192787612"
     variation       1587
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369303003"
     variation       1613
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200323558"
     variation       1669
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376777596"
     variation       1675
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370049023"
     variation       1681
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374581994"
     variation       1731
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377395999"
     variation       1741
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370348129"
     variation       1779
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370445193"
     variation       1781
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200220681"
     variation       1803
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377095494"
     variation       1853
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370562618"
     variation       1931
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375044202"
     variation       1933
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368459977"
     variation       1979
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372157483"
     variation       2001
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374796247"
     variation       2002
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139622677"
     variation       2026
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:367672377"
     variation       2028
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371194420"
     variation       2043
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375013992"
     variation       2049
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368221756"
     variation       2065
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201489639"
     variation       2085
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376398807"
     variation       2118
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369747236"
     variation       2133
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374435750"
     variation       2175
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373095386"
     variation       2199
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:185478571"
     variation       2213
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369938492"
     variation       2266
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199531988"
     variation       2310
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:376213760"
     variation       2330
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:370683344"
     variation       2360
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:189475790"
     variation       2435
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:118038939"
     variation       2447
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:377330360"
     variation       2454
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3799895"
     variation       2460
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370853193"
     variation       2470
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374310883"
     variation       2495
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373335807"
     variation       2586
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:191911199"
     variation       2595
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201271265"
     variation       2601
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368553205"
     variation       2627
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371069501"
     variation       2666
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184335133"
     variation       2686
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:201494268"
     variation       2740
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202224866"
     variation       2780
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:137945652"
     variation       2813
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199818755"
     variation       2917
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201306147"
     variation       2932
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368026528"
     variation       2952..2953
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="c"
                     /db_xref="dbSNP:34572105"
     variation       2978
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:117850701"
     variation       3002
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:149473817"
     variation       3019
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201974982"
     variation       3023
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376299045"
     variation       3042
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:369795421"
     variation       3059
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114897724"
     variation       3125
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:375785540"
     variation       3191
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369132664"
     variation       3222
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370730058"
     STS             3451..3607
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="STS-H50583"
                     /db_xref="UniSTS:2284"
     variation       3466
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:373329038"
     variation       3503
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1064002"
     variation       3531
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:143076875"
     variation       3568
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:182864217"
     variation       3695
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:41273333"
     variation       3721
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:116614248"
     variation       3775
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201597048"
     variation       3777
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199918891"
     variation       3779
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:73752819"
     variation       3782
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:201506096"
     variation       3810
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376295745"
     variation       3817
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200866261"
     variation       3818
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374748337"
     variation       3834
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369576046"
     variation       3864
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367664392"
     variation       3877
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370073401"
     variation       3879
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374343288"
     variation       3907
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:186180164"
     variation       3914
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148256815"
     variation       3923
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375610839"
     variation       3930
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141249173"
     variation       3956
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372787304"
     variation       3957
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375991831"
     variation       4000
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370120781"
     variation       4020
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:371257885"
     variation       4026
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374774067"
     variation       4079
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369180336"
     variation       4085
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:78396072"
     variation       4116
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147437828"
     variation       4123
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376211225"
     variation       4200
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369714914"
     variation       4233
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373655186"
     variation       4368
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376852526"
     variation       4450
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139736386"
     variation       4451
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:143016644"
     variation       4455
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371559146"
     variation       4489
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190118214"
     variation       4601
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75601500"
     variation       4656
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:60966143"
     variation       4704
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200433993"
     variation       4761..4778
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="gacatctttgcccagaca"
                     /db_xref="dbSNP:202116886"
     variation       4766
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202101805"
     variation       4768
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200213073"
     variation       4774
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201189413"
     variation       4777
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:202111256"
     variation       4779
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199694900"
     variation       4780
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200862023"
     variation       4781
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201534830"
     variation       4782
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:199515704"
     variation       4901
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139983441"
     variation       4930
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150022229"
     variation       4954
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369757511"
     variation       4980
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368260598"
     variation       4998
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371881005"
     variation       5011
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111766212"
     variation       5030
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375182927"
     variation       5038
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3799896"
     variation       5041
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:372893351"
     variation       5098..5099
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:34373654"
     variation       5105
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:374695928"
     variation       5113
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200556402"
     variation       5185
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369072391"
     variation       5186
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371594163"
     variation       5201
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199714955"
     variation       5205
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369451328"
     variation       5223
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:200853389"
     variation       5246
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:377357235"
     variation       5267
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369858460"
     variation       5269
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:117650507"
     variation       5289
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377396142"
     variation       5300
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370442854"
     variation       5361
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:374893112"
     variation       5367
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377482246"
     variation       5372
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:73752820"
     variation       5382
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374232968"
     variation       5389
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368605777"
     variation       5399
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371085535"
     variation       5430
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374618973"
     variation       5463
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368658707"
     STS             5465..5702
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="SHGC-52865"
                     /db_xref="UniSTS:38874"
     variation       5484
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:371166110"
     variation       5488
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200564116"
     variation       5578
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:201549866"
     variation       5581
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:200157861"
     variation       5669
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1062121"
     variation       5714
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199771380"
     variation       5740
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:182937785"
     variation       5761
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:367942163"
     variation       5795
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372229978"
     variation       5878
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369939894"
     variation       5894
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200753477"
     variation       5928
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374433157"
     variation       6013
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370975833"
     variation       6038
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376095529"
     variation       6048
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367794675"
     variation       6085
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:11752373"
     variation       6152
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368628751"
     variation       6160
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:112756481"
     variation       6198
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371344448"
     variation       6357
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372563597"
     variation       6377
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:370145460"
     STS             6406..6547
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /standard_name="RH47433"
                     /db_xref="UniSTS:49695"
     variation       6487
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:142161883"
     variation       6554..6555
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
                     /replace=""
                     /replace="tt"
                     /db_xref="dbSNP:71864478"
     polyA_signal    6613..6618
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
     polyA_site      6639
                     /gene="CASP8AP2"
                     /gene_synonym="CED-4; FLASH; RIP25"
ORIGIN      
aaaggaaccgggttgtcttgggccgggcagggcgggtggtgactctcaaaaggaaataggatcatggcagcagatgatgacaatggtgatggaacaagtttatttgatgtcttttctgcttctcctcttaagaacaatgatgaaggctcactggacatatacgctgggttggacagtgctgtttctgacagcgcttccaaatcctgtgtaccatcaagaaattgtttggacttatatgaagagatcctgactgaagaaggaactgcaaaggaggcaacatataatgatttgcaagtagaatatggaaaatgtcaactacaaatgaaagagctgatgaaaaaatttaaagaaatacagacacagaatttcagcttaataaacgaaaaccagtctcttaagaagaatatttcagcacttatcaaaactgccagagtggaaataaaccgcaaggatgaagaaataagtaatcttcaccaaagattgtctgagtttccacattttcgaaataatcataaaactgcaaggacatttgatacagttaaaacaaaagatcttaaatctagatctccacatttggatgattgttcaaagactgatcacagagctaaaagtgatgtttctaaagatgtacatcatagcacttcactgccaaatctggaaaaggaaggaaaaccacattctgataaaaggagtacttcacatttacctacatctgttgagaaacactgcactaatggtgtttggtcacgttctcattatcaggttggcgagggtagctcaaatgaggatagtagaagaggaagaaaagatattagacatagccagtttaacagaggaactgaaagagtacgaaaagacttaagtactggctgtggtgatggtgaaccaaggatattggaggctagtcaaaggctacaaggacatcctgagaaatatggtaaaggtgaaccaaagactgaaagcaaaagttcgaagtttaaaagtaactcagattctgactataaaggtgaacgcattaactcttcttgggagaaagagacccctggagaaaggtcacacagtcgagtagactctcaaagtgacaaaaaactagaaagacaaagtgaaagatcacaaaatataaataggaaagaagttaaatcacaagacaaagaagaaagaaaagttgatcaaaaacctaaatcagtagtaaaggaccaagatcactggagaagatctgaacgagcatcacttcctcattccaagaatgaaataacattttctcataattcaagtaaataccatctagaagagagaagaggatgggaagattgtaaaagagacaagagtgtaaacagtcatagttttcaagatggaagatgtccatcttctctttcaaacagtagaactcacaaaaacattgactctaaggaagttgatgccatgcatcagtgggaaaatacacctttaaaagcagaaagacatagaactgaagataagaggaaaagagaacaagaaagcaaagaagaaaataggcatattagaaatgaaaaaagagtacctacagaacatttgcagaagactaataaggaaactaagaaaaccactactgatttaaagaaacagaatgaaccaaagactgataagggagaagtccttgataatggtgtttctgaaggagcagataataaagagcttgcaatgaaagctgagagtggtccaaatgaaacaaaaaacaaggacctaaaattgagttttatgaaaaaattgaacttaactctttctcctgctaaaaagcaacctgtttcccaggataatcagcataaaataactgatattcccaagtccagtggtgtatgtgattcagagtcttcaatgcaagttaaaacagtggcatatgttccctccataagtgaacatatcttgggggaagcagctgtcagtgaacataccatgggggaaaccaagtcaacgttattggaaccaaaggttgctcttctagcagtgactgaacccaggatcggtatctcagaaaccaacaaggaagacgaaaatagtttgttagttaggtctgttgacaatactatgcattgtgaagagcccatttgtggtacagagacttccttcccatctcctatggaaatacaacagacagaatccttgtttccatcaacaggaatgaaacaaaccattaataatggaagggcagcagctcctgtggtaatggatgtattacaaacagatgtgtctcaaaactttggcttggaattggataccaaaagaaatgataattcagattattgtggtatttctgaaggtatggagatgaaggtggcactttcaacaacagtgagtgaaaccactgaaagcattttgcagccttcaattgaggaagctgatattttgccaataatgctttcagaagataataacccaaaatttgagccttctgttatagttacaccactggttgagagtaagtcgtgtcatctggagccttgcttacctaaagagactctagattcttcacttcagcagactgagttaatggaccacagaatggcaactggtgaaacaaactcagtatatcatgatgatgataactcggttttgagcattgaccttaatcacctgagacctattccagaagccatcagtcctctgaatagtccagtgagacctgtagcaaaagttcttagaaatgaaagcccacctcaagttccagtgtataataacagtcataaagatgtgtttttaccaaattcagctcattctacctctaagagtcagtctgatctcaataaggaaaatcaaaagccaatttacaaatctgacaaatgtacagaagcagacacatgtaagaattcaccattagatgaattagaagaaggagaaattagaagtgatagtgaaacatctaaaccacaagaaagttttgaaaaaaattccaaacgtagagtgtcagctgatgtgcggaagtcaaagactatcccacgacgtgggaaaagtactgtgtgtttagataaagacagtaggaaaacacatgtaagaatccatcagaccaataacaaatggaataaaagacctgataaatctagcagatcttcaaaaacagagaagaaagataaagtgatgagcacttccagcttggaaaaaatagttccaattattgctgtaccctcttctgaacaagagatcatgcacatgttacgaatgataagaaaacatgtaagaaaaaattatatgaaattcaaggcaaaattttcattaatacaatttcacagaattattgagtcagcaattttgagttttacatctttaattaaacatctcaacttacacaaaatctctaagtcagtgactaccttacagaagaatctctgtgatattatagagtctaaacttaagcaagttaaaaagaatggcatagttgatcgtttatttgaacagcaactaccagatatgaaaaaaaaattgtggaagtttgtagatgaccaacttgattatttgtttgcaaagcttaagaaaatcttagtatgtgattccaaaagctttggaagagatagtgatgaaggcaaacttgaaaaaacaagtaaacagaatgcacagtattcaaatagtcagaaaaggagtgtggacaactccaacagagaattgctgaaagaaaaattatcaaaatcagaagaccctgttcattataagtctttagtgggatgtaaaaaatctgaggaaaattatcaagaccaaaataactccagtattaacactgtaaagcatgacattaaaaaaaattttaacatctgctttgataatataaagaactctcaatccgaagagcgctccttggaagtacactgtccaagcaccccaaagtcagaaaaaaacgaaggaagcagcatagaggatgcacagacatcccagcatgcaactttgaagccagaacgaagtttcgagattcttaccgaacagcaagcatcgagccttacttttaatttagtgagtgatgcacaaatgggtgaaatatttaaaagtttgttgcaaggttctgatcttttagacagcagtgttaactgtactgaaaaaagtgagtgggagttaaagactccagagaagcagctgctagagactcttaagtgcgagtctataccagcttgtacaacagaagagctagtttcaggggtggcttctccatgtcctaaaatgattagtgatgataattggtcattattatcatctgaaaaaggtccatctctgtcttcagggctttcattgccggttcatcctgatgtgttggatgaaagttgtatgtttgaagtgtctactaacctacctttaagtaaagataatgtgtgtagtgtagaaaagagcaagccctgcgtttcttccatacttcttgaagatctagcagtctctttaacagtaccatcgcctctgaagtcagatggtcatctcagttttttaaagcctgatatgtcgtccagttcaactcctgaagaagtcattagtgctcattttagtgaagatgccttacttgaggaagaggatgcatctgagcaagatattcatttagctctggagtctgataattcaagcagtaaatcaagttgttcttcttcctggacaagccgatctgttgctccaggctttcagtaccaccctaatctacctatgcatgccgtcataatggaaaagtccaatgatcatttcattgtgaaaatacgacgtgcaacaccatctacctcttctggccttaaacagagtatgatgcctgatgaattattgacatctttgcccagacatggaaaggaagctgatgaaggaccagagaaagaatatatttcatgtcagaacacagtttttaaatctgtggaggaattggaaaactccaacaaaaatgttgatggcagcaagtcaactcatgaagaacagagctctatgatacaaacacaggttcctgatatatatgaatttcttaaagatgcttcagataagatgggtcatagtgatgaagtggctgatgaatgtttcaaattgcatcaagtatgggaaacaaaagtgcctgaaagcattgaagaattgccttcaatggaagaaatctcacactctgttggggaacatcttccaaacacatacgtagatctaacgaaagatccagtcactgaaaccaaaaacttgggggaattcatagaagtaacagttttacatattgatcagttgggatgttctggaggcaatttaaatcagagtgctcaaatattagacaattctttgcaggctgatactgtaggtgcttttattgatttgacacaagatgcttcaagtgaggctaaaagtgaaggtaatcatcctgcattagctgtggaagacttgggatgtggggtgatacaggtagatgaagataattgtaaggaagaaaaggcacaagtggcaaacaggcctttaaaatgcattgttgaggaaacctatatcgacttgaccacagaatctcccagttcatgtgaagtaaaaaaagatgagttaaaatcagagccaggatcaaattgtgataactcggagttgcctgggactttgcataattctcacaaaaagagaagaaacatttctgatctaaatcatcctcataaaaaacaaagaaaggaaacagacttaactaataaggaaaagaccaagaaacctacccaagattcttgtgagaatactgaagctcaccaaaagaaagccagtaagaagaaggcccctcctgtgactaaagatccctcatcattaaaggcaaccccagggattaaggattcatcagcagcacttgccacttctacaagtctttctgcaaaaaatgttattaaaaagaagggagaaattatcattttatggacaagaaatgatgaccgggaaattttattggagtgtcagaaaagagggccatcatttaaaacatttgcatatttagccgccaagttggataaaaatccaaatcaggtctcagaaagattccagcagctaatgaagctctttgaaaagtcaaaatgcagataagttgctgaattcctgggactcttaactgatattgcatactacacagaagcttcaaattcctcatgttttaaatgagcactagagggaggtttatcacctttttggttaccagatgataatctatatttgttattactcagtgactctctaatttcacatcagcatgttcagcttgtgctagtcatcattctgatttgcttatctgtttttggtcaaaatatttatttttaaacatgttagaacttaccaaaatgaaagcaacagtgatgtattgaaatcttagttttgatattttaaagaaatgactttctagattaaaaaaatagttttgtagcattttaaacttagtgactatttagttcaattgttcatccattttttatttgcttttataattgcctccttgttttggtatattgtaaaataatttaaataatgtatttataaatatgtataattatgatgtaaaataccgtgtgtatatgtatgtatgtgtgtttctgtatatgcacacacataaacggctttgcctagccaaggattttttttatctgtataaaactttttgtataaagtttgctttcaataacagtaatgtataataaaaccatgtaaagttttgttgtaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:9994 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:9994 -> Molecular function: GO:0003714 [transcription corepressor activity] evidence: IDA
            GeneID:9994 -> Molecular function: GO:0005123 [death receptor binding] evidence: TAS
            GeneID:9994 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:9994 -> Molecular function: GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Molecular function: GO:0016505 [peptidase activator activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Molecular function: GO:0032184 [SUMO polymer binding] evidence: IDA
            GeneID:9994 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:9994 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
            GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: IMP
            GeneID:9994 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: ISS
            GeneID:9994 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:9994 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
            GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
            GeneID:9994 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: ISS
            GeneID:9994 -> Biological process: GO:0036337 [Fas signaling pathway] evidence: IMP
            GeneID:9994 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
            GeneID:9994 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:9994 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
            GeneID:9994 -> Cellular component: GO:0016605 [PML body] evidence: IDA

by @meso_cacase at DBCLS
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