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2024-04-27 03:55:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001136191 5224 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens KN motif and ankyrin repeat domains 2 (KANK2),
transcript variant 2, mRNA.
ACCESSION NM_001136191
VERSION NM_001136191.2 GI:258645111
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5224)
AUTHORS Kakinuma,N., Zhu,Y., Wang,Y., Roy,B.C. and Kiyama,R.
TITLE Kank proteins: structure, functions and diseases
JOURNAL Cell. Mol. Life Sci. 66 (16), 2651-2659 (2009)
PUBMED 19554261
REMARK Review article
REFERENCE 2 (bases 1 to 5224)
AUTHORS Zhu,Y., Kakinuma,N., Wang,Y. and Kiyama,R.
TITLE Kank proteins: a new family of ankyrin-repeat domain-containing
proteins
JOURNAL Biochim. Biophys. Acta 1780 (2), 128-133 (2008)
PUBMED 17996375
REFERENCE 3 (bases 1 to 5224)
AUTHORS Zhang,Y., Zhang,H., Liang,J., Yu,W. and Shang,Y.
TITLE SIP, a novel ankyrin repeat containing protein, sequesters steroid
receptor coactivators in the cytoplasm
JOURNAL EMBO J. 26 (11), 2645-2657 (2007)
PUBMED 17476305
REMARK GeneRIF: SIP, a novel ankyrin repeat containing protein, sequesters
steroid receptor coactivators in the cytoplasm.
REFERENCE 4 (bases 1 to 5224)
AUTHORS Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of human RPE/choroid for the
NEIBank Project: over 6000 non-redundant transcripts, novel genes
and splice variants
JOURNAL Mol. Vis. 8, 205-220 (2002)
PUBMED 12107410
REMARK Publication Status: Online-Only
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC009000.6, BC082762.1, AB040951.2 and BQ007409.1.
On Sep 18, 2009 this sequence version replaced gi:209969811.
Transcript Variant: This variant (2) differs in the 5' UTR, and
uses an alternate in-frame splice site in the central coding
region, compared to variant 1. The encoded isoform (2) is shorter
than isoform 1.
##Evidence-Data-START##
Transcript exon combination :: BC082762.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-46 AC009000.6 8005-8050
47-3076 BC082762.1 1-3030
3077-5204 AB040951.2 3029-5156
5205-5224 BQ007409.1 1-20 c
FEATURES Location/Qualifiers
source 1..5224
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="19"
/map="19p13.2"
gene 1..5224
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="KN motif and ankyrin repeat domains 2"
/db_xref="GeneID:25959"
/db_xref="HGNC:29300"
/db_xref="MIM:614610"
exon 1..83
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 84..282
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
variation 188..207
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace=""
/replace="agagacgtggagagacacag"
/db_xref="dbSNP:71164166"
exon 283..398
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
misc_feature 284..286
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="upstream in-frame stop codon"
variation 304
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="a"
/replace="g"
/db_xref="dbSNP:754528"
CDS 362..2917
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="isoform 2 is encoded by transcript variant 2;
matrix-remodelling associated 3; ankyrin repeat domain 25;
KN motif and ankyrin repeat domain-containing protein 2;
kidney ankyrin repeat-containing protein 2; SRC-1
interacting protein; SRC1-interacting protein;
SRC-1-interacting protein; matrix-remodeling-associated
protein 3; ankyrin repeat domain-containing protein 25;
SRC-interacting protein"
/codon_start=1
/product="KN motif and ankyrin repeat domain-containing
protein 2 isoform 2"
/protein_id="NP_001129663.1"
/db_xref="GI:209969812"
/db_xref="CCDS:CCDS12255.1"
/db_xref="GeneID:25959"
/db_xref="HGNC:29300"
/db_xref="MIM:614610"
/translation="
MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE
"
misc_feature 362..577
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: Interaction with AIFM1"
misc_feature 416..418
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 455..556
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="KN motif; Region: KN_motif; pfam12075"
/db_xref="CDD:152510"
misc_feature 1427..1429
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 1484..1486
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q63ZY3.1); phosphorylation site"
misc_feature 1775..1777
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q63ZY3.1); phosphorylation site"
misc_feature 2243..2668
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 2342..2737
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
misc_feature 2357..2449
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: ANK 1"
misc_feature 2366..2866
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q63ZY3.1);
Region: Interaction with NCOA1"
misc_feature 2588..2845
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="Ankyrin repeats (3 copies); Region: Ank_2;
pfam12796"
/db_xref="CDD:205076"
misc_feature 2657..>2845
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/note="ankyrin repeats; ankyrin repeats mediate
protein-protein interactions in very diverse families of
proteins. The number of ANK repeats in a protein can range
from 2 to over 20 (ankyrins, for example). ANK repeats may
occur in combinations with other...; Region: ANK; cd00204"
/db_xref="CDD:29261"
variation 388
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:754529"
exon 399..1610
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1611..1778
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1779..1881
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 1882..2121
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2122..2209
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2210..2429
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2430..2572
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2573..2773
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2774..2863
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
exon 2864..5208
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/inference="alignment:Splign:1.39.8"
variation 3407
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:892112"
STS 3670..3853
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/standard_name="RH45741"
/db_xref="UniSTS:16416"
variation 4217
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="a"
/replace="c"
/db_xref="dbSNP:892113"
variation 4309
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:3185010"
variation 4338..4339
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace=""
/replace="ca"
/db_xref="dbSNP:16423"
variation 4893
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="c"
/replace="t"
/db_xref="dbSNP:7187"
STS 4947..5119
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/standard_name="STS-W84522"
/db_xref="UniSTS:53506"
variation 5012
/gene="KANK2"
/gene_synonym="ANKRD25; MXRA3; SIP"
/replace="g"
/replace="t"
/db_xref="dbSNP:7188"
ORIGIN
gagggccgggcgcccaggctgcggcgcgcgcgaagacgctcgggcggcgggacccagggaaggcagcggccggagcgcgcaaggtgttgaaagacagagaagcgaagacagagacgtggaaagacagggagagagacacggagagagacgcagaaggacagagacgtggagagagacgcagagagacagagacgtggagagacacagagagacgtggagagacacagagagacttggagagagacaaagcaagacaggacgggagaacaaggacaagctcaggtaagcctcagccggtgctgcaggcagtctgactcgcagtccctcaagtgacttccaaggagcatctgtagaaaagaagatggcccaggtcctgcacgtgcctgctcccttcccagggacccctggcccagcctccccacctgccttccctgccaaggaccccgatccaccctactccgtggagaccccctatggctaccgcctggacctggacttcctcaagtacgtggatgacatcgagaagggccacacgctgcgacgcgtggcagtgcagcgccgcccccgcctgagctcgctgccccgtggccctggctcctggtggacgtccactgagtcgctgtgctccaatgccagtggggacagccgccactcagcctattcctactgcggccgtggcttctaccctcagtatggtgctctggagacccgcggtggcttcaatccgcgggtggagcgcacgctgctggatgcccgtcgccgtctcgaggaccaggcggccacacccaccggcctgggctccctgacccccagtgcggccggctcgacagcctccctggtgggcgtggggttgccacccccgacaccacggagttcaggactgtccacaccggtgcctcccagtgccgggcacctggcccacgtgcgggagcagatggcgggtgccctgcggaagctgcggcagctggaggagcaggtgaagctgatccctgtgctccaggtgaagctctcggtgctccaggaggaaaagcggcagctcacagtacaacttaagagccagaagttcctgggccaccccacagcgggccggggtcgcagcgagctctgcctggacctccccgatcccccagaggacccagtggcactggagacccggagtgtgggcacctgggttcgagaacgggacttgggcatgcctgatggggaggctgccctcgccgccaaggtcgctgtgctggagacccagctcaagaaggcgctgcaggagctgcaggcagctcaggcccggcaggctgacccccagccccaggcctggccaccgccggacagcccggtccgcgtggatacagtccgggtggtagaagggccacgggaggtggaggtggtggccagcacagccgctggcgcccccgcacagcgggcccagagcctggagccttacggcacagggctgagggccctggcaatgcctggtaggcctgagagcccacctgtgttccgcagccaggaggtggtggagacaatgtgcccagtgcccgctgcagctaccagcaacgtccatatggtgaagaagattagcatcacagagcgaagctgcgatggagcagcaggcctcccagaagttcctgccgaatcgtcttcgtcacccccggggtccgaggtagcctcccttacacagcctgagaagagcacaggccgagtgcccacccaggagcccacccacagggagcccaccaggcaagcagcctcccaagagtccgaggaggccgggggcaccggcgggcccccggcaggcgtgcgatctatcatgaaacggaaagaggaggttgcagaccccacggcccaccggaggagcctccagttcgtgggggtcaacggcgggtatgagtcgtcatccgaggactccagcacagcagagaacatctcagacaacgacagcacagagaacgaggccccagagccgagggagagggttccgagtgtggccgaagccccccagctcaggcctgcagggacggcagcggccaagaccagccggcaggagtgtcagctgtctcgagaatctcagcacatacccactgctgagggggcatcaggatcaaacacggaggaggagatcaggatggagctaagccctgacctcatctcagcctgcttggccctggaaaagtacctggacaatcccaacgccctcacagagcgggagctgaaagtggcctacaccacagtgctgcaggagtggctgcgcctggcctgccgcagcgacgcacaccccgagctggtgcggcggcacctggtcacgttccgggccatgtctgcgcggctgctggactacgtggtcaacatcgccgacagcaacggcaacacagccctgcactactccgtgtctcatgccaacttccccgtggtgcagcagctgctcgacagcggtgtctgcaaggtggacaaacagaaccgtgctggctacagccctattatgctcaccgccctggccaccctgaagacccaggacgacatcgagactgtccttcagctcttccggcttggcaacatcaatgccaaagccagccaggcaggacagacggccctgatgctggccgtcagccacgggcgggtggacgttgtcaaagccctgctggcctgtgaggcagatgtcaacgtgcaagatgatgacggctccacggccctcatgtgcgcctgtgagcacggccacaaggagatcgcggggctgctgctggccgtgcccagctgtgacatctcactcacagatcgcgatgggagcacagctctgatggtggccttggacgcagggcagagtgagattgcgtccatgctgtattcccgcatgaacatcaagtgctcgtttgccccaatgtcagatgacgagagccctacatcatcctcggcagaagagtagccgtgagggaggcggggaccagccagaccgggagcaaaccgtcccttgtccccgtctcctccctgttcccgttcctccctggcccaccccactcacactccccaaggcccacggctcaaaggcaagcgagctctccctctgcttccctgggggagccccgacggccacaggactccagctccaagtgggttttcttggctcccctgttcaaagtggccacagcgcagaccgaagcaaaattcttgtatacattggcgccagggctgatgctggggtgtgggttttatgaagaacattgagaacaatcagctggtaattatggatggaggaagagggagaggaaaaaaatattgtatttttgaatcattgttgcaggagggggtgggaatcttaggatttgttgccagatttgaaagtcactggaacttgcatattttcattttaatcctaagtgttattacgcaccagttggggttcacccttcatcccccacatttaattgtctgatatagaatagtgttgtgtccactgccccgctagacggctttcttaggggaattttcttctggttgtttcacaagacagattctgtccttgtcacccgggacagaaaactcagtcttttcaccctcattcagatgaagggactcaggacaggctctgtgacttacagggacccaatcaattcacaatgagaaattaccggccaggcgtggtgactcacgtctgtaatcccagcactttgggagggcaaggcaagagcttgagcttgagcctagacgttaaagaccagcctgggcaacacagcaagacccatctctacaagaaatttaaaaactagccaggcgtggtggtgcgcgcctgtagtcccagctacttgggaggctgagccctggaggtcgaggctacagtgagctatgatcacaccattgcacttcagcctgggcgacacagcgagaccctgtctcaagaaagaaaagaaaaagagacaaattacccagaaacccctcccttccccacatggaggccttggcaaatgttaattttcctagaaaatccttcagacctgaagacgcaggaaaagaatctggctctcagggtggcttctgcgtccccgccgccaggccccagactatggtcacagggccgtcctgttcctccccgggactccagaatttctctcctcaaaggaaagaaaacagggcatgcgcttgttggcaaaacgcagggccggctcccaaaaaccccatgtgtgtacgattaaaagttggccgtccccaggcctcccagcgcaaacttaaagagacagggctttgctgaaaaccaaacatgggccagctgggctttttaacaacctagagactttccggagctgcctggaacagagcctgcgggaaacggggcttgccagagacactcacagtttccttcatggcctgttttggtcccctaagaatctccacatcattgtctttcttgtgccttttccttggtgagcaacagaaagggaagggttccaagcctctaaaaatgtgctttgtgatcaggagtgcgctccaaaccaaatacgcgcgctgccctttcgaggccagtgagctcagcctccaaggctttaaagccacatttcagcaagagaaagcgctgagagctcgcaggttcattaaagaaggcaaagcactggtttctctccttagaaaagtaggtttcttggcttgatgtagactggcttgctttgatttttagtgaagggaatgtacgtaaaacaaaatagggcttggctggtcaaaggagacaagcaggatggatggatggatggatggatggatggatggatggatggatggatgaatagatagatggtgtttgcatgtaaattgcagagaaaacaaaaccaaagctgattggaaacaattaattgtgggtgtctgagggggaaggtcgcagctttgggcagctttgagaagcggtacaagagttctgtgcctgtgtgtccagccctggagccagccagtgcatttattttaagctcttagaagcaactccttggcccaggaatgcgtgacccctgagatgggtccacgcatctctctacacttccttctctccgtgggatactggactcgtgcctctgcgcccattctcttctcacgcatatccatgagctttaatttcactttctgatcacggtacgtccataaagccagtattacacttaaatgaagtattcttttttgtaatcgttttttttagaaggtaaacaaatttaataaagctaccaataatgttgatgaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:25959 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:25959 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:25959 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:25959 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:25959 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA
GeneID:25959 -> Biological process: GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway] evidence: IDA
GeneID:25959 -> Biological process: GO:0043069 [negative regulation of programmed cell death] evidence: IDA
GeneID:25959 -> Biological process: GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] evidence: IDA
GeneID:25959 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:25959 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA
by
@meso_cacase at
DBCLS
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