2024-04-23 21:28:41, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001135701 3023 bp mRNA linear PRI 01-JUL-2013 DEFINITION Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide (YWHAZ), transcript variant 5, mRNA. ACCESSION NM_001135701 VERSION NM_001135701.1 GI:208973241 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3023) AUTHORS Riou,P., Kjaer,S., Garg,R., Purkiss,A., George,R., Cain,R.J., Bineva,G., Reymond,N., McColl,B., Thompson,A.J., O'Reilly,N., McDonald,N.Q., Parker,P.J. and Ridley,A.J. TITLE 14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins JOURNAL Cell 153 (3), 640-653 (2013) PUBMED 23622247 REMARK GeneRIF: Study reports a high-affinity 14-3-3-binding site at the C terminus of Rnd3 consisting of both the Cys241-farnesyl moiety and a Rho-associated coiled coil containing protein kinase (ROCK)-dependent Ser240 phosphorylation site. REFERENCE 2 (bases 1 to 3023) AUTHORS Nishimura,Y., Komatsu,S., Ichikawa,D., Nagata,H., Hirajima,S., Takeshita,H., Kawaguchi,T., Arita,T., Konishi,H., Kashimoto,K., Shiozaki,A., Fujiwara,H., Okamoto,K., Tsuda,H. and Otsuji,E. TITLE Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma JOURNAL Br. J. Cancer 108 (6), 1324-1331 (2013) PUBMED 23422756 REMARK GeneRIF: Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma. REFERENCE 3 (bases 1 to 3023) AUTHORS Bergamaschi,A., Frasor,J., Borgen,K., Stanculescu,A., Johnson,P., Rowland,K., Wiley,E.L. and Katzenellenbogen,B.S. TITLE 14-3-3zeta as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers JOURNAL Breast Cancer Res. Treat. 137 (3), 689-696 (2013) PUBMED 23271328 REMARK GeneRIF: 14-3-3zeta as a predictor of early time to recurrence and distant metastasis in hormone receptor-positive and -negative breast cancers. REFERENCE 4 (bases 1 to 3023) AUTHORS Boon,S.S. and Banks,L. TITLE High-risk human papillomavirus E6 oncoproteins interact with 14-3-3zeta in a PDZ binding motif-dependent manner JOURNAL J. Virol. 87 (3), 1586-1595 (2013) PUBMED 23175360 REMARK GeneRIF: The interaction is direct and specific for the high-risk HPV E6 oncoproteins, although there are significant differences in the efficiencies with which HPV-16, HPV-18, and HPV-31 E6 oncoproteins can associate with 14-3-3zeta. REFERENCE 5 (bases 1 to 3023) AUTHORS Skwarczynska,M., Molzan,M. and Ottmann,C. TITLE Activation of NF-kappaB signalling by fusicoccin-induced dimerization JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (5), E377-E386 (2013) PUBMED 23269842 REMARK GeneRIF: Data indicate that fusicoccin (FC)-mediated dimerization of the NF-kappaB-C terminus(CT) with a constitutively nuclear-localized 14-3-3 protein led to an NF-kappaB-specific cellular response by inducing IL-8 secretion. REFERENCE 6 (bases 1 to 3023) AUTHORS Koyama,S., Williams,L.T. and Kikuchi,A. TITLE Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in intact cells JOURNAL FEBS Lett. 368 (2), 321-325 (1995) PUBMED 7628630 REFERENCE 7 (bases 1 to 3023) AUTHORS Liu,D., Bienkowska,J., Petosa,C., Collier,R.J., Fu,H. and Liddington,R. TITLE Crystal structure of the zeta isoform of the 14-3-3 protein JOURNAL Nature 376 (6536), 191-194 (1995) PUBMED 7603574 REFERENCE 8 (bases 1 to 3023) AUTHORS Sato,T., Irie,S., Kitada,S. and Reed,J.C. TITLE FAP-1: a protein tyrosine phosphatase that associates with Fas JOURNAL Science 268 (5209), 411-415 (1995) PUBMED 7536343 REFERENCE 9 (bases 1 to 3023) AUTHORS Kawamoto,S., Shoji,M., Setoguchi,Y., Kato,M., Hashizume,S., Ichikawa,A., Osada,K., Katakura,Y., Tachibana,H. and Murakami,H. TITLE Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an antigen recognized by the lung cancer-specific human monoclonal antibody, AE6F4 JOURNAL Cytotechnology 17 (2), 103-108 (1995) PUBMED 7547034 REFERENCE 10 (bases 1 to 3023) AUTHORS Zupan,L.A., Steffens,D.L., Berry,C.A., Landt,M. and Gross,R.W. TITLE Cloning and expression of a human 14-3-3 protein mediating phospholipolysis. Identification of an arachidonoyl-enzyme intermediate during catalysis JOURNAL J. Biol. Chem. 267 (13), 8707-8710 (1992) PUBMED 1577711 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CR996247.1, CN276627.1, BC072426.1 and BM783874.1. Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]. Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. All six transcripts encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU153643.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-56 CR996247.1 1-56 57-147 CN276627.1 2-92 148-2906 BC072426.1 97-2855 2907-3023 BM783874.1 221-337 FEATURES Location/Qualifiers source 1..3023 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="8" /map="8q23.1" gene 1..3023 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide" /db_xref="GeneID:7534" /db_xref="HGNC:12855" /db_xref="MIM:601288" exon 1..147 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" exon 148..452 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" CDS 159..896 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /note="14-3-3 delta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; 14-3-3 zeta; phospholipase A2; protein kinase C inhibitor protein-1; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide; 14-3-3 protein/cytosolic phospholipase A2; protein kinase C inhibitor protein 1" /codon_start=1 /product="14-3-3 protein zeta/delta" /protein_id="NP_001129173.1" /db_xref="GI:208973242" /db_xref="CCDS:CCDS6290.1" /db_xref="GeneID:7534" /db_xref="HGNC:12855" /db_xref="MIM:601288" /translation="
MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
" misc_feature 159..161 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="N-acetylmethionine; propagated from UniProtKB/Swiss-Prot (P63104.1); acetylation site" misc_feature 162..848 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /note="14-3-3 beta and zeta isoforms of 14-3-3 protein; Region: 14-3-3_beta_zeta; cd10022" /db_xref="CDD:206758" misc_feature 165..167 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P63104.1); acetylation site" misc_feature order(171..173,180..185,192..197,201..206,210..212, 219..221,330..332,339..341,351..353,381..383,390..395, 402..404,411..416,423..425) /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:206758" misc_feature order(279..284,291..296,303..305,507..509,516..518, 537..542,651..653,663..665,672..677,684..686,783..797, 804..809,816..818,828..830) /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /note="peptide binding site [polypeptide binding]; other site" /db_xref="CDD:206758" misc_feature 324..326 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="non-experimental evidence, no additional details recorded" /note="Interaction with phosphoserine on interacting protein (By similarity); propagated from UniProtKB/Swiss-Prot (P63104.1); other site" misc_feature 330..332 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by PKA and PKB/AKT1; propagated from UniProtKB/Swiss-Prot (P63104.1); phosphorylation site" misc_feature 360..362 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P63104.1); acetylation site" misc_feature 537..539 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="non-experimental evidence, no additional details recorded" /note="Interaction with phosphoserine on interacting protein (By similarity); propagated from UniProtKB/Swiss-Prot (P63104.1); other site" misc_feature 708..710 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine, by MAPK8; propagated from UniProtKB/Swiss-Prot (P63104.1); phosphorylation site" misc_feature 777..779 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P63104.1); phosphorylation site" misc_feature 852..854 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine, by CK1; propagated from UniProtKB/Swiss-Prot (P63104.1); phosphorylation site" STS 359..602 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /standard_name="PMC150726P7" /db_xref="UniSTS:271079" variation 385 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="a" /replace="g" /db_xref="dbSNP:11551365" variation 419 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="a" /replace="g" /db_xref="dbSNP:41473144" exon 453..576 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" exon 577..740 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" exon 741..836 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" exon 837..3013 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /inference="alignment:Splign:1.39.8" variation 982 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="g" /replace="t" /db_xref="dbSNP:11551354" STS 1165..1258 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /standard_name="PMC126239P3" /db_xref="UniSTS:270535" variation 1254 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="g" /replace="t" /db_xref="dbSNP:11551357" STS 1284..2032 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /standard_name="YWHAZ_1120.2" /db_xref="UniSTS:281082" variation 1363 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="c" /replace="t" /db_xref="dbSNP:11545396" polyA_signal 1869..1874 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" polyA_site 1900 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" variation 2383 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="c" /replace="t" /db_xref="dbSNP:11551356" variation 2668 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="c" /replace="g" /db_xref="dbSNP:1062376" variation 2688 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="a" /replace="c" /db_xref="dbSNP:1062382" variation 2814 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="c" /replace="t" /db_xref="dbSNP:1139382" variation 2830 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="a" /replace="c" /db_xref="dbSNP:1062393" polyA_signal 2843..2848 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" polyA_site 2866 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" polyA_site 2906 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" variation 2908 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" /replace="a" /replace="c" /db_xref="dbSNP:3203463" polyA_signal 2995..3000 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" polyA_site 3013 /gene="YWHAZ" /gene_synonym="14-3-3-zeta; KCIP-1; YWHAD" ORIGIN
ggcggggaggggccgggggcctcggggacccaagcgcgagggaaaggcctggccgagagcgggccggagcccaggcctggcgcggcggcgcccgccaggtagaccggggcgaggctgcgcgccggcgggaggggagtccactgcgggaacatccagtcatggataaaaatgagctggttcagaaggccaaactggccgagcaggctgagcgatatgatgacatggcagcctgcatgaagtctgtaactgagcaaggagctgaattatccaatgaggagaggaatcttctctcagttgcttataaaaatgttgtaggagcccgtaggtcatcttggagggtcgtctcaagtattgaacaaaagacggaaggtgctgagaaaaaacagcagatggctcgagaatacagagagaaaattgagacggagctaagagatatctgcaatgatgtactgtctcttttggaaaagttcttgatccccaatgcttcacaagcagagagcaaagtcttctatttgaaaatgaaaggagattactaccgttacttggctgaggttgccgctggtgatgacaagaaagggattgtcgatcagtcacaacaagcataccaagaagcttttgaaatcagcaaaaaggaaatgcaaccaacacatcctatcagactgggtctggcccttaacttctctgtgttctattatgagattctgaactccccagagaaagcctgctctcttgcaaagacagcttttgatgaagccattgctgaacttgatacattaagtgaagagtcatacaaagacagcacgctaataatgcaattactgagagacaacttgacattgtggacatcggatacccaaggagacgaagctgaagcaggagaaggaggggaaaattaaccggccttccaacttttgtctgcctcattctaaaatttacacagtagaccatttgtcatccatgctgtcccacaaatagttttttgtttacgatttatgacaggtttatgttacttctatttgaatttctatatttcccatgtggtttttatgtttaatattaggggagtagagccagttaacatttagggagttatctgttttcatcttgaggtggccaatatggggatgtggaatttttatacaagttataagtgtttggcatagtacttttggtacattgtggcttcaaaagggccagtgtaaaactgcttccatgtctaagcaaagaaaactgcctacatactggtttgtcctggcggggaataaaagggatcattggttccagtcacaggtgtagtaattgtgggtactttaaggtttggagcacttacaaggctgtggtagaatcataccccatggataccacatattaaaccatgtatatctgtggaatactcaatgtgtacacctttgactacagctgcagaagtgttcctttagacaaagttgtgacccattttactctggataagggcagaaacggttcacattccattatttgtaaagttacctgctgttagctttcattatttttgctacactcattttatttgtatttaaatgttttaggcaacctaagaacaaatgtaaaagtaaagatgcaggaaaaatgaattgcttggtattcattacttcatgtatatcaagcacagcagtaaaacaaaaacccatgtatttaacttttttttaggatttttgcttttgtgatttttttttttttgatacttgcctaacatgcatgtgctgtaaaaatagttaacagggaaataacttgagatgatggctagctttgtttaatgtcttatgaaattttcatgaacaatccaagcataattgttaagaacacgtgtattaaattcatgtaagtggaataaaagttttatgaatggacttttcaactactttctctacagcttttcatgtaaattagtcttggttctgaaacttctctaaaggaaattgtacattttttgaaatttattccttattccctcttggcagctaatgggctcttaccaagtttaaacacaaaatttatcataacaaaaatactactaatataactactgtttccatgtcccatgatcccctctcttcctccccaccctgaaaaaaatgagttcctattttttctgggagagggggggattgattagaaaaaaatgtagtgtgttccatttaaaattttggcatatggcattttctaacttaggaagccacaatgttcttggcccatcatgacattgggtagcattaactgtaagttttgtgcttccaaatcactttttggtttttaagaatttcttgatactcttatagcctgccttcaattttgatcctttattctttctatttgtcaggtgcacaagattaccttcctgttttagccttctgtcttgtcaccaaccattcttacttggtggccatgtacttggaaaaaggccgcatgatctttctggctccactcagtgtctaaggcaccctgcttcctttgcttgcatcccacagactatttccctcatcctatttactgcagcaaatctctccttagttgatgagactgtgtttatctccctttaaaaccctacctatcctgaatggtctgtcattgtctgcctttaaaatccttcctctttcttcctcctctattctctaaataatgatggggctaagttatacccaaagctcactttacaaaatatttcctcagtactttgcagaaaacaccaaacaaaaatgccattttaaaaaaggtgtattttttcttttagaatgtaagctcctcaagagcagggacaatgttttctgtatgttctattgtgcctagtacactgtaaatgctcaataaatattgatgatgggaggcagtgagtcttgatgataagggtgagaaactgaaatcccaaacactgttttgttgcttgttttattatgacctcagattaaattgggaaatattggcccttttgaataattgtcccaaatattacattcaaataaaagtgcaatggagaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:7534 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:7534 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI GeneID:7534 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI GeneID:7534 -> Molecular function: GO:0019904 [protein domain specific binding] evidence: IEA GeneID:7534 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA GeneID:7534 -> Biological process: GO:0002553 [histamine secretion by mast cell] evidence: IEA GeneID:7534 -> Biological process: GO:0006626 [protein targeting to mitochondrion] evidence: IEA GeneID:7534 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:7534 -> Biological process: GO:0007165 [signal transduction] evidence: TAS GeneID:7534 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS GeneID:7534 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:7534 -> Biological process: GO:0016044 [cellular membrane organization] evidence: TAS GeneID:7534 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:7534 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:7534 -> Biological process: GO:0030168 [platelet activation] evidence: TAS GeneID:7534 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:7534 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:7534 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:7534 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:7534 -> Cellular component: GO:0005737 [cytoplasm] evidence: TAS GeneID:7534 -> Cellular component: GO:0005739 [mitochondrion] evidence: IEA GeneID:7534 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:7534 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IEA GeneID:7534 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: TAS GeneID:7534 -> Cellular component: GO:0031252 [cell leading edge] evidence: IEA GeneID:7534 -> Cellular component: GO:0042470 [melanosome] evidence: IEA GeneID:7534 -> Cellular component: GO:0043234 [protein complex] evidence: IEA GeneID:7534 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA
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