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2024-04-25 22:33:01, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001135685 2753 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens leukocyte receptor tyrosine kinase (LTK), transcript
variant 3, mRNA.
ACCESSION NM_001135685
VERSION NM_001135685.1 GI:208879422
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2753)
AUTHORS Roll,J.D. and Reuther,G.W.
TITLE ALK-activating homologous mutations in LTK induce cellular
transformation
JOURNAL PLoS ONE 7 (2), E31733 (2012)
PUBMED 22347506
REMARK GeneRIF: aberrant activation of LTK may contribute to neoplastic
cell growth.
REFERENCE 2 (bases 1 to 2753)
AUTHORS Yamada,S., Uchimura,E., Ueda,T., Nomura,T., Fujita,S.,
Matsumoto,K., Funeriu,D.P., Miyake,M. and Miyake,J.
TITLE Identification of twinfilin-2 as a factor involved in neurite
outgrowth by RNAi-based screen
JOURNAL Biochem. Biophys. Res. Commun. 363 (4), 926-930 (2007)
PUBMED 17910947
REFERENCE 3 (bases 1 to 2753)
AUTHORS Li,N., Nakamura,K., Jiang,Y., Tsurui,H., Matsuoka,S., Abe,M.,
Ohtsuji,M., Nishimura,H., Kato,K., Kawai,T., Atsumi,T., Koike,T.,
Shirai,T., Ueno,H. and Hirose,S.
TITLE Gain-of-function polymorphism in mouse and human Ltk: implications
for the pathogenesis of systemic lupus erythematosus
JOURNAL Hum. Mol. Genet. 13 (2), 171-179 (2004)
PUBMED 14695357
REMARK GeneRIF: polymorphic LTKs cause up-regulation of the PI3K pathway
and possibly form one genetic component of susceptibility to
abnormal proliferation of self-reactive B cells in systemic lupus
erythematosus
REFERENCE 4 (bases 1 to 2753)
AUTHORS Espanel,X., Huguenin-Reggiani,M. and Hooft van Huijsduijnen,R.
TITLE The SPOT technique as a tool for studying protein tyrosine
phosphatase substrate specificities
JOURNAL Protein Sci. 11 (10), 2326-2334 (2002)
PUBMED 12237455
REFERENCE 5 (bases 1 to 2753)
AUTHORS Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
TITLE Expressed sequence tag analysis of human RPE/choroid for the
NEIBank Project: over 6000 non-redundant transcripts, novel genes
and splice variants
JOURNAL Mol. Vis. 8, 205-220 (2002)
PUBMED 12107410
REMARK Publication Status: Online-Only
REFERENCE 6 (bases 1 to 2753)
AUTHORS Toyoshima,H., Kozutsumi,H., Maru,Y., Hagiwara,K., Furuya,A.,
Mioh,H., Hanai,N., Takaku,F., Yazaki,Y. and Hirai,H.
TITLE Differently spliced cDNAs of human leukocyte tyrosine kinase
receptor tyrosine kinase predict receptor proteins with and without
a tyrosine kinase domain and a soluble receptor protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 90 (12), 5404-5408 (1993)
PUBMED 7685902
REFERENCE 7 (bases 1 to 2753)
AUTHORS Krolewski,J.J. and Dalla-Favera,R.
TITLE The ltk gene encodes a novel receptor-type protein tyrosine kinase
JOURNAL EMBO J. 10 (10), 2911-2919 (1991)
PUBMED 1655406
REFERENCE 8 (bases 1 to 2753)
AUTHORS Krolewski,J.J., Lee,R., Eddy,R., Shows,T.B. and Dalla-Favera,R.
TITLE Identification and chromosomal mapping of new human tyrosine kinase
genes
JOURNAL Oncogene 5 (3), 277-282 (1990)
PUBMED 2156206
REFERENCE 9 (bases 1 to 2753)
AUTHORS Maru,Y., Hirai,H. and Takaku,F.
TITLE Human ltk: gene structure and preferential expression in human
leukemic cells
JOURNAL Oncogene Res. 5 (3), 199-204 (1990)
PUBMED 2320375
REFERENCE 10 (bases 1 to 2753)
AUTHORS Ben-Neriah,Y. and Bauskin,A.R.
TITLE Leukocytes express a novel gene encoding a putative transmembrane
protein-kinase devoid of an extracellular domain
JOURNAL Nature 333 (6174), 672-676 (1988)
PUBMED 2836739
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK296892.1, AC016134.7 and
CA394397.1.
Summary: The protein encoded by this gene is a member of the
ros/insulin receptor family of tyrosine kinases. Tyrosine-specific
phosphorylation of proteins is a key to the control of diverse
pathways leading to cell growth and differentiation. Multiple
transcript variants encoding different isoforms have been found for
this gene. [provided by RefSeq, Oct 2008].
Transcript Variant: This variant (3) lacks two internal coding
exons and uses an alternate splice site in the central coding
region, compared to variant 1. The resulting isoform (3) is missing
two internal segments and has a short segment in an alternate
reading frame but with the same N- and C-termini, compared to
isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK296892.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025088, ERS025093 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-493 AK296892.1 1-493
494-494 AC016134.7 8528-8528 c
495-2412 AK296892.1 495-2412
2413-2753 CA394397.1 244-584
FEATURES Location/Qualifiers
source 1..2753
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q15.1-q21.1"
gene 1..2753
/gene="LTK"
/gene_synonym="TYK1"
/note="leukocyte receptor tyrosine kinase"
/db_xref="GeneID:4058"
/db_xref="HGNC:6721"
/db_xref="MIM:151520"
exon 1..221
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(87)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11631555"
misc_feature 122..124
/gene="LTK"
/gene_synonym="TYK1"
/note="upstream in-frame stop codon"
variation complement(133)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372897286"
variation complement(148)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202179022"
variation complement(149)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139430007"
variation complement(163)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200386770"
variation complement(174)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201187554"
CDS 179..2383
/gene="LTK"
/gene_synonym="TYK1"
/EC_number="2.7.10.1"
/note="isoform 3 precursor is encoded by transcript
variant 3; leukocyte tyrosine kinase receptor; protein
tyrosine kinase 1"
/codon_start=1
/product="leukocyte tyrosine kinase receptor isoform 3
precursor"
/protein_id="NP_001129157.1"
/db_xref="GI:208879423"
/db_xref="CCDS:CCDS45237.1"
/db_xref="GeneID:4058"
/db_xref="HGNC:6721"
/db_xref="MIM:151520"
/translation="
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKPPGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWLSSGLKPLKSRGLQPQNLWNPTYRS
"
sig_peptide 179..226
/gene="LTK"
/gene_synonym="TYK1"
mat_peptide 227..2380
/gene="LTK"
/gene_synonym="TYK1"
/product="leukocyte tyrosine kinase receptor isoform 3"
misc_feature 1418..2125
/gene="LTK"
/gene_synonym="TYK1"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:213116"
misc_feature order(1418..1420,1508..1510,1556..1567,1577..1579,
1583..1585,1715..1717,1721..1723,1727..1732,1736..1738,
1778..1780,1787..1789,1841..1852)
/gene="LTK"
/gene_synonym="TYK1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(1418..1420,1508..1510,1556..1567,1577..1579,
1715..1717,1721..1723,1727..1732,1736..1738,1778..1780)
/gene="LTK"
/gene_synonym="TYK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature 1421..2119
/gene="LTK"
/gene_synonym="TYK1"
/note="Protein tyrosine kinase; Region: Pkinase_Tyr;
pfam07714"
/db_xref="CDD:203736"
misc_feature order(1577..1579,1583..1585,1715..1717,1721..1723,
1727..1729,1787..1789,1841..1852)
/gene="LTK"
/gene_synonym="TYK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(1775..1795,1841..1852)
/gene="LTK"
/gene_synonym="TYK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
variation complement(179..180)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:67686933"
variation complement(208)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:150347278"
exon 222..365
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(237)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371616916"
variation complement(256)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:58650201"
variation complement(262)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:56063273"
variation complement(265)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199595844"
variation complement(297)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374021880"
variation complement(299)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140343272"
variation complement(303)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2305030"
variation complement(306..307)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:71431816"
variation complement(325)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144899424"
variation complement(330)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372292312"
variation complement(341)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368397565"
exon 366..537
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(366)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377388642"
variation complement(374)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201734476"
variation complement(398)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374997462"
variation complement(410)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370330041"
variation complement(439)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140771942"
variation complement(442)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377098802"
variation complement(478)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:372924578"
variation complement(488)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:199617843"
variation complement(537)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201107692"
exon 538..688
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(567)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200377822"
variation complement(594)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:371228281"
variation complement(597)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200347907"
variation complement(638)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142529901"
variation complement(655)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148848607"
exon 689..835
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(721)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:113941585"
variation complement(805..806)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="gtggcgggg"
/db_xref="dbSNP:71812607"
variation complement(806..807)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="gtggcgggg"
/db_xref="dbSNP:5812191"
variation complement(813..814)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="ggtggcggg"
/db_xref="dbSNP:34293426"
variation complement(821..822)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:71431815"
exon 836..992
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(858)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55739813"
variation complement(906)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192402541"
exon 993..1091
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(998)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145538913"
variation complement(1000)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150023038"
variation complement(1001)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140090710"
variation complement(1028)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147526720"
variation complement(1065)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144944868"
variation complement(1066)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200847666"
variation complement(1076)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371209349"
exon 1092..1244
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1096)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377698700"
variation complement(1100)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201581050"
variation complement(1106)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141049740"
variation complement(1122)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:150610943"
variation complement(1144)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376133874"
variation complement(1145)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55683312"
exon 1245..1340
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1252)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:10152795"
variation complement(1261)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:56043216"
variation complement(1299)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:75763687"
variation complement(1323)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370151127"
exon 1341..1420
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1343)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141101544"
variation complement(1355)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138110106"
variation complement(1388)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150296915"
exon 1421..1485
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1423)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370616929"
variation complement(1432)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199965576"
variation complement(1436)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:200508070"
variation complement(1440)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201486520"
variation complement(1441)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375203744"
variation complement(1464)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141718457"
variation complement(1477)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373419915"
exon 1486..1615
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1493)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:148513655"
variation complement(1495)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368274639"
variation complement(1512)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377126031"
variation complement(1519)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372785537"
variation complement(1534)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372702626"
variation complement(1544)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202096075"
variation complement(1545)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144858308"
variation complement(1546)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368562166"
variation complement(1574)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375596775"
variation complement(1579)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370064896"
variation complement(1581)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367724896"
variation complement(1590)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:373977718"
variation complement(1605)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141010188"
variation complement(1607)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370582280"
exon 1616..1713
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1640)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149973033"
variation complement(1641)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139262290"
variation complement(1648)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201253904"
variation complement(1649)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200355589"
variation complement(1651)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149800453"
variation complement(1654)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140764829"
variation complement(1666)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:75428074"
variation complement(1667)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201789947"
variation complement(1687)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201048749"
variation complement(1693)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138900025"
variation complement(1697)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:368975307"
variation complement(1710)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:377092265"
variation complement(1713)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200215271"
exon 1714..1806
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1724)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145997165"
variation complement(1728)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142613322"
variation complement(1746)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148048753"
variation complement(1747)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143606508"
variation complement(1748)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148814029"
variation complement(1755)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372848485"
variation complement(1756)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:68185454"
variation complement(1756)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368900972"
variation complement(1761)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367918796"
variation complement(1777)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371592300"
variation complement(1794)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138393348"
variation complement(1796)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374062033"
variation complement(1800)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:377404643"
variation complement(1805)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201289718"
variation complement(1806)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55876255"
exon 1807..1908
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1813)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372223410"
variation complement(1821)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142798669"
variation complement(1822..1823)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:67754618"
variation complement(1825)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:146757784"
variation complement(1833)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141045322"
variation complement(1843)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140642102"
variation complement(1877)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370182079"
variation complement(1882)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375465862"
variation complement(1899)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372800939"
variation complement(1900)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:142986350"
variation complement(1908)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2278658"
exon 1909..2043
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(1914)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148593397"
variation complement(1925)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368310218"
variation complement(1941)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:145702407"
variation complement(1947)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375669533"
variation complement(1959)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200739696"
variation complement(1967)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143635378"
variation complement(1968)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199935291"
variation complement(1997)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140077464"
variation complement(2009)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370375739"
variation complement(2010)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:142515948"
variation complement(2021)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55900837"
exon 2044..2134
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2048)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139153755"
variation complement(2064)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368134355"
variation complement(2072)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370848239"
variation complement(2075)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:76282169"
variation complement(2078)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376706397"
variation complement(2087)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373539281"
variation complement(2088)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369598804"
variation complement(2114)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150790185"
variation complement(2115)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375277507"
exon 2135..2737
/gene="LTK"
/gene_synonym="TYK1"
/inference="alignment:Splign:1.39.8"
variation complement(2140)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141324634"
variation complement(2204)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:367898414"
variation complement(2207..2208)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="g"
/db_xref="dbSNP:71973453"
variation complement(2225)
/gene="LTK"
/gene_synonym="TYK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148281714"
variation complement(2244)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372296391"
variation complement(2248)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201855640"
variation complement(2272)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145757122"
variation complement(2277)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:199957230"
variation complement(2300)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:56367146"
variation complement(2311)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368306708"
variation complement(2322..2323)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:67078727"
variation complement(2327)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200704162"
variation complement(2347)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:143467076"
variation complement(2387..2388)
/gene="LTK"
/gene_synonym="TYK1"
/replace=""
/replace="c"
/db_xref="dbSNP:66782809"
STS 2406..2639
/gene="LTK"
/gene_synonym="TYK1"
/standard_name="RH80861"
/db_xref="UniSTS:85260"
variation complement(2433)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368427145"
variation complement(2479)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187315130"
variation complement(2578)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368815371"
variation complement(2580)
/gene="LTK"
/gene_synonym="TYK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150595531"
variation complement(2677)
/gene="LTK"
/gene_synonym="TYK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:316617"
polyA_signal 2718..2723
/gene="LTK"
/gene_synonym="TYK1"
polyA_site 2737
/gene="LTK"
/gene_synonym="TYK1"
ORIGIN
ggggtctgaggtgggcgtggccagaccagctttaggtccggggagtgtctcgccagcggcagcacacccctgtaagtggtggccagggctgccgtggcaaaatgagctgtcaactttaggttgacaggggtgtggccgcgaccgcaagggcttttgttgccgggtggacccaacagggatgggctgctggggacagctgctggtgtggttcggagccgcgggcgccattctctgctctagcccggggtcccaggagacttttctgcggtcctcgcccctgccgctggcaagtcccagcccccgggacccgaaagtcagcgccccgcctagtatcttggagccagcctccccgctgaattctccgggcaccgaggggtcttggctgttttctacctgcggggccagcggccggcatgggcccacacagacacaatgtgacggggcgtacgcggggaccagcgtggtggtgaccgtgggggccgccgggcagctgagaggcgtgcagctgtggcgcgtgccgggccctggccagtatctgatctcagcctacggagccgcgggcggcaaaggcgccaagaaccacctgtcgcgggcgcatggcgtcttcgtctcagcaatcttctccctcggtctcggggagtcgctgtacatcctggtggggcagcagggagaggacgcctgtcccggaggtagcccggagagccagctcgtctgcctcggggagtctcgagccgttgaagagcacgcggcgatggatgggagcgaaggggtcccggggtcgcggcgctgggcgggaggtggcgggggtggcgggggcgccacctacgttttccgggtgcgcgctggcgagctggaaccgttgctggtggcggccggaggcggcggtcgggcctacctgaggccgcgggaccgaggccggactcaggcctcccccgagaaactggagaaccgctcggaggcgcccgggagcggcgggagaggcggggcggcagggggcgacgcttcagagactgacaacctctgggctgatggggaagatggagtatccttcatacaccccagcagcgagctcttcctgcagcctctggcagtcaccgagaaccacggagaggtagagatccgaaggcacctcaactgcagtcactgccctttgagagactgccaatggcaggcagagctccagctggctgaatgcctgtgcccagaaggcatggagctagctgtggataacgtcacctgcatggacctgcacaagcccccaggccctctggttctgatggtggctgtggtggcaacctcaacactgagcctccttatggtgtgtggggtcctgattctgggtggggcttggcccggcccagtcctggcctctgccaccaggtgtcaccgaggtttccccagccaatgttactctgctcagaccctgccagaactctgctcgcctcaggatgagctggatttcctcatggaggccctcatcatcagcaagtttcgccatcagaacattgtgcggtgtgtggggctcagcctcagggccacccctcgcctcattctgctggaactgatgtctggaggggacatgaagagtttcctgaggcacagtcggccacacctgggccagccatcacctctggtcatgcgggacctgctgcaactggcccaggacatagcccagggctgccactacctggaggaaaatcacttcatccacagggatattgccgcccggaactgcctgctgagctgcgctggacccagccgagtggccaagattggggactttgggatggcacgagatatctaccgggccagttattaccgcaggggggaccgggccttgctcccagtcaagtggatgcccccagaggccttcctggagggcatcttcacatccaagacagattcctggtcttttggggtgctgctctgggagatcttctcactgggctacatgccctatcctgggcgcaccaaccaggaggtgctggacttcgtcgttggaggaggccggatggaccctcctaggggctgcccagggcctgtgtaccgcatcatgacccagtgttggcagcacgagcctgagctccgccctagctttgccagcatcttggagcgtctgcagtactgcactcaggacccggatgtgctgaattcactcctgccaatggagctggggcccaccccagaggaggaagggacttctgggctggggaacagatctttggagtgcctaagacccccacagccccaggaactgagtccagagaagttgaaaagctggggaggtagccctcttggcccctggctgtcctctggcctcaagcccctcaaatccaggggcctccaacctcagaacctttggaatcccacttatcgctcctgagccccaaggggccctgagggtaaggactgaggcactgagggtccctccctatactcctcaggctcctgggtggcctgttatgccagcggcctctgttccctgcagtctgtgctgtgtgtctgggcctgtctcggggctggcctggcagcgctgcacttgccatgctggaaaccagcccaggcctcccagggaagggcccagccacttccagcttttgatcttggggccagaggccgccttacacacaccccaggtgtccatggggagcactggattgctctcccattatgagcatccttcatctgggcagaccccccaccctgcagatgcttctaataaaaagctcttctcatcaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:4058 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:4058 -> Molecular function: GO:0004713 [protein tyrosine kinase activity] evidence: TAS
GeneID:4058 -> Molecular function: GO:0004714 [transmembrane receptor protein tyrosine kinase activity] evidence: IEA
GeneID:4058 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:4058 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:4058 -> Biological process: GO:0006915 [apoptotic process] evidence: IMP
GeneID:4058 -> Biological process: GO:0007165 [signal transduction] evidence: TAS
GeneID:4058 -> Biological process: GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] evidence: IEA
GeneID:4058 -> Biological process: GO:0008283 [cell proliferation] evidence: IDA
GeneID:4058 -> Biological process: GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] evidence: IDA
GeneID:4058 -> Biological process: GO:0010976 [positive regulation of neuron projection development] evidence: IMP
GeneID:4058 -> Biological process: GO:0014065 [phosphatidylinositol 3-kinase cascade] evidence: IMP
GeneID:4058 -> Biological process: GO:0071300 [cellular response to retinoic acid] evidence: IMP
GeneID:4058 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:4058 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:4058 -> Cellular component: GO:0016020 [membrane] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001129157 -> EC 2.7.10.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.