GGRNA | NM_001135092.1

LOCUS       NM_001135092            3259 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens mucin 15, cell surface associated (MUC15), transcript
            variant 3, mRNA.
ACCESSION   NM_001135092
VERSION     NM_001135092.1  GI:205360924
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3259)
  AUTHORS   Dizier,M.H., Margaritte-Jeannin,P., Madore,A.M.,
            Esparza-Gordillo,J., Moffatt,M., Corda,E., Monier,F.,
            Guilloud-Bataille,M., Franke,A., Weidinger,S., Annesi-Maesano,I.,
            Just,J., Pin,I., Kauffmann,F., Cookson,W., Lee,Y.A., Laprise,C.,
            Lathrop,M., Bouzigon,E. and Demenais,F.
  TITLE     The ANO3/MUC15 locus is associated with eczema in families
            ascertained through asthma
  JOURNAL   J. Allergy Clin. Immunol. 129 (6), 1547-1553 (2012)
   PUBMED   22657408
  REMARK    GeneRIF: MUC15 is a strong candidate for eczema.
REFERENCE   2  (bases 1 to 3259)
  AUTHORS   Nam,K.H., Noh,T.W., Chung,S.H., Lee,S.H., Lee,M.K., Hong,S.W.,
            Chung,W.Y., Lee,E.J. and Park,C.S.
  TITLE     Expression of the membrane mucins MUC4 and MUC15, potential markers
            of malignancy and prognosis, in papillary thyroid carcinoma
  JOURNAL   Thyroid 21 (7), 745-750 (2011)
   PUBMED   21615302
  REMARK    GeneRIF: MUC4 and MUC15 were overexpressed in papillary thyroid
            carcinoma, and high MUC15 expression was associated with high
            malignant potential.
REFERENCE   3  (bases 1 to 3259)
  AUTHORS   Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum
            PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM,
            Schadt EE, Hirschhorn JN, Kaplan LM and Daly MJ.
  CONSRTM   GIANT Consortium
  TITLE     Common body mass index-associated variants confer risk of extreme
            obesity
  JOURNAL   Hum. Mol. Genet. 18 (18), 3502-3507 (2009)
   PUBMED   19553259
  REMARK    Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1]
REFERENCE   4  (bases 1 to 3259)
  AUTHORS   Huang,J., Che,M.I., Huang,Y.T., Shyu,M.K., Huang,Y.M., Wu,Y.M.,
            Lin,W.C., Huang,P.H., Liang,J.T., Lee,P.H. and Huang,M.C.
  TITLE     Overexpression of MUC15 activates extracellular signal-regulated
            kinase 1/2 and promotes the oncogenic potential of human colon
            cancer cells
  JOURNAL   Carcinogenesis 30 (8), 1452-1458 (2009)
   PUBMED   19520792
  REMARK    GeneRIF: Overexpression of MUC15 activates extracellular
            signal-regulated kinase 1/2 and promotes the oncogenic potential of
            colon cancer cells.
REFERENCE   5  (bases 1 to 3259)
  AUTHORS   Samuels,T.L., Handler,E., Syring,M.L., Pajewski,N.M., Blumin,J.H.,
            Kerschner,J.E. and Johnston,N.
  TITLE     Mucin gene expression in human laryngeal epithelia: effect of
            laryngopharyngeal reflux
  JOURNAL   Ann. Otol. Rhinol. Laryngol. 117 (9), 688-695 (2008)
   PUBMED   18834073
  REMARK    GeneRIF: Reflux laryngitis is associated with down-regulation of
            mucin gene expression.
REFERENCE   6  (bases 1 to 3259)
  AUTHORS   Shyu,M.K., Lin,M.C., Shih,J.C., Lee,C.N., Huang,J., Liao,C.H.,
            Huang,I.F., Chen,H.Y., Huang,M.C. and Hsieh,F.J.
  TITLE     Mucin 15 is expressed in human placenta and suppresses invasion of
            trophoblast-like cells in vitro
  JOURNAL   Hum. Reprod. 22 (10), 2723-2732 (2007)
   PUBMED   17720698
  REMARK    GeneRIF: MUC15 was expressed most highly in human placenta. MUC15
            mRNA & protein increased with gestational age (P < 0.05, 1st versus
            3rd trimester). Differential expression of MUC15 in human placentas
            may play critical role in regulation of trophoblast invasion.
REFERENCE   7  (bases 1 to 3259)
  AUTHORS   Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z.,
            Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S.,
            McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J.,
            Dunham,I., Hill,D.E. and Vidal,M.
  TITLE     hORFeome v3.1: a resource of human open reading frames representing
            over 10,000 human genes
  JOURNAL   Genomics 89 (3), 307-315 (2007)
   PUBMED   17207965
REFERENCE   8  (bases 1 to 3259)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res. 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 3259)
  AUTHORS   Pallesen,L.T., Berglund,L., Rasmussen,L.K., Petersen,T.E. and
            Rasmussen,J.T.
  TITLE     Isolation and characterization of MUC15, a novel cell
            membrane-associated mucin
  JOURNAL   Eur. J. Biochem. 269 (11), 2755-2763 (2002)
   PUBMED   12047385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA842986.1, AY358668.1, AJ507429.1, AC036114.7 and BU676338.1.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 3' coding region, compared to variant 1. The resulting
            isoform (c) is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ507429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025091 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DA842986.1         1-35
            36-959              AY358668.1         1-924
            960-1512            AJ507429.1         834-1386
            1513-1969           AY358668.1         1628-2084
            1970-3183           AC036114.7         95881-97094         c
            3184-3259           BU676338.1         1-76                c
FEATURES             Location/Qualifiers
     source          1..3259
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.3"
     gene            1..3259
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="mucin 15, cell surface associated"
                     /db_xref="GeneID:143662"
                     /db_xref="HGNC:14956"
                     /db_xref="MIM:608566"
     exon            1..228
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:1.39.8"
     exon            229..316
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:1.39.8"
     CDS             274..1209
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="isoform c is encoded by transcript variant 3;
                     mucin-15"
                     /codon_start=1
                     /product="mucin-15 isoform c"
                     /protein_id="NP_001128564.1"
                     /db_xref="GI:205360925"
                     /db_xref="CCDS:CCDS44556.1"
                     /db_xref="GeneID:143662"
                     /db_xref="HGNC:14956"
                     /db_xref="MIM:608566"
                     /translation="

MGIIQSILATSRDCYSFKKKPIPKKPTMLALAKILLISTLFYSLLSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKENITTSNLKASHSPPLNLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKVPWNAPIADEDLLPISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSVTPLIVEPSGWLTTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKVLRLDNAPEPYDVSFGNSSYYNPTLNDSAMPESEENARDGIPMDDIPPLRTSV

"
     exon            317..1048
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:1.39.8"
     variation       410
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:293979"
     variation       742
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:35317037"
     STS             792..943
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="SGC34286"
                     /db_xref="UniSTS:11092"
     STS             809..937
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="RH16467"
                     /db_xref="UniSTS:40969"
     exon            1049..3242
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:1.39.8"
     STS             1264..1411
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="RH35938"
                     /db_xref="UniSTS:65063"
     STS             1406..1556
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="D11S4348"
                     /db_xref="UniSTS:11588"
     STS             1700..1823
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="RH78143"
                     /db_xref="UniSTS:79408"
     STS             1936..2113
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="RH16157"
                     /db_xref="UniSTS:74325"
     STS             1985..2119
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="A004R23"
                     /db_xref="UniSTS:9525"
     variation       2398..2399
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /replace=""
                     /replace="gt"
                     /db_xref="dbSNP:71047866"
     variation       2399..2406
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /replace=""
                     /replace="gtgtgtgtgt"
                     /db_xref="dbSNP:71311918"
     STS             2735..2867
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /standard_name="RH102097"
                     /db_xref="UniSTS:96431"
ORIGIN

atcttaatgcttacagctgagaagcaggtcagtcaggttcctgggcgctctgttacacaagcaagatacagccagccccacctaattttgtttccctggcaccctcctgctcagtgcgacattgtcacacttaacccatctgttttctctaatgcacgacagattcctttcagacaggacaactgtgatatttcagttcctgattgtaaatacctcctaagcctgaagcttctgttactagccattgtgagcttcagtttcttcatctgcaaaatgggcataatacaatctattcttgccacatcaagggattgttattcctttaaaaaaaaaccaataccaaagaagcctacaatgttggccttagccaaaattctgttgatttcaacgttgttttattcacttctatcggggagccatggaaaagaaaatcaagacataaacacaacacagaacattgcagaagtttttaaaacaatggaaaataaacctatttctttggaaagtgaagcaaacttaaactcagataaagaaaatataaccacctcaaatctcaaggcgagtcattcccctcctttgaatctacccaacaacagccacggaataacagatttctccagtaactcatcagcagagcattctttgggcagtctaaaacccacatctaccatttccacaagccctcccttgatccatagctttgtttctaaagtgccttggaatgcacctatagcagatgaagatcttttgcccatctcagcacatcccaatgctacacctgctctgtcttcagaaaacttcacttggtctttggtcaatgacaccgtgaaaactcctgataacagttccattacagttagcatcctctcttcagaaccaacttctccatctgtgacccccttgatagtggaaccaagtggatggcttaccacaaacagtgatagcttcactgggtttaccccttatcaagaaaaaacaactctacagcctaccttaaaattcaccaataattcaaaactctttccaaatacgtcagatccccaaaaagttctgcgattagacaatgcaccggaaccttatgatgtgagttttgggaattctagctactacaatccaactttgaatgattcagccatgccagaaagtgaagaaaatgcacgtgatggcattcctatggatgacatacctccacttcgtacttctgtatagaactaacagcaaaaaggcgttaaacagcaagtgtcatctacatcctagccttttgacaaattcatctttcaaaaggttacacaaaattactgtcacgtggattttgtcaaggagaatcataaaagcaggagaccagtagcagaaatgtagacaggatgtatcatccaaaggttttctttcttacaatttttggccatcctgaggcatttactaagtagccttaatttgtattttagtagtattttcttagtagaaaatatttgtggaatcagataaaactaaaagatttcaccattacagccctgcctcataactaaataataaaaattattccaccaaaaaattctaaaacaatgaagatgactctttactgctctgcctgaagccctagtaccataattcaagattgcattttcttaaatgaaaattgaaagggtgctttttaaagaaaatttgacttaaagctaaaaagaggacatagcccagagtttctgttattgggaaattgaggcaatagaaatgacagacctgtattctagtacgttataattttctagatcagcacacacatgatcagcccactgagttatgaagctgacaatgactgcattcaacggggccatggcaggaaagctgaccctacccaggaaagtaatagcttctttaaaagtcttcaaaggttttgggaattttaacttgtcttaatatatcttaggcttcaattatttgggtgccttaaaaactcaatgagaatcatggtaaaaaaaaaaagttaaccaaagaatatacctgtacataatttgtacagttttaagttgttagataggaactggatttcttatgtattagacattattgctcaatcataatggaatagattctgcatccctaaatgtatgaaccataaggttaaaaaagatgaatggaaatatcaaacaactttttactgagcatcagtttcataatcaataatataagaagattaatttggattctagtatgtttcagtttgtttttaattaccaccttcctttggtagaaaaaatatgttccttgatgtaggaaagtctaggttttagagattagaggatgagatcaagagttaaattcctaaagaagcactgaatatatgaagagagcaaacaaatcaagtaccaacctagaggctttatttttgaattgattcatggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaacacagaaacagcttcagaaaataagggatagaaagtaatgaagaaagtacttaccccatattgccataaaaatagcaaagaagactgtccctccattatcgaacaaatatgtcacctgagtagaaaacaaacagaaatattagtcatgcaaattgattataataagccagtgaatactgtttgcactcaggtactatgattttttctcaaatagaatcatattattttatagtacagaaatattatatatgaattcctttcatgggtcttgcaacaatttcacatgatttttctcatggggagaggtgaagaaacaacattagccctcttctctcctctcttgattccctttataccccaccatcatttctgattataaataattctaccattctatggaagtatttgtgggtcacagattgtcaaactacttaatgaaagttgtatgaaattagtttttcaggtgaggcattcctagttgcaattcctgttagcaaaacttctaggagtggggaagttggaaaatgcaggattcttccagtgagccagcatttcccatagctaaccctattctcttagtctttcaaaatgtagaatgggtccaataatggctataagatgtaataaatcccatcttaatttgttttaaaagtttcataaatcactgaacacttatgaaacaaagtgttttttaatcagatatcaactgaaacttcataaaggatgcatagttttataatgttattgaatcaaattttaaggcttgtattgtttgattttaataaagtataaattcaatttaaaaaaaaaaaaaaaaaa

//

Annotations: