2024-04-24 16:57:29, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001135092 3259 bp mRNA linear PRI 07-JUL-2013 DEFINITION Homo sapiens mucin 15, cell surface associated (MUC15), transcript variant 3, mRNA. ACCESSION NM_001135092 VERSION NM_001135092.1 GI:205360924 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3259) AUTHORS Dizier,M.H., Margaritte-Jeannin,P., Madore,A.M., Esparza-Gordillo,J., Moffatt,M., Corda,E., Monier,F., Guilloud-Bataille,M., Franke,A., Weidinger,S., Annesi-Maesano,I., Just,J., Pin,I., Kauffmann,F., Cookson,W., Lee,Y.A., Laprise,C., Lathrop,M., Bouzigon,E. and Demenais,F. TITLE The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma JOURNAL J. Allergy Clin. Immunol. 129 (6), 1547-1553 (2012) PUBMED 22657408 REMARK GeneRIF: MUC15 is a strong candidate for eczema. REFERENCE 2 (bases 1 to 3259) AUTHORS Nam,K.H., Noh,T.W., Chung,S.H., Lee,S.H., Lee,M.K., Hong,S.W., Chung,W.Y., Lee,E.J. and Park,C.S. TITLE Expression of the membrane mucins MUC4 and MUC15, potential markers of malignancy and prognosis, in papillary thyroid carcinoma JOURNAL Thyroid 21 (7), 745-750 (2011) PUBMED 21615302 REMARK GeneRIF: MUC4 and MUC15 were overexpressed in papillary thyroid carcinoma, and high MUC15 expression was associated with high malignant potential. REFERENCE 3 (bases 1 to 3259) AUTHORS Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, Lum PY, Suver C, Chudin E, Kemp D, Reitman M, Voight BF, Neale BM, Schadt EE, Hirschhorn JN, Kaplan LM and Daly MJ. CONSRTM GIANT Consortium TITLE Common body mass index-associated variants confer risk of extreme obesity JOURNAL Hum. Mol. Genet. 18 (18), 3502-3507 (2009) PUBMED 19553259 REMARK Erratum:[Hum Mol Genet. 2010 Sep 15;19(18):3690-1] REFERENCE 4 (bases 1 to 3259) AUTHORS Huang,J., Che,M.I., Huang,Y.T., Shyu,M.K., Huang,Y.M., Wu,Y.M., Lin,W.C., Huang,P.H., Liang,J.T., Lee,P.H. and Huang,M.C. TITLE Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of human colon cancer cells JOURNAL Carcinogenesis 30 (8), 1452-1458 (2009) PUBMED 19520792 REMARK GeneRIF: Overexpression of MUC15 activates extracellular signal-regulated kinase 1/2 and promotes the oncogenic potential of colon cancer cells. REFERENCE 5 (bases 1 to 3259) AUTHORS Samuels,T.L., Handler,E., Syring,M.L., Pajewski,N.M., Blumin,J.H., Kerschner,J.E. and Johnston,N. TITLE Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux JOURNAL Ann. Otol. Rhinol. Laryngol. 117 (9), 688-695 (2008) PUBMED 18834073 REMARK GeneRIF: Reflux laryngitis is associated with down-regulation of mucin gene expression. REFERENCE 6 (bases 1 to 3259) AUTHORS Shyu,M.K., Lin,M.C., Shih,J.C., Lee,C.N., Huang,J., Liao,C.H., Huang,I.F., Chen,H.Y., Huang,M.C. and Hsieh,F.J. TITLE Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro JOURNAL Hum. Reprod. 22 (10), 2723-2732 (2007) PUBMED 17720698 REMARK GeneRIF: MUC15 was expressed most highly in human placenta. MUC15 mRNA & protein increased with gestational age (P < 0.05, 1st versus 3rd trimester). Differential expression of MUC15 in human placentas may play critical role in regulation of trophoblast invasion. REFERENCE 7 (bases 1 to 3259) AUTHORS Lamesch,P., Li,N., Milstein,S., Fan,C., Hao,T., Szabo,G., Hu,Z., Venkatesan,K., Bethel,G., Martin,P., Rogers,J., Lawlor,S., McLaren,S., Dricot,A., Borick,H., Cusick,M.E., Vandenhaute,J., Dunham,I., Hill,D.E. and Vidal,M. TITLE hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes JOURNAL Genomics 89 (3), 307-315 (2007) PUBMED 17207965 REFERENCE 8 (bases 1 to 3259) AUTHORS Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J., Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B., Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E., Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S., Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C., Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V., Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K., Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z., Goddard,A., Wood,W.I., Godowski,P. and Gray,A. TITLE The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment JOURNAL Genome Res. 13 (10), 2265-2270 (2003) PUBMED 12975309 REMARK Erratum:[Genome Res. 2003 Dec;13(12):2759] REFERENCE 9 (bases 1 to 3259) AUTHORS Pallesen,L.T., Berglund,L., Rasmussen,L.K., Petersen,T.E. and Rasmussen,J.T. TITLE Isolation and characterization of MUC15, a novel cell membrane-associated mucin JOURNAL Eur. J. Biochem. 269 (11), 2755-2763 (2002) PUBMED 12047385 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA842986.1, AY358668.1, AJ507429.1, AC036114.7 and BU676338.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a. ##Evidence-Data-START## Transcript exon combination :: AJ507429.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084, ERS025091 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-35 DA842986.1 1-35 36-959 AY358668.1 1-924 960-1512 AJ507429.1 834-1386 1513-1969 AY358668.1 1628-2084 1970-3183 AC036114.7 95881-97094 c 3184-3259 BU676338.1 1-76 c FEATURES Location/Qualifiers source 1..3259 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p14.3" gene 1..3259 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /note="mucin 15, cell surface associated" /db_xref="GeneID:143662" /db_xref="HGNC:14956" /db_xref="MIM:608566" exon 1..228 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /inference="alignment:Splign:1.39.8" exon 229..316 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /inference="alignment:Splign:1.39.8" CDS 274..1209 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /note="isoform c is encoded by transcript variant 3; mucin-15" /codon_start=1 /product="mucin-15 isoform c" /protein_id="NP_001128564.1" /db_xref="GI:205360925" /db_xref="CCDS:CCDS44556.1" /db_xref="GeneID:143662" /db_xref="HGNC:14956" /db_xref="MIM:608566" /translation="
MGIIQSILATSRDCYSFKKKPIPKKPTMLALAKILLISTLFYSLLSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKENITTSNLKASHSPPLNLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKVPWNAPIADEDLLPISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSVTPLIVEPSGWLTTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKVLRLDNAPEPYDVSFGNSSYYNPTLNDSAMPESEENARDGIPMDDIPPLRTSV
" exon 317..1048 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /inference="alignment:Splign:1.39.8" variation 410 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /replace="c" /replace="g" /db_xref="dbSNP:293979" variation 742 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /replace="a" /replace="g" /db_xref="dbSNP:35317037" STS 792..943 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="SGC34286" /db_xref="UniSTS:11092" STS 809..937 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="RH16467" /db_xref="UniSTS:40969" exon 1049..3242 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /inference="alignment:Splign:1.39.8" STS 1264..1411 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="RH35938" /db_xref="UniSTS:65063" STS 1406..1556 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="D11S4348" /db_xref="UniSTS:11588" STS 1700..1823 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="RH78143" /db_xref="UniSTS:79408" STS 1936..2113 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="RH16157" /db_xref="UniSTS:74325" STS 1985..2119 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="A004R23" /db_xref="UniSTS:9525" variation 2398..2399 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /replace="" /replace="gt" /db_xref="dbSNP:71047866" variation 2399..2406 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:71311918" STS 2735..2867 /gene="MUC15" /gene_synonym="MUC-15; PAS3; PASIII" /standard_name="RH102097" /db_xref="UniSTS:96431" ORIGIN
atcttaatgcttacagctgagaagcaggtcagtcaggttcctgggcgctctgttacacaagcaagatacagccagccccacctaattttgtttccctggcaccctcctgctcagtgcgacattgtcacacttaacccatctgttttctctaatgcacgacagattcctttcagacaggacaactgtgatatttcagttcctgattgtaaatacctcctaagcctgaagcttctgttactagccattgtgagcttcagtttcttcatctgcaaaatgggcataatacaatctattcttgccacatcaagggattgttattcctttaaaaaaaaaccaataccaaagaagcctacaatgttggccttagccaaaattctgttgatttcaacgttgttttattcacttctatcggggagccatggaaaagaaaatcaagacataaacacaacacagaacattgcagaagtttttaaaacaatggaaaataaacctatttctttggaaagtgaagcaaacttaaactcagataaagaaaatataaccacctcaaatctcaaggcgagtcattcccctcctttgaatctacccaacaacagccacggaataacagatttctccagtaactcatcagcagagcattctttgggcagtctaaaacccacatctaccatttccacaagccctcccttgatccatagctttgtttctaaagtgccttggaatgcacctatagcagatgaagatcttttgcccatctcagcacatcccaatgctacacctgctctgtcttcagaaaacttcacttggtctttggtcaatgacaccgtgaaaactcctgataacagttccattacagttagcatcctctcttcagaaccaacttctccatctgtgacccccttgatagtggaaccaagtggatggcttaccacaaacagtgatagcttcactgggtttaccccttatcaagaaaaaacaactctacagcctaccttaaaattcaccaataattcaaaactctttccaaatacgtcagatccccaaaaagttctgcgattagacaatgcaccggaaccttatgatgtgagttttgggaattctagctactacaatccaactttgaatgattcagccatgccagaaagtgaagaaaatgcacgtgatggcattcctatggatgacatacctccacttcgtacttctgtatagaactaacagcaaaaaggcgttaaacagcaagtgtcatctacatcctagccttttgacaaattcatctttcaaaaggttacacaaaattactgtcacgtggattttgtcaaggagaatcataaaagcaggagaccagtagcagaaatgtagacaggatgtatcatccaaaggttttctttcttacaatttttggccatcctgaggcatttactaagtagccttaatttgtattttagtagtattttcttagtagaaaatatttgtggaatcagataaaactaaaagatttcaccattacagccctgcctcataactaaataataaaaattattccaccaaaaaattctaaaacaatgaagatgactctttactgctctgcctgaagccctagtaccataattcaagattgcattttcttaaatgaaaattgaaagggtgctttttaaagaaaatttgacttaaagctaaaaagaggacatagcccagagtttctgttattgggaaattgaggcaatagaaatgacagacctgtattctagtacgttataattttctagatcagcacacacatgatcagcccactgagttatgaagctgacaatgactgcattcaacggggccatggcaggaaagctgaccctacccaggaaagtaatagcttctttaaaagtcttcaaaggttttgggaattttaacttgtcttaatatatcttaggcttcaattatttgggtgccttaaaaactcaatgagaatcatggtaaaaaaaaaaagttaaccaaagaatatacctgtacataatttgtacagttttaagttgttagataggaactggatttcttatgtattagacattattgctcaatcataatggaatagattctgcatccctaaatgtatgaaccataaggttaaaaaagatgaatggaaatatcaaacaactttttactgagcatcagtttcataatcaataatataagaagattaatttggattctagtatgtttcagtttgtttttaattaccaccttcctttggtagaaaaaatatgttccttgatgtaggaaagtctaggttttagagattagaggatgagatcaagagttaaattcctaaagaagcactgaatatatgaagagagcaaacaaatcaagtaccaacctagaggctttatttttgaattgattcatggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaacacagaaacagcttcagaaaataagggatagaaagtaatgaagaaagtacttaccccatattgccataaaaatagcaaagaagactgtccctccattatcgaacaaatatgtcacctgagtagaaaacaaacagaaatattagtcatgcaaattgattataataagccagtgaatactgtttgcactcaggtactatgattttttctcaaatagaatcatattattttatagtacagaaatattatatatgaattcctttcatgggtcttgcaacaatttcacatgatttttctcatggggagaggtgaagaaacaacattagccctcttctctcctctcttgattccctttataccccaccatcatttctgattataaataattctaccattctatggaagtatttgtgggtcacagattgtcaaactacttaatgaaagttgtatgaaattagtttttcaggtgaggcattcctagttgcaattcctgttagcaaaacttctaggagtggggaagttggaaaatgcaggattcttccagtgagccagcatttcccatagctaaccctattctcttagtctttcaaaatgtagaatgggtccaataatggctataagatgtaataaatcccatcttaatttgttttaaaagtttcataaatcactgaacacttatgaaacaaagtgttttttaatcagatatcaactgaaacttcataaaggatgcatagttttataatgttattgaatcaaattttaaggcttgtattgtttgattttaataaagtataaattcaatttaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:143662 -> Biological process: GO:0016266 [O-glycan processing] evidence: TAS GeneID:143662 -> Biological process: GO:0043687 [post-translational protein modification] evidence: TAS GeneID:143662 -> Biological process: GO:0044267 [cellular protein metabolic process] evidence: TAS GeneID:143662 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA GeneID:143662 -> Cellular component: GO:0005796 [Golgi lumen] evidence: TAS GeneID:143662 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA GeneID:143662 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
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