GGRNA | NM_001135032.1

LOCUS       NM_001135032            1872 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens eva-1 homolog A (C. elegans) (EVA1A), transcript
            variant 1, mRNA.
ACCESSION   NM_001135032
VERSION     NM_001135032.1  GI:205277348
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1872)
  AUTHORS   Kamboh,M.I., Wang,X., Kao,A.H., Barmada,M.M., Clarke,A.,
            Ramsey-Goldman,R., Manzi,S. and Demirci,F.Y.
  TITLE     Genome-wide association study of antiphospholipid antibodies
  JOURNAL   Autoimmune Dis 2013, 761046 (2013)
   PUBMED   23509613
REFERENCE   2  (bases 1 to 1872)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 1872)
  AUTHORS   Sun,W., Ma,X.M., Bai,J.P., Zhang,G.Q., Zhu,Y.J., Ma,H.M., Guo,H.,
            Chen,Y.Y. and Ding,J.B.
  TITLE     Transmembrane protein 166 expression in esophageal squamous cell
            carcinoma in Xinjiang, China
  JOURNAL   Asian Pac. J. Cancer Prev. 13 (8), 3713-3716 (2012)
   PUBMED   23098460
  REMARK    GeneRIF: Low TMEM166 mRNA and protein expression is associated with
            esophageal squamous cell carcinoma.
REFERENCE   4  (bases 1 to 1872)
  AUTHORS   Wang,L., Yu,C., Lu,Y., He,P., Guo,J., Zhang,C., Song,Q., Ma,D.,
            Shi,T. and Chen,Y.
  TITLE     TMEM166, a novel transmembrane protein, regulates cell autophagy
            and apoptosis
  JOURNAL   Apoptosis 12 (8), 1489-1502 (2007)
   PUBMED   17492404
  REMARK    GeneRIF: TMEM166 is a novel regulator involved in both autophagy
            and apoptosis.
REFERENCE   5  (bases 1 to 1872)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP276065.1, BE892427.1, BC016157.1 and AW016395.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016157.1, BU526860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025097 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               BP276065.1         1-150
            151-356             BE892427.1         103-308
            357-1703            BC016157.1         293-1639
            1704-1872           AW016395.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..1872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..1872
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="eva-1 homolog A (C. elegans)"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:25816"
     exon            1..287
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    116..118
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="upstream in-frame stop codon"
     exon            288..410
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     variation       354
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11538748"
     exon            411..563
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     CDS             479..937
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /note="transmembrane protein 166; protein FAM176A; family
                     with sequence similarity 176, member A"
                     /codon_start=1
                     /product="protein eva-1 homolog A"
                     /protein_id="NP_001128504.1"
                     /db_xref="GI:205277349"
                     /db_xref="CCDS:CCDS1959.1"
                     /db_xref="GeneID:84141"
                     /db_xref="HGNC:25816"
                     /translation="

MRLPLSHSPEHVEMALLSNILAAYSFVSENPERAALYFVSGVCIGLVLTLAALVIRISCHTDCRRRPGKKFLQDRESSSDSSDSEDGSEDTVSDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY

"
     misc_feature    479..658
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H8M9.1);
                     Region: Necessary for the localization and biological
                     activity"
     misc_feature    581..643
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H8M9.1);
                     transmembrane region"
     exon            564..1855
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /inference="alignment:Splign:1.39.8"
     STS             1142..1339
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /standard_name="RH69495"
                     /db_xref="UniSTS:80382"
     variation       1813
                     /gene="EVA1A"
                     /gene_synonym="FAM176A; TMEM166"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2215872"
ORIGIN

aaggaaatgagacaaccttttcctcccactgactcgggctcctgcagcttctgcggggcttggcgccgccgtccgtgagcacccaggccgggaccccacatccccaggccagccctgaccccggcggcccctccgccgggattcctttccgaggtactggtgccggcccaagacccgggcagcgctttgtcgtgtccgcccctcagtgatcagctccgggtccccctgctcggccccgcgcgccccaagcgcagtccccggaagtgcgcgccggggccccagcaaagagtctgagaagccaactggggccaaacaagttttagaacctctactggctgatgccaacatcatcagagatgaactgttcttaccagaaacttctctgctcctgacaccccacctctccccagaagagaagaaggagagtggccacgttgattcagccaagcacctccaggaggtcccctctggatgtcccatgaggctgcccctcagccacagcccagagcacgtggagatggctttgctcagcaacatcctagcggcctattcctttgtctcagaaaatcctgagcgagcagctctgtactttgtttctggcgtgtgcatcgggctggtgctgaccctggctgctctggtgataaggatctcttgccacacagactgcaggcggcgtcccgggaagaagttcctgcaggacagagagagcagcagcgacagcagcgacagcgaggatggcagtgaggacaccgtgtccgatctctccgtgcggagacaccgccgcttcgagaggactttgaacaagaatgtgttcacctctgcggaggagctggagcgcgcccagcggctggaggagcgcgagcgcatcatcagggagatctggatgaatggccagcctgaggtgcccgggaccaggagcctgaatcgctactattagggagcagcaggaccccggaaaccactggaggccgcctggaaaggagagcgtctgcagggacagtgggcacaaggaactgaacccagctctgctaatattgtgatttcagagaaaaagcaggacatgccccttttctagccaggaggattgctcctttttggccaaatgtatggagaagtagaaaaatcaaagcagttcatcaccctttccaggtctcggaatggtgctgaaaaatcctctccaacactgtggatggagatcggagaaacgcgactgtggtttctcttgatttctgaggatctcagaagtttcagcagacttccttgctctgtgttattcctttgcaaaaggaaagatcattatagcatgagggctgggaatagcagggtgaacttaacccaataaatgcaatttcctaaatgacttcatgctatggaggtgattctgattcaaatagcatgatccatgcttattatttaaggctgatttttaaaatcttgtgttgcaagggcaacctcgtccattttaactggcacctcagggattaaaatcctactttttagtgtagttcccacctcattcatgaaaatgaatagaactattgtattatgggagatgtgtcagtgaactagaaaatgtcaataacctcaaaggatgaagggtttttattttaaatagtttataaaatatatattgacatgcatatttgaaaatgctgcataaaaataaaagtggtgtgttttccccctctttggagacaagaaaattttattatgactctagataattgtgattttaaacactttgtttttttttttttttttaattggatttcaaagaaaagaatggaaatgagaggtaaggattaaagccaaagttaggatgggaattaaaaaaataaacattacataaaatcttaaaaaaaaaaaaaaaaa

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