2024-04-27 05:31:57, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001134870 2969 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens protein phosphatase 1, regulatory subunit 18 (PPP1R18), transcript variant 2, mRNA. ACCESSION NM_001134870 XM_003119436 VERSION NM_001134870.1 GI:199559804 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2969) AUTHORS Lin,Y.S., Huang,K.Y., Wang,T.F., Huang,H.L., Yu,H.C., Yen,J.Y., Hung,S.H., Liu,S.Q., Lai,N.S. and Huang,H.B. TITLE Immunolocalization of phostensin in lymphatic cells and tissues JOURNAL J. Histochem. Cytochem. 59 (8), 741-749 (2011) PUBMED 21804078 REMARK GeneRIF: phostensin is a ubiquitous protein in leukocytes, and it may play an important role in modulating the cellular functions of leukocytes. REFERENCE 2 (bases 1 to 2969) AUTHORS Lai,N.S., Wang,T.F., Wang,S.L., Chen,C.Y., Yen,J.Y., Huang,H.L., Li,C., Huang,K.Y., Liu,S.Q., Lin,T.H. and Huang,H.B. TITLE Phostensin caps to the pointed end of actin filaments and modulates actin dynamics JOURNAL Biochem. Biophys. Res. Commun. 387 (4), 676-681 (2009) PUBMED 19622346 REMARK GeneRIF: phostensin is an actin filament pointed end-capping protein that is capable of modulating actin dynamics. REFERENCE 3 (bases 1 to 2969) AUTHORS Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A., Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A., Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G., Harley,J.B., Gaffney,P.M. and Criswell,L.A. TITLE High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions JOURNAL PLoS Genet. 5 (10), E1000696 (2009) PUBMED 19851445 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 2969) AUTHORS Kao,S.C., Chen,C.Y., Wang,S.L., Yang,J.J., Hung,W.C., Chen,Y.C., Lai,N.S., Liu,H.T., Huang,H.L., Chen,H.C., Lin,T.H. and Huang,H.B. TITLE Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit JOURNAL Biochem. Biophys. Res. Commun. 356 (3), 594-598 (2007) PUBMED 17374523 REMARK GeneRIF: our data shows that phostensin targets PP1 to F-actin cytoskeleton. REFERENCE 5 (bases 1 to 2969) AUTHORS Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E., Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P. TITLE Large-scale characterization of HeLa cell nuclear phosphoproteins JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135 (2004) PUBMED 15302935 REFERENCE 6 (bases 1 to 2969) AUTHORS Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y., Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y., Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N. and Nakagawara,A. TITLE Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas JOURNAL Oncogene 23 (35), 5901-5911 (2004) PUBMED 15221005 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA788428.1, BX647622.1 and BC006176.1. On Nov 16, 2010 this sequence version replaced gi:310125191. Summary: Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BX647622.1, AB073600.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025083 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-100 DA788428.1 1-100 101-2839 BX647622.1 1-2739 2840-2969 BC006176.1 1294-1423 FEATURES Location/Qualifiers source 1..2969 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="6" /map="6p21.3" gene 1..2969 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /note="protein phosphatase 1, regulatory subunit 18" /db_xref="GeneID:170954" /db_xref="HGNC:29413" /db_xref="MIM:610990" exon 1..203 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /inference="alignment:Splign:1.39.8" exon 204..1842 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /inference="alignment:Splign:1.39.8" CDS 232..2073 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /note="protein phosphatase 1 regulatory subunit 18; protein phosphatase 1 F-actin cytoskeleton targeting subunit" /codon_start=1 /product="phostensin" /protein_id="NP_001128342.1" /db_xref="GI:199559805" /db_xref="CCDS:CCDS43444.1" /db_xref="GeneID:170954" /db_xref="HGNC:29413" /db_xref="MIM:610990" /translation="
MATIPDWKLQLLARRRQEEASVRGREKAERERLSQMPAWKRGLLERRRAKLGLSPGEPSPVLGTVEAGPPDPDESAVLLEAIGPVHQNRFIRQERQQQQQQQQRSEELLAERKPGPLEARERRPSPGEMRDQSPKGRESREERLSPRETRERRLGIGGAQELSLRPLEARDWRQSPGEVGDRSSRLSEAWKWRLSPGETPERSLRLAESREQSPRRKEVESRLSPGESAYQKLGLTEAHKWRPDSRESQEQSLVQLEATEWRLRSGEERQDYSEECGRKEEWPVPGVAPKETAELSETLTREAQGNSSAGVEAAEQRPVEDGERGMKPTEGWKWTLNSGKAREWTPRDIEAQTQKPEPPESAEKLLESPGVEAGEGEAEKEEAGAQGRPLRALQNCCSVPSPLPPEDAGTGGLRQQEEEAVELQPPPPAPLSPPPPAPTAPQPPGDPLMSRLFYGVKAGPGVGAPRRSGHTFTVNPRRSVPPATPATPTSPATVDAAVPGAGKKRYPTAEEILVLGGYLRLSRSCLAKGSPERHHKQLKISFSETALETTYQYPSESSVLEELGPEPEVPSAPNPPAAQPDDEEDEEELLLLQPELQGGLRTKALIVDESCRR
" misc_feature 313..579 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /note="PP1-regulatory protein, Phostensin N-terminal; Region: Phostensin_N; pfam13916" /db_xref="CDD:206087" misc_feature 391..393 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 628..630 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 754..756 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 814..816 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 826..828 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphothreonine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 901..903 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 1333..1335 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (Q6NYC8.1); phosphorylation site" misc_feature 1564..1890 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /note="Phostensin PP1-binding and SH3-binding region; Region: Phostensin; pfam13914" /db_xref="CDD:206085" variation 1155 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /replace="c" /replace="t" /db_xref="dbSNP:2269706" exon 1843..2053 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /inference="alignment:Splign:1.39.8" exon 2054..2953 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /inference="alignment:Splign:1.39.8" STS 2359..2463 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /standard_name="D6S1376" /db_xref="UniSTS:153697" variation 2595 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /replace="c" /replace="t" /db_xref="dbSNP:2269707" STS 2743..2948 /gene="PPP1R18" /gene_synonym="HKMT1098; KIAA1949" /standard_name="RH81008" /db_xref="UniSTS:88485" ORIGIN
cttagacaaagcggtcgccgcccccgcccggccccctggtctctgtctccgtccctcctcctttgctgcctctttccctcctcctctccctccctcctcccctccctccagtctccggatctccctcggtccctctctcctcctcttcctctctctggacgcccggctcctccgcaccccctcccccgggggtcccgcggccttgctccctaccctcacctcaagacgaccatggccaccatcccagactggaagctacagctgctagcccggcgccggcaggaggaggcgtccgttcgaggccgagagaaagcagaacgggagcgcctgtcccagatgccagcctggaaacgagggctcctggagcgccgccgggccaagcttgggctgtcccctggggagcctagccctgtgctagggactgtagaggctggacctccagacccggatgagtctgcggtccttctggaggccatcgggccagtgcaccagaaccgattcatccggcaggagcggcagcagcagcagcagcaacaacaacggagtgaagagctgctagcagagagaaagcctgggcctctggaggcccgggagcggagacccagccctggggagatgcgggatcagagccccaagggaagagagtcaagagaagagagactaagtccgagggagaccagagagaggaggctggggatagggggagcccaagagttgagcctgaggcctctggaggctcgggactggaggcaaagcccaggagaggtgggagacaggagctcccgactgtcagaggcatggaaatggaggctgagtcctggagaaactccagagcggagtctgagactagcagagtctcgagagcaaagccccaggagaaaagaggtggaaagtagactgagcccaggggaatctgcctaccagaagttgggcctgacagaggcccataaatggagacctgactccagagagtctcaggaacagagtttggtacaactggaggcaacagagtggaggctgaggtcaggagaagaaagacaagactactcggaagaatgtgggagaaaagaagagtggccagttccaggggtagctccaaaagagactgcagagctgtccgagaccctgacaagggaggcccaaggcaacagttccgcaggagtggaggcagcagagcagaggcctgtggaagatggcgagaggggcatgaagccaacagaagggtggaaatggaccctgaactccgggaaggctcgagaatggacacccagggacatagaggctcaaactcagaaaccagaacctccagagtcagcagagaagcttctggaatctcccggtgtggaggctggagaaggggaggctgagaaggaggaggcgggggctcagggcaggcctctgagagccctgcagaactgctgctctgtgccctcccccctcccaccagaggacgctgggactggaggcctgagacagcaggaagaggaagcagtggagctccagcccccaccaccagcccctctgtctcccccacccccagccccaactgccccccaacctcctggggatcccctcatgagccgcctgttctatggggtgaaggcagggccaggggtgggggccccccgccgcagtggacacaccttcaccgtcaacccccggcggtctgtgccccctgcgaccccagccaccccaacctctccagccacagttgatgctgcagtcccgggggctgggaagaagcggtacccaactgccgaggagatcttggttctggggggctacctccgtctcagccgcagctgccttgccaaggggtcccccgaaagacaccacaaacagcttaagatctccttcagcgagacagccctggagaccacgtaccaatacccctccgagagttcggtactggaggagctgggcccggagcctgaggtccccagtgcccccaaccctccagcagcccaacccgacgacgaagaggatgaggaagagctgctgctgctgcagccagagctccagggcgggctgcgcaccaaggccctgattgtggatgagtcctgccggcggtgaccatcttccaacatagggatatacctccctccttcttataactgaagatcctggagcccggaagattcagggcagacagaccctgataatgagcctggcagggaagggcaaccaacatcttgtaacttgctttccccaccctgtttctgggggcagagccaattgcccaatttctaccctaatccaaagtccctggtgtgggtggggttaaacgtgctggtgcatcctaggtcatccaagagtgagcgccaagtcctgagaaggggcacagaactccctggagggtggagatggagcacctgccccccatggcagggtacactctccccacagccttcctccccaccatcccgtggggactctcgggatttaagcactcgtctctctgggaggcccagaccccactccatttataggcacatctccttcatttcctaggtcactgcccctttgtttacagctcctgcctcctcccttgaccacagcctggtttacaaattccatcagctcccagccccacctgccaaagtcccaggtttacaagccacgcttacttgctgtgtctgcgtggaattctctcctctgtcccctccagtctcctcattggagtgacctgaaggtgtggcttcctccactttttctcagtattactttgccttagttttccccaagagggaaggctggaactcttaactctgtaccccttgatagttatttaattctgtttctcctagtggttcacaattgaactgaattgagatggtgtcgggtggctaaggagacacctcacctctccttccccattgtgccgcctttatcaattgcctgttttgttttgtttgttttttaactttccataataaaatggagttctcttcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:170954 -> Molecular function: GO:0003779 [actin binding] evidence: IEA GeneID:170954 -> Molecular function: GO:0019902 [phosphatase binding] evidence: IEA GeneID:170954 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA GeneID:170954 -> Cellular component: GO:0005856 [cytoskeleton] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.