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2024-03-28 22:53:13, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001134462            1448 bp    mRNA    linear   PRI 18-APR-2013
DEFINITION  Homo sapiens notochord homeobox (NOTO), mRNA.
ACCESSION   NM_001134462 XM_001719354 XM_292889 XM_941998
VERSION     NM_001134462.1  GI:197333836
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Abdelkhalek,H.B., Beckers,A., Schuster-Gossler,K., Pavlova,M.N.,
            Burkhardt,H., Lickert,H., Rossant,J., Reinhardt,R., Schalkwyk,L.C.,
            Muller,I., Herrmann,B.G., Ceolin,M., Rivera-Pomar,R. and Gossler,A.
  TITLE     The mouse homeobox gene Not is required for caudal notochord
            development and affected by the truncate mutation
  JOURNAL   Genes Dev. 18 (14), 1725-1736 (2004)
   PUBMED   15231714
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK295936.1.
            On or before Sep 4, 2008 this sequence version replaced
            gi:169164049, gi:88955180, gi:51460702.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK295936.1, AK316410.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.2"
     gene            1..1448
                     /gene="NOTO"
                     /note="notochord homeobox"
                     /db_xref="GeneID:344022"
                     /db_xref="HGNC:31839"
     exon            1..791
                     /gene="NOTO"
                     /inference="alignment:Splign:1.39.8"
     variation       54..56
                     /gene="NOTO"
                     /replace=""
                     /replace="aag"
                     /db_xref="dbSNP:200690845"
     variation       176
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:376444482"
     variation       209
                     /gene="NOTO"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370757843"
     variation       357
                     /gene="NOTO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:60009779"
     CDS             410..1165
                     /gene="NOTO"
                     /note="notochord homolog"
                     /codon_start=1
                     /product="homeobox protein notochord"
                     /protein_id="NP_001127934.1"
                     /db_xref="GI:197333837"
                     /db_xref="CCDS:CCDS46335.1"
                     /db_xref="GeneID:344022"
                     /db_xref="HGNC:31839"
                     /translation="
MPSPRPRGSPPPAPSGSRVRPPRSGRSPAPRSPTGPNTPRAPGRFESPFSVEAILARPDPCAPAASQPSGSACVHPAFWTAASLCATGGLPWACPTSWLPAYLSVGFYPVPGPRVAPVCGLLGFGVTGLELAHCSGLWAFPDWAPTEDLQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIASIQSDDAESGVDG
"
     misc_feature    878..1054
                     /gene="NOTO"
                     /note="Homeodomain;  DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:28970"
     misc_feature    order(878..892,896..898,947..949,965..967,1004..1006,
                     1010..1015,1022..1027,1031..1039,1043..1048)
                     /gene="NOTO"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:28970"
     misc_feature    order(884..886,893..895,1013..1015,1022..1027,1034..1036)
                     /gene="NOTO"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:28970"
     variation       423
                     /gene="NOTO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1864492"
     variation       491
                     /gene="NOTO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:199642782"
     variation       495
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111611158"
     variation       699
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:114247644"
     variation       736
                     /gene="NOTO"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:148083845"
     exon            792..1006
                     /gene="NOTO"
                     /inference="alignment:Splign:1.39.8"
     variation       846
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371162071"
     variation       850
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377208204"
     variation       865
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17008862"
     variation       870
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139177410"
     variation       901
                     /gene="NOTO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:13418681"
     variation       922
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376416587"
     variation       942
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371155152"
     variation       947
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147100544"
     exon            1007..1448
                     /gene="NOTO"
                     /inference="alignment:Splign:1.39.8"
     variation       1051
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:112634793"
     variation       1119
                     /gene="NOTO"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:372916128"
     variation       1124
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373915911"
     variation       1145
                     /gene="NOTO"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192237334"
     variation       1337
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377356858"
     variation       1379
                     /gene="NOTO"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79263212"
     variation       1381
                     /gene="NOTO"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:10184355"
     variation       1388..1389
                     /gene="NOTO"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:36050629"
     variation       1399
                     /gene="NOTO"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:144035887"
ORIGIN      
agctccgcctctgcaaggccccggggaaacgggcatcccttcttcagtgagcaaaggagaaagacggagcccggtggctgggtgtttcgcccaggatcaccagcgagctcagagtcctccccacgaccgccccagggtgggcatttttaaaagcggaggaagggagggaacacactctttggtgctgtgcccaccttgcctcgcacagagcgggcgctcacaggctttgggggccccgcccggaccgcagtggggagaggccgccccatgccccgccccgccaaatttaagagccttcgccgagcgccaggaggttcccagacaaccggtcttgctcgctgccttttgcagaatcttctcacttctcccgagctcccttccttgcgtccgtccgggcaacggccgcgtcatgcctagccccaggccgcgaggcagcccgccacccgctccctcgggctctcgggtccgacctccgcgctctggccgctctccggcgcccaggtcccctactggcccgaacacgccccgcgctcccggacgcttcgagtcccctttctcggtcgaggccatcctggcgaggcccgacccctgcgcgccggcggcctcccagccgtcgggctccgcctgcgtccacccggccttctggaccgctgcttccctgtgcgccaccgggggtctgccctgggcttgcccgacatcgtggctgcccgcctacctgagcgtaggtttttaccctgtgccagggccgcgcgtggctcccgtctgcggcctgctgggcttcggcgtcacagggttggagctggctcactgctcaggactctgggccttcccagactgggccccaacggaggacctacaggacactgagagacagcaaaagagagtccgaactatgtttaacttggagcagctggaagagttggagaaagtgtttgcaaaacagcacaatctggtggggaagaagagagcccagctggcagctcggctcaaacttacagagaaccaggtgagagtctggttccagaaccgcagggtcaagtatcagaagcagcaaaagctgagggcagcagttacatctgccgaggctgcctccctggatgagccttccagcagctccatcgccagtatccagagtgatgatgccgagtcaggagtggacggctgaagactgggacagaggccctagccaggctgcctggactagttcctcctgggggtacccactggagctccctgcctcacacctcaacgaaaagcctcctcaaccagaagaatctgagctgtcaagcagggacccccttttctatactgattcctggaaactggaataatgtaatgattggaggcacagactctggccttcagctatgtccttggccaacctatggaacttccgagccttttttctttatctgtataatgggtgcattcataacttagatcaccca
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:344022 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IEA
            GeneID:344022 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:344022 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:344022 -> Biological process: GO:0007368 [determination of left/right symmetry] evidence: IEA
            GeneID:344022 -> Biological process: GO:0009880 [embryonic pattern specification] evidence: IEA
            GeneID:344022 -> Biological process: GO:0009953 [dorsal/ventral pattern formation] evidence: IEA
            GeneID:344022 -> Biological process: GO:0030903 [notochord development] evidence: IEA
            GeneID:344022 -> Biological process: GO:0060271 [cilium morphogenesis] evidence: IEA
            GeneID:344022 -> Cellular component: GO:0005634 [nucleus] evidence: IEA

by @meso_cacase at DBCLS
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