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2019-03-26 14:49:31, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001134408            4745 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate
            2A (GRIN2A), transcript variant 3, mRNA.
ACCESSION   NM_001134408
VERSION     NM_001134408.1  GI:197313637
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Smoller JW, Craddock N, Kendler K, Lee PH, Neale BM, Nurnberger JI,
            Ripke S, Santangelo S and Sullivan PF.
  CONSRTM   Cross-Disorder Group of the Psychiatric Genomics Consortium
  TITLE     Identification of risk loci with shared effects on five major
            psychiatric disorders: a genome-wide analysis
  JOURNAL   Lancet 381 (9875), 1371-1379 (2013)
   PUBMED   23453885
  REMARK    Erratum:[Lancet. 2013 Apr 20;381(9875):1360]
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Del-Aguila,J.L., Beitelshees,A.L., Cooper-Dehoff,R.M.,
            Chapman,A.B., Gums,J.G., Bailey,K., Gong,Y., Turner,S.T.,
            Johnson,J.A. and Boerwinkle,E.
  TITLE     Genome-wide association analyses suggest NELL1 influences adverse
            metabolic response to HCTZ in African Americans
  JOURNAL   Pharmacogenomics J. (2013) In press
   PUBMED   23400010
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Lieberman,R., Levine,E.S., Kranzler,H.R., Abreu,C. and Covault,J.
  TITLE     Pilot study of iPS-derived neural cells to examine biologic effects
            of alcohol on human neurons in vitro
  JOURNAL   Alcohol. Clin. Exp. Res. 36 (10), 1678-1687 (2012)
   PUBMED   22486492
  REMARK    GeneRIF: After 7 days of chronic alcohol exposure there are
            significant increases in mRNA expression of GRIN2A in cultured
            neurons derived from alcoholic subjects, but not in cultures from
            nonalcoholics.
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Liu,L., Li,J., Yao,J., Yu,J., Zhang,J., Ning,Q., Wen,Z., Yang,D.,
            He,Y., Kong,X., Song,Q., Chen,M., Yang,H., Liu,Q., Li,S. and Lin,J.
  TITLE     A genome-wide association study with DNA pooling identifies the
            variant rs11866328 in the GRIN2A gene that affects disease
            progression of chronic HBV infection
  JOURNAL   Viral Immunol. 24 (5), 397-402 (2011)
   PUBMED   22004137
  REMARK    GeneRIF: Polymorphism rs11866328 in the GRIN2A gene might be a
            genetic variant underlying the susceptibility of HBV carriers to
            disease progression.
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Tarabeux J, Kebir O, Gauthier J, Hamdan FF, Xiong L, Piton A,
            Spiegelman D, Henrion E, Millet B, Fathalli F, Joober R, Rapoport
            JL, DeLisi LE, Fombonne E, Mottron L, Forget-Dubois N, Boivin M,
            Michaud JL, Drapeau P, Lafreniere RG, Rouleau GA and Krebs MO.
  CONSRTM   S2D team
  TITLE     Rare mutations in N-methyl-D-aspartate glutamate receptors in
            autism spectrum disorders and schizophrenia
  JOURNAL   Transl Psychiatry 1, E55 (2011)
   PUBMED   22833210
  REMARK    GeneRIF: Two de novo mutations in GRIN2A are identified in patients
            with sporadic schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Magnuson,D.S., Knudsen,B.E., Geiger,J.D., Brownstone,R.M. and
            Nath,A.
  TITLE     Human immunodeficiency virus type 1 tat activates
            non-N-methyl-D-aspartate excitatory amino acid receptors and causes
            neurotoxicity
  JOURNAL   Ann. Neurol. 37 (3), 373-380 (1995)
   PUBMED   7695237
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Sakimura,K., Kutsuwada,T., Ito,I., Manabe,T., Takayama,C.,
            Kushiya,E., Yagi,T., Aizawa,S., Inoue,Y., Sugiyama,H. et al.
  TITLE     Reduced hippocampal LTP and spatial learning in mice lacking NMDA
            receptor epsilon 1 subunit
  JOURNAL   Nature 373 (6510), 151-155 (1995)
   PUBMED   7816096
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Sokolov,B.P. and Prockop,D.J.
  TITLE     A rapid and simple PCR-based method for isolation of cDNAs from
            differentially expressed genes
  JOURNAL   Nucleic Acids Res. 22 (19), 4009-4015 (1994)
   PUBMED   7524031
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Monyer,H., Sprengel,R., Schoepfer,R., Herb,A., Higuchi,M.,
            Lomeli,H., Burnashev,N., Sakmann,B. and Seeburg,P.H.
  TITLE     Heteromeric NMDA receptors: molecular and functional distinction of
            subtypes
  JOURNAL   Science 256 (5060), 1217-1221 (1992)
   PUBMED   1350383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U90277.1, BC117131.1 and
            AK295620.1.
            
            Summary: N-methyl-D-aspartate (NMDA) receptors are a class of
            ionotropic glutamate-gated ion channels. These receptors have been
            shown to be involved in long-term potentiation, an
            activity-dependent increase in the efficiency of synaptic
            transmission thought to underlie certain kinds of memory and
            learning. NMDA receptor channels are heteromers composed of the key
            receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2
            subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and
            NMDAR2D (GRIN2D). Alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (3) is alternatively spliced at
            the 3' end compared to variant 1, resulting in a frame-shift and a
            shorter isoform (2) with a different C-terminus compared to isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC143273.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025082, ERS025083 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               U90277.1           102-283
            183-4319            BC117131.1         3-4139
            4320-4745           AK295620.1         3752-4177
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.2"
     gene            1..4745
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="glutamate receptor, ionotropic, N-methyl
                     D-aspartate 2A"
                     /db_xref="GeneID:2903"
                     /db_xref="HGNC:4585"
                     /db_xref="MIM:138253"
     exon            1..191
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    126..128
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="upstream in-frame stop codon"
     exon            192..623
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     CDS             210..4055
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; N-methyl-D-aspartate receptor channel, subunit
                     epsilon-1; glutamate [NMDA] receptor subunit epsilon-1;
                     N-methyl-D-aspartate receptor subunit 2A; NMDA receptor
                     subtype 2A; hNR2A; N-methyl D-aspartate receptor subtype
                     2A; glutamate receptor ionotropic, NMDA 2A"
                     /codon_start=1
                     /product="glutamate receptor ionotropic, NMDA 2A isoform 2
                     precursor"
                     /protein_id="NP_001127880.1"
                     /db_xref="GI:197313638"
                     /db_xref="CCDS:CCDS45407.1"
                     /db_xref="GeneID:2903"
                     /db_xref="HGNC:4585"
                     /db_xref="MIM:138253"
                     /translation="
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNHKTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGMTNAWLLGDAPRTLTNTRCHPRR
"
     sig_peptide     210..269
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
     mat_peptide     270..4052
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /product="glutamate receptor ionotropic, NMDA 2A isoform
                     2"
     misc_feature    303..1385
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="N-terminal leucine/isoleucine/valine-binding
                     protein (LIVBP)-like domain of the NR2 subunit of NMDA
                     receptor family; Region: PBP1_iGluR_NMDA_NR2; cd06378"
                     /db_xref="CDD:107373"
     misc_feature    order(447..449,453..458,465..470,567..569,774..776,
                     783..785,825..827,831..833)
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="putative dimerization interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:107373"
     misc_feature    1581..>1850
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="Bacterial periplasmic transport systems use
                     membrane-bound complexes and substrate-bound,
                     membrane-associated, periplasmic binding proteins (PBPs)
                     to transport a wide variety of  substrates, such as, amino
                     acids, peptides, sugars, vitamins and inorganic...;
                     Region: PBPb; cd00134"
                     /db_xref="CDD:29040"
     misc_feature    1740..1748
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
                     Region: Glutamate binding (By similarity)"
     misc_feature    1875..2693
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="Ligand-gated ion channel; Region: Lig_chan;
                     pfam00060"
                     /db_xref="CDD:189368"
     misc_feature    1875..1937
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
                     transmembrane region"
     misc_feature    2049..2051
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Functional determinant of NMDA receptors (By
                     similarity); propagated from UniProtKB/Swiss-Prot
                     (Q12879.1); other site"
     misc_feature    2109..2171
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
                     transmembrane region"
     misc_feature    <2250..2597
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="Bacterial periplasmic transport systems use
                     membrane-bound complexes and substrate-bound,
                     membrane-associated, periplasmic binding proteins (PBPs)
                     to transport a wide variety of  substrates, such as, amino
                     acids, peptides, sugars, vitamins and inorganic...;
                     Region: PBPb; cd00134"
                     /db_xref="CDD:29040"
     misc_feature    2274..2279
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
                     Region: Glutamate binding (By similarity)"
     misc_feature    order(2349..2351,2361..2363,2379..2381)
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="membrane-bound complex binding site; other site"
                     /db_xref="CDD:29040"
     misc_feature    2478..2495
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="hinge residues; other site"
                     /db_xref="CDD:29040"
     misc_feature    2658..2720
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q12879.1);
                     transmembrane region"
     misc_feature    2724..>3983
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /note="N-methyl D-aspartate receptor 2B3 C-terminus;
                     Region: NMDAR2_C; pfam10565"
                     /db_xref="CDD:151103"
     variation       497
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:74853460"
     variation       606
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77288930"
     exon            624..1216
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     variation       631
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78631453"
     variation       1112
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:78241448"
     exon            1217..1331
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     variation       1278
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:78929970"
     variation       1314
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77772378"
     exon            1332..1537
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     variation       1484
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2229193"
     exon            1538..1706
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1707..1860
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1861..1986
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            1987..2216
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2217..2377
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     variation       2233
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75130648"
     exon            2378..2565
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2566..2804
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     exon            2805..3981
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     variation       2969
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:80138441"
     variation       3092
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:77705198"
     STS             3584..3719
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /standard_name="D16S2608E"
                     /db_xref="UniSTS:151676"
     variation       3787
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75761674"
     exon            3982..4735
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /inference="alignment:Splign:1.39.8"
     STS             3999..4223
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /standard_name="Grin2a"
                     /db_xref="UniSTS:143261"
     variation       4025
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:78444267"
     variation       4071
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74935155"
     variation       4173
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77029288"
     STS             4336..4569
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /standard_name="G10721"
                     /db_xref="UniSTS:65875"
     STS             4544..4643
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /standard_name="D16S2596E"
                     /db_xref="UniSTS:19233"
     STS             4567..4621
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
                     /standard_name="GRIN2A"
                     /db_xref="UniSTS:480253"
     polyA_signal    4714..4719
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
     polyA_site      4734
                     /gene="GRIN2A"
                     /gene_synonym="EPND; GluN2A; NMDAR2A; NR2A"
ORIGIN      
agccctgctgcagagcctccggctgggatagccgccccccgtgggggcgatgcggacagcgcgggacagccaggggagcgcgctggggccgcagcatgcgggaacccgctaaacccggtggctgctgaggcggccgagatgctcgtgcgcgcagcgcgccccactgcatcctcgaccttctcgggctacagggaccgtcagtggcgactatgggcagagtgggctattggaccctgctggtgctgccggcccttctggtctggcgcggtccggcgccgagcgcggcggcggagaagggtccccccgcgctaaatattgcggtgatgctgggtcacagccacgacgtgacagagcgcgaacttcgaacactgtggggccccgagcaggcggcggggctgcccctggacgtgaacgtggtagctctgctgatgaaccgcaccgaccccaagagcctcatcacgcacgtgtgcgacctcatgtccggggcacgcatccacggcctcgtgtttggggacgacacggaccaggaggccgtagcccagatgctggattttatctcctcccacaccttcgtccccatcttgggcattcatgggggcgcatctatgatcatggctgacaaggatccgacgtctaccttcttccagtttggagcgtccatccagcagcaagccacggtcatgctgaagatcatgcaggattatgactggcatgtcttctccctggtgaccactatcttccctggctacagggaattcatcagcttcgtcaagaccacagtggacaacagctttgtgggctgggacatgcagaatgtgatcacactggacacttcctttgaggatgcaaagacacaagtccagctgaagaagatccactcttctgtcatcttgctctactgttccaaagacgaggctgttctcattctgagtgaggcccgctcccttggcctcaccgggtatgatttcttctggattgtccccagcttggtctctgggaacacggagctcatcccaaaagagtttccatcgggactcatttctgtctcctacgatgactgggactacagcctggaggcgagagtgagggacggcattggcatcctaaccaccgctgcatcttctatgctggagaagttctcctacatccccgaggccaaggccagctgctacgggcagatggagaggccagaggtcccgatgcacaccttgcacccatttatggtcaatgttacatgggatggcaaagacttatccttcactgaggaaggctaccaggtgcaccccaggctggtggtgattgtgctgaacaaagaccgggaatgggaaaaggtgggcaagtgggagaaccatacgctgagcctgaggcacgccgtgtggcccaggtacaagtccttctccgactgtgagccggatgacaaccatctcagcatcgtcaccctggaggaggccccattcgtcatcgtggaagacatagaccccctgaccgagacgtgtgtgaggaacaccgtgccatgtcggaagttcgtcaaaatcaacaattcaaccaatgaggggatgaatgtgaagaaatgctgcaaggggttctgcattgatattctgaagaagctttccagaactgtgaagtttacttacgacctctatctggtgaccaatgggaagcatggcaagaaagttaacaatgtgtggaatggaatgatcggtgaagtggtctatcaacgggcagtcatggcagttggctcgctcaccatcaatgaggaacgttctgaagtggtggacttctctgtgccctttgtggaaacgggaatcagtgtcatggtttcaagaagtaatggcaccgtctcaccttctgcttttctagaaccattcagcgcctctgtctgggtgatgatgtttgtgatgctgctcattgtttctgccatagctgtttttgtctttgaatacttcagccctgttggatacaacagaaacttagccaaagggaaagcaccccatgggccttcttttacaattggaaaagctatatggcttctttggggcctggtgttcaataactccgtgcctgtccagaatcctaaagggaccaccagcaagatcatggtatctgtatgggccttcttcgctgtcatattcctggctagctacacagccaatctggctgccttcatgatccaagaggaatttgtggaccaagtgaccggcctcagtgacaaaaagtttcagagacctcatgactattccccaccttttcgatttgggacagtgcctaatggaagcacggagagaaacattcggaataactatccctacatgcatcagtacatgaccaaatttaatcagaaaggagtagaggacgccttggtcagcctgaaaacggggaagctggacgctttcatctacgatgccgcagtcttgaattacaaggctgggagggatgaaggctgcaagctggtgaccatcgggagtgggtacatctttgccaccaccggttatggaattgcccttcagaaaggctctccttggaagaggcagatcgacctggccttgcttcagtttgtgggtgatggtgagatggaggagctggagaccctgtggctcactgggatctgccacaacgagaagaacgaggtgatgagcagccagctggacattgacaacatggcgggcgtattctacatgctggctgccgccatggcccttagcctcatcaccttcatctgggagcacctcttctactggaagctgcgcttctgtttcacgggcgtgtgctccgaccggcctgggttgctcttctccatcagcaggggcatctacagctgcattcatggagtgcacattgaagaaaagaagaagtctccagacttcaatctgacgggatcccagagcaacatgttaaaactcctccggtcagccaaaaacatttccagcatgtccaacatgaactcctcaagaatggactcacccaaaagagctgctgacttcatccaaagaggttccctcatcatggacatggtttcagataaggggaatttgatgtactcagacaacaggtcctttcaggggaaagagagcatttttggagacaacatgaacgaactccaaacatttgtggccaaccggcagaaggataacctcaataactatgtattccagggacaacatcctcttactctcaatgagtccaaccctaacacggtggaggtggccgtgagcacagaatccaaagcgaactctagaccccggcagctgtggaagaaatccgtggattccatacgccaggattcactatcccagaatccagtctcccagagggatgaggcaacagcagagaataggacccactccctaaagagccctaggtatcttccagaagagatggcccactctgacatttcagaaacgtcaaatcgggccacgtgccacagggaacctgacaacagtaagaaccacaaaaccaaggacaactttaaaaggtcagtggcctccaaataccccaaggactgtagtgaggtcgagcgcacctacctgaaaaccaaatcaagctcccctagagacaagatctacactatagatggtgagaaggagcctggtttccacttagatccaccccagtttgttgaaaatgtgaccctgcccgagaacgtggacttcccggacccctaccaggatcccagtgaaaacttccgcaagggggactccacgctgccaatgaaccggaaccccttgcataatgaagaggggctttccaacaacgaccagtataaactctactccaagcacttcaccttgaaagacaagggttccccgcacagtgagaccagcgagcgataccggcagaactccacgcactgcagaagctgcctttccaacatgcccacctattcaggccacttcaccatgaggtcccccttcaagtgcgatgcctgcctgcggatggggaacctctatgacatcgatgaagaccagatgcttcaggagacagggatgaccaacgcttggttattgggagatgcccctcggacccttacaaacactcgttgccatcccaggcggtgaatgacagctatcttcggtcgtccttgaggtcaacggcatcgtactgttccagggacagtcggggccacaatgatgtgtatatttcggagcatgttatgccttatgctgcaaataagaataatatgtactctacccccagggttttaaattcctgcagcaatagacgcgtgtacaagaaaatgcctagtatcgaatctgatgtttaaaaatcttccattaatgttttatctatagggaaatatacgtaatggccaatgttctggagggtaaatgttggatgtccaatagtgccctgctaagaggaagaagatgtagggaggtattttgttgttgttgttgttggctcttttgcacacggcttcatgccataatcttccactcaaggaatcttgtgaggtgtgtgctgagcatggcagacaccagataggtgagtccttaaccaaaaataactaactacataagggcaagtctccgggacatgcctactgggtatgttggcaataatgatgcattggatgccaatggtgatgttatgatttcctatattccaaattccattaaggtcagcccaccatgtaattttctcatcagaaatgcctaatggtttctctaatacagaataagcaatatggtgtgcatgtaaacctgacacagacaaaataaaaacagttaagaatgcaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2903 -> Molecular function: GO:0004972 [N-methyl-D-aspartate selective glutamate receptor activity] evidence: IEA
            GeneID:2903 -> Molecular function: GO:0005234 [extracellular-glutamate-gated ion channel activity] evidence: IEA
            GeneID:2903 -> Molecular function: GO:0005262 [calcium channel activity] evidence: IEA
            GeneID:2903 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2903 -> Molecular function: GO:0008270 [zinc ion binding] evidence: ISS
            GeneID:2903 -> Biological process: GO:0001964 [startle response] evidence: IEA
            GeneID:2903 -> Biological process: GO:0001975 [response to amphetamine] evidence: IEA
            GeneID:2903 -> Biological process: GO:0006810 [transport] evidence: TAS
            GeneID:2903 -> Biological process: GO:0007215 [glutamate receptor signaling pathway] evidence: TAS
            GeneID:2903 -> Biological process: GO:0007268 [synaptic transmission] evidence: TAS
            GeneID:2903 -> Biological process: GO:0007611 [learning or memory] evidence: TAS
            GeneID:2903 -> Biological process: GO:0007613 [memory] evidence: IEA
            GeneID:2903 -> Biological process: GO:0008104 [protein localization] evidence: IEA
            GeneID:2903 -> Biological process: GO:0008542 [visual learning] evidence: IEA
            GeneID:2903 -> Biological process: GO:0009611 [response to wounding] evidence: IEA
            GeneID:2903 -> Biological process: GO:0019233 [sensory perception of pain] evidence: IEA
            GeneID:2903 -> Biological process: GO:0022008 [neurogenesis] evidence: IEA
            GeneID:2903 -> Biological process: GO:0030431 [sleep] evidence: IEA
            GeneID:2903 -> Biological process: GO:0033058 [directional locomotion] evidence: IEA
            GeneID:2903 -> Biological process: GO:0042177 [negative regulation of protein catabolic process] evidence: IEA
            GeneID:2903 -> Biological process: GO:0042417 [dopamine metabolic process] evidence: IEA
            GeneID:2903 -> Biological process: GO:0042428 [serotonin metabolic process] evidence: IEA
            GeneID:2903 -> Biological process: GO:0042493 [response to drug] evidence: IEA
            GeneID:2903 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:2903 -> Biological process: GO:0045471 [response to ethanol] evidence: IDA
            GeneID:2903 -> Biological process: GO:0048167 [regulation of synaptic plasticity] evidence: IEA
            GeneID:2903 -> Biological process: GO:0051930 [regulation of sensory perception of pain] evidence: IEA
            GeneID:2903 -> Biological process: GO:0060079 [regulation of excitatory postsynaptic membrane potential] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
            GeneID:2903 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
            GeneID:2903 -> Cellular component: GO:0008021 [synaptic vesicle] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0009986 [cell surface] evidence: ISS
            GeneID:2903 -> Cellular component: GO:0014069 [postsynaptic density] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0017146 [N-methyl-D-aspartate selective glutamate receptor complex] evidence: IDA
            GeneID:2903 -> Cellular component: GO:0030054 [cell junction] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0042734 [presynaptic membrane] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA
            GeneID:2903 -> Cellular component: GO:0045211 [postsynaptic membrane] evidence: IEA

by @meso_cacase at DBCLS
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