2024-04-20 06:22:18, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001130967 2353 bp mRNA linear PRI 17-APR-2013 DEFINITION Homo sapiens zinc finger protein 385A (ZNF385A), transcript variant 1, mRNA. ACCESSION NM_001130967 VERSION NM_001130967.1 GI:195972902 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2353) AUTHORS Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M., Toyama,S., Usami,R., Ohtoko,K. and Kato,S. TITLE Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method JOURNAL Invest. Ophthalmol. Vis. Sci. 52 (9), 6662-6670 (2011) PUBMED 21697133 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2353) AUTHORS Das,S., Raj,L., Zhao,B., Kimura,Y., Bernstein,A., Aaronson,S.A. and Lee,S.W. TITLE Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation JOURNAL Cell 130 (4), 624-637 (2007) PUBMED 17719541 REFERENCE 3 (bases 1 to 2353) AUTHORS Sharma,S., Dimasi,D., Higginson,K. and Della,N.G. TITLE RZF, a zinc-finger protein in the photoreceptors of human retina JOURNAL Gene 342 (2), 219-229 (2004) PUBMED 15527981 REMARK GeneRIF: Results suggest that RZF is a shuttling regulatory protein expressed in photoreceptors of the human retina that may be involved in mRNA or protein regulation of photoreceptor-specific genes and therefore have role in retinal disease mechanisms. REFERENCE 4 (bases 1 to 2353) AUTHORS Kimura,Y., Hart,A., Hirashima,M., Wang,C., Holmyard,D., Pittman,J., Pang,X.L., Jackson,C.W. and Bernstein,A. TITLE Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis JOURNAL J. Exp. Med. 195 (7), 941-952 (2002) PUBMED 11927637 REFERENCE 5 (bases 1 to 2353) AUTHORS Hidaka,M., Caruana,G., Stanford,W.L., Sam,M., Correll,P.H. and Bernstein,A. TITLE Gene trapping of two novel genes, Hzf and Hhl, expressed in hematopoietic cells JOURNAL Mech. Dev. 90 (1), 3-15 (2000) PUBMED 10585558 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB116264.1, BC029752.1 and AF304052.1. Summary: Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]. Transcript Variant: This variant (1) encodes the largest isoform (a). ##Evidence-Data-START## Transcript exon combination :: BC029752.1, AK315613.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-13 DB116264.1 1-13 14-420 BC029752.1 1-407 421-2353 AF304052.1 489-2421 FEATURES Location/Qualifiers source 1..2353 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q13.13" gene 1..2353 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /note="zinc finger protein 385A" /db_xref="GeneID:25946" /db_xref="HGNC:17521" /db_xref="MIM:609124" exon 1..65 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" CDS 56..1216 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /note="isoform a is encoded by transcript variant 1; zinc finger protein 385; retinal zinc finger protein; hematopoietic zinc finger protein" /codon_start=1 /product="zinc finger protein 385A isoform a" /protein_id="NP_001124439.1" /db_xref="GI:195972903" /db_xref="CCDS:CCDS44911.1" /db_xref="GeneID:25946" /db_xref="HGNC:17521" /db_xref="MIM:609124" /translation="
MILGSLSRAGPLPLLRQPPIMQPPLDLKQILPFPLEPAPTLGLFSNYSTMDPVQKAVLSHTFGGPLLKTKRPVISCNICQIRFNSQSQAEAHYKGNRHARRVKGIEAAKTRGREPGVREPGDPAPPGSTPTNGDGVAPRPVSMENGLGPAPGSPEKQPGSPSPPSIPETGQGVTKGEGGTPAPASLPGGSKEEEEKAKRLLYCALCKVAVNSLSQLEAHNKGTKHKTILEARSGLGPIKAYPRLGPPTPGEPEAPAQDRTFHCEICNVKVNSEVQLKQHISSRRHRDGVAGKPNPLLSRHKKSRGAGELAGTLTFSKELPKSLAGGLLPSPLAVAAVMAAAAGSPLSLRPAPAAPLLQGPPITHPLLHPAPGPIRTAHGPILFSPY
" misc_feature 281..349 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /note="Zinc-finger of C2H2 type; Region: zf-met; pfam12874" /db_xref="CDD:205121" misc_feature 656..730 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /note="Zinc-finger of C2H2 type; Region: zf-met; pfam12874" /db_xref="CDD:205121" misc_feature 836..910 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /note="Zinc-finger of C2H2 type; Region: zf-met; pfam12874" /db_xref="CDD:205121" exon 66..202 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" exon 203..313 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" exon 314..476 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" variation 421 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:2887875" exon 477..719 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" STS 666..847 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /standard_name="MARC_17697-17698:1031753921:1" /db_xref="UniSTS:268380" exon 720..889 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" exon 890..985 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" exon 986..2336 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /inference="alignment:Splign:1.39.8" variation 1334 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /replace="" /replace="c" /db_xref="dbSNP:3215379" STS 2105..2304 /gene="ZNF385A" /gene_synonym="HZF; RZF; ZFP385; ZNF385" /standard_name="RH158" /db_xref="UniSTS:9346" ORIGIN
cagaacggcccccgggacagagcgacgcggaaccccgggcgcctgggtccccagcatgatcctcggcagcctgagccgggcagggcccctgcctctgctacggcagcccccgatcatgcagcccccactggacctcaagcagatcctgcccttcccactcgagccagcccctacccttggcctcttcagcaactacagcaccatggaccctgtgcagaaggctgtgctctcccacacttttgggggacccttgctcaagaccaagcggcccgtcatttcctgtaatatctgtcaaatccgcttcaattctcagagccaggctgaggcgcactacaaaggtaatcgccacgcccgacgagtcaaaggcattgaggctgccaagaccagaggcagggagcctggcgtccgagaacctggagacccagctcccccaggcagcaccccaacaaatggggatggtgtagcaccccgtccagtttccatggagaatggactggggccagccccaggatccccagagaaacagcctggctccccatcccctcccagcattccggagactggtcagggtgtaaccaagggtgaaggggggactccagccccggcttccttgcctgggggtagcaaggaagaggaggagaaagccaagcggctgctctactgtgctctgtgcaaggtggctgtgaactccctgtcccagcttgaggcacataacaaaggtactaagcacaagacaattctggaggcccgaagtgggctcgggcccatcaaagcttaccctcggctggggcctcccaccccgggggaaccagaggctcctgcccaggaccgaactttccactgtgagatctgcaatgtcaaggtcaactcggaggtccaactgaaacagcacatctccagccggcggcaccgagacggcgtggccgggaagcccaacccactactgagccgtcacaagaagtctaggggcgccggggagctggcgggcacgctgactttctccaaggagctgcccaagtccctggcgggcggcctgctccccagccccctggcggtggctgcagtgatggcagcggcagcaggctcgccgctgtccctgcgcccggctccagccgcacctcttctccagggaccgccgatcactcaccctctgcttcacccggcccccggacccatccgaactgcgcacggacccatcctcttctccccgtactgacctcaaccctgaacccctcccattcaactccccacctccagccgggacccaggcgtccgggctcccagcccgcccctcctcccggcactccctaaatgatctctccttccccccccccaccccgagatacggggttccaggaaaggggaggggtagcgggggaggggggcttcagaagggggggaacaccccagatctcagggaaccccgccccctgcctttccctctcccctagaaaagggggggccgtctcacccccgagcccccttggagacaccccccctcccaaaagccatgtccatccagcccttccccccaaacctagcacaaaacggggttcacaagccatggtcggggtccgggggggacagaaatggattttcttggcaataagcggactctgggactccggctccctaccccaaactgaagcgcttccgtgaacacccccgtcctccgtagggggaggggagcaggcgggatcctgggtccctcataagcactttggttttaccgcctgcaacctcactgtgcccgccccgcaccatgccctagccccaggtctagccgggcccattgcagggggcagcacttgggggcatctccggcacttgggtgggaccaaggagatgccaccatagacctttccctcgccttcttcctccctagtccgggttccattcttttcaccagcacccatcgcccaaggggtaccgaggggggcaaggggtgtccagtccaagcccacccccgcctcgccttccgcaaaactgtgagcaaaaagcaatagaagcctcgcccccgcccttccccttcgcaggattcgccgagtctgtagcctccccgatccaagttcctagacctcatggctgtcccctcccaccagtcacctccactgcacaactcgggcgggggtgtgacacctctcccccacccccgactccgtggtttccgtatcgtcaacccttcagccgccgacccgggaggggtctggcctacactggtcttccccttcccatcaactctttctgcttgacaatgtagcaacccaggccccccacccacggtcctcccctttttcctctccctgacaataaagtctgaatttgttctgccctccaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:25946 -> Molecular function: GO:0002039 [p53 binding] evidence: IPI GeneID:25946 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA GeneID:25946 -> Molecular function: GO:0003730 [mRNA 3'-UTR binding] evidence: ISS GeneID:25946 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:25946 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA GeneID:25946 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA GeneID:25946 -> Biological process: GO:0006915 [apoptotic process] evidence: ISS GeneID:25946 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: ISS GeneID:25946 -> Biological process: GO:0010609 [mRNA localization resulting in posttranscriptional regulation of gene expression] evidence: ISS GeneID:25946 -> Biological process: GO:0035855 [megakaryocyte development] evidence: ISS GeneID:25946 -> Biological process: GO:0045600 [positive regulation of fat cell differentiation] evidence: ISS GeneID:25946 -> Biological process: GO:1902164 [positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IMP GeneID:25946 -> Biological process: GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IMP GeneID:25946 -> Biological process: GO:2000765 [regulation of cytoplasmic translation] evidence: ISS GeneID:25946 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IDA GeneID:25946 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA GeneID:25946 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA GeneID:25946 -> Cellular component: GO:0030425 [dendrite] evidence: ISS GeneID:25946 -> Cellular component: GO:0043025 [neuronal cell body] evidence: ISS
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