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2024-03-29 20:31:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001130867            1753 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens excision repair cross-complementing rodent repair
            deficiency, complementation group 2 (ERCC2), transcript variant 2,
            mRNA.
ACCESSION   NM_001130867
VERSION     NM_001130867.1  GI:195947406
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   Dong,Y., Zhuang,L. and Ma,W.
  TITLE     Comprehensive assessment of the association of ERCC2 Lys751Gln
            polymorphism with susceptibility to cutaneous melanoma
  JOURNAL   Tumour Biol. 34 (2), 1155-1160 (2013)
   PUBMED   23494240
  REMARK    GeneRIF: ERCC2 Lys751Gln polymorphism is associated with
            susceptibility to cutaneous melanoma.
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   Zhang,R.C. and Mou,S.H.
  TITLE     Polymorphisms of excision repair gene XPD Lys751Gln and hOGG1
            Ser326Cys might not be associated with hepatocellular carcinoma
            risk: a meta-analysis
  JOURNAL   Tumour Biol. 34 (2), 901-907 (2013)
   PUBMED   23271362
  REMARK    GeneRIF: Polymorphisms of excision repair gene XPD Lys751Gln is not
            associated with hepatocellular carcinoma risk.
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Abdulrahman,W., Iltis,I., Radu,L., Braun,C., Maglott-Roth,A.,
            Giraudon,C., Egly,J.M. and Poterszman,A.
  TITLE     ARCH domain of XPD, an anchoring platform for CAK that conditions
            TFIIH DNA repair and transcription activities
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 110 (8), E633-E642 (2013)
   PUBMED   23382212
  REMARK    GeneRIF: results identify the ARCH domain of XPD as a platform for
            the recruitment of CAK and as a molecular switch that might control
            TFIIH composition and play a role in conversion of TFIIH from a
            factor active in transcription to a factor involved in DNA repair
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Yang,L.M., Li,X.H. and Bao,C.F.
  TITLE     Glutathione S-transferase P1 and DNA polymorphisms influence
            response to chemotherapy and prognosis of bone tumors
  JOURNAL   Asian Pac. J. Cancer Prev. 13 (11), 5883-5886 (2012)
   PUBMED   23317281
  REMARK    GeneRIF: ERCC2 polymorphisms influence response to chemotherapy in
            bone tumors
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Gan,Y., Li,X.R., Chen,D.J. and Wu,J.H.
  TITLE     Association between polymorphisms of XRCC1 Arg399Gln and XPD
            Lys751Gln genes and prognosis of colorectal cancer in a Chinese
            population
  JOURNAL   Asian Pac. J. Cancer Prev. 13 (11), 5721-5724 (2012)
   PUBMED   23317245
  REMARK    GeneRIF: Polymorphisms of XPD Lys751Gln are associated with
            colorectal cancer.
REFERENCE   6  (bases 1 to 1753)
  AUTHORS   Flejter,W.L., McDaniel,L.D., Johns,D., Friedberg,E.C. and
            Schultz,R.A.
  TITLE     Correction of xeroderma pigmentosum complementation group D mutant
            cell phenotypes by chromosome and gene transfer: involvement of the
            human ERCC2 DNA repair gene
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 89 (1), 261-265 (1992)
   PUBMED   1729695
REFERENCE   7  (bases 1 to 1753)
  AUTHORS   Jacob,G.A., Luse,S.W. and Luse,D.S.
  TITLE     Abortive initiation is increased only for the weakest members of a
            set of down mutants of the adenovirus 2 major late promoter
  JOURNAL   J. Biol. Chem. 266 (33), 22537-22544 (1991)
   PUBMED   1939271
REFERENCE   8  (bases 1 to 1753)
  AUTHORS   Weber,C.A., Salazar,E.P., Stewart,S.A. and Thompson,L.H.
  TITLE     ERCC2: cDNA cloning and molecular characterization of a human
            nucleotide excision repair gene with high homology to yeast RAD3
  JOURNAL   EMBO J. 9 (5), 1437-1447 (1990)
   PUBMED   2184031
REFERENCE   9  (bases 1 to 1753)
  AUTHORS   Weber,C.A., Salazar,E.P., Stewart,S.A. and Thompson,L.H.
  TITLE     Molecular cloning and biological characterization of a human gene,
            ERCC2, that corrects the nucleotide excision repair defect in CHO
            UV5 cells
  JOURNAL   Mol. Cell. Biol. 8 (3), 1137-1146 (1988)
   PUBMED   2835663
REFERENCE   10 (bases 1 to 1753)
  AUTHORS   Conaway,R.C. and Conaway,J.W.
  TITLE     ATP activates transcription initiation from promoters by RNA
            polymerase II in a reversible step prior to RNA synthesis
  JOURNAL   J. Biol. Chem. 263 (6), 2962-2968 (1988)
   PUBMED   2449431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA409300.1, AL535248.3,
            BG719746.1, BT006883.1 and BC008346.1.
            
            Summary: The nucleotide excision repair pathway is a mechanism to
            repair damage to DNA. The protein encoded by this gene is involved
            in transcription-coupled nucleotide excision repair and is an
            integral member of the basal transcription factor BTF2/TFIIH
            complex. The gene product has ATP-dependent DNA helicase activity
            and belongs to the RAD3/XPD subfamily of helicases. Defects in this
            gene can result in three different disorders, the cancer-prone
            syndrome xeroderma pigmentosum complementation group D,
            trichothiodystrophy, and Cockayne syndrome. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (2) has an additional segment in
            the 5' region, which results in a downstream AUG start codon, and
            lacks multiple 3' exons but has an alternate 3' exon, as compared
            to variant 1. The resulting isoform (2) has a shorter N-terminus
            and a distinct and shorter C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008346.1, BT006883.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DA409300.1         2-53
            53-56               AL535248.3         14-17
            57-422              BG719746.1         8-373
            423-1639            BT006883.1         1-1217
            1640-1753           BC008346.1         1437-1550
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.3"
     gene            1..1753
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /note="excision repair cross-complementing rodent repair
                     deficiency, complementation group 2"
                     /db_xref="GeneID:2068"
                     /db_xref="HGNC:3434"
                     /db_xref="MIM:126340"
     exon            1..455
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     STS             20..962
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /standard_name="GDB:364012"
                     /db_xref="UniSTS:156797"
     variation       74..75
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:3916792"
     variation       97
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3826908"
     variation       160
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3916793"
     misc_feature    231..233
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /note="upstream in-frame stop codon"
     variation       422
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:41549115"
     CDS             423..1640
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /EC_number="3.6.4.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     xeroderma pigmentosum complementary group D; TFIIH basal
                     transcription factor complex helicase subunit; TFIIH basal
                     transcription factor complex helicase XPD subunit;
                     xeroderma pigmentosum group D-complementing protein; TFIIH
                     basal transcription factor complex 80 kDa subunit; CXPD;
                     BTF2 p80; TFIIH p80; TFIIH 80 kDa subunit; DNA excision
                     repair protein ERCC-2; DNA repair protein complementing
                     XP-D cells; basic transcription factor 2 80 kDa subunit"
                     /codon_start=1
                     /product="TFIIH basal transcription factor complex
                     helicase XPD subunit isoform 2"
                     /protein_id="NP_001124339.1"
                     /db_xref="GI:195947407"
                     /db_xref="CCDS:CCDS46112.1"
                     /db_xref="GeneID:2068"
                     /db_xref="HGNC:3434"
                     /db_xref="MIM:126340"
                     /translation="
MRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGQAQHCGSSRNQKRSHP
"
     misc_feature    423..1190
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /note="DEAD-like helicases superfamily; Region: DEXDc2;
                     smart00488"
                     /db_xref="CDD:128764"
     misc_feature    564..1118
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /note="DEAD_2; Region: DEAD_2; pfam06733"
                     /db_xref="CDD:191597"
     misc_feature    1152..1589
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /note="Protein of unknown function (DUF1227); Region:
                     DUF1227; pfam06777"
                     /db_xref="CDD:191608"
     exon            456..533
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            534..596
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            597..710
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     STS             674..1357
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /standard_name="GDB:364015"
                     /db_xref="UniSTS:156798"
     exon            711..827
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            828..944
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            945..1068
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     variation       947
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1799791"
     variation       951
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1799792"
     exon            1069..1165
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            1166..1299
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     variation       1284
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1799793"
     exon            1300..1468
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            1469..1587
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     exon            1588..1741
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /inference="alignment:Splign:1.39.8"
     polyA_signal    1693..1698
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
     variation       1731
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:3916842"
     variation       1736
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3916843"
     polyA_site      1741
                     /gene="ERCC2"
                     /gene_synonym="COFS2; EM9; TTD; XPD"
ORIGIN      
ttcatgagggaggcgggtcgaccccgctgcacagtccggccggcgccatgaagtgagaagggggctgggggtcgcgctcgctagcgggcgcggggggtcttgaagatggggtcatcggtgggcgcgcctgggtccccaagggggcgaggggagggtgaaggggtgggacgggggcagccgcagggagcagcagtgatagcgaggagacactgagggggccccgaggctcctgaggacctgagggttaccgggggcgccgggcccgtcacccttctctgggctcgacgaccgggcactgtggaggcgggagaggggctgaggggacgggaactgacccagcagcccctgccgccaggctcaacgtggacgggctcctggtctacttcccgtacgactacatctaccccgagcagttctcctacatgcgggagctcaaacgcacgctggacgccaagggtcatggagtcctggagatgccctcaggcaccgggaagacagtatccctgttggccctgatcatggcataccagagagcatatccgctggaggtgaccaaactcatctactgctcaagaactgtgccagagattgagaaggtgattgaagagcttcgaaagttgctcaacttctatgagaagcaggagggcgagaagctgccgtttctgggactggctctgagctcccgcaaaaacttgtgtattcaccctgaggtgacacccctgcgctttgggaaggacgtcgatgggaaatgccacagcctcacagcctcctatgtgcgggcgcagtaccagcatgacaccagcctgccccactgccgattctatgaggaatttgatgcccatgggcgtgaggtgcccctccccgctggcatctacaacctggatgacctgaaggccctggggcggcgccagggctggtgcccatacttccttgctcgatactcaatcctgcatgccaatgtggtggtttatagctaccactacctcctggaccccaagattgcagacctggtgtccaaggaactggcccgcaaggccgtcgtggtcttcgacgaggcccacaacattgacaacgtctgcatcgactccatgagcgtcaacctcacccgccggacccttgaccggtgccagggcaacctggagaccctgcagaagacggtgctcaggatcaaagagacagacgagcagcgcctgcgggacgagtaccggcgtctggtggaggggctgcgggaggccagcgccgcccgggagacggacgcccacctggccaaccccgtgctgcccgacgaagtgctgcaggaggcagtgcctggctccatccgcacggccgagcatttcctgggcttcctgaggcggctgctggagtacgtgaagtggcggctgcgtgtgcagcatgtggtgcaggagagcccgcccgccttcctgagcggcctggcccagcgcgtgtgcatccagcgcaagcccctcagattctgtgctgaacgcctccggtccctgctgcatactctggagatcaccgaccttgctgacttctccccgctcaccctccttgctaactttgccacccttgtcagcacctacgccaaaggccaggctcagcactgtggaagcagcaggaaccaaaaaagatctcatccctaaccccccagaacttatattccagatgggaaaaccagtagcaaagatgcagccaaataaacaaggaaataattccagaaagtgacagttatcatgaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:2068 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:2068 -> Molecular function: GO:0004003 [ATP-dependent DNA helicase activity] evidence: IEA
            GeneID:2068 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
            GeneID:2068 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:2068 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:2068 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: IPI
            GeneID:2068 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: IDA
            GeneID:2068 -> Molecular function: GO:0008094 [DNA-dependent ATPase activity] evidence: TAS
            GeneID:2068 -> Molecular function: GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity] evidence: IDA
            GeneID:2068 -> Molecular function: GO:0043139 [5'-3' DNA helicase activity] evidence: IDA
            GeneID:2068 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:2068 -> Molecular function: GO:0047485 [protein N-terminus binding] evidence: IPI
            GeneID:2068 -> Molecular function: GO:0051539 [4 iron, 4 sulfur cluster binding] evidence: IEA
            GeneID:2068 -> Biological process: GO:0000075 [cell cycle checkpoint] evidence: IMP
            GeneID:2068 -> Biological process: GO:0000718 [nucleotide-excision repair, DNA damage removal] evidence: TAS
            GeneID:2068 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
            GeneID:2068 -> Biological process: GO:0001701 [in utero embryonic development] evidence: IEA
            GeneID:2068 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: IDA
            GeneID:2068 -> Biological process: GO:0006283 [transcription-coupled nucleotide-excision repair] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: IGI
            GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: NAS
            GeneID:2068 -> Biological process: GO:0006289 [nucleotide-excision repair] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006360 [transcription from RNA polymerase I promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006361 [transcription initiation from RNA polymerase I promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006362 [transcription elongation from RNA polymerase I promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006363 [termination of RNA polymerase I transcription] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:2068 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006367 [transcription initiation from RNA polymerase II promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006368 [transcription elongation from RNA polymerase II promoter] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006370 [7-methylguanosine mRNA capping] evidence: TAS
            GeneID:2068 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:2068 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:2068 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IMP
            GeneID:2068 -> Biological process: GO:0006979 [response to oxidative stress] evidence: IMP
            GeneID:2068 -> Biological process: GO:0007059 [chromosome segregation] evidence: IMP
            GeneID:2068 -> Biological process: GO:0007568 [aging] evidence: IEA
            GeneID:2068 -> Biological process: GO:0008283 [cell proliferation] evidence: IEA
            GeneID:2068 -> Biological process: GO:0009650 [UV protection] evidence: IGI
            GeneID:2068 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
            GeneID:2068 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:2068 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:2068 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:2068 -> Biological process: GO:0021510 [spinal cord development] evidence: IEA
            GeneID:2068 -> Biological process: GO:0030198 [extracellular matrix organization] evidence: IEA
            GeneID:2068 -> Biological process: GO:0030282 [bone mineralization] evidence: IEA
            GeneID:2068 -> Biological process: GO:0032289 [central nervous system myelin formation] evidence: IEA
            GeneID:2068 -> Biological process: GO:0033683 [nucleotide-excision repair, DNA incision] evidence: IMP
            GeneID:2068 -> Biological process: GO:0035264 [multicellular organism growth] evidence: IEA
            GeneID:2068 -> Biological process: GO:0035315 [hair cell differentiation] evidence: IMP
            GeneID:2068 -> Biological process: GO:0040016 [embryonic cleavage] evidence: IEA
            GeneID:2068 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
            GeneID:2068 -> Biological process: GO:0043249 [erythrocyte maturation] evidence: IEA
            GeneID:2068 -> Biological process: GO:0043388 [positive regulation of DNA binding] evidence: IEA
            GeneID:2068 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:2068 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:2068 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:2068 -> Biological process: GO:0048820 [hair follicle maturation] evidence: IEA
            GeneID:2068 -> Biological process: GO:0050434 [positive regulation of viral transcription] evidence: TAS
            GeneID:2068 -> Biological process: GO:0060218 [hematopoietic stem cell differentiation] evidence: IEA
            GeneID:2068 -> Cellular component: GO:0000441 [SSL2-core TFIIH complex] evidence: IEA
            GeneID:2068 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:2068 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:2068 -> Cellular component: GO:0005675 [holo TFIIH complex] evidence: IDA
            GeneID:2068 -> Cellular component: GO:0005675 [holo TFIIH complex] evidence: TAS
            GeneID:2068 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:2068 -> Cellular component: GO:0005819 [spindle] evidence: IDA
            GeneID:2068 -> Cellular component: GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] evidence: IDA
            GeneID:2068 -> Cellular component: GO:0071817 [MMXD complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001124339 -> EC 3.6.4.12

by @meso_cacase at DBCLS
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