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2024-04-17 01:56:50, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001128925 2385 bp mRNA linear PRI 11-MAY-2013
DEFINITION Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 18
(CYP2C18), transcript variant 2, mRNA.
ACCESSION NM_001128925
VERSION NM_001128925.1 GI:193083147
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2385)
AUTHORS Flachsbart,F., Ufer,M., Kleindorp,R., Nikolaus,S., Schreiber,S. and
Nebel,A.
TITLE Genetic variation in the CYP2C monooxygenase enzyme subfamily shows
no association with longevity in a German population
JOURNAL J. Gerontol. A Biol. Sci. Med. Sci. 66 (11), 1186-1191 (2011)
PUBMED 21798861
REMARK GeneRIF: These results suggest that there is no notable influence
of sequence variation in the CYP2C genes on longevity in the
examined German population
REFERENCE 2 (bases 1 to 2385)
AUTHORS Howard,T.D., Hsu,F.C., Grzywacz,J.G., Chen,H., Quandt,S.A.,
Vallejos,Q.M., Whalley,L.E., Cui,W., Padilla,S. and Arcury,T.A.
TITLE Evaluation of candidate genes for cholinesterase activity in
farmworkers exposed to organophosphorus pesticides: association of
single nucleotide polymorphisms in BCHE
JOURNAL Environ. Health Perspect. 118 (10), 1395-1399 (2010)
PUBMED 20529763
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 3 (bases 1 to 2385)
AUTHORS Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
Christiani,D.C.
TITLE A Large-scale genetic association study of esophageal
adenocarcinoma risk
JOURNAL Carcinogenesis 31 (7), 1259-1263 (2010)
PUBMED 20453000
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 2385)
AUTHORS Lee,M.T., Chen,C.H., Chou,C.H., Lu,L.S., Chuang,H.P., Chen,Y.T.,
Saleem,A.N., Wen,M.S., Chen,J.J., Wu,J.Y. and Chen,Y.T.
TITLE Genetic determinants of warfarin dosing in the Han-Chinese
population
JOURNAL Pharmacogenomics 10 (12), 1905-1913 (2009)
PUBMED 19958090
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 5 (bases 1 to 2385)
AUTHORS Satyanarayana,C.R., Devendran,A., Jayaraman,M., Mannu,J.,
Mathur,P.P., Gopal,S.D., Rajagopal,K. and Chandrasekaran,A.
TITLE Influence of the genetic polymorphisms in the 5' flanking and
exonic regions of CYP2C19 on proguanil oxidation
JOURNAL Drug Metab. Pharmacokinet. 24 (6), 537-548 (2009)
PUBMED 20045989
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 2385)
AUTHORS Nelson,D.R., Zeldin,D.C., Hoffman,S.M., Maltais,L.J., Wain,H.M. and
Nebert,D.W.
TITLE Comparison of cytochrome P450 (CYP) genes from the mouse and human
genomes, including nomenclature recommendations for genes,
pseudogenes and alternative-splice variants
JOURNAL Pharmacogenetics 14 (1), 1-18 (2004)
PUBMED 15128046
REMARK Review article
REFERENCE 7 (bases 1 to 2385)
AUTHORS Goldstein,J.A. and de Morais,S.M.
TITLE Biochemistry and molecular biology of the human CYP2C subfamily
JOURNAL Pharmacogenetics 4 (6), 285-299 (1994)
PUBMED 7704034
REMARK Review article
REFERENCE 8 (bases 1 to 2385)
AUTHORS Ged,C. and Beaune,P.
TITLE Partial sequence and polymerase chain reaction-mediated analysis of
expression of the human CYP2C18 gene
JOURNAL Pharmacogenetics 2 (3), 109-115 (1992)
PUBMED 1306110
REFERENCE 9 (bases 1 to 2385)
AUTHORS Furuya,H., Meyer,U.A., Gelboin,H.V. and Gonzalez,F.J.
TITLE Polymerase chain reaction-directed identification, cloning, and
quantification of human CYP2C18 mRNA
JOURNAL Mol. Pharmacol. 40 (3), 375-382 (1991)
PUBMED 1896026
REFERENCE 10 (bases 1 to 2385)
AUTHORS Romkes,M., Faletto,M.B., Blaisdell,J.A., Raucy,J.L. and
Goldstein,J.A.
TITLE Cloning and expression of complementary DNAs for multiple members
of the human cytochrome P450IIC subfamily
JOURNAL Biochemistry 30 (13), 3247-3255 (1991)
PUBMED 2009263
REMARK Erratum:[Biochemistry. 1993 Feb 9;32(5):1390. PMID: 8095407]
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BJ993698.1, BC096260.1,
M61856.1, M61853.1 and BX538127.1.
Summary: This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum but its
specific substrate has not yet been determined. The gene is located
within a cluster of cytochrome P450 genes on chromosome 10q24. An
additional gene, CYP2C17, was once thought to exist; however,
CYP2C17 is now considered an artefact based on a chimera of CYP2C18
and CYP2C19. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (2) lacks a coding exon in the
middle region, but the reading frame is not affected, as compared
to variant 1. The resulting isoform (2) lacks an internal segment,
as compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC096260.1, CD013966.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-281 BJ993698.1 1-281
282-1752 BC096260.1 1-1471
1753-1945 M61856.1 1803-1995
1946-2213 M61853.1 1839-2106
2214-2385 BX538127.1 1525-1696
FEATURES Location/Qualifiers
source 1..2385
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q24"
gene 1..2385
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="cytochrome P450, family 2, subfamily C, polypeptide
18"
/db_xref="GeneID:1562"
/db_xref="HGNC:2620"
/db_xref="MIM:601131"
exon 1..494
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:879406"
variation 28
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:148696174"
variation 60..62
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="aac"
/db_xref="dbSNP:376114020"
variation 61..62
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="caa"
/db_xref="dbSNP:368050072"
variation 164
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:79340481"
variation 261
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:374585526"
STS 282..1753
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/db_xref="UniSTS:482629"
misc_feature 309..311
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="upstream in-frame stop codon"
variation 311
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:201820267"
variation 312
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201110913"
variation 314
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142036845"
variation 316
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:374064225"
variation 318
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:377514919"
CDS 327..1622
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/EC_number="1.14.14.1"
/note="isoform 2 precursor is encoded by transcript
variant 2; microsomal monooxygenase; flavoprotein-linked
monooxygenase; cytochrome P450, subfamily IIC (mephenytoin
4-hydroxylase), polypeptide 18; cytochrome P450, subfamily
IIC (mephenytoin 4-hydroxylase), polypeptide 17;
cytochrome P450 2C18; (S)-mephenytoin hydroxylase
associated cytochrome P450; unspecific monooxygenase;
CYPIIC18; cytochrome P450-6B/29C"
/codon_start=1
/product="cytochrome P450 2C18 isoform 2 precursor"
/protein_id="NP_001122397.1"
/db_xref="GI:193083148"
/db_xref="CCDS:CCDS44460.1"
/db_xref="GeneID:1562"
/db_xref="HGNC:2620"
/db_xref="MIM:601131"
/translation="
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
"
sig_peptide 327..401
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 408..>932
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="Cytochrome P450 [Secondary metabolites
biosynthesis, transport, and catabolism]; Region: CypX;
cl12078"
/db_xref="CDD:212625"
misc_feature 414..1610
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="Cytochrome P450; Region: p450; pfam00067"
/db_xref="CDD:200971"
misc_feature <1005..1559
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/note="Cytochrome P450 [Secondary metabolites
biosynthesis, transport, and catabolism]; Region: CypX;
cl12078"
/db_xref="CDD:212625"
variation 360
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:370987812"
variation 473
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:56113807"
exon 495..657
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 512
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143341184"
variation 519
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:146239394"
variation 520
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:202113535"
variation 529..530
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="t"
/db_xref="dbSNP:372279673"
variation 530
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:41291550"
variation 548
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:375505433"
variation 555
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143695270"
variation 565
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:368264095"
variation 592
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:372444081"
variation 609
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200398730"
variation 651
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:145731435"
exon 658..807
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 674
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:371597682"
variation 679
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201048148"
variation 692
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:190647817"
variation 696
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:117111102"
variation 700
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142985033"
variation 749
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:151106761"
variation 757
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:115091705"
variation 774
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:371910428"
variation 796
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:375267413"
exon 808..968
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 809
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:202163378"
variation 818
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:373749082"
variation 821
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:116092201"
variation 834
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:11188056"
variation 853
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:139238143"
variation 879
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:376802839"
variation 882
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:141271146"
variation 887
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200638718"
variation 889
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41303835"
variation 893
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:374650806"
variation 902
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:115269792"
variation 908..909
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="t"
/db_xref="dbSNP:72558183"
variation 931
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:137908489"
variation 948
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:11188057"
variation 953
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:149450201"
exon 969..1110
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 973
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:117601208"
variation 974
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:146257549"
variation 1045
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:60181876"
variation 1050
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:202032764"
variation 1055
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:200741772"
variation 1060
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:201878313"
variation 1064
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:201426134"
variation 1079
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:143695504"
variation 1091
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:375872072"
exon 1111..1298
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1111
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:191275957"
variation 1137
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:59636573"
variation 1152
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:140111676"
variation 1153
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286880"
variation 1161
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41286882"
variation 1183
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200587027"
variation 1197
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:145173626"
variation 1209
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:142667327"
variation 1241
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:76498052"
variation 1243
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:144917969"
variation 1244
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:147932613"
variation 1257
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:373928015"
variation 1265
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:199696917"
variation 1274
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:141702647"
variation 1283
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:377123025"
variation 1297
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:370873051"
exon 1299..1440
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1303
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:1126545"
variation 1304
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:114879149"
variation 1317
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:371155124"
variation 1328
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:78319229"
variation 1360
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:201690300"
variation 1367
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201619531"
variation 1369
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:150095869"
variation 1373
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="g"
/db_xref="dbSNP:367800235"
variation 1406
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:138527038"
variation 1420
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:374042569"
variation 1434
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:200735820"
variation 1439
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:145480465"
exon 1441..2368
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/inference="alignment:Splign:1.39.8"
variation 1473
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:79500998"
variation 1474
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:111489446"
variation 1500
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:202042825"
variation 1503
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:201218429"
variation 1538
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:371529582"
variation 1542
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="t"
/db_xref="dbSNP:138045916"
variation 1574
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:149500379"
variation 1582
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:41286884"
variation 1589
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:115308818"
variation 1628
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:184489530"
variation 1653
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:2860840"
variation 1687
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:3740367"
variation 1705
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1042192"
variation 1732
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="g"
/db_xref="dbSNP:74696697"
variation 1831
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41291552"
variation 1902
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:190761792"
variation 1905
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:1042194"
variation 1976
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:76680226"
variation 2008
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="a"
/replace="c"
/db_xref="dbSNP:181997244"
variation 2048
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="c"
/replace="t"
/db_xref="dbSNP:41291554"
STS 2065..2202
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/standard_name="RH2"
/db_xref="UniSTS:58153"
variation 2168..2169
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace=""
/replace="a"
/db_xref="dbSNP:140228918"
variation 2214
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:1326830"
variation 2306
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
/replace="g"
/replace="t"
/db_xref="dbSNP:115365853"
polyA_site 2367
/gene="CYP2C18"
/gene_synonym="CPCI; CYP2C; CYP2C17; P450-6B/29C;
P450IIC17"
ORIGIN
gagatcttgccattgcactccagcctgggcaacaagagcgaaactccatctcaaggaaaaacaacaacaacaacaacaaaatcctgggctctgcttcagactagttaaaccagaatctccagggtggggcaccggaaagaacaagaaaaaagaacaccttatttttatcttcttcagtgagccaatgttcattcaaaagagagattaaagtgctttttgctgactagtcacagtcagagtcagaatcacaggtggattagtagggagtgttataaaagccttgaagtgaaagcccgcagttgtcttactaagaagagaagccttcaatggatccagctgtggctctggtgctctgtctctcctgtttgtttctcctttcactctggaggcagagctctggaagagggaggctcccgtctggccccactcctctcccgattattggaaatatcctgcagttagatgttaaggacatgagcaaatccttaaccaatttctcaaaagtctatggccctgtgttcactgtgtattttggcctgaagcccattgtggtgttgcatggatatgaagcagtgaaggaggccctgattgatcatggagaggagttttctggaagaggaagttttccagtggctgaaaaagttaacaaaggacttggaatccttttcagcaatggaaagagatggaaggagatccggcgtttctgcctcatgactctgcggaattttgggatggggaagaggagcatcgaggaccgtgttcaagaggaagcccgctgccttgtggaggagttgagaaaaaccaatgcctcaccctgtgatcccactttcatcctgggctgtgctccctgcaatgtgatctgctctgttattttccatgatcgatttgattataaagatcagaggtttcttaacttgatggaaaaattcaatgaaaacctcaggattctgagctctccatggatccaggaaaagcacaatcaacagtctgaatttactgttgaaagcttgatagccactgtaactgatatgtttggggctggaacagagacaacgagcaccactctgagatatggactcctgctcctgctgaagtacccagaggtcacagctaaagtccaggaagagattgaatgtgtagttggcagaaaccggagcccctgtatgcaggacaggagtcacatgccctacacagatgctgtggtgcacgagatccagagatacattgacctcctccccaccaacctgccccatgcagtgacctgtgatgttaaattcaaaaactacctcatccccaagggcacgaccataataacatccctgacttctgtgctgcacaatgacaaagaattccccaacccagagatgtttgaccctggccactttctggataagagtggcaactttaagaaaagtgactacttcatgcctttctcagcaggaaaacggatgtgtatgggagagggcctggcccgcatggagctgtttttattcctgaccaccattttgcagaactttaacctgaaatctcaggttgacccaaaggatattgacatcacccccattgccaatgcatttggtcgtgtgccacccttgtaccagctctgcttcattcctgtctgaagaagggcagatagtttggctgctcctgtgctgtcacctgcaattctcccttatcagggccattggcctctcccttctctctgtgagggatattttctctgacttgtcaatccacatcttcccattccctcaagatccaatgaacatccaacctccattaaagagagtttcttgggtcacttcctaaatatatctgctattctccatactctgtatcacttgtattgaccaccacatatgctaatacctatctactgctgagttgtcagtatgttatcactagaaaacaaagaaaaatgattaataaatgacaattcagagccatttattctctgcatgctctagataaaaatgattattatttactgggtcagttcttagatttctttcttttgagtaaaatgaaagtaagaaatgaaagaaaatagaatgtgaagaggctgtgctggccctcatagtgttaagcacaaaaagggagaaaggtaagagggtaggaaagctgttttagctaaatgccacctagagttattggaggtctgaatttggaaaaaaaaactatgtccaggagcagctgtaacctgtagggaaatactggaacaatcatccataagagggatgaacattaagtgtttgaattcatgctctgcttttgtgttactgtaaacacaagatcaagatttggataatctttttcctttgtgtttccaacttagatcatgtctaaatatatgctttcatatggctaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1562 -> Molecular function: GO:0004497 [monooxygenase activity] evidence: TAS
GeneID:1562 -> Molecular function: GO:0005506 [iron ion binding] evidence: IEA
GeneID:1562 -> Molecular function: GO:0009055 [electron carrier activity] evidence: IEA
GeneID:1562 -> Molecular function: GO:0019825 [oxygen binding] evidence: TAS
GeneID:1562 -> Molecular function: GO:0020037 [heme binding] evidence: IEA
GeneID:1562 -> Molecular function: GO:0070330 [aromatase activity] evidence: IEA
GeneID:1562 -> Biological process: GO:0006805 [xenobiotic metabolic process] evidence: TAS
GeneID:1562 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
GeneID:1562 -> Cellular component: GO:0005789 [endoplasmic reticulum membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001122397 -> EC 1.14.14.1
by
@meso_cacase at
DBCLS
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