2024-04-19 23:46:42, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001128629 3808 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), transcript variant 3, mRNA. ACCESSION NM_001128629 VERSION NM_001128629.2 GI:456367263 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 3808) AUTHORS Liu,T., Li,Y., Gu,H., Zhu,G., Li,J., Cao,L. and Li,F. TITLE p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via phosphorylation of androgen receptor and tumorigenic E3 ligase murine double minute-2 (Mdm2) JOURNAL J. Biol. Chem. 288 (5), 3359-3369 (2013) PUBMED 23132866 REMARK GeneRIF: PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation. REFERENCE 2 (bases 1 to 3808) AUTHORS Shepelev,M.V. and Korobko,I.V. TITLE Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV JOURNAL Biochemistry Mosc. 77 (1), 26-32 (2012) PUBMED 22339630 REFERENCE 3 (bases 1 to 3808) AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K., Gibbs,R.A. and Butte,N.F. TITLE Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population JOURNAL PLoS ONE 7 (12), E51954 (2012) PUBMED 23251661 REFERENCE 4 (bases 1 to 3808) AUTHORS McCarty,S.K., Saji,M., Zhang,X., Jarjoura,D., Fusco,A., Vasko,V.V. and Ringel,M.D. TITLE Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion JOURNAL Endocr. Relat. Cancer 17 (4), 989-999 (2010) PUBMED 20817787 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 3808) AUTHORS Wells,C.M. and Jones,G.E. TITLE The emerging importance of group II PAKs JOURNAL Biochem. J. 425 (3), 465-473 (2010) PUBMED 20070256 REMARK Review article Publication Status: Online-Only REFERENCE 6 (bases 1 to 3808) AUTHORS Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A. TITLE p21 activated kinase 5 activates Raf-1 and targets it to mitochondria JOURNAL J. Cell. Biochem. 105 (1), 167-175 (2008) PUBMED 18465753 REMARK GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may control Raf-1 dependent signaling at mitochondria REFERENCE 7 (bases 1 to 3808) AUTHORS Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P., Schneider,M.C. and Lu,M.L. TITLE Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase JOURNAL J. Biol. Chem. 280 (5), 3323-3330 (2005) PUBMED 15550393 REMARK GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6 suggests that PAK6 plays a role in the cellular response to stress-related signals. REFERENCE 8 (bases 1 to 3808) AUTHORS Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and Bokoch,G.M. TITLE Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling JOURNAL J. Biol. Chem. 279 (3), 1922-1931 (2004) PUBMED 14573606 REFERENCE 9 (bases 1 to 3808) AUTHORS Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and Balk,S.P. TITLE AR and ER interaction with a p21-activated kinase (PAK6) JOURNAL Mol. Endocrinol. 16 (1), 85-99 (2002) PUBMED 11773441 REFERENCE 10 (bases 1 to 3808) AUTHORS Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z. TITLE Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6 JOURNAL J. Biol. Chem. 276 (18), 15345-15353 (2001) PUBMED 11278661 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315817.1, BC035596.1, AK131522.1 and AK026592.1. On Mar 1, 2013 this sequence version replaced gi:191252781. Summary: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315817.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1343 AK315817.1 1-1343 1344-2414 BC035596.1 1098-2168 2415-3098 AK131522.1 2835-3518 3099-3376 AK131522.1 3529-3806 3377-3808 AK026592.1 1-432 FEATURES Location/Qualifiers source 1..3808 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q14" gene 1..3808 /gene="PAK6" /gene_synonym="PAK5" /note="p21 protein (Cdc42/Rac)-activated kinase 6" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" exon 1..240 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 116 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:28989184" variation 142 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:145639700" variation 150 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:151035388" variation 152 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:141119531" variation 153 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:28989183" variation 167 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:74380950" variation 174 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:139066741" variation 175 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:143232848" exon 241..352 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 300 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:11636097" misc_feature 316..318 /gene="PAK6" /gene_synonym="PAK5" /note="upstream in-frame stop codon" exon 353..561 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 354 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201707008" CDS 358..2403 /gene="PAK6" /gene_synonym="PAK5" /EC_number="2.7.11.1" /note="isoform 1 is encoded by transcript variant 3; p21(CDKN1A)-activated kinase 6; serine/threonine-protein kinase PAK 6" /codon_start=1 /product="serine/threonine-protein kinase PAK 6 isoform 1" /protein_id="NP_001122101.1" /db_xref="GI:191252782" /db_xref="CCDS:CCDS10054.1" /db_xref="GeneID:56924" /db_xref="HGNC:16061" /db_xref="MIM:608110" /translation="
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
" misc_feature 385..522 /gene="PAK6" /gene_synonym="PAK5" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; Region: CRIB_PAK_like; cd01093" /db_xref="CDD:29038" misc_feature order(391..393,400..402,409..411,415..417,424..426, 475..477,487..489) /gene="PAK6" /gene_synonym="PAK5" /note="GTPase interaction site [polypeptide binding]; other site" /db_xref="CDD:29038" misc_feature 433..1575 /gene="PAK6" /gene_synonym="PAK5" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q9NQU5.1); Region: Linker" misc_feature 1510..2400 /gene="PAK6" /gene_synonym="PAK5" /note="Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 6; Region: STKc_PAK6; cd06659" /db_xref="CDD:132990" misc_feature 1591..2331 /gene="PAK6" /gene_synonym="PAK5" /note="Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220" /db_xref="CDD:197582" misc_feature order(1594..1608,1618..1620,1657..1659,1663..1665, 1690..1692,1750..1752,1798..1812,1816..1821,1828..1830, 1933..1935,1939..1950,1954..1956,1984..1989,1996..1998, 2035..2049,2053..2055,2134..2136,2161..2169) /gene="PAK6" /gene_synonym="PAK5" /note="active site" /db_xref="CDD:132990" misc_feature order(1594..1608,1618..1620,1657..1659,1663..1665, 1750..1752,1798..1812,1816..1821,1828..1830,1945..1950, 1954..1956,1984..1989) /gene="PAK6" /gene_synonym="PAK5" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature order(1603..1608,1690..1692,1933..1935,1939..1947, 1996..1998,2035..2049,2053..2055,2134..2136,2161..2169) /gene="PAK6" /gene_synonym="PAK5" /note="substrate binding site [chemical binding]; other site" /db_xref="CDD:132990" misc_feature 1984..2055 /gene="PAK6" /gene_synonym="PAK5" /note="activation loop (A-loop); other site" /db_xref="CDD:132990" variation 365 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201346085" variation 383 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61733786" variation 387 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:139649727" variation 398 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11544039" variation 399 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145212795" variation 405 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371968905" variation 426 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202083311" variation 435 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376250193" variation 436 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149132419" variation 469 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372639063" variation 470 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:142256590" variation 499 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369235955" variation 507 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:199695379" variation 512 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146905959" variation 514 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371738802" variation 517 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147960311" variation 539 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:376432897" variation 558 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372069647" exon 562..1215 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 583 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:2412504" variation 606 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:2016902" variation 618 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:138470960" variation 664 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36081263" variation 678 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:150318570" variation 679 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:137969148" variation 682 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375852612" variation 686 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149461942" variation 712 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370496102" variation 729 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200035365" variation 730 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:202073596" variation 753 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:375526083" variation 758 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:373050572" variation 774 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:376277766" variation 781 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201017672" variation 789 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34608644" variation 801 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369750707" variation 802 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373280531" variation 807 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:138761742" variation 809 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35593179" variation 820 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370397655" variation 822 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141846316" variation 834 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373870185" variation 835 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:146254732" variation 836 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:67578703" variation 885 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377362218" variation 899 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:191280501" variation 907 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56349744" variation 916 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:376068775" variation 920 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:368829109" variation 924 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138937506" variation 926 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149315160" variation 929 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61732685" variation 942 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371505679" variation 944 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200417617" variation 945 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371452582" variation 950 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144246288" variation 952 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55741128" variation 971 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:55920845" variation 977 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:141487285" variation 979 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:35501648" variation 986 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:34869667" variation 987 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:368535824" variation 989 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147727470" variation 991 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:371550083" variation 993 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:370838549" variation 1001 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:3743135" variation 1021 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:181253186" variation 1035 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:185330250" variation 1053 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:376968689" variation 1062 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:148386599" variation 1068 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:375014773" variation 1081 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367656601" variation 1102 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371445081" variation 1116 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:374286048" variation 1129 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:143324236" variation 1131 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201350352" variation 1142 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:61739745" variation 1200 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202230516" variation 1212 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:373963726" exon 1216..1713 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1225..1229 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tcttt" /db_xref="dbSNP:144811359" variation 1229 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:75694545" variation 1232 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:150100570" variation 1235 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371298913" variation 1236 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138523206" variation 1239 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141886873" variation 1266 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:146266050" variation 1289 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:374205024" variation 1290 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:149513654" variation 1296 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371922217" variation 1299 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200815331" variation 1315 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:200107644" variation 1329 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:367831338" variation 1357 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:143993282" variation 1367 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:3743137" variation 1381 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371395174" variation 1390 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371593698" variation 1403 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201684963" variation 1414 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369825628" variation 1460 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:142340502" variation 1466 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:202233605" variation 1469 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377762904" variation 1472 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67864419" variation 1484 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:55806501" variation 1493 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:139850733" variation 1519 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145336671" variation 1535 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147750062" variation 1565 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:5021809" variation 1611 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149826022" variation 1630 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:145812191" variation 1631 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145647822" variation 1648 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369042481" variation 1650 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:35119729" variation 1693..1694 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:35003343" variation 1709 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="a" /db_xref="dbSNP:68158967" variation 1710 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:1006606" exon 1714..1847 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1726 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:201655600" variation 1745 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201153660" variation 1746 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:144657412" variation 1780 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34445577" STS 1806..2932 /gene="PAK6" /gene_synonym="PAK5" /standard_name="D1S3693" /db_xref="UniSTS:474271" variation 1809 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:200429138" variation 1831 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:140245743" variation 1843 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:372547442" exon 1848..1974 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1851 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:146088177" variation 1857 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:145203209" variation 1858 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:377397005" variation 1966 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:148062077" exon 1975..2100 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 1979 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:373086987" variation 2010 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:199802493" variation 2012 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:113493588" variation 2019 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:201198106" variation 2020 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:141761526" variation 2040 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:35644942" exon 2101..2235 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2121 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:149385124" variation 2138 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:147489955" variation 2179 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:74468066" variation 2190 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:139943572" variation 2193 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201804704" variation 2198 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:143844489" variation 2199 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:375706027" variation 2220 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:56111625" variation 2230 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:371992889" exon 2236..3796 /gene="PAK6" /gene_synonym="PAK5" /inference="alignment:Splign:1.39.8" variation 2244 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:201093320" variation 2260 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:369819404" variation 2267 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:147232997" variation 2277 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:186069684" variation 2307 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:374185464" variation 2365 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:201637258" variation 2378 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:377614111" variation 2418..2419 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="g" /db_xref="dbSNP:373523942" variation 2443 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:370753710" variation 2499 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="t" /db_xref="dbSNP:67409239" variation 2549 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:34376657" variation 2755 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:34276379" variation 2793 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="t" /db_xref="dbSNP:2242120" variation 2832 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:192345226" variation 2842 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:36068492" variation 2861 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:34042288" variation 2931 /gene="PAK6" /gene_synonym="PAK5" /replace="g" /replace="t" /db_xref="dbSNP:2242119" variation 3018 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="g" /db_xref="dbSNP:189289921" variation 3021 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:144984113" variation 3058..3059 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:371193727" variation 3059..3068 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:113864236" variation 3059..3066 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:376406581" variation 3080..3087 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72058737" variation 3082..3089 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:71898851" variation 3088..3089 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="tgtgtgtg" /db_xref="dbSNP:72216147" variation 3089..3090 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /replace="gtgtgtgtgtgt" /db_xref="dbSNP:67649145" variation 3091..3098 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgt" /db_xref="dbSNP:58716292" variation 3098..3099 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="ac" /replace="acacacacac" /replace="cacacac" /db_xref="dbSNP:67205800" variation 3099..3100 /gene="PAK6" /gene_synonym="PAK5" /replace="" /replace="gtgtgtgtgt" /db_xref="dbSNP:72212801" variation 3146 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:75122003" variation 3170 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:371075338" variation 3245 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:183657807" variation 3257 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:111385535" variation 3328 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:187963215" variation 3360 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="c" /db_xref="dbSNP:55738516" variation 3378 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:116029092" STS 3487..3767 /gene="PAK6" /gene_synonym="PAK5" /standard_name="WI-21468" /db_xref="UniSTS:26519" STS 3528..3679 /gene="PAK6" /gene_synonym="PAK5" /standard_name="RH15701" /db_xref="UniSTS:82077" variation 3548 /gene="PAK6" /gene_synonym="PAK5" /replace="c" /replace="t" /db_xref="dbSNP:11635121" variation 3549 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:75108621" variation 3592 /gene="PAK6" /gene_synonym="PAK5" /replace="a" /replace="g" /db_xref="dbSNP:138256759" polyA_signal 3774..3779 /gene="PAK6" /gene_synonym="PAK5" polyA_site 3796 /gene="PAK6" /gene_synonym="PAK5" ORIGIN
aaagaccagctatgcagcttctttcatggcctatttttattatctccttctcttaaatctgggctcagaatccacgatccctatgattgtaacaagaacaatcaagctttgaagatagtggacttttcctacagtgttgaccttagggtgcagctggatgtttttaccctcagcggctttcggactgtacagatcctggaaggacaaaagatcctggctaactgttcttctccctaccaggcctgcggaggactggcccagcaaggtcccaggtcttccctctcctcagcgcctaagagagaggcccagtgcgggtgaggagtcgcgaggaagaggcggaaggcgccggaaggcaccatgttccgcaagaaaaagaagaaacgccctgagatctcagcgccacagaacttccagcaccgtgtccacacctccttcgaccccaaagaaggcaagtttgtgggcctccccccacaatggcagaacatcctggacacactgcggcgccccaagcccgtggtggacccttcgcgaatcacacgggtgcagctccagcccatgaagacagtggtgcggggcagcgcgatgcctgtggatggctacatctcggggctgctcaacgacatccagaagttgtcagtcatcagctccaacaccctgcgtggccgcagccccaccagccggcggcgggcacagtccctggggctgctgggggatgagcactgggccaccgacccagacatgtacctccagagcccccagtctgagcgcactgacccccacggcctctacctcagctgcaacgggggcacaccagcaggccacaagcagatgccgtggcccgagccacagagcccacgggtcctgcccaatgggctggctgcaaaggcacagtccctgggccccgccgagtttcagggtgcctcgcagcgctgtctgcagctgggtgcctgcctgcagagctccccaccaggagcctcgccccccacgggcaccaataggcatggaatgaaggctgccaagcatggctctgaggaggcccggccacagtcctgcctggtgggctcagccacaggcaggccaggtggggaaggcagccctagccctaagacccgggagagcagcctgaagcgcaggctattccgaagcatgttcctgtccactgctgccacagcccctccaagcagcagcaagccaggccctccaccacagagcaagcccaactcctctttccgaccgccgcagaaagacaaccccccaagcctggtggccaaggcccagtccttgccctcggaccagccggtggggaccttcagccctctgaccacttcggataccagcagcccccagaagtccctccgcacagccccggccacaggccagcttccaggccggtcttccccagcgggatccccccgcacctggcacgcccagatcagcaccagcaacctgtacctgccccaggaccccacggttgccaagggtgccctggctggtgaggacacaggtgttgtgacacatgagcagttcaaggctgcgctcaggatggtggtggaccagggtgacccccggctgctgctggacagctacgtgaagattggcgagggctccaccggcatcgtctgcttggcccgggagaagcactcgggccgccaggtggccgtcaagatgatggacctcaggaagcagcagcgcagggagctgctcttcaacgaggtggtgatcatgcgggactaccagcacttcaacgtggtggagatgtacaagagctacctggtgggcgaggagctgtgggtgctcatggagttcctgcagggaggagccctcacagacatcgtctcccaagtcaggctgaatgaggagcagattgccactgtgtgtgaggctgtgctgcaggccctggcctacctgcatgctcagggtgtcatccaccgggacatcaagagtgactccatcctgctgaccctcgatggcagggtgaagctctcggacttcggattctgtgctcagatcagcaaagacgtccctaagaggaagtccctggtgggaaccccctactggatggctcctgaagtgatctccaggtctttgtatgccactgaggtggatatctggtctctgggcatcatggtgattgagatggtagatggggagccaccgtacttcagtgactccccagtgcaagccatgaagaggctccgggacagccccccacccaagctgaaaaactctcacaaggtctccccagtgctgcgagacttcctggagcggatgctggtgcgggacccccaagagagagccacagcccaggagctcctagaccaccccttcctgctgcagacagggctacctgagtgcctggtgcccctgatccagctctaccgaaagcagacctccacctgctgagcccaccccaagtatgcctgccacctacgcccacaggcagggcacactgggcagccagcctgccggcaggacttgcctgcctcctcctctcagtattctctccaaagattgaaatgtgaagccccagccccaccctctgcccttcagcctactgggccaggccggacctgccccctcagtgtctctccctcccgagtccccagatggagacccctttctacaggatgaccccttgatatttgcacagggatatttctaagaaacgcagaggccagcgttcctggcctctgcagccaacacagtagaaaaggctgctgtggttttttaaaggcagttgtccactagtgtcctaggccactgcagagggcagactgctggtctccacagatacctgctgttctcagctccagcttcaaacctcgagtctcgagagggccacggggtggtttttatgaccggaatcccgcttcctccctcacgtctgatgtcctgaaggtgcagtcccacctgtacagcccctccccgcccagaactgtgaatggcctgctccaggccatggctgggggcagggagtgaggggacaatttctgagtgaaagagaaagaatggggtcggtggtgaaggtgctctcactttacagaatggagagaacatcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaggggaggaaagccaccttgacagcccaggtccctccaggtcacccacagccagtttcaggaaggctgcccctctctcccactaagttctggcctgaagggacctgctttcttggcctggcttccacctctccactcctgtgtctacctggccagtggagtggtccatgctaagtctaacactcctgggagctcaggaggcttctgagcttctcctgtactgtgcatcgtgagggccagagacaggaatgtaaggattggcaactgtgttacctttcaagtttatctcaataaccaggtcatcagggacccattgttctcttcagaaccctatctgggagagaaggcgaaccacctccgggtttccatcatgtcaaggtcacaggcatccatgtgtgcaaaccatctgccccagctgcctccacagactgctgtctccttgtcctcctcggccctgccccacttcagggctgctgtgagatggaattccaggaaagaacttcaggtgtctggaccctttctatctagataatatttttagattcttctgctccctagtgacctacctgggggcaaagaaattgcaaggacttttttttaagggtcagagttttcaaaacaaaagcatcttccctagaaatttttgtgaattgtttgcacttgtgcctgttttaaattaaattgagtgttcaaagccaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:56924 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA GeneID:56924 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA GeneID:56924 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS GeneID:56924 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:56924 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS GeneID:56924 -> Cellular component: GO:0005634 [nucleus] evidence: IEA GeneID:56924 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001122101 -> EC 2.7.11.1
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@meso_cacase at
DBCLS
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