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2024-04-26 10:01:31, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001128628 3891 bp mRNA linear PRI 17-JUN-2013
DEFINITION Homo sapiens p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6),
transcript variant 2, mRNA.
ACCESSION NM_001128628
VERSION NM_001128628.2 GI:456367262
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3891)
AUTHORS Liu,T., Li,Y., Gu,H., Zhu,G., Li,J., Cao,L. and Li,F.
TITLE p21-Activated kinase 6 (PAK6) inhibits prostate cancer growth via
phosphorylation of androgen receptor and tumorigenic E3 ligase
murine double minute-2 (Mdm2)
JOURNAL J. Biol. Chem. 288 (5), 3359-3369 (2013)
PUBMED 23132866
REMARK GeneRIF: PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is
critical for AR ubiquitin-mediated degradation.
REFERENCE 2 (bases 1 to 3891)
AUTHORS Shepelev,M.V. and Korobko,I.V.
TITLE Pak6 protein kinase is a novel effector of an atypical Rho family
GTPase Chp/RhoV
JOURNAL Biochemistry Mosc. 77 (1), 26-32 (2012)
PUBMED 22339630
REFERENCE 3 (bases 1 to 3891)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 4 (bases 1 to 3891)
AUTHORS McCarty,S.K., Saji,M., Zhang,X., Jarjoura,D., Fusco,A., Vasko,V.V.
and Ringel,M.D.
TITLE Group I p21-activated kinases regulate thyroid cancer cell
migration and are overexpressed and activated in thyroid cancer
invasion
JOURNAL Endocr. Relat. Cancer 17 (4), 989-999 (2010)
PUBMED 20817787
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 3891)
AUTHORS Wells,C.M. and Jones,G.E.
TITLE The emerging importance of group II PAKs
JOURNAL Biochem. J. 425 (3), 465-473 (2010)
PUBMED 20070256
REMARK Review article
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 3891)
AUTHORS Wu,X., Carr,H.S., Dan,I., Ruvolo,P.P. and Frost,J.A.
TITLE p21 activated kinase 5 activates Raf-1 and targets it to
mitochondria
JOURNAL J. Cell. Biochem. 105 (1), 167-175 (2008)
PUBMED 18465753
REMARK GeneRIF: PAK5 is a potent regulator of Raf-1 activity and may
control Raf-1 dependent signaling at mitochondria
REFERENCE 7 (bases 1 to 3891)
AUTHORS Kaur,R., Liu,X., Gjoerup,O., Zhang,A., Yuan,X., Balk,S.P.,
Schneider,M.C. and Lu,M.L.
TITLE Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38
MAP kinase
JOURNAL J. Biol. Chem. 280 (5), 3323-3330 (2005)
PUBMED 15550393
REMARK GeneRIF: The activation of PAK6 by both p38 MAP kinase and MKK6
suggests that PAK6 plays a role in the cellular response to
stress-related signals.
REFERENCE 8 (bases 1 to 3891)
AUTHORS Schrantz,N., da Silva Correia,J., Fowler,B., Ge,Q., Sun,Z. and
Bokoch,G.M.
TITLE Mechanism of p21-activated kinase 6-mediated inhibition of androgen
receptor signaling
JOURNAL J. Biol. Chem. 279 (3), 1922-1931 (2004)
PUBMED 14573606
REFERENCE 9 (bases 1 to 3891)
AUTHORS Lee,S.R., Ramos,S.M., Ko,A., Masiello,D., Swanson,K.D., Lu,M.L. and
Balk,S.P.
TITLE AR and ER interaction with a p21-activated kinase (PAK6)
JOURNAL Mol. Endocrinol. 16 (1), 85-99 (2002)
PUBMED 11773441
REFERENCE 10 (bases 1 to 3891)
AUTHORS Yang,F., Li,X., Sharma,M., Zarnegar,M., Lim,B. and Sun,Z.
TITLE Androgen receptor specifically interacts with a novel p21-activated
kinase, PAK6
JOURNAL J. Biol. Chem. 276 (18), 15345-15353 (2001)
PUBMED 11278661
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA414215.1, AK290227.1,
BC035596.1, AK131522.1 and AK026592.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 1, 2013 this sequence version replaced gi:191252779.
Summary: This gene encodes a member of a family of p21-stimulated
serine/threonine protein kinases, which contain an amino-terminal
Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal
kinase domain. These kinases function in a number of cellular
processes, including cytoskeleton rearrangement, apoptosis, and the
mitogen-activated protein (MAP) kinase signaling pathway. The
protein encoded by this gene interacts with androgen receptor (AR)
and translocates to the nucleus, where it is involved in
transcriptional regulation. Changes in expression of this gene have
been linked to prostate cancer. Alternative splicing results in
multiple transcript variants. [provided by RefSeq, Mar 2013].
Transcript Variant: This variant (2) differs in the 5' UTR,
compared to variant 1. Variants 1, 2, 3, and 4 encode the same
isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK315813.1, AK290227.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-159 DA414215.1 1-159
160-688 AK290227.1 1-529
689-2497 BC035596.1 360-2168
2498-3181 AK131522.1 2835-3518
3182-3459 AK131522.1 3529-3806
3460-3891 AK026592.1 1-432
FEATURES Location/Qualifiers
source 1..3891
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q14"
gene 1..3891
/gene="PAK6"
/gene_synonym="PAK5"
/note="p21 protein (Cdc42/Rac)-activated kinase 6"
/db_xref="GeneID:56924"
/db_xref="HGNC:16061"
/db_xref="MIM:608110"
exon 1..240
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 116
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:28989184"
variation 142
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:145639700"
variation 150
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:151035388"
variation 152
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:141119531"
variation 153
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:28989183"
variation 167
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:74380950"
variation 174
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139066741"
variation 175
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:143232848"
exon 241..323
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 266
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:184060506"
variation 309
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:4924439"
exon 324..435
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 383
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:11636097"
misc_feature 399..401
/gene="PAK6"
/gene_synonym="PAK5"
/note="upstream in-frame stop codon"
exon 436..644
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 437
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201707008"
CDS 441..2486
/gene="PAK6"
/gene_synonym="PAK5"
/EC_number="2.7.11.1"
/note="isoform 1 is encoded by transcript variant 2;
p21(CDKN1A)-activated kinase 6; serine/threonine-protein
kinase PAK 6"
/codon_start=1
/product="serine/threonine-protein kinase PAK 6 isoform 1"
/protein_id="NP_001122100.1"
/db_xref="GI:191252780"
/db_xref="CCDS:CCDS10054.1"
/db_xref="GeneID:56924"
/db_xref="HGNC:16061"
/db_xref="MIM:608110"
/translation="
MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRITRVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDEHWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSLGPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQISTSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
"
misc_feature 468..605
/gene="PAK6"
/gene_synonym="PAK5"
/note="PAK (p21 activated kinase) Binding Domain (PBD),
binds Cdc42p- and/or Rho-like small GTPases; also known as
the Cdc42/Rac interactive binding (CRIB) motif; has been
shown to inhibit transcriptional activation and cell
transformation mediated by the...; Region: CRIB_PAK_like;
cd01093"
/db_xref="CDD:29038"
misc_feature order(474..476,483..485,492..494,498..500,507..509,
558..560,570..572)
/gene="PAK6"
/gene_synonym="PAK5"
/note="GTPase interaction site [polypeptide binding];
other site"
/db_xref="CDD:29038"
misc_feature 516..1658
/gene="PAK6"
/gene_synonym="PAK5"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9NQU5.1);
Region: Linker"
misc_feature 1593..2483
/gene="PAK6"
/gene_synonym="PAK5"
/note="Catalytic domain of the Protein Serine/Threonine
Kinase, p21-activated kinase 6; Region: STKc_PAK6;
cd06659"
/db_xref="CDD:132990"
misc_feature 1674..2414
/gene="PAK6"
/gene_synonym="PAK5"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature order(1677..1691,1701..1703,1740..1742,1746..1748,
1773..1775,1833..1835,1881..1895,1899..1904,1911..1913,
2016..2018,2022..2033,2037..2039,2067..2072,2079..2081,
2118..2132,2136..2138,2217..2219,2244..2252)
/gene="PAK6"
/gene_synonym="PAK5"
/note="active site"
/db_xref="CDD:132990"
misc_feature order(1677..1691,1701..1703,1740..1742,1746..1748,
1833..1835,1881..1895,1899..1904,1911..1913,2028..2033,
2037..2039,2067..2072)
/gene="PAK6"
/gene_synonym="PAK5"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:132990"
misc_feature order(1686..1691,1773..1775,2016..2018,2022..2030,
2079..2081,2118..2132,2136..2138,2217..2219,2244..2252)
/gene="PAK6"
/gene_synonym="PAK5"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:132990"
misc_feature 2067..2138
/gene="PAK6"
/gene_synonym="PAK5"
/note="activation loop (A-loop); other site"
/db_xref="CDD:132990"
variation 448
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201346085"
variation 466
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61733786"
variation 470
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:139649727"
variation 481
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:11544039"
variation 482
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145212795"
variation 488
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371968905"
variation 509
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202083311"
variation 518
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376250193"
variation 519
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149132419"
variation 552
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372639063"
variation 553
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:142256590"
variation 582
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369235955"
variation 590
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:199695379"
variation 595
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146905959"
variation 597
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371738802"
variation 600
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:147960311"
variation 622
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:376432897"
variation 641
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372069647"
exon 645..1298
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 666
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:2412504"
variation 689
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:2016902"
variation 701
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:138470960"
variation 747
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:36081263"
variation 761
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:150318570"
variation 762
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:137969148"
variation 765
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375852612"
variation 769
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149461942"
variation 795
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370496102"
variation 812
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200035365"
variation 813
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:202073596"
variation 836
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:375526083"
variation 841
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:373050572"
variation 857
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:376277766"
variation 864
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201017672"
variation 872
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:34608644"
variation 884
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369750707"
variation 885
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373280531"
variation 890
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:138761742"
variation 892
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:35593179"
variation 903
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370397655"
variation 905
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141846316"
variation 917
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373870185"
variation 918
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:146254732"
variation 919
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="g"
/db_xref="dbSNP:67578703"
variation 968
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377362218"
variation 982
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:191280501"
variation 990
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:56349744"
variation 999
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:376068775"
variation 1003
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:368829109"
variation 1007
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138937506"
variation 1009
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149315160"
variation 1012
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61732685"
variation 1025
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:371505679"
variation 1027
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200417617"
variation 1028
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371452582"
variation 1033
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144246288"
variation 1035
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:55741128"
variation 1054
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:55920845"
variation 1060
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:141487285"
variation 1062
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:35501648"
variation 1069
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:34869667"
variation 1070
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:368535824"
variation 1072
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:147727470"
variation 1074
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:371550083"
variation 1076
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:370838549"
variation 1084
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:3743135"
variation 1104
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:181253186"
variation 1118
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:185330250"
variation 1136
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:376968689"
variation 1145
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:148386599"
variation 1151
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:375014773"
variation 1164
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367656601"
variation 1185
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371445081"
variation 1199
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:374286048"
variation 1212
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:143324236"
variation 1214
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201350352"
variation 1225
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:61739745"
variation 1283
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202230516"
variation 1295
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:373963726"
exon 1299..1796
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 1308..1312
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="tcttt"
/db_xref="dbSNP:144811359"
variation 1312
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:75694545"
variation 1315
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:150100570"
variation 1318
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371298913"
variation 1319
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138523206"
variation 1322
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:141886873"
variation 1349
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:146266050"
variation 1372
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:374205024"
variation 1373
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:149513654"
variation 1379
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:371922217"
variation 1382
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200815331"
variation 1398
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:200107644"
variation 1412
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:367831338"
variation 1440
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:143993282"
variation 1450
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:3743137"
variation 1464
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371395174"
variation 1473
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371593698"
variation 1486
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201684963"
variation 1497
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369825628"
variation 1543
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:142340502"
variation 1549
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:202233605"
variation 1552
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377762904"
variation 1555
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="t"
/db_xref="dbSNP:67864419"
variation 1567
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:55806501"
variation 1576
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:139850733"
variation 1602
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145336671"
variation 1618
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147750062"
variation 1648
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:5021809"
variation 1694
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149826022"
variation 1713
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:145812191"
variation 1714
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145647822"
variation 1731
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369042481"
variation 1733
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:35119729"
variation 1776..1777
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="g"
/db_xref="dbSNP:35003343"
variation 1792
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="a"
/db_xref="dbSNP:68158967"
variation 1793
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:1006606"
exon 1797..1930
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 1809
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:201655600"
variation 1828
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201153660"
variation 1829
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:144657412"
variation 1863
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:34445577"
STS 1889..3015
/gene="PAK6"
/gene_synonym="PAK5"
/standard_name="D1S3693"
/db_xref="UniSTS:474271"
variation 1892
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:200429138"
variation 1914
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:140245743"
variation 1926
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:372547442"
exon 1931..2057
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 1934
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:146088177"
variation 1940
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:145203209"
variation 1941
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:377397005"
variation 2049
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:148062077"
exon 2058..2183
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 2062
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:373086987"
variation 2093
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:199802493"
variation 2095
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:113493588"
variation 2102
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:201198106"
variation 2103
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:141761526"
variation 2123
/gene="PAK6"
/gene_synonym="PAK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:35644942"
exon 2184..2318
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 2204
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:149385124"
variation 2221
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:147489955"
variation 2262
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:74468066"
variation 2273
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:139943572"
variation 2276
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:201804704"
variation 2281
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:143844489"
variation 2282
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:375706027"
variation 2303
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:56111625"
variation 2313
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:371992889"
exon 2319..3879
/gene="PAK6"
/gene_synonym="PAK5"
/inference="alignment:Splign:1.39.8"
variation 2327
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:201093320"
variation 2343
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:369819404"
variation 2350
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:147232997"
variation 2360
/gene="PAK6"
/gene_synonym="PAK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:186069684"
variation 2390
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:374185464"
variation 2448
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:201637258"
variation 2461
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:377614111"
variation 2501..2502
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="g"
/db_xref="dbSNP:373523942"
variation 2526
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:370753710"
variation 2582
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="t"
/db_xref="dbSNP:67409239"
variation 2632
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:34376657"
variation 2838
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:34276379"
variation 2876
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="t"
/db_xref="dbSNP:2242120"
variation 2915
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:192345226"
variation 2925
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:36068492"
variation 2944
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:34042288"
variation 3014
/gene="PAK6"
/gene_synonym="PAK5"
/replace="g"
/replace="t"
/db_xref="dbSNP:2242119"
variation 3101
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="g"
/db_xref="dbSNP:189289921"
variation 3104
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:144984113"
variation 3141..3142
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgtgtgt"
/db_xref="dbSNP:371193727"
variation 3142..3151
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgtgt"
/db_xref="dbSNP:113864236"
variation 3142..3149
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgt"
/db_xref="dbSNP:376406581"
variation 3163..3170
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="tgtgtgtg"
/db_xref="dbSNP:72058737"
variation 3165..3172
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="tgtgtgtg"
/db_xref="dbSNP:71898851"
variation 3171..3172
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="tgtgtgtg"
/db_xref="dbSNP:72216147"
variation 3172..3173
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgt"
/replace="gtgtgtgtgtgt"
/db_xref="dbSNP:67649145"
variation 3174..3181
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgt"
/db_xref="dbSNP:58716292"
variation 3181..3182
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="ac"
/replace="acacacacac"
/replace="cacacac"
/db_xref="dbSNP:67205800"
variation 3182..3183
/gene="PAK6"
/gene_synonym="PAK5"
/replace=""
/replace="gtgtgtgtgt"
/db_xref="dbSNP:72212801"
variation 3229
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:75122003"
variation 3253
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:371075338"
variation 3328
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:183657807"
variation 3340
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:111385535"
variation 3411
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:187963215"
variation 3443
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="c"
/db_xref="dbSNP:55738516"
variation 3461
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:116029092"
STS 3570..3850
/gene="PAK6"
/gene_synonym="PAK5"
/standard_name="WI-21468"
/db_xref="UniSTS:26519"
STS 3611..3762
/gene="PAK6"
/gene_synonym="PAK5"
/standard_name="RH15701"
/db_xref="UniSTS:82077"
variation 3631
/gene="PAK6"
/gene_synonym="PAK5"
/replace="c"
/replace="t"
/db_xref="dbSNP:11635121"
variation 3632
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:75108621"
variation 3675
/gene="PAK6"
/gene_synonym="PAK5"
/replace="a"
/replace="g"
/db_xref="dbSNP:138256759"
polyA_signal 3857..3862
/gene="PAK6"
/gene_synonym="PAK5"
polyA_site 3879
/gene="PAK6"
/gene_synonym="PAK5"
ORIGIN
aaagaccagctatgcagcttctttcatggcctatttttattatctccttctcttaaatctgggctcagaatccacgatccctatgattgtaacaagaacaatcaagctttgaagatagtggacttttcctacagtgttgaccttagggtgcagctggatgtttttaccctcagcggctttcggactgtacagatcctggaaggacaaaagatcctggctaactgttcttctccctaccagggagtgccgcttcctgggctagagacaagcaccagcctgcagtggagaacgcaggaccccgctgcccagaaggagcagccacggcctgcggaggactggcccagcaaggtcccaggtcttccctctcctcagcgcctaagagagaggcccagtgcgggtgaggagtcgcgaggaagaggcggaaggcgccggaaggcaccatgttccgcaagaaaaagaagaaacgccctgagatctcagcgccacagaacttccagcaccgtgtccacacctccttcgaccccaaagaaggcaagtttgtgggcctccccccacaatggcagaacatcctggacacactgcggcgccccaagcccgtggtggacccttcgcgaatcacacgggtgcagctccagcccatgaagacagtggtgcggggcagcgcgatgcctgtggatggctacatctcggggctgctcaacgacatccagaagttgtcagtcatcagctccaacaccctgcgtggccgcagccccaccagccggcggcgggcacagtccctggggctgctgggggatgagcactgggccaccgacccagacatgtacctccagagcccccagtctgagcgcactgacccccacggcctctacctcagctgcaacgggggcacaccagcaggccacaagcagatgccgtggcccgagccacagagcccacgggtcctgcccaatgggctggctgcaaaggcacagtccctgggccccgccgagtttcagggtgcctcgcagcgctgtctgcagctgggtgcctgcctgcagagctccccaccaggagcctcgccccccacgggcaccaataggcatggaatgaaggctgccaagcatggctctgaggaggcccggccacagtcctgcctggtgggctcagccacaggcaggccaggtggggaaggcagccctagccctaagacccgggagagcagcctgaagcgcaggctattccgaagcatgttcctgtccactgctgccacagcccctccaagcagcagcaagccaggccctccaccacagagcaagcccaactcctctttccgaccgccgcagaaagacaaccccccaagcctggtggccaaggcccagtccttgccctcggaccagccggtggggaccttcagccctctgaccacttcggataccagcagcccccagaagtccctccgcacagccccggccacaggccagcttccaggccggtcttccccagcgggatccccccgcacctggcacgcccagatcagcaccagcaacctgtacctgccccaggaccccacggttgccaagggtgccctggctggtgaggacacaggtgttgtgacacatgagcagttcaaggctgcgctcaggatggtggtggaccagggtgacccccggctgctgctggacagctacgtgaagattggcgagggctccaccggcatcgtctgcttggcccgggagaagcactcgggccgccaggtggccgtcaagatgatggacctcaggaagcagcagcgcagggagctgctcttcaacgaggtggtgatcatgcgggactaccagcacttcaacgtggtggagatgtacaagagctacctggtgggcgaggagctgtgggtgctcatggagttcctgcagggaggagccctcacagacatcgtctcccaagtcaggctgaatgaggagcagattgccactgtgtgtgaggctgtgctgcaggccctggcctacctgcatgctcagggtgtcatccaccgggacatcaagagtgactccatcctgctgaccctcgatggcagggtgaagctctcggacttcggattctgtgctcagatcagcaaagacgtccctaagaggaagtccctggtgggaaccccctactggatggctcctgaagtgatctccaggtctttgtatgccactgaggtggatatctggtctctgggcatcatggtgattgagatggtagatggggagccaccgtacttcagtgactccccagtgcaagccatgaagaggctccgggacagccccccacccaagctgaaaaactctcacaaggtctccccagtgctgcgagacttcctggagcggatgctggtgcgggacccccaagagagagccacagcccaggagctcctagaccaccccttcctgctgcagacagggctacctgagtgcctggtgcccctgatccagctctaccgaaagcagacctccacctgctgagcccaccccaagtatgcctgccacctacgcccacaggcagggcacactgggcagccagcctgccggcaggacttgcctgcctcctcctctcagtattctctccaaagattgaaatgtgaagccccagccccaccctctgcccttcagcctactgggccaggccggacctgccccctcagtgtctctccctcccgagtccccagatggagacccctttctacaggatgaccccttgatatttgcacagggatatttctaagaaacgcagaggccagcgttcctggcctctgcagccaacacagtagaaaaggctgctgtggttttttaaaggcagttgtccactagtgtcctaggccactgcagagggcagactgctggtctccacagatacctgctgttctcagctccagcttcaaacctcgagtctcgagagggccacggggtggtttttatgaccggaatcccgcttcctccctcacgtctgatgtcctgaaggtgcagtcccacctgtacagcccctccccgcccagaactgtgaatggcctgctccaggccatggctgggggcagggagtgaggggacaatttctgagtgaaagagaaagaatggggtcggtggtgaaggtgctctcactttacagaatggagagaacatcgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaggggaggaaagccaccttgacagcccaggtccctccaggtcacccacagccagtttcaggaaggctgcccctctctcccactaagttctggcctgaagggacctgctttcttggcctggcttccacctctccactcctgtgtctacctggccagtggagtggtccatgctaagtctaacactcctgggagctcaggaggcttctgagcttctcctgtactgtgcatcgtgagggccagagacaggaatgtaaggattggcaactgtgttacctttcaagtttatctcaataaccaggtcatcagggacccattgttctcttcagaaccctatctgggagagaaggcgaaccacctccgggtttccatcatgtcaaggtcacaggcatccatgtgtgcaaaccatctgccccagctgcctccacagactgctgtctccttgtcctcctcggccctgccccacttcagggctgctgtgagatggaattccaggaaagaacttcaggtgtctggaccctttctatctagataatatttttagattcttctgctccctagtgacctacctgggggcaaagaaattgcaaggacttttttttaagggtcagagttttcaaaacaaaagcatcttccctagaaatttttgtgaattgtttgcacttgtgcctgttttaaattaaattgagtgttcaaagccaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:56924 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
GeneID:56924 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:56924 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:56924 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:56924 -> Biological process: GO:0007010 [cytoskeleton organization] evidence: TAS
GeneID:56924 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:56924 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001122100 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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