Home |
Help |
Advanced search
2024-04-19 07:20:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001128211 3865 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens NudC domain containing 1 (NUDCD1), transcript variant
2, mRNA.
ACCESSION NM_001128211
VERSION NM_001128211.1 GI:189571678
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3865)
AUTHORS Wang,Q., Li,M., Wang,Y., Zhang,Y., Jin,S., Xie,G., Liu,Z., Wang,S.,
Zhang,H., Shen,L. and Ge,H.
TITLE RNA interference targeting CML66, a novel tumor antigen, inhibits
proliferation, invasion and metastasis of HeLa cells
JOURNAL Cancer Lett. 269 (1), 127-138 (2008)
PUBMED 18534745
REMARK GeneRIF: CML66 may play an oncogenic role in ways of favoring tumor
cells proliferation, invasion and metastasis-associated with
multiple pathways.
REFERENCE 2 (bases 1 to 3865)
AUTHORS Jin,S., Wang,Y., Zhang,Y., Zhang,H.Z., Wang,S.J., Tang,J.Q.,
Chen,H.J. and Ge,H.L.
TITLE Humoral immune responses against tumor-associated antigen OVA66
originally defined by serological analysis of recombinant cDNA
expression libraries and its potentiality in cellular immunity
JOURNAL Cancer Sci. 99 (8), 1670-1678 (2008)
PUBMED 18754882
REMARK GeneRIF: study identified a novel gene, OVA66, which was expressed
significantly higher in cancer patients than normal controls; IgG
level against OVA66 was significantly elevated in the serum of
cancer patients from different histological types of cancer [OVA66]
REFERENCE 3 (bases 1 to 3865)
AUTHORS Yan,Y., Phan,L., Yang,F., Talpaz,M., Yang,Y., Xiong,Z., Ng,B.,
Timchenko,N.A., Wu,C.J., Ritz,J., Wang,H. and Yang,X.F.
TITLE A novel mechanism of alternative promoter and splicing regulates
the epitope generation of tumor antigen CML66-L
JOURNAL J. Immunol. 172 (1), 651-660 (2004)
PUBMED 14688378
REMARK GeneRIF: An alternative promoter (CML66-S short isoform) has been
identified in combination with alternative splicing as a novel
mechanism for regulation of the epitope generation of a self-tumor
antigen.
REFERENCE 4 (bases 1 to 3865)
AUTHORS Yang,X.F., Wu,C.J., McLaughlin,S., Chillemi,A., Wang,K.S.,
Canning,C., Alyea,E.P., Kantoff,P., Soiffer,R.J., Dranoff,G. and
Ritz,J.
TITLE CML66, a broadly immunogenic tumor antigen, elicits a humoral
immune response associated with remission of chronic myelogenous
leukemia
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 98 (13), 7492-7497 (2001)
PUBMED 11416219
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AK307663.1, AC021237.5 and BC043406.1.
Transcript Variant: This variant (2) differs in the 5' UTR and 5'
CDS, compared to variant 1, resulting in a protein (isoform 2) with
a shorter, distinct N-terminus, compared to isoform 1.
##Evidence-Data-START##
Transcript exon combination :: AF521133.1, AF283302.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1757 AK307663.1 2-1758
1758-3459 AC021237.5 136900-138601
3460-3865 BC043406.1 3528-3933
FEATURES Location/Qualifiers
source 1..3865
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q23"
gene 1..3865
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/note="NudC domain containing 1"
/db_xref="GeneID:84955"
/db_xref="HGNC:24306"
/db_xref="MIM:606109"
exon 1..129
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
misc_feature 72..74
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/note="upstream in-frame stop codon"
CDS 99..1763
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/note="isoform 2 is encoded by transcript variant 2;
chronic myelogenous leukemia tumor antigen 66; nudC
domain-containing protein 1; tumor antigen CML66"
/codon_start=1
/product="nudC domain-containing protein 1 isoform 2"
/protein_id="NP_001121683.1"
/db_xref="GI:189571679"
/db_xref="CCDS:CCDS47910.1"
/db_xref="GeneID:84955"
/db_xref="HGNC:24306"
/db_xref="MIM:606109"
/translation="
MLYLQGWSMPAVAEVKLRDDQYTLEHMHAFGMYNYLHCDSWYQDSVYYIDTLGRIMNLTVMLDTALGKPREVFRLPTDLTACDNRLCASIHFSSSTWVTLSDGTGRLYVIGTGERGNSASEKWEIMFNEELGDPFIIIHSISLLNAEEHSIATLLLRIEKEELDMKGSGFYVSLEWVTISKKNQDNKKYEIIKRDILRGKSVPHYAAIEPDGNGLMIVSYKSLTFVQAGQDLEENMDEDISEKIKEPLYYWQQTEDDLTVTIRLPEDSTKEDIQIQFLPDHINIVLKDHQFLEGKLYSSIDHESSTWIIKESNSLEISLIKKNEGLTWPELVIGDKQGELIRDSAQCAAIAERLMHLTSEELNPNPDKEKPPCNAQELEECDIFFEESSSLCRFDGNTLKTTHVVNLGSNQYLFSVIVDPKEMPCFCLRHDVDALLWQPHSSKQDDMWEHIATFNALGYVQASKRDKKFFACAPNYSYAALCECLRRVFIYRQPAPMSTVLYNRKEGRQVGQVAKQQVASLETNDPILGFQATNERLFVLTTKNLFLIKVNTEN
"
misc_feature 843..1094
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/note="p23_NUDCD1: p23-like NUD (nuclear distribution)
C-like domain found in human NUD (nuclear distribution) C
domain-containing protein 1, NUDCD1 (also known as CML66),
and similar proteins. NUDCD1/CML66 is a broadly
immunogenic tumor associated antigen; Region:
p23_NUDCD1_like; cd06493"
/db_xref="CDD:107242"
exon 130..284
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 285..470
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
variation 307
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550168"
exon 471..651
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 652..834
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 835..1039
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 1040..1184
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 1185..1310
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
variation 1288
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550169"
exon 1311..1470
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
exon 1471..3853
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/inference="alignment:Splign:1.39.8"
STS 1771..1973
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/standard_name="STS-AA009819"
/db_xref="UniSTS:11395"
STS 1923..2053
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/standard_name="STS-N32587"
/db_xref="UniSTS:78028"
variation 2049
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/replace="a"
/replace="g"
/db_xref="dbSNP:11550167"
variation 2106
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/replace="g"
/replace="t"
/db_xref="dbSNP:1548082"
variation 3122
/gene="NUDCD1"
/gene_synonym="CML66; OVA66"
/replace="a"
/replace="t"
/db_xref="dbSNP:1548083"
ORIGIN
gtacttcatagactttatcatacttcgtagcatccagtatgttttctttgctaagattattgattttgtattgaagggtcccatgtccatcgttttcaatgctttatctccagggttggagcatgcctgctgtggcagaggtaaaacttcgagatgatcaatatacactggaacacatgcatgcttttggaatgtataattacctgcactgtgattcatggtatcaagacagtgtctactatattgatacccttggaagaattatgaatttaacagtaatgctggacactgccttaggaaaaccacgagaggtgtttcgacttcctacagatttgacagcatgtgacaaccgtctttgtgcatctatccatttctcatcttctacctgggttaccttgtcagatggaactggaagattgtatgtcattggaacaggtgaacgtggaaatagcgcttctgaaaaatgggagattatgtttaatgaagaacttggggatccttttattataattcacagtatctcactgctaaatgctgaagaacattctatagctaccctacttcttcgaatagagaaagaggaattggatatgaaaggaagtggtttctatgtttctctggagtgggtcactatcagtaagaaaaatcaagataataaaaaatatgaaattattaagcgtgatattctccgtggaaagtcagtgccacattatgctgctattgagcctgatggaaatggtctaatgattgtatcctacaagtctttaacatttgttcaggctggtcaagatcttgaagaaaatatggatgaagacatatcagagaaaatcaaagaacctctgtattactggcaacagactgaagatgatttgacagtaaccatacggcttccagaagacagtactaaggaggacattcaaatacagtttttgcctgatcacatcaacattgtactgaaggatcaccagtttttagaaggaaaactctattcatctattgatcatgaaagcagtacatggataattaaagagagtaatagcttggagatttccttgattaagaagaatgaaggactgacctggccagagctagtaattggagataaacaaggggaacttataagagattcagcccagtgtgctgcaatagctgaacgtttgatgcatttgacctctgaagaactgaatccaaatccagataaagaaaaaccaccttgcaatgctcaagagttagaagaatgtgatattttctttgaagagagctccagtttatgcagatttgatggcaatacattaaaaactactcatgtggtgaatcttggaagcaaccagtaccttttctctgtcatagtggatcctaaagaaatgccctgcttctgtttgcgccatgatgttgatgccctactctggcaaccacactccagcaaacaagatgatatgtgggagcacatcgcaactttcaatgctttaggctatgtccaagcatcaaagagagacaaaaaattttttgcctgtgctccaaattactcgtatgcagccctttgtgagtgccttcgtcgagtattcatctatcgtcagcctgctcccatgtccactgtactttacaacagaaaggaaggcaggcaagtaggacaggttgctaagcagcaagtagcaagcctagaaaccaatgatcctattttaggatttcaggcaacaaatgagagattatttgttcttactaccaaaaacctctttttaataaaagtaaatacagagaattaattattctaacatattggcctctttgtactggaaaagtattcagtggtacctggaggtctggacagttatactgtaacctcttaagttttaatgtgctaaatatatcttgtatgattttttattttttaataacattggaaatatattcaagagattatgattctgtaaagctgtggaatgaagctgcagatttagagaacattggcttctgaaaaaaaaaaagagtgaagatagtactagcaagtatacttattttttaaaacaggctagaatctcatgttttatatgaaagatgtacaattcagtgtttaaaaataaaaatatttattgtgtactctgttcgttgattagttgctacaggctgtacctataagatgtacaggataatagttaaatgttgagtattgtacatatgtatttaagtggattgaataactgagtctacatggaggaggaaatgctagagaacagcaggtctaatattttttaagtttactgagagacctttattattattttcaaattaagtatagctttatgtaacttttagccagttgctctgccacagacatagacaaagagagataagatttcacattatccatcactgcataacaaaccacaccaaaactcagtggtttaaaacaaggacttttattatttttcacgattcagtgagttggctgtctctgctgtacagggcctctcagcctccagtagactagacgaatcttctttccatagtagagaaaacatcttaagagagcaagctccaatatgcaagagcttatcgatcctgtacatctatcatatttactaatgttccattggacaaagcaaatcacatggccaagtctagagtcagaatgaggggactacacaagctgacagcggatggtatgactcattgggggccattgatggaacaatcttaccacacaaggacaaattataatttatccttgtggctctctttatttttctaacaacttcaacaaaataatcctgtttatatgttatagtttcttgccacaaattttgttttttcaaacttacctttccaggtttgttttagtatgtatgtacctggaaatttttattactttttataccatttcaagatatgtatcttatataaacctcaagttggattttatattttaataaggaagttaagaccttcatttaagaggcagaagattaagataagaaatataagatagaaaagctttgttcctaacatatcttttgcctgtctgggcaagtatttgactcaactaaattttaatgaacgaatgaatgacagagaggaggaaaaaagatgaggattgcatacatgttctaaaccctttgtcagattgcagtttcctagagagtattgaggtgctaggtagaaagttaggaaaggtcctgaggactggtattgacaattggagtcctaatagtactctattcgtattaggaaagagagactagataccaaacatcacgagatcatagagatggaaaactgtatagtaaccaaaaaccaaaacagtgatatttccagaactttttagtattgttgtaaaacttcatgaaacaaaagaccatttaaatagtgaattattaaaaatctttatgatgggaaagtagatctaaattttctctaaaattttccccaaagataatatcctcttagggaacataagaaaaatgtataataaaaatgtggtgcttaattaaccatgactatgtatatattgccaattttagtaatcaatattctttgtgcatgtgatttttttgcatgattaatgttgaattgaaagctctcaggataattaatcctaaatattgtcgcatgttgacctacgttaaaagatgaataggtctagagccgtgatttcaagctattttcctgaaatgcttcagggattccataaacatttaaacaatgttctaaggtacatatacttagaacattgagatatatactacaagtgctaagaatatagtaccttgtatttttgttgatttttatcatgttttaaataggaatttataaaatatttatgatagtaataaagtagtattttatgtgttttgcaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:84955 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:84955 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.