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2024-04-20 19:50:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001127671 10258 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens leukemia inhibitory factor receptor alpha (LIFR),
transcript variant 1, mRNA.
ACCESSION NM_001127671
VERSION NM_001127671.1 GI:189083785
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10258)
AUTHORS Conrady,C.D., Zheng,M., van Rooijen,N., Drevets,D.A., Royer,D.,
Alleman,A. and Carr,D.J.
TITLE Microglia and a functional type I IFN pathway are required to
counter HSV-1-driven brain lateral ventricle enlargement and
encephalitis
JOURNAL J. Immunol. 190 (6), 2807-2817 (2013)
PUBMED 23382563
REMARK GeneRIF: Because acute ventricle enlargement is observed in
susceptible CD118-deficient mice, the phenomenon may occur in a
subpopulation of human adults with herpes simplex encephalitis.
REFERENCE 2 (bases 1 to 10258)
AUTHORS Chen,D., Sun,Y., Wei,Y., Zhang,P., Rezaeian,A.H.,
Teruya-Feldstein,J., Gupta,S., Liang,H., Lin,H.K., Hung,M.C. and
Ma,L.
TITLE LIFR is a breast cancer metastasis suppressor upstream of the
Hippo-YAP pathway and a prognostic marker
JOURNAL Nat. Med. 18 (10), 1511-1517 (2012)
PUBMED 23001183
REMARK GeneRIF: findings identify LIFR as a metastasis suppressor that
functions through the Hippo-YAP pathway and has significant
prognostic power.
REFERENCE 3 (bases 1 to 10258)
AUTHORS Chollangi,S., Mather,T., Rodgers,K.K. and Ash,J.D.
TITLE A unique loop structure in oncostatin M determines binding affinity
toward oncostatin M receptor and leukemia inhibitory factor
receptor
JOURNAL J. Biol. Chem. 287 (39), 32848-32859 (2012)
PUBMED 22829597
REMARK GeneRIF: A unique loop structure in oncostatin M determines binding
affinity toward oncostatin M receptor and leukemia inhibitory
factor receptor.
REFERENCE 4 (bases 1 to 10258)
AUTHORS Iorns,E., Ward,T.M., Dean,S., Jegg,A., Thomas,D., Murugaesu,N.,
Sims,D., Mitsopoulos,C., Fenwick,K., Kozarewa,I.,
Naceur-Lombarelli,C., Zvelebil,M., Isacke,C.M., Lord,C.J.,
Ashworth,A., Hnatyszyn,H.J., Pegram,M. and Lippman,M.
TITLE Whole genome in vivo RNAi screening identifies the leukemia
inhibitory factor receptor as a novel breast tumor suppressor
JOURNAL Breast Cancer Res. Treat. 135 (1), 79-91 (2012)
PUBMED 22535017
REMARK GeneRIF: findings show that LIFR is a key novel tumor suppressor,
whose deregulation may drive the transformation of a significant
proportion of human breast cancers
REFERENCE 5 (bases 1 to 10258)
AUTHORS Kang,W.S., Kim,S.K., Park,J.K., Cho,A.R., Park,H.J., Chung,J.H. and
Kim,J.W.
TITLE Association between promoter polymorphisms of the LIFR gene and
schizophrenia with persecutory delusion in a Korean population
JOURNAL Mol Med Rep 5 (1), 270-274 (2012)
PUBMED 21971603
REMARK GeneRIF: A significant association was detected between the LIFR
gene polymorphisms and schizophrenia patients with persecutory
delusion
REFERENCE 6 (bases 1 to 10258)
AUTHORS Schiemann,W.P., Graves,L.M., Baumann,H., Morella,K.K.,
Gearing,D.P., Nielsen,M.D., Krebs,E.G. and Nathanson,N.M.
TITLE Phosphorylation of the human leukemia inhibitory factor (LIF)
receptor by mitogen-activated protein kinase and the regulation of
LIF receptor function by heterologous receptor activation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5361-5365 (1995)
PUBMED 7777512
REFERENCE 7 (bases 1 to 10258)
AUTHORS Gearing,D.P., Druck,T., Huebner,K., Overhauser,J., Gilbert,D.J.,
Copeland,N.G. and Jenkins,N.A.
TITLE The leukemia inhibitory factor receptor (LIFR) gene is located
within a cluster of cytokine receptor loci on mouse chromosome 15
and human chromosome 5p12-p13
JOURNAL Genomics 18 (1), 148-150 (1993)
PUBMED 8276403
REFERENCE 8 (bases 1 to 10258)
AUTHORS Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
TITLE The IL-6 signal transducer, gp130: an oncostatin M receptor and
affinity converter for the LIF receptor
JOURNAL Science 255 (5050), 1434-1437 (1992)
PUBMED 1542794
REFERENCE 9 (bases 1 to 10258)
AUTHORS Gearing,D.P. and Bruce,A.G.
TITLE Oncostatin M binds the high-affinity leukemia inhibitory factor
receptor
JOURNAL New Biol. 4 (1), 61-65 (1992)
PUBMED 1536831
REFERENCE 10 (bases 1 to 10258)
AUTHORS Gearing,D.P., Thut,C.J., VandeBos,T., Gimpel,S.D., Delaney,P.B.,
King,J., Price,V., Cosman,D. and Beckmann,M.P.
TITLE Leukemia inhibitory factor receptor is structurally related to the
IL-6 signal transducer, gp130
JOURNAL EMBO J. 10 (10), 2839-2848 (1991)
PUBMED 1915266
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK290059.1, BP219669.1 and
AC010457.7.
Summary: This gene encodes a protein that belongs to the type I
cytokine receptor family. This protein combines with a
high-affinity converter subunit, gp130, to form a receptor complex
that mediates the action of the leukemia inhibitory factor, a
polyfunctional cytokine that is involved in cellular
differentiation, proliferation and survival in the adult and the
embryo. Mutations in this gene cause Schwartz-Jampel syndrome type
2, a disease belonging to the group of the bent-bone dysplasias. A
translocation that involves the promoter of this gene,
t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated
with salivary gland pleiomorphic adenoma, a common type of benign
epithelial tumor of the salivary gland. Multiple splice variants
encoding the same protein have been found for this gene. [provided
by RefSeq, Jul 2008].
Transcript Variant: This variant (1) represents the longer
transcript. Variants 1 and 2 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK290059.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025098 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-1053 AK290059.1 1-1053
1054-1061 BP219669.1 387-394
1062-3558 AK290059.1 1062-3558
3559-10258 AC010457.7 44671-51370 c
FEATURES Location/Qualifiers
source 1..10258
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="5"
/map="5p13-p12"
gene 1..10258
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="leukemia inhibitory factor receptor alpha"
/db_xref="GeneID:3977"
/db_xref="HGNC:6597"
/db_xref="MIM:151443"
exon 1..313
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
misc_feature 294..296
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="upstream in-frame stop codon"
exon 314..474
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
CDS 333..3626
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="CD118 antigen; LIF receptor"
/codon_start=1
/product="leukemia inhibitory factor receptor precursor"
/protein_id="NP_001121143.1"
/db_xref="GI:189083786"
/db_xref="CCDS:CCDS3927.1"
/db_xref="GeneID:3977"
/db_xref="HGNC:6597"
/db_xref="MIM:151443"
/translation="
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEEDLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQNKPND
"
sig_peptide 333..464
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
mat_peptide 465..3623
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/product="leukemia inhibitory factor receptor"
misc_feature 1629..1922
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1629..1631,1833..1835,1884..1886)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature 1887..1901
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
Region: WSXWS motif"
misc_feature order(1887..1892,1896..1901)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature <1998..2189
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cl00065"
/db_xref="CDD:206813"
misc_feature 2502..2819
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(2502..2504,2739..2741,2784..2786)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(2787..2792,2796..2801)
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 2832..2906
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
transmembrane region"
misc_feature 2937..2963
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P42702.1);
Region: Box 1 motif"
misc_feature 3111..3113
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P42702.1); phosphorylation site"
variation 360
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729732"
exon 475..589
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 590..729
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 678
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729734"
exon 730..893
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 894..1068
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1069..1323
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1324..1453
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1454..1623
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1624..1769
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1770..1932
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 1933..2003
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2004..2217
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 2064
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="g"
/db_xref="dbSNP:3729740"
exon 2218..2397
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
variation 2323
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729744"
exon 2398..2499
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2500..2667
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2668..2829
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2830..2923
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 2924..3002
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
exon 3003..10258
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/inference="alignment:Splign:1.39.8"
STS 3401..3650
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH41252"
/db_xref="UniSTS:90279"
STS 3514..3728
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH93532"
/db_xref="UniSTS:89153"
variation 3620
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:3729751"
STS 3624..3726
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="PMC311006P4"
/db_xref="UniSTS:272831"
STS 3630..3724
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="human.LIFR"
/db_xref="UniSTS:181772"
variation 3943
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:201394596"
variation 3988
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="g"
/db_xref="dbSNP:1005017"
variation 4586
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042795"
STS 4600..5479
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="LIFR_185"
/db_xref="UniSTS:277451"
variation 5180
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="g"
/db_xref="dbSNP:1428604"
variation 5240
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042798"
variation 5241
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="a"
/replace="t"
/db_xref="dbSNP:1042799"
STS 5247..5392
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="STS-R38064"
/db_xref="UniSTS:65610"
polyA_signal 5352..5357
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
polyA_site 5373
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
STS 5401..5495
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="SHGC-60516"
/db_xref="UniSTS:30425"
STS 7034..7153
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH48815"
/db_xref="UniSTS:2234"
polyA_signal 7254..7259
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
polyA_site 7282
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
STS 7466..7605
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S1675E"
/db_xref="UniSTS:151064"
STS 8409..8685
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S2471"
/db_xref="UniSTS:5248"
STS 8421..8565
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH91753"
/db_xref="UniSTS:89967"
STS 9165..9254
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="D5S1570E"
/db_xref="UniSTS:150998"
STS 9419..9567
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH26031"
/db_xref="UniSTS:87596"
STS 9737..9977
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/standard_name="RH65837"
/db_xref="UniSTS:92084"
variation 9816
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
/replace="c"
/replace="t"
/db_xref="dbSNP:1046224"
polyA_signal 10234..10239
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
polyA_site 10258
/gene="LIFR"
/gene_synonym="CD118; LIF-R; SJS2; STWS; SWS"
ORIGIN
agtcccggctggagcgactcggccgtggcggtggccgttaccgttgcctctgggaggctctggcggcggcggcggcccgcggggttcgcggagcgcagcgggccgcccttcgcccgtggccgcctcaagcagcctcgcgccgacacaggggaggcgagacggcggctgcggaggcggcggcgcattgtgcccggccccctccttggcggctcctgcccccgggcggctgtgggatctgggcagccccggggcggcggccgaggctacagagccggcggcaggggatggcaagatagcggcgcgggagcgtaccgactgactgcattgcacagatgatggatatttacgtatgtttgaaacgaccatcctggatggtggacaataaaagaatgaggactgcttcaaatttccagtggctgttatcaacatttattcttctatatctaatgaatcaagtaaatagccagaaaaagggggctcctcatgatttgaagtgtgtaactaacaatttgcaagtgtggaactgttcttggaaagcaccctctggaacaggccgtggtactgattatgaagtttgcattgaaaacaggtcccgttcttgttatcagttggagaaaaccagtattaaaattccagctctttcacatggtgattatgaaataacaataaattctctacatgattttggaagttctacaagtaaattcacactaaatgaacaaaacgtttccttaattccagatactccagagatcttgaatttgtctgctgatttctcaacctctacattatacctaaagtggaacgacaggggttcagtttttccacaccgctcaaatgttatctgggaaattaaagttctacgtaaagagagtatggagctcgtaaaattagtgacccacaacacaactctgaatggcaaagatacacttcatcactggagttgggcctcagatatgcccttggaatgtgccattcattttgtggaaattagatgctacattgacaatcttcatttttctggtctcgaagagtggagtgactggagccctgtgaagaacatttcttggatacctgattctcagactaaggtttttcctcaagataaagtgatacttgtaggctcagacataacattttgttgtgtgagtcaagaaaaagtgttatcagcactgattggccatacaaactgccccttgatccatcttgatggggaaaatgttgcaatcaagattcgtaatatttctgtttctgcaagtagtggaacaaatgtagtttttacaaccgaagataacatatttggaaccgttatttttgctggatatccaccagatactcctcaacaactgaattgtgagacacatgatttaaaagaaattatatgtagttggaatccaggaagggtgacagcgttggtgggcccacgtgctacaagctacactttagttgaaagtttttcaggaaaatatgttagacttaaaagagctgaagcacctacaaacgaaagctatcaattattatttcaaatgcttccaaatcaagaaatatataattttactttgaatgctcacaatccgctgggtcgatcacaatcaacaattttagttaatataactgaaaaagtttatccccatactcctacttcattcaaagtgaaggatattaattcaacagctgttaaactttcttggcatttaccaggcaactttgcaaagattaattttttatgtgaaattgaaattaagaaatctaattcagtacaagagcagcggaatgtcacaatcaaaggagtagaaaattcaagttatcttgttgctctggacaagttaaatccatacactctatatacttttcggattcgttgttctactgaaactttctggaaatggagcaaatggagcaataaaaaacaacatttaacaacagaagccagtccttcaaaggggcctgatacttggagagagtggagttctgatggaaaaaatttaataatctattggaagcctttacccattaatgaagctaatggaaaaatactttcctacaatgtatcgtgttcatcagatgaggaaacacagtccctttctgaaatccctgatcctcagcacaaagcagagatacgacttgataagaatgactacatcatcagcgtagtggctaaaaattctgtgggctcatcaccaccttccaaaatagcgagtatggaaattccaaatgatgatctcaaaatagaacaagttgttgggatgggaaaggggattctcctcacctggcattacgaccccaacatgacttgcgactacgtcattaagtggtgtaactcgtctcggtcggaaccatgccttatggactggagaaaagttccctcaaacagcactgaaactgtaatagaatctgatgagtttcgaccaggtataagatataattttttcctgtatggatgcagaaatcaaggatatcaattattacgctccatgattggatatatagaagaattggctcccattgttgcaccaaattttactgttgaggatacttctgcagattcgatattagtaaaatgggaagacattcctgtggaagaacttagaggctttttaagaggatatttgttttactttggaaaaggagaaagagacacatctaagatgagggttttagaatcaggtcgttctgacataaaagttaagaatattactgacatatcccagaagacactgagaattgctgatcttcaaggtaaaacaagttaccacctggtcttgcgagcctatacagatggtggagtgggcccggagaagagtatgtatgtggtgacaaaggaaaattctgtgggattaattattgccattctcatcccagtggcagtggctgtcattgttggagtggtgacaagtatcctttgctatcggaaacgagaatggattaaagaaaccttctaccctgatattccaaatccagaaaactgtaaagcattacagtttcaaaagagtgtctgtgagggaagcagtgctcttaaaacattggaaatgaatccttgtaccccaaataatgttgaggttctggaaactcgatcagcatttcctaaaatagaagatacagaaataatttccccagtagctgagcgtcctgaagatcgctctgatgcagagcctgaaaaccatgtggttgtgtcctattgtccacccatcattgaggaagaaataccaaacccagccgcagatgaagctggagggactgcacaggttatttacattgatgttcagtcgatgtatcagcctcaagcaaaaccagaagaagaacaagaaaatgaccctgtaggaggggcaggctataagccacagatgcacctccccattaattctactgtggaagatatagctgcagaagaggacttagataaaactgcgggttacagacctcaggccaatgtaaatacatggaatttagtgtctccagactctcctagatccatagacagcaacagtgagattgtctcatttggaagtccatgctccattaattcccgacaatttttgattcctcctaaagatgaagactctcctaaatctaatggaggagggtggtcctttacaaacttttttcagaacaaaccaaacgattaacagtgtcaccgtgtcacttcagtcagccatctcaataagctcttactgctagtgttgctacatcagcactgggcattcttggagggatcctgtgaagtattgttaggaggtgaacttcactacatgttaagttacactgaaagtgttcatgtgcttttaatgtagtctaaaagccaaagtatagtgactcagaatcctcaatccacaaaactcaagattgggagctctttgtgatcaagccaaagaattctcatgtactctaccttcaagaagcatttcaaggctaatacctacttgtacgtacatgtaaaacaaatcccgccgcaactgttttctgttctgttgtttgtggttttctcatgtgtatacttggtggaattgtaagtggatttgcaggccagggagaaaatgtccaagtaacaggtgaagtttatttgcctgacgtttactcctttctagatgaaaaccaagcacagattttaaaacttctaagattattctcctctatccacagcattcacaaaaattaatataatttttaatgtagtgacagcgatttagtgttttgtttgataaagtatgcttatttctgtgcctactgtataatggttatcaaacagttgtctcaggggtacaaactttgaaaacaagtgtgacactgaccagcccaaatcataatcatgttttcttgctgtgataggttttgcaagccttttcattattttttagcttttatgcttgcttccattatttcagttggttgccctaatatttaaaatttacacttctaagactagagacccacattttttaaaaatcattttattttgtgatacagtgacagctttatatgagcaaattcaatattattcataagcatgtaattccagtgacttactatgtgagatgactactaagcaatatctagcagcgttagctgtccatatagttctgattggatttcgttcctcctgaggagaccatgccgttgagcttggctacccaggcagtggtgatctttgacaccttctggtggatgttcctcccactcatgagtcttttcatcatgccacattatctgatccagtcctcacatttttaaatataaaactaaagagagaatgcttcttacaggaacagttacccaagggctgtttcttagtaactgtcataaactgatctgaatccatgggcatacctgtgttgcaggtgcagcaattgcttggtgagctgtgcagaattgattgccttcagcacagcatcctctgcccacccttgtttctcataagcgatgtctggagtgattgtggttcttggaaaagcagaaggaaaaactaaaaagtgtatcttgtattttccctgccctcaggttgcctatgtattttaccttttcatatttaaggcaaaagtacttgaaaattttaagtgtccgaataagatatgtcttttttgtttgttttttttggttgtttgtttgttttttatcatctgagattctgtaatgtatttgcaaataatggatcaattaattttttttgaagctcatattgtatctttttaaaaaccatgttgtggaaaaaagccagagtgacaagtgacaaaatctatttaggttctctgtgtatgaatcctgattttaactgctaggattcagctaaatttctgagctttatgatctgtggaaatttggaatgaaatgcaattcattttgtacatacatagtatattaaaactatataatagttcatagaaatgttcagtaatgaaaaatatatccaatcagagccatccctaaagagtgttctcttgtcttcctttgtatcctctttggctccttcccttagcttccaccccagacatcagacctggggctgccttctctccctgccaaagcttgctgttagcattgtctgcttgccctcaactcctgccttgttccctgttgaaatgtatcaatcccgtactttatctctccaggacaaggataagtgtggctacagtaaaagtttattgctctaaacggcgctaacctgagataatgagaaaaggccagaagagattgtttgatctctgtctgtcaatatatatgcatttcaactgtgaccatctggatccagggccctttctaacctatataacgactcatttgtttggttaatgatgaatatcactggggctcttaagtcctttcgttctatccaagacttcattgtttttttctgtatgaaaaaagtgcagaatatcactcacctttcccctacttttggatcccctacacgaggatcactagcttaatgagaagcagagtaacgctattaagtctgggcaagctccttataagttgctgtgtgcttaaaagaatgtgatttatgtctggggccaaagcagttttccttcttttccctcattgaattcaagacagctagacccttgtgtagatcccaggatattacctctactccccccaacctgtgtgtgtagggagagtaacaacacgggaagaggggagggaagttggaaggagattggtcacatgttcagttgtctgagatactggtaaatgtgcgctgtttgtcaatgaaggttgcatgcctgcatttacaaggtggtctcatactgattgtgctctgtccagttagattcgtggcttctcccttggaagctacaattaaggactagttagaagcagaggctagatgtgttctctccagcccttactaactgggaaaataattgagaaatccctcttttcctcagtgaaagcccagtcattggttagaaaaatctaattgtcaaactagcattatgttccatcatatctgtgggatagtaattcatgtaagacacatttttacctctcttacaagtcaattcacttacaagccagtttcaaatcaagcttcccttgcgaggaatggagatcattatggggcttattatgactacatttcttttatgagtgaccattttaaataattaatattttatttaatattaaattattaaagacttagctagacttttaacattagatgaaccttgtgaatcatatattgcatagattagcacatgtatgcaatctaggtcatcaatttgttgaatttatacagccctagatttgagattgtggccctgagtatctggatagttgagttgtgtgtttatgtgcttatatgatagaggtgctttgttcctgcagcttagaaacagaagcagccattcactgagaagcttaagagaggaagtatcaacctcattttccaaaccagcattactttcaccgctcgtggatctgaaagattacatttagaacatttagtactattacactctcagaaactgtggtaaaaagtcacattttcaaaacttcatgcatattgtattcttgttggaaataagtcctatagtttcttaattgtcttcatgccgtccatatttaacaaacattgcaagtcctttttatatttgggtaattatttgtaatttagtgaaggagactaggggatgttttcttccaaagggaatttaaaatcaattttatggtattttgaaagtaaaatactccttaacgtgtcaatatttttaaaatgttatctcgaagttttctattgctcaggtatataatctaataaaattttttgtttgctctaaggttatttttgctattctctattttgaattatgttaaaatttgtgtgcattttatgaaatgccttttttcttattttgaaagtgtaaaattgggcatctcagagtaaaatgtgggattattagctacaaagactaggcacatcgtgaaagctcagtaactaattttcttgactgagtcctatcccagagtgtcacagattcaacagaattttcctgaagggtgatacacaccaaaatctagcttgtgtggatctgagactattgactcaaagattcaaatctacttcggaagtgactccacggtttgagtgaaaactgaggaaggactcatgcctgtatatcactagatatcttatttctccataattttaagtgttcataatttcttcttctttgatgggtgtgcaactggggcatgtttgtaccagccagcatgtgttctgcccaacagtgtgtccgtgtgtgaggttaactgattcagaactcattctcttgataaactatttcttgaaagcatttattttaagtctttatttcctgctgaaatgaagtttcatgctgtcatgcccatcttatttattctagaagaaaattttcatagaagaaaatgatttatggccaaagttacagaacattcatcttttagacttagccttagaatatcattggaaattacttggcttgaatttggttcgtttttatctttatggattatgtaccagggctattaataatacttaaaccccttattttgctatggtggttagatttttttattccttttcaattagtgctattaattattacatggtcgtattcatgcttattacagatgaactatttttagtgccagtgtaaaggattaagaataacattcaattagttggctatttcaggctttattgtacatggtaatgtttcagggagtgtgatttggtctagaatatatccagatccttgtaattatgatattgggttatgacaggattctattatttttagctatgaatggtgcttatttttccctatattaggaatgttaatatttggattatcagagtccatgttataaacagaatttacctatgcaagacaaattctaactgtgcaacattttcatgagaattaaaagttgtgtgttaaggggaaaaccctctgaatgtttttatgtgtaagtgcctaaagaaccgtagaaacagtacatcaaaagctcttataaaagaaaaactgattgaacattagccagaaacaaaatatgatttacatttttttttttggttgctgggactgaataccctaaaaactaagagatgtgagtggggaaaatgtctaattgataagaaagttgatttatattatatttacatgcatcttctaagattgcctttacagtagccaatcagaactttaaaaaaaaaaaagctaacaacatagatcctatgtgttgcccttaagactaaaatactttgcacacgtgattgaatggctcacttaagttgttgaatttccttatacatttaaagtgtacttccgttaagaattattccattttaaatgggtaactttcagcttccgaactattttcctaaacattccagttgtgtattataaaagatcaaaatatctctaggtggtagtacaattttcatttataacgtggaaaagttaactgttaggtttaacattagtattagtgtttttgcaattgctcatagaaaagaacactgaataatggttttcatacaatttttgtaaaacattcttctcccagtttgattccaaatgcttttccccaaattgtctaatatatcataagctagtgtttccttgtatttaatttttccttccaacacaatatttaggaaaaatatgaataacattgtgagtagcgggagacaacacgaaaaagaaacctttcattgttgtggaggggtaggtgttatgtgattgatgcccttcctggcgtttgttttatcctgttattttctcaaaaaagagcacggctttttcttaaatacatttaaattcagaattgcttgcaaaagattggcctggatagatagacatcctagatttaagatagtaccatcttaaaagtatgttgaaaggtaaaataaatcatttcaaaatacttaactttcctaataaggatgttaggttttcttctctttcattagctggccataagtcaaggtccttataacactaggaaattacctttttttactttcaaaattgcattatagtgaattactgtttacaaaatacacatactgtgaacagatataagtttctgtcttttataaggtttgtagaatgaatgtttttttaaagtgagtattatatgttaaatattttaagttttttataaatactagtaactgtttactaatttttgtttggtcaaatgcttgtaaatgtagctgaaagaagatagggagaaactgcggatcccaaactgttccctttttcatttcttgaaatgttaccactacagacatttttttaaggtgaataaacagttgtgatgtgctgtacctaaaatcatgtttaatcgtataaggaaacatttcaatacacttatacaggaagaaaactatagatgaagtacatgtgtgtgattcagtctgattcacagaattctgagagtaatatggaataaaacaactccacttagatgataactgaagcatttcctgccttgtgaaaatttggattttaaattgctgttagaatgggaaatttggacactttatatcattgtataatttcagaatttagtttctgtatcttttggaaaacatgattatagcaaaaacatagaaaataatctattactaaaacaccataaatgtaaaactagtatgcttggctgttaactctaaagatgttacttatgtctgtttttaaaacatgcatgtatttaacaattttatcatagtattgtcatggaaaaaataaatatattttcttacatctta
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3977 -> Molecular function: GO:0004897 [ciliary neurotrophic factor receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0004923 [leukemia inhibitory factor receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0004924 [oncostatin-M receptor activity] evidence: IDA
GeneID:3977 -> Molecular function: GO:0005127 [ciliary neurotrophic factor receptor binding] evidence: IPI
GeneID:3977 -> Molecular function: GO:0019838 [growth factor binding] evidence: IPI
GeneID:3977 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:3977 -> Biological process: GO:0008284 [positive regulation of cell proliferation] evidence: IDA
GeneID:3977 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0034097 [response to cytokine stimulus] evidence: IDA
GeneID:3977 -> Biological process: GO:0038165 [oncostatin-M-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0048861 [leukemia inhibitory factor signaling pathway] evidence: IDA
GeneID:3977 -> Biological process: GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] evidence: IDA
GeneID:3977 -> Cellular component: GO:0005576 [extracellular region] evidence: IEA
GeneID:3977 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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