2024-04-20 04:01:05, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001127667 2747 bp mRNA linear PRI 16-JUN-2013 DEFINITION Homo sapiens gelsolin (GSN), transcript variant 8, mRNA. ACCESSION NM_001127667 VERSION NM_001127667.1 GI:189083781 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2747) AUTHORS DiNubile,M.J. TITLE Plasma gelsolin levels in the diagnosis, prognosis, and treatment of lung complications of prematurity JOURNAL Am. J. Respir. Crit. Care Med. 186 (11), 1195-1196 (2012) PUBMED 23204381 REMARK GeneRIF: Circulating gelsolin level is an important biomarker in preterm infants, developing bronchopulmonary dysplasia. REFERENCE 2 (bases 1 to 2747) AUTHORS Li,G.H., Arora,P.D., Chen,Y., McCulloch,C.A. and Liu,P. TITLE Multifunctional roles of gelsolin in health and diseases JOURNAL Med Res Rev 32 (5), 999-1025 (2012) PUBMED 22886630 REMARK GeneRIF: REVIEW: functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging Review article REFERENCE 3 (bases 1 to 2747) AUTHORS Shirkoohi,R., Fujita,H., Darmanin,S. and Takimoto,M. TITLE Gelsolin induces promonocytic leukemia differentiation accompanied by upregulation of p21CIP1 JOURNAL Asian Pac. J. Cancer Prev. 13 (9), 4827-4834 (2012) PUBMED 23167427 REMARK GeneRIF: Our work confirms that the cytoskeletal tumor suppressor, gelsolin, can induce monocytic myeloid differentiation in addition to growth retardation in the human monocytic cell line U937. REFERENCE 4 (bases 1 to 2747) AUTHORS Mazumdar,B., Meyer,K. and Ray,R. TITLE N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism JOURNAL PLoS ONE 7 (8), E44461 (2012) PUBMED 22952982 REMARK GeneRIF: Gelsolin modulation of cell death involved upregulation of TRAIL-R1 and TRAIL-R2, and involved caspase 3 activation by extrinsic pathway. REFERENCE 5 (bases 1 to 2747) AUTHORS Zhuo,J., Tan,E.H., Yan,B., Tochhawng,L., Jayapal,M., Koh,S., Tay,H.K., Maciver,S.K., Hooi,S.C., Salto-Tellez,M., Kumar,A.P., Goh,Y.C., Lim,Y.C. and Yap,C.T. TITLE Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade JOURNAL PLoS ONE 7 (8), E43594 (2012) PUBMED 22927998 REMARK GeneRIF: novel functions of gelsolin in colorectal tumor cell invasion through its modulation of the uPA/uPAR cascade REFERENCE 6 (bases 1 to 2747) AUTHORS de la Chapelle,A., Tolvanen,R., Boysen,G., Santavy,J., Bleeker-Wagemakers,L., Maury,C.P. and Kere,J. TITLE Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187 JOURNAL Nat. Genet. 2 (2), 157-160 (1992) PUBMED 1338910 REFERENCE 7 (bases 1 to 2747) AUTHORS Yu,F.X., Sun,H.Q., Janmey,P.A. and Yin,H.L. TITLE Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin JOURNAL J. Biol. Chem. 267 (21), 14616-14621 (1992) PUBMED 1321812 REFERENCE 8 (bases 1 to 2747) AUTHORS de la Chapelle,A., Kere,J., Sack,G.H. Jr., Tolvanen,R. and Maury,C.P. TITLE Familial amyloidosis, Finnish type: G654----a mutation of the gelsolin gene in Finnish families and an unrelated American family JOURNAL Genomics 13 (3), 898-901 (1992) PUBMED 1322359 REFERENCE 9 (bases 1 to 2747) AUTHORS Paunio,T., Kiuru,S., Hongell,V., Mustonen,E., Syvanen,A.C., Bengstrom,M., Palo,J. and Peltonen,L. TITLE Solid-phase minisequencing test reveals Asp187----Asn (G654----A) mutation of gelsolin in all affected individuals with Finnish type of familial amyloidosis JOURNAL Genomics 13 (1), 237-239 (1992) PUBMED 1315718 REFERENCE 10 (bases 1 to 2747) AUTHORS Haltia,M., Levy,E., Meretoja,J., Fernandez-Madrid,I., Koivunen,O. and Frangione,B. TITLE Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay JOURNAL Am. J. Med. Genet. 42 (3), 357-359 (1992) PUBMED 1311149 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA294394.1, DC316173.1, AK096280.1 and BC017491.1. Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 7 and 8 both encode isoform c. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AK295572.1, AK307859.1 [ECO:0000331] RNAseq introns :: single sample supports all introns ERS025082, ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-39 DA294394.1 1-39 40-607 DC316173.1 1-568 608-2613 AK096280.1 519-2524 2614-2747 BC017491.1 996-1129 FEATURES Location/Qualifiers source 1..2747 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q33" gene 1..2747 /gene="GSN" /gene_synonym="ADF; AGEL" /note="gelsolin" /db_xref="GeneID:2934" /db_xref="HGNC:4620" /db_xref="MIM:137350" exon 1..118 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" exon 119..211 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 129 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:151083385" variation 165 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:11550200" exon 212..273 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" misc_feature 235..237 /gene="GSN" /gene_synonym="ADF; AGEL" /note="upstream in-frame stop codon" variation 236 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:202184446" variation 248 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:369491966" CDS 250..2478 /gene="GSN" /gene_synonym="ADF; AGEL" /note="isoform c is encoded by transcript variant 8; brevin; actin-depolymerizing factor" /codon_start=1 /product="gelsolin isoform c" /protein_id="NP_001121139.1" /db_xref="GI:189083782" /db_xref="CCDS:CCDS48011.1" /db_xref="GeneID:2934" /db_xref="HGNC:4620" /db_xref="MIM:137350" /translation="
MEKLFCCFPNSMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
" misc_feature 304..642 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S1_like; cd11290" /db_xref="CDD:200446" misc_feature order(355..360,475..477,493..498,502..510,514..522, 526..531,562..564,568..570) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative actin binding interface [polypeptide binding]; other site" /db_xref="CDD:200446" misc_feature order(406..408,499..501) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200446" misc_feature 535..537 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 1 Ca binding site [ion binding]; other site" /db_xref="CDD:200446" misc_feature 685..954 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S2_like; cd11289" /db_xref="CDD:200445" misc_feature order(769..771,835..837) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200445" misc_feature 1012..1314 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S3_like; cd11292" /db_xref="CDD:200448" misc_feature order(1117..1119,1189..1191) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200448" misc_feature order(1297..1299,1312..1314) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding site [chemical binding]; other site" /db_xref="CDD:200448" misc_feature 1444..1746 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S4_like; cd11293" /db_xref="CDD:200449" misc_feature order(1492..1497,1609..1611,1627..1632,1636..1644, 1648..1656,1660..1665,1696..1698,1702..1704) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative actin binding interface [polypeptide binding]; other site" /db_xref="CDD:200449" misc_feature order(1543..1545,1633..1635) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200449" misc_feature 1669..1671 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 1 Ca binding site [ion binding]; other site" /db_xref="CDD:200449" misc_feature 1717..1719 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding residue [chemical binding]; other site" /db_xref="CDD:200449" misc_feature 1810..2076 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S5_like; cd11288" /db_xref="CDD:200444" misc_feature 1834..1836 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding residue [chemical binding]; other site" /db_xref="CDD:200444" misc_feature order(1900..1905,1969..1971) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200444" misc_feature 2125..2421 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S6_like; cd11291" /db_xref="CDD:200447" misc_feature order(2218..2220,2284..2286) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200447" variation 258 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:201734352" exon 274..478 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 276 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:150353588" variation 289 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:138068754" STS 296..476 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="GSN" /db_xref="UniSTS:253982" variation 301 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143781307" variation 311 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:115224458" STS 336..613 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="MARC_23632-23633:1027531903:1" /db_xref="UniSTS:268728" variation 343 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373791435" variation 357 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:149415778" variation 368 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:149556868" variation 370 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376961112" variation 372 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:201642174" variation 381 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:370368742" variation 392 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:144219139" variation 399 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374052802" variation 408 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200027070" variation 409 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:148748121" variation 414 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368210196" variation 415 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142305374" variation 438 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201102347" variation 440 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="g" /db_xref="dbSNP:368868605" variation 444 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146365204" variation 462 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:139689268" variation 468 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144551136" exon 479..633 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 483 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373229223" variation 504 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376627635" variation 505 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:369305328" variation 507 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371165744" variation 509 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:79630438" variation 513 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:140734150" variation 514 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:2230287" variation 523 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:145441439" variation 525 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:116956127" variation 553 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146956976" variation 554 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:138153246" variation 567 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142155964" variation 569 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201920706" variation 585 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373779982" variation 604 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:367933536" exon 634..795 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 663 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:180689280" variation 664 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:41305623" variation 675 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:186654124" variation 679 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368197143" STS 685..794 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="GDB:597556" /db_xref="UniSTS:158100" variation 702 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143628574" variation 712 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:138951454" variation 713 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:144099356" variation 716 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141314418" variation 725 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:150617780" variation 769 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:121909715" exon 796..945 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 820 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:11550199" variation 829 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371175865" variation 830 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375589943" variation 879 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146329975" variation 898 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376060588" variation 913 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:369788495" variation 920 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371320840" variation 941 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:374011467" exon 946..1035 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 962 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:202067009" variation 971 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:139723535" variation 991 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376744130" variation 1003 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:150568054" variation 1004 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144375242" variation 1005 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:377624593" variation 1012 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:188214536" variation 1018 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146112795" variation 1034 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148800857" exon 1036..1168 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1036 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:113759985" variation 1062 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201395524" variation 1123 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142435036" variation 1137 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374571846" variation 1138 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:151155909" exon 1169..1257 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1210..1211 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ac" /replace="c" /db_xref="dbSNP:148582809" variation 1229 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:139028645" exon 1258..1473 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1263 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:145170518" variation 1319 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:372681751" variation 1326 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:377247829" variation 1329 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:367632035" variation 1360 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:75508371" variation 1364 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:370764119" variation 1378 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375323203" variation 1380 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201325199" variation 1383 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371171301" variation 1395 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200399610" variation 1396 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:200018246" variation 1426 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376180600" variation 1440 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201365952" variation 1441 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:372218880" variation 1452 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:147583697" variation 1453 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142034230" variation 1462 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376488491" variation 1472 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368537807" exon 1474..1607 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1482 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371836872" variation 1485 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:202240818" variation 1486 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368079865" variation 1503 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:111273576" variation 1507 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:140042418" variation 1521 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:149375418" variation 1535 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375227932" variation 1542 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:2304393" variation 1570 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:116185403" variation 1577 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148309276" variation 1582 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368923816" exon 1608..1698 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1632 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:141406100" variation 1681 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:145721476" exon 1699..1869 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1699 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:370997492" variation 1702 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:138341672" variation 1703 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142828669" variation 1725 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200156774" variation 1726 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375902120" variation 1747 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:146125870" variation 1767 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374982895" variation 1769 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139832048" variation 1788 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:199681748" variation 1795 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:58750568" variation 1817 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:77681311" variation 1820 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148410442" variation 1836 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:145051977" variation 1837 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:147554026" variation 1845 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:140414249" exon 1870..2044 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1876 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:371993530" variation 1919 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:184844415" variation 1922 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376326631" variation 1928 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201307081" variation 1944 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:144259173" variation 1945 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:151208452" variation 1947 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:374022157" variation 1962 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:73660439" variation 1972 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368207411" variation 1976 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:76463933" variation 1983 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:369846947" exon 2045..2169 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2064 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139239940" variation 2067 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:145066574" variation 2068 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141082919" variation 2096 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:200319453" variation 2132 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:9696578" variation 2161 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371328761" exon 2170..2247 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2213 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144434647" variation 2239 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:186351262" variation 2242 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:377710586" exon 2248..2308 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2259 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:201752493" exon 2309..2717 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2327 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142854368" variation 2338 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375881478" variation 2339 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143285592" variation 2347 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:148360076" variation 2351 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141510612" variation 2364 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368986042" variation 2397 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:9102" variation 2398 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139420096" STS 2409..2565 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="RH17399" /db_xref="UniSTS:34031" variation 2505 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371549019" variation 2506 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376801564" STS 2507..2672 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="G10520" /db_xref="UniSTS:56986" STS 2508..2698 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="SHGC-132035" /db_xref="UniSTS:173882" STS 2510..2637 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="STS-X04412" /db_xref="UniSTS:16463" STS 2523..2683 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="D9S1050E" /db_xref="UniSTS:29132" STS 2535..2641 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="D9S1953" /db_xref="UniSTS:63945" variation 2540 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:1051142" variation 2551 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:374518331" variation 2552 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:143181937" variation 2566 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:1051174" variation 2574..2575 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:147410423" variation 2575..2576 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:372955427" variation 2595..2596 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:71694034" variation 2600..2601 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:377469209" variation 2600 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:15034" variation 2603 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /replace="tt" /db_xref="dbSNP:66991108" variation 2606..2607 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ttt" /db_xref="dbSNP:369363704" variation 2606 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:71663525" variation 2607..2608 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:376569726" variation 2613..2614 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /replace="tt" /db_xref="dbSNP:71680051" variation 2615..2616 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="tttt" /db_xref="dbSNP:71659520" variation 2618 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:73660440" variation 2620 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:11550202" variation 2646..2647 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ag" /db_xref="dbSNP:71695753" variation 2665 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:1051286" ORIGIN
tcccgcccgcgccctgcccaccccggccgcgcgcaccacaacgcccccgccccgccgcccggaaccagctgagcgcagctggacccagcagccgctgtctccagtgccgcagcagcaggtagtgctcatagctctctttgtccagtgcttcggccttggtcccagcgccttcccacggagcagcactcttcaccctgcacagccttgttagatacagcgctaggaaaaggggagtaattcaggtctagaatggaaaaactgttttgttgctttcccaacagcatggtggtggaacaccccgagttcctcaaggcagggaaggagcctggcctgcagatctggcgtgtggagaagttcgatctggtgcccgtgcccaccaacctttatggagacttcttcacgggcgacgcctacgtcatcctgaagacagtgcagctgaggaacggaaatctgcagtatgacctccactactggctgggcaatgagtgcagccaggatgagagcggggcggccgccatctttaccgtgcagctggatgactacctgaacggccgggccgtgcagcaccgtgaggtccagggcttcgagtcggccaccttcctaggctacttcaagtctggcctgaagtacaagaaaggaggtgtggcatcaggattcaagcacgtggtacccaacgaggtggtggtgcagagactcttccaggtcaaagggcggcgtgtggtccgtgccaccgaggtacctgtgtcctgggagagcttcaacaatggcgactgcttcatcctggacctgggcaacaacatccaccagtggtgtggttccaacagcaatcggtatgaaagactgaaggccacacaggtgtccaagggcatccgggacaacgagcggagtggccgggcccgagtgcacgtgtctgaggagggcactgagcccgaggcgatgctccaggtgctgggccccaagccggctctgcctgcaggtaccgaggacaccgccaaggaggatgcggccaaccgcaagctggccaagctctacaaggtctccaatggtgcagggaccatgtccgtctccctcgtggctgatgagaaccccttcgcccagggggccctgaagtcagaggactgcttcatcctggaccacggcaaagatgggaaaatctttgtctggaaaggcaagcaggcaaacacggaggagaggaaggctgccctcaaaacagcctctgacttcatcaccaagatggactaccccaagcagactcaggtctcggtccttcctgagggcggtgagaccccactgttcaagcagttcttcaagaactggcgggacccagaccagacagatggcctgggcttgtcctacctttccagccatatcgccaacgtggagcgggtgcccttcgacgccgccaccctgcacacctccactgccatggccgcccagcacggcatggatgacgatggcacaggccagaaacagatctggagaatcgaaggttccaacaaggtgcccgtggaccctgccacatatggacagttctatggaggcgacagctacatcattctgtacaactaccgccatggtggccgccaggggcagataatctataactggcagggtgcccagtctacccaggatgaggtcgctgcatctgccatcctgactgctcagctggatgaggagctgggaggtacccctgtccagagccgtgtggtccaaggcaaggagcccgcccacctcatgagcctgtttggtgggaagcccatgatcatctacaagggcggcacctcccgcgagggcgggcagacagcccctgccagcacccgcctcttccaggtccgcgccaacagcgctggagccacccgggctgttgaggtattgcctaaggctggtgcactgaactccaacgatgcctttgttctgaaaaccccctcagccgcctacctgtgggtgggtacaggagccagcgaggcagagaagacgggggcccaggagctgctcagggtgctgcgggcccaacctgtgcaggtggcagaaggcagcgagccagatggcttctgggaggccctgggcgggaaggctgcctaccgcacatccccacggctgaaggacaagaagatggatgcccatcctcctcgcctctttgcctgctccaacaagattggacgttttgtgatcgaagaggttcctggtgagctcatgcaggaagacctggcaacggatgacgtcatgcttctggacacctgggaccaggtctttgtctgggttggaaaggattctcaagaagaagaaaagacagaagccttgacttctgctaagcggtacatcgagacggacccagccaatcgggatcggcggacgcccatcaccgtggtgaagcaaggctttgagcctccctcctttgtgggctggttccttggctgggatgatgattactggtctgtggaccccttggacagggccatggctgagctggctgcctgaggaggggcagggcccacccatgtcaccggtcagtgccttttggaactgtccttccctcaaagaggccttagagcgagcagagcagctctgctatgagtgtgtgtgtgtgtgtgtgttgtttcttttttttttttttacagtatccaaaaatagccctgcaaaaattcagagtccttgcaaaattgtctaaaatgtcagtgtttgggaaattaaatccaataaaaacattttgaagtgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:2934 -> Molecular function: GO:0003779 [actin binding] evidence: IEA GeneID:2934 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS GeneID:2934 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:2934 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:2934 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:2934 -> Biological process: GO:0007568 [aging] evidence: IEA GeneID:2934 -> Biological process: GO:0014003 [oligodendrocyte development] evidence: IEA GeneID:2934 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IEA GeneID:2934 -> Biological process: GO:0030041 [actin filament polymerization] evidence: IDA GeneID:2934 -> Biological process: GO:0030041 [actin filament polymerization] evidence: ISS GeneID:2934 -> Biological process: GO:0030155 [regulation of cell adhesion] evidence: IEA GeneID:2934 -> Biological process: GO:0042246 [tissue regeneration] evidence: IEA GeneID:2934 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA GeneID:2934 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: IEA GeneID:2934 -> Biological process: GO:0051014 [actin filament severing] evidence: IDA GeneID:2934 -> Biological process: GO:0051014 [actin filament severing] evidence: ISS GeneID:2934 -> Biological process: GO:0051016 [barbed-end actin filament capping] evidence: TAS GeneID:2934 -> Biological process: GO:0051593 [response to folic acid] evidence: IEA GeneID:2934 -> Biological process: GO:0060271 [cilium morphogenesis] evidence: IMP GeneID:2934 -> Biological process: GO:0071276 [cellular response to cadmium ion] evidence: IEA GeneID:2934 -> Cellular component: GO:0001726 [ruffle] evidence: IEA GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: IDA GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: ISS GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS GeneID:2934 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: ISS GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:2934 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IEA GeneID:2934 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA GeneID:2934 -> Cellular component: GO:0043234 [protein complex] evidence: IEA GeneID:2934 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA GeneID:2934 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
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@meso_cacase at
DBCLS
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