2024-04-27 11:23:48, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001127663 2797 bp mRNA linear PRI 17-JUN-2013 DEFINITION Homo sapiens gelsolin (GSN), transcript variant 4, mRNA. ACCESSION NM_001127663 VERSION NM_001127663.1 GI:189083773 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2797) AUTHORS DiNubile,M.J. TITLE Plasma gelsolin levels in the diagnosis, prognosis, and treatment of lung complications of prematurity JOURNAL Am. J. Respir. Crit. Care Med. 186 (11), 1195-1196 (2012) PUBMED 23204381 REMARK GeneRIF: Circulating gelsolin level is an important biomarker in preterm infants, developing bronchopulmonary dysplasia. REFERENCE 2 (bases 1 to 2797) AUTHORS Li,G.H., Arora,P.D., Chen,Y., McCulloch,C.A. and Liu,P. TITLE Multifunctional roles of gelsolin in health and diseases JOURNAL Med Res Rev 32 (5), 999-1025 (2012) PUBMED 22886630 REMARK GeneRIF: REVIEW: functions of the plasma and cytoplasmic forms of gelsolin, and their manifold impacts on cancer, apoptosis, infection and inflammation, cardiac injury, pulmonary diseases, and aging Review article REFERENCE 3 (bases 1 to 2797) AUTHORS Shirkoohi,R., Fujita,H., Darmanin,S. and Takimoto,M. TITLE Gelsolin induces promonocytic leukemia differentiation accompanied by upregulation of p21CIP1 JOURNAL Asian Pac. J. Cancer Prev. 13 (9), 4827-4834 (2012) PUBMED 23167427 REMARK GeneRIF: Our work confirms that the cytoskeletal tumor suppressor, gelsolin, can induce monocytic myeloid differentiation in addition to growth retardation in the human monocytic cell line U937. REFERENCE 4 (bases 1 to 2797) AUTHORS Mazumdar,B., Meyer,K. and Ray,R. TITLE N-terminal region of gelsolin induces apoptosis of activated hepatic stellate cells by a caspase-dependent mechanism JOURNAL PLoS ONE 7 (8), E44461 (2012) PUBMED 22952982 REMARK GeneRIF: Gelsolin modulation of cell death involved upregulation of TRAIL-R1 and TRAIL-R2, and involved caspase 3 activation by extrinsic pathway. REFERENCE 5 (bases 1 to 2797) AUTHORS Zhuo,J., Tan,E.H., Yan,B., Tochhawng,L., Jayapal,M., Koh,S., Tay,H.K., Maciver,S.K., Hooi,S.C., Salto-Tellez,M., Kumar,A.P., Goh,Y.C., Lim,Y.C. and Yap,C.T. TITLE Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade JOURNAL PLoS ONE 7 (8), E43594 (2012) PUBMED 22927998 REMARK GeneRIF: novel functions of gelsolin in colorectal tumor cell invasion through its modulation of the uPA/uPAR cascade REFERENCE 6 (bases 1 to 2797) AUTHORS de la Chapelle,A., Tolvanen,R., Boysen,G., Santavy,J., Bleeker-Wagemakers,L., Maury,C.P. and Kere,J. TITLE Gelsolin-derived familial amyloidosis caused by asparagine or tyrosine substitution for aspartic acid at residue 187 JOURNAL Nat. Genet. 2 (2), 157-160 (1992) PUBMED 1338910 REFERENCE 7 (bases 1 to 2797) AUTHORS Yu,F.X., Sun,H.Q., Janmey,P.A. and Yin,H.L. TITLE Identification of a polyphosphoinositide-binding sequence in an actin monomer-binding domain of gelsolin JOURNAL J. Biol. Chem. 267 (21), 14616-14621 (1992) PUBMED 1321812 REFERENCE 8 (bases 1 to 2797) AUTHORS de la Chapelle,A., Kere,J., Sack,G.H. Jr., Tolvanen,R. and Maury,C.P. TITLE Familial amyloidosis, Finnish type: G654----a mutation of the gelsolin gene in Finnish families and an unrelated American family JOURNAL Genomics 13 (3), 898-901 (1992) PUBMED 1322359 REFERENCE 9 (bases 1 to 2797) AUTHORS Paunio,T., Kiuru,S., Hongell,V., Mustonen,E., Syvanen,A.C., Bengstrom,M., Palo,J. and Peltonen,L. TITLE Solid-phase minisequencing test reveals Asp187----Asn (G654----A) mutation of gelsolin in all affected individuals with Finnish type of familial amyloidosis JOURNAL Genomics 13 (1), 237-239 (1992) PUBMED 1315718 REFERENCE 10 (bases 1 to 2797) AUTHORS Haltia,M., Levy,E., Meretoja,J., Fernandez-Madrid,I., Koivunen,O. and Frangione,B. TITLE Gelsolin gene mutation--at codon 187--in familial amyloidosis, Finnish: DNA-diagnostic assay JOURNAL Am. J. Med. Genet. 42 (3), 357-359 (1992) PUBMED 1311149 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA294394.1, DA394782.1, AK096280.1 and BC017491.1. Summary: The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-37 DA294394.1 1-37 38-323 DA394782.1 1-286 324-331 DA294394.1 212-219 332-634 DA394782.1 287-589 635-2663 AK096280.1 496-2524 2664-2797 BC017491.1 996-1129 FEATURES Location/Qualifiers source 1..2797 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="9" /map="9q33" gene 1..2797 /gene="GSN" /gene_synonym="ADF; AGEL" /note="gelsolin" /db_xref="GeneID:2934" /db_xref="HGNC:4620" /db_xref="MIM:137350" exon 1..118 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" exon 119..211 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 129 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:151083385" variation 165 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:11550200" exon 212..323 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" misc_feature 222..224 /gene="GSN" /gene_synonym="ADF; AGEL" /note="upstream in-frame stop codon" CDS 225..2528 /gene="GSN" /gene_synonym="ADF; AGEL" /note="isoform f is encoded by transcript variant 4; brevin; actin-depolymerizing factor" /codon_start=1 /product="gelsolin isoform f" /protein_id="NP_001121135.2" /db_xref="GI:390517030" /db_xref="GeneID:2934" /db_xref="HGNC:4620" /db_xref="MIM:137350" /translation="
MNTGLTRLLWPSWLPDGDMSHPQPELFLFPKAQPNSMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWSVDPLDRAMAELAA
" misc_feature 354..692 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S1_like; cd11290" /db_xref="CDD:200446" misc_feature order(405..410,525..527,543..548,552..560,564..572, 576..581,612..614,618..620) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative actin binding interface [polypeptide binding]; other site" /db_xref="CDD:200446" misc_feature order(456..458,549..551) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200446" misc_feature 585..587 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 1 Ca binding site [ion binding]; other site" /db_xref="CDD:200446" misc_feature 735..1004 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S2_like; cd11289" /db_xref="CDD:200445" misc_feature order(819..821,885..887) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200445" misc_feature 1062..1364 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S3_like; cd11292" /db_xref="CDD:200448" misc_feature order(1167..1169,1239..1241) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200448" misc_feature order(1347..1349,1362..1364) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding site [chemical binding]; other site" /db_xref="CDD:200448" misc_feature 1494..1796 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S4_like; cd11293" /db_xref="CDD:200449" misc_feature order(1542..1547,1659..1661,1677..1682,1686..1694, 1698..1706,1710..1715,1746..1748,1752..1754) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative actin binding interface [polypeptide binding]; other site" /db_xref="CDD:200449" misc_feature order(1593..1595,1683..1685) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200449" misc_feature 1719..1721 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 1 Ca binding site [ion binding]; other site" /db_xref="CDD:200449" misc_feature 1767..1769 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding residue [chemical binding]; other site" /db_xref="CDD:200449" misc_feature 1860..2126 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S5_like; cd11288" /db_xref="CDD:200444" misc_feature 1884..1886 /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative nucleotide binding residue [chemical binding]; other site" /db_xref="CDD:200444" misc_feature order(1950..1955,2019..2021) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200444" misc_feature 2175..2471 /gene="GSN" /gene_synonym="ADF; AGEL" /note="Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Region: gelsolin_S6_like; cd11291" /db_xref="CDD:200447" misc_feature order(2268..2270,2334..2336) /gene="GSN" /gene_synonym="ADF; AGEL" /note="putative type 2 Ca binding site [ion binding]; other site" /db_xref="CDD:200447" variation 243 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:145775883" exon 324..528 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 326 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:150353588" variation 339 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:138068754" STS 346..526 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="GSN" /db_xref="UniSTS:253982" variation 351 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143781307" variation 361 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:115224458" STS 386..663 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="MARC_23632-23633:1027531903:1" /db_xref="UniSTS:268728" variation 393 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373791435" variation 407 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:149415778" variation 418 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:149556868" variation 420 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376961112" variation 422 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:201642174" variation 431 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:370368742" variation 442 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:144219139" variation 449 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374052802" variation 458 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200027070" variation 459 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:148748121" variation 464 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368210196" variation 465 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142305374" variation 488 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201102347" variation 490 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="g" /db_xref="dbSNP:368868605" variation 494 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146365204" variation 512 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:139689268" variation 518 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144551136" exon 529..683 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 533 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373229223" variation 554 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376627635" variation 555 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:369305328" variation 557 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371165744" variation 559 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:79630438" variation 563 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:140734150" variation 564 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:2230287" variation 573 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:145441439" variation 575 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:116956127" variation 603 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146956976" variation 604 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:138153246" variation 617 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142155964" variation 619 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201920706" variation 635 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:373779982" variation 654 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:367933536" exon 684..845 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 713 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:180689280" variation 714 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:41305623" variation 725 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:186654124" variation 729 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368197143" STS 735..844 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="GDB:597556" /db_xref="UniSTS:158100" variation 752 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143628574" variation 762 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:138951454" variation 763 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:144099356" variation 766 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141314418" variation 775 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:150617780" variation 819 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:121909715" exon 846..995 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 870 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:11550199" variation 879 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371175865" variation 880 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375589943" variation 929 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146329975" variation 948 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376060588" variation 963 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:369788495" variation 970 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371320840" variation 991 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:374011467" exon 996..1085 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1012 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:202067009" variation 1021 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:139723535" variation 1041 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376744130" variation 1053 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:150568054" variation 1054 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144375242" variation 1055 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:377624593" variation 1062 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:188214536" variation 1068 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:146112795" variation 1084 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148800857" exon 1086..1218 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1086 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:113759985" variation 1112 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201395524" variation 1173 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142435036" variation 1187 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374571846" variation 1188 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:151155909" exon 1219..1307 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1260..1261 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ac" /replace="c" /db_xref="dbSNP:148582809" variation 1279 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /replace="t" /db_xref="dbSNP:139028645" exon 1308..1523 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1313 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:145170518" variation 1369 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:372681751" variation 1376 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:377247829" variation 1379 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:367632035" variation 1410 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:75508371" variation 1414 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:370764119" variation 1428 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375323203" variation 1430 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:201325199" variation 1433 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371171301" variation 1445 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200399610" variation 1446 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:200018246" variation 1476 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376180600" variation 1490 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201365952" variation 1491 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:372218880" variation 1502 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:147583697" variation 1503 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142034230" variation 1512 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376488491" variation 1522 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368537807" exon 1524..1657 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1532 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:371836872" variation 1535 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:202240818" variation 1536 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368079865" variation 1553 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:111273576" variation 1557 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:140042418" variation 1571 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:149375418" variation 1585 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375227932" variation 1592 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:2304393" variation 1620 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:116185403" variation 1627 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148309276" variation 1632 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368923816" exon 1658..1748 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1682 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:141406100" variation 1731 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:145721476" exon 1749..1919 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1749 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:370997492" variation 1752 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:138341672" variation 1753 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:142828669" variation 1775 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:200156774" variation 1776 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375902120" variation 1797 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:146125870" variation 1817 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:374982895" variation 1819 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139832048" variation 1838 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:199681748" variation 1845 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:58750568" variation 1867 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:77681311" variation 1870 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:148410442" variation 1886 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:145051977" variation 1887 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:147554026" variation 1895 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:140414249" exon 1920..2094 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 1926 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="c" /db_xref="dbSNP:371993530" variation 1969 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:184844415" variation 1972 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:376326631" variation 1978 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:201307081" variation 1994 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:144259173" variation 1995 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:151208452" variation 1997 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:374022157" variation 2012 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:73660439" variation 2022 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:368207411" variation 2026 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:76463933" variation 2033 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:369846947" exon 2095..2219 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2114 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139239940" variation 2117 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:145066574" variation 2118 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141082919" variation 2146 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:200319453" variation 2182 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:9696578" variation 2211 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371328761" exon 2220..2297 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2263 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:144434647" variation 2289 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:186351262" variation 2292 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:377710586" exon 2298..2358 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2309 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:201752493" exon 2359..2767 /gene="GSN" /gene_synonym="ADF; AGEL" /inference="alignment:Splign:1.39.8" variation 2377 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:142854368" variation 2388 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:375881478" variation 2389 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:143285592" variation 2397 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:148360076" variation 2401 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:141510612" variation 2414 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:368986042" variation 2447 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:9102" variation 2448 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:139420096" STS 2459..2615 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="RH17399" /db_xref="UniSTS:34031" variation 2555 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:371549019" variation 2556 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:376801564" STS 2557..2722 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="G10520" /db_xref="UniSTS:56986" STS 2558..2748 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="SHGC-132035" /db_xref="UniSTS:173882" STS 2560..2687 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="STS-X04412" /db_xref="UniSTS:16463" STS 2573..2733 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="D9S1050E" /db_xref="UniSTS:29132" STS 2585..2691 /gene="GSN" /gene_synonym="ADF; AGEL" /standard_name="D9S1953" /db_xref="UniSTS:63945" variation 2590 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:1051142" variation 2601 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="g" /db_xref="dbSNP:374518331" variation 2602 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:143181937" variation 2616 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:1051174" variation 2624..2625 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:147410423" variation 2625..2626 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:372955427" variation 2645..2646 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="gtgt" /db_xref="dbSNP:71694034" variation 2650..2651 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:377469209" variation 2650 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="g" /db_xref="dbSNP:15034" variation 2653 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /replace="tt" /db_xref="dbSNP:66991108" variation 2656..2657 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ttt" /db_xref="dbSNP:369363704" variation 2656 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:71663525" variation 2657..2658 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /db_xref="dbSNP:376569726" variation 2663..2664 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="t" /replace="tt" /db_xref="dbSNP:71680051" variation 2665..2666 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="tttt" /db_xref="dbSNP:71659520" variation 2668 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="g" /replace="t" /db_xref="dbSNP:73660440" variation 2670 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="a" /replace="t" /db_xref="dbSNP:11550202" variation 2696..2697 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="" /replace="ag" /db_xref="dbSNP:71695753" variation 2715 /gene="GSN" /gene_synonym="ADF; AGEL" /replace="c" /replace="t" /db_xref="dbSNP:1051286" ORIGIN
tcccgcccgcgccctgcccaccccggccgcgcgcaccacaacgcccccgccccgccgcccggaaccagctgagcgcagctggacccagcagccgctgtctccagtgccgcagcagcaggtagtgctcatagctctctttgtccagtgcttcggccttggtcccagcgccttcccacggagcagcactcttcaccctgcacagccttgttaggagaaggggatgaatgaatacaggacttacgcgtctgctgtggcccagctggcttccagatggtgacatgagccacccacagccggagctgttcctctttcccaaagctcagcccaacagcatggtggtggaacaccccgagttcctcaaggcagggaaggagcctggcctgcagatctggcgtgtggagaagttcgatctggtgcccgtgcccaccaacctttatggagacttcttcacgggcgacgcctacgtcatcctgaagacagtgcagctgaggaacggaaatctgcagtatgacctccactactggctgggcaatgagtgcagccaggatgagagcggggcggccgccatctttaccgtgcagctggatgactacctgaacggccgggccgtgcagcaccgtgaggtccagggcttcgagtcggccaccttcctaggctacttcaagtctggcctgaagtacaagaaaggaggtgtggcatcaggattcaagcacgtggtacccaacgaggtggtggtgcagagactcttccaggtcaaagggcggcgtgtggtccgtgccaccgaggtacctgtgtcctgggagagcttcaacaatggcgactgcttcatcctggacctgggcaacaacatccaccagtggtgtggttccaacagcaatcggtatgaaagactgaaggccacacaggtgtccaagggcatccgggacaacgagcggagtggccgggcccgagtgcacgtgtctgaggagggcactgagcccgaggcgatgctccaggtgctgggccccaagccggctctgcctgcaggtaccgaggacaccgccaaggaggatgcggccaaccgcaagctggccaagctctacaaggtctccaatggtgcagggaccatgtccgtctccctcgtggctgatgagaaccccttcgcccagggggccctgaagtcagaggactgcttcatcctggaccacggcaaagatgggaaaatctttgtctggaaaggcaagcaggcaaacacggaggagaggaaggctgccctcaaaacagcctctgacttcatcaccaagatggactaccccaagcagactcaggtctcggtccttcctgagggcggtgagaccccactgttcaagcagttcttcaagaactggcgggacccagaccagacagatggcctgggcttgtcctacctttccagccatatcgccaacgtggagcgggtgcccttcgacgccgccaccctgcacacctccactgccatggccgcccagcacggcatggatgacgatggcacaggccagaaacagatctggagaatcgaaggttccaacaaggtgcccgtggaccctgccacatatggacagttctatggaggcgacagctacatcattctgtacaactaccgccatggtggccgccaggggcagataatctataactggcagggtgcccagtctacccaggatgaggtcgctgcatctgccatcctgactgctcagctggatgaggagctgggaggtacccctgtccagagccgtgtggtccaaggcaaggagcccgcccacctcatgagcctgtttggtgggaagcccatgatcatctacaagggcggcacctcccgcgagggcgggcagacagcccctgccagcacccgcctcttccaggtccgcgccaacagcgctggagccacccgggctgttgaggtattgcctaaggctggtgcactgaactccaacgatgcctttgttctgaaaaccccctcagccgcctacctgtgggtgggtacaggagccagcgaggcagagaagacgggggcccaggagctgctcagggtgctgcgggcccaacctgtgcaggtggcagaaggcagcgagccagatggcttctgggaggccctgggcgggaaggctgcctaccgcacatccccacggctgaaggacaagaagatggatgcccatcctcctcgcctctttgcctgctccaacaagattggacgttttgtgatcgaagaggttcctggtgagctcatgcaggaagacctggcaacggatgacgtcatgcttctggacacctgggaccaggtctttgtctgggttggaaaggattctcaagaagaagaaaagacagaagccttgacttctgctaagcggtacatcgagacggacccagccaatcgggatcggcggacgcccatcaccgtggtgaagcaaggctttgagcctccctcctttgtgggctggttccttggctgggatgatgattactggtctgtggaccccttggacagggccatggctgagctggctgcctgaggaggggcagggcccacccatgtcaccggtcagtgccttttggaactgtccttccctcaaagaggccttagagcgagcagagcagctctgctatgagtgtgtgtgtgtgtgtgtgttgtttcttttttttttttttacagtatccaaaaatagccctgcaaaaattcagagtccttgcaaaattgtctaaaatgtcagtgtttgggaaattaaatccaataaaaacattttgaagtgtgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:2934 -> Molecular function: GO:0003779 [actin binding] evidence: IEA GeneID:2934 -> Molecular function: GO:0005509 [calcium ion binding] evidence: TAS GeneID:2934 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:2934 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:2934 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:2934 -> Biological process: GO:0007568 [aging] evidence: IEA GeneID:2934 -> Biological process: GO:0014003 [oligodendrocyte development] evidence: IEA GeneID:2934 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IEA GeneID:2934 -> Biological process: GO:0030041 [actin filament polymerization] evidence: IDA GeneID:2934 -> Biological process: GO:0030041 [actin filament polymerization] evidence: ISS GeneID:2934 -> Biological process: GO:0030155 [regulation of cell adhesion] evidence: IEA GeneID:2934 -> Biological process: GO:0042246 [tissue regeneration] evidence: IEA GeneID:2934 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA GeneID:2934 -> Biological process: GO:0048015 [phosphatidylinositol-mediated signaling] evidence: IEA GeneID:2934 -> Biological process: GO:0051014 [actin filament severing] evidence: IDA GeneID:2934 -> Biological process: GO:0051014 [actin filament severing] evidence: ISS GeneID:2934 -> Biological process: GO:0051016 [barbed-end actin filament capping] evidence: TAS GeneID:2934 -> Biological process: GO:0051593 [response to folic acid] evidence: IEA GeneID:2934 -> Biological process: GO:0060271 [cilium morphogenesis] evidence: IMP GeneID:2934 -> Biological process: GO:0071276 [cellular response to cadmium ion] evidence: IEA GeneID:2934 -> Cellular component: GO:0001726 [ruffle] evidence: IEA GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: IDA GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: ISS GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS GeneID:2934 -> Cellular component: GO:0005576 [extracellular region] evidence: TAS GeneID:2934 -> Cellular component: GO:0005615 [extracellular space] evidence: IEA GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: IDA GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: ISS GeneID:2934 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:2934 -> Cellular component: GO:0015629 [actin cytoskeleton] evidence: IEA GeneID:2934 -> Cellular component: GO:0030027 [lamellipodium] evidence: IEA GeneID:2934 -> Cellular component: GO:0043234 [protein complex] evidence: IEA GeneID:2934 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IEA GeneID:2934 -> Cellular component: GO:0070062 [extracellular vesicular exosome] evidence: IDA
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@meso_cacase at
DBCLS
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