2024-04-25 07:36:15, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001127584 1449 bp mRNA linear PRI 02-JUN-2013 DEFINITION Homo sapiens inhibitor of growth family, member 4 (ING4), transcript variant 4, mRNA. ACCESSION NM_001127584 VERSION NM_001127584.1 GI:189083827 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1449) AUTHORS Zeng,Z.L., Li,F.J., Gao,F., Sun,D.S. and Yao,L. TITLE Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma JOURNAL J Surg Oncol 107 (2), 105-110 (2013) PUBMED 22767438 REMARK GeneRIF: Data suggested that miR-650 is correlated with the pathogenesis of hepatocellular carcinoma (HCC) and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4. REFERENCE 2 (bases 1 to 1449) AUTHORS Lou,C., Jiang,S., Guo,X. and Dong,X.S. TITLE ING4 is negatively correlated with microvessel density in colon cancer JOURNAL Tumour Biol. 33 (6), 2357-2364 (2012) PUBMED 23055189 REMARK GeneRIF: Loss of ING4 expression is associated with lymphatic metastasis in colon cancer. REFERENCE 3 (bases 1 to 1449) AUTHORS Zhang,L., Wang,Y., Zhang,F., Wang,Y. and Zhang,Q. TITLE Correlation between tumor suppressor inhibitor of growth family member 4 expression and microvessel density in breast cancer JOURNAL Hum. Pathol. 43 (10), 1611-1617 (2012) PUBMED 22436625 REMARK GeneRIF: Inhibitor of growth 4 may represent an important biomarker for assessing the severity of breast cancer REFERENCE 4 (bases 1 to 1449) AUTHORS Tzouvelekis,A., Ntolios,P., Karameris,A., Koutsopoulos,A., Boglou,P., Koulelidis,A., Archontogeorgis,K., Zacharis,G., Drakopanagiotakis,F., Steiropoulos,P., Anevlavis,S., Polychronopoulos,V., Mikroulis,D. and Bouros,D. TITLE Expression of hypoxia-inducible factor (HIF)-1a-vascular endothelial growth factor (VEGF)-inhibitory growth factor (ING)-4- axis in sarcoidosis patients JOURNAL BMC Res Notes 5, 654 (2012) PUBMED 23181555 REMARK GeneRIF: Report up-regulation of ING4 expression in sarcoid granulomas. Publication Status: Online-Only REFERENCE 5 (bases 1 to 1449) AUTHORS Byron,S.A., Min,E., Thal,T.S., Hostetter,G., Watanabe,A.T., Azorsa,D.O., Little,T.H., Tapia,C. and Kim,S. TITLE Negative regulation of NF-kappaB by the ING4 tumor suppressor in breast cancer JOURNAL PLoS ONE 7 (10), E46823 (2012) PUBMED 23056468 REMARK GeneRIF: ING4 negatively regulates NF-kappaB in breast cancer REFERENCE 6 (bases 1 to 1449) AUTHORS Raho,G., Miranda,C., Tamborini,E., Pierotti,M.A. and Greco,A. TITLE Detection of novel mRNA splice variants of human ING4 tumor suppressor gene JOURNAL Oncogene 26 (36), 5247-5257 (2007) PUBMED 17325660 REMARK GeneRIF: data suggest that alternative splicing could modulate the activity of ING4 tumor suppressor protein REFERENCE 7 (bases 1 to 1449) AUTHORS Zhang,X., Xu,L.S., Wang,Z.Q., Wang,K.S., Li,N., Cheng,Z.H., Huang,S.Z., Wei,D.Z. and Han,Z.G. TITLE ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells JOURNAL FEBS Lett. 570 (1-3), 7-12 (2004) PUBMED 15251430 REMARK GeneRIF: ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells REFERENCE 8 (bases 1 to 1449) AUTHORS Garkavtsev,I., Kozin,S.V., Chernova,O., Xu,L., Winkler,F., Brown,E., Barnett,G.H. and Jain,R.K. TITLE The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis JOURNAL Nature 428 (6980), 328-332 (2004) PUBMED 15029197 REMARK GeneRIF: In mice, xenografts of human glioblastoma U87MG, which has decreased expression of ING4, grow significantly faster and have higher vascular volume fractions than control tumours REFERENCE 9 (bases 1 to 1449) AUTHORS Shiseki,M., Nagashima,M., Pedeux,R.M., Kitahama-Shiseki,M., Miura,K., Okamura,S., Onogi,H., Higashimoto,Y., Appella,E., Yokota,J. and Harris,C.C. TITLE p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity JOURNAL Cancer Res. 63 (10), 2373-2378 (2003) PUBMED 12750254 REMARK GeneRIF: p29ING4 and p28ING5 may be significant modulators of p53 function. REFERENCE 10 (bases 1 to 1449) AUTHORS Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X., Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H., Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J., Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M., Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L. TITLE Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (17), 9543-9548 (2000) PUBMED 10931946 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP303219.1, AB197697.1, AF156552.1 and AW614868.1. Summary: This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (4) uses a different splice site in the coding region, compared to variant 9. The resulting protein (isoform 4) is shorter by 4 aa compared to isoform 9. Other names for this variant are ING4_v4 and '12 bp skip variant'. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX421859.2, AL526123.3 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025084 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-41 BP303219.1 1-41 42-779 AB197697.1 1-738 780-1383 AF156552.1 768-1371 1384-1449 AW614868.1 1-66 c FEATURES Location/Qualifiers source 1..1449 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12p13.31" gene 1..1449 /gene="ING4" /gene_synonym="my036; p29ING4" /note="inhibitor of growth family, member 4" /db_xref="GeneID:51147" /db_xref="HGNC:19423" /db_xref="MIM:608524" exon 1..78 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(6) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:374390006" variation complement(26) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:199768855" CDS 42..779 /gene="ING4" /gene_synonym="my036; p29ING4" /note="isoform 4 is encoded by transcript variant 4; candidate tumor suppressor p33 ING1 homolog; brain my036 protein; inhibitor of growth protein 4" /codon_start=1 /product="inhibitor of growth protein 4 isoform 4" /protein_id="NP_001121056.1" /db_xref="GI:189083828" /db_xref="CCDS:CCDS44815.1" /db_xref="GeneID:51147" /db_xref="HGNC:19423" /db_xref="MIM:608524" /translation="
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
" misc_feature 54..362 /gene="ING4" /gene_synonym="my036; p29ING4" /note="Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998" /db_xref="CDD:205182" misc_feature 60..764 /gene="ING4" /gene_synonym="my036; p29ING4" /note="Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; Region: TNG2; COG5034" /db_xref="CDD:34639" misc_feature 621..764 /gene="ING4" /gene_synonym="my036; p29ING4" /note="PHD-finger; Region: PHD; pfam00628" /db_xref="CDD:201356" variation complement(50) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:147493061" variation complement(56) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:190900185" variation complement(68) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:143202414" variation complement(70) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="t" /db_xref="dbSNP:371180258" variation complement(78) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="t" /db_xref="dbSNP:376965069" exon 79..150 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(117) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="g" /db_xref="dbSNP:140970573" exon 151..317 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(199) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:144340616" variation complement(202) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:371595694" variation complement(213) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:139185675" variation complement(224) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="c" /db_xref="dbSNP:201959427" exon 318..423 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation 367 /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="c" /db_xref="dbSNP:193921122" variation complement(397) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:11551179" variation complement(403) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:374543463" exon 424..529 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(427) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:374663258" variation complement(454) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:371095155" variation complement(460) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:149630308" variation complement(464) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:117012163" variation complement(479) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:201626425" variation complement(489) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:150080565" variation complement(522) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:186742663" variation complement(523) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="g" /replace="t" /db_xref="dbSNP:113932069" variation complement(529) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:142380796" exon 530..677 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(545) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="g" /replace="t" /db_xref="dbSNP:371654809" variation complement(551) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:146347929" variation complement(633..634) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="" /replace="g" /db_xref="dbSNP:11426491" variation complement(638) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="g" /replace="t" /db_xref="dbSNP:369007352" variation complement(669) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:201257362" variation complement(677) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:77283008" exon 678..739 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" variation complement(683) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:371902029" variation complement(686) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:140339044" variation complement(708) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:139075674" exon 740..1436 /gene="ING4" /gene_synonym="my036; p29ING4" /inference="alignment:Splign:1.39.8" STS 762..1408 /gene="ING4" /gene_synonym="my036; p29ING4" /standard_name="ING4_9672" /db_xref="UniSTS:468482" variation complement(765) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:199800012" variation complement(773) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:76327967" variation complement(831) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="t" /db_xref="dbSNP:369960359" variation complement(851) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:373140860" STS 1022..1296 /gene="ING4" /gene_synonym="my036; p29ING4" /standard_name="WI-19753" /db_xref="UniSTS:66995" variation complement(1047) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:76290581" STS 1079..1308 /gene="ING4" /gene_synonym="my036; p29ING4" /standard_name="RH11183" /db_xref="UniSTS:66445" variation complement(1082) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="c" /db_xref="dbSNP:184942338" STS 1095..1352 /gene="ING4" /gene_synonym="my036; p29ING4" /standard_name="A001T24" /db_xref="UniSTS:59161" STS 1095..1352 /gene="ING4" /gene_synonym="my036; p29ING4" /standard_name="G19629" /db_xref="UniSTS:59160" variation complement(1146) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="g" /db_xref="dbSNP:114082659" variation complement(1170) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="t" /db_xref="dbSNP:150675992" variation complement(1202) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="a" /replace="g" /db_xref="dbSNP:14542" variation complement(1206) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="t" /db_xref="dbSNP:145532274" variation complement(1246) /gene="ING4" /gene_synonym="my036; p29ING4" /replace="c" /replace="g" /db_xref="dbSNP:376640690" polyA_signal 1364..1369 /gene="ING4" /gene_synonym="my036; p29ING4" polyA_site 1383 /gene="ING4" /gene_synonym="my036; p29ING4" ORIGIN
acttccggggcggatcggaagttgctttgttttgcttcgagatggctgcggggatgtatttggaacattatctggacagtattgaaaaccttccctttgaattacagagaaactttcagctcatgagggacctagaccaaagaacagaggacctgaaggctgaaattgacaagttggccactgagtatatgagtagtgcccgcagcctgagctccgaggaaaaattggcccttctcaaacagatccaggaagcctatggcaagtgcaaggaatttggtgacgacaaggtgcagcttgccatgcagacctatgagatggtggacaaacacattcggcggctggacacagacctggcccgttttgaggctgatctcaaggagaaacagattgagtcaagtgactatgacagctcttccagcaaaggccggactcaaaaggagaagaaagctgctcgtgctcgttccaaagggaaaaactcggatgaagaagcccccaagactgcccagaagaagttaaagctcgtgcgcacaagtcctgagtatgggatgccctcagtgacctttggcagtgtccacccctctgatgtgttggatatgcctgtggatcccaacgaacccacctattgcctttgtcaccaggtctcctatggagagatgattggctgtgacaaccctgattgttccattgagtggttccattttgcctgtgtggggctgacaaccaagcctcgggggaaatggttttgcccacgctgctcccaagaacggaagaagaaatagataagggccttggattccaacacagtttcttccacatcccctgacttgggctagtgggcagaggaatgcctgtgctggggccaggggttcagggaggagtggatggcacagtgctgtcatcccttctcctcccctctccccactcccggtgctgaggctgcatcagaccctggtagggaggggtgccgcagccactaacggtatgtgctctccttcagccctctcccttcggagggacgtggtcttgcccactgtccttttgcctccatgctgaggtcggtgctgtatttcagagggagggtccttttcattctccttgctttgtatttaaggactggggcatagcatgggggcagtcccccagacctcttcattccccctcctgtggtgagggctaggtgtgatcaacacttttcttctccattcccttcctgcttttttcatggtgggggatccaccaggtcatctaggctctggccctagttgaaggggcaccccttcctctgtgccaagaggattcatcctgggagagggggcaaggtggaatgcagataactcacatgtaaaaggaacttgggtaggtaaataaaagctatacatgttggcctgctgtgtttattgtagagacactgttttagtaaacatgctgagcattcaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:51147 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: IDA GeneID:51147 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:51147 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA GeneID:51147 -> Molecular function: GO:0035064 [methylated histone residue binding] evidence: IDA GeneID:51147 -> Biological process: GO:0006260 [DNA replication] evidence: IDA GeneID:51147 -> Biological process: GO:0006473 [protein acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA GeneID:51147 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IDA GeneID:51147 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IDA GeneID:51147 -> Biological process: GO:0008285 [negative regulation of cell proliferation] evidence: IDA GeneID:51147 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IDA GeneID:51147 -> Biological process: GO:0043966 [histone H3 acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0043981 [histone H4-K5 acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0043982 [histone H4-K8 acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0043983 [histone H4-K12 acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0043984 [histone H4-K16 acetylation] evidence: IDA GeneID:51147 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA GeneID:51147 -> Biological process: GO:0045926 [negative regulation of growth] evidence: IDA GeneID:51147 -> Cellular component: GO:0000123 [histone acetyltransferase complex] evidence: IDA GeneID:51147 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
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