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2024-04-20 03:43:56, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001127323 3873 bp mRNA linear PRI 02-JUN-2013
DEFINITION Homo sapiens glutamate receptor, metabotropic 8 (GRM8), transcript
variant 2, mRNA.
ACCESSION NM_001127323
VERSION NM_001127323.1 GI:187960068
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3873)
AUTHORS Yanagawa,M., Yamashita,T. and Shichida,Y.
TITLE Glutamate acts as a partial inverse agonist to metabotropic
glutamate receptor with a single amino acid mutation in the
transmembrane domain
JOURNAL J. Biol. Chem. 288 (14), 9593-9601 (2013)
PUBMED 23420844
REMARK GeneRIF: Glutamate acts as a partial inverse agonist to
metabotropic glutamate receptor with a single amino acid mutation
in the transmembrane domain
REFERENCE 2 (bases 1 to 3873)
AUTHORS Girotto,G., Pirastu,N., Sorice,R., Biino,G., Campbell,H.,
d'Adamo,A.P., Hastie,N.D., Nutile,T., Polasek,O., Portas,L.,
Rudan,I., Ulivi,S., Zemunik,T., Wright,A.F., Ciullo,M., Hayward,C.,
Pirastu,M. and Gasparini,P.
TITLE Hearing function and thresholds: a genome-wide association study in
European isolated populations identifies new loci and pathways
JOURNAL J. Med. Genet. 48 (6), 369-374 (2011)
PUBMED 21493956
REMARK GeneRIF: Eight suggestive significant loci were detected with a
series of genes expressed within the inner ear that underlie the
auditory function, such as: DCLK1, PTPRD, GRM8, CMIP.
REFERENCE 3 (bases 1 to 3873)
AUTHORS Terracciano,A., Tanaka,T., Sutin,A.R., Sanna,S., Deiana,B., Lai,S.,
Uda,M., Schlessinger,D., Abecasis,G.R., Ferrucci,L. and Costa,P.T.
Jr.
TITLE Genome-wide association scan of trait depression
JOURNAL Biol. Psychiatry 68 (9), 811-817 (2010)
PUBMED 20800221
REFERENCE 4 (bases 1 to 3873)
AUTHORS Saus,E., Brunet,A., Armengol,L., Alonso,P., Crespo,J.M.,
Fernandez-Aranda,F., Guitart,M., Martin-Santos,R., Menchon,J.M.,
Navines,R., Soria,V., Torrens,M., Urretavizcaya,M., Valles,V.,
Gratacos,M. and Estivill,X.
TITLE Comprehensive copy number variant (CNV) analysis of neuronal
pathways genes in psychiatric disorders identifies rare variants
within patients
JOURNAL J Psychiatr Res 44 (14), 971-978 (2010)
PUBMED 20398908
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 5 (bases 1 to 3873)
AUTHORS Fonseca,F., Gratacos,M., Escaramis,G., De Cid,R., Martin-Santos,R.,
Fernandez-Espejo,E., Estivill,X. and Torrens,M.
TITLE Response to methadone maintenance treatment is associated with the
MYOCD and GRM6 genes
JOURNAL Mol Diagn Ther 14 (3), 171-178 (2010)
PUBMED 20560679
REMARK GeneRIF: Observational study of gene-disease association,
gene-environment interaction, and pharmacogenomic / toxicogenomic.
(HuGE Navigator)
REFERENCE 6 (bases 1 to 3873)
AUTHORS Thomas,N.K., Wright,R.A., Howson,P.A., Kingston,A.E., Schoepp,D.D.
and Jane,D.E.
TITLE (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist,
activates metabotropic glutamate receptors on primary afferent
terminals in the neonatal rat spinal cord
JOURNAL Neuropharmacology 40 (3), 311-318 (2001)
PUBMED 11166323
REFERENCE 7 (bases 1 to 3873)
AUTHORS Malherbe,P., Kratzeisen,C., Lundstrom,K., Richards,J.G., Faull,R.L.
and Mutel,V.
TITLE Cloning and functional expression of alternative spliced variants
of the human metabotropic glutamate receptor 8
JOURNAL Brain Res. Mol. Brain Res. 67 (2), 201-210 (1999)
PUBMED 10216218
REFERENCE 8 (bases 1 to 3873)
AUTHORS Wu,S., Wright,R.A., Rockey,P.K., Burgett,S.G., Arnold,J.S.,
Rosteck,P.R. Jr., Johnson,B.G., Schoepp,D.D. and Belagaje,R.M.
TITLE Group III human metabotropic glutamate receptors 4, 7 and 8:
molecular cloning, functional expression, and comparison of
pharmacological properties in RGT cells
JOURNAL Brain Res. Mol. Brain Res. 53 (1-2), 88-97 (1998)
PUBMED 9473604
REFERENCE 9 (bases 1 to 3873)
AUTHORS Scherer,S.W., Soder,S., Duvoisin,R.M., Huizenga,J.J. and Tsui,L.C.
TITLE The human metabotropic glutamate receptor 8 (GRM8) gene: a
disproportionately large gene located at 7q31.3-q32.1
JOURNAL Genomics 44 (2), 232-236 (1997)
PUBMED 9299241
REFERENCE 10 (bases 1 to 3873)
AUTHORS Scherer,S.W., Duvoisin,R.M., Kuhn,R., Heng,H.H., Belloni,E. and
Tsui,L.C.
TITLE Localization of two metabotropic glutamate receptor genes, GRM3 and
GRM8, to human chromosome 7q
JOURNAL Genomics 31 (2), 230-233 (1996)
PUBMED 8824806
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK315203.1, AJ236921.1,
BG202742.1 and BG211606.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: L-glutamate is the major excitatory neurotransmitter in
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. [provided by
RefSeq, Jul 2008].
Transcript Variant: This variant (2) uses an alternate donor splice
site at the penultimate exon compared to transcript variant 1,
resulting in an isoform (b) of the same length, but with 16
different amino acids at the C-terminus compared to isoform a. This
variant was designated as HmGluR8b by Malherbe et al, 1999
(PMID:10216218).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AK315203.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025084 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2338 AK315203.1 1-2338
2339-3627 AJ236921.1 1797-3085
3628-3856 BG202742.1 342-570
3857-3873 BG211606.1 558-574
FEATURES Location/Qualifiers
source 1..3873
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q31.3-q32.1"
gene 1..3873
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="glutamate receptor, metabotropic 8"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
exon 1..246
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 247..1067
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
STS 377..636
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN114199"
/db_xref="UniSTS:438994"
variation 383
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:76817979"
misc_feature 465..467
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="upstream in-frame stop codon"
variation 465
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75009171"
CDS 558..3284
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="isoform b precursor is encoded by transcript
variant 2"
/codon_start=1
/product="metabotropic glutamate receptor 8 isoform b
precursor"
/protein_id="NP_001120795.1"
/db_xref="GI:187960069"
/db_xref="CCDS:CCDS47696.1"
/db_xref="GeneID:2918"
/db_xref="HGNC:4600"
/db_xref="MIM:601116"
/translation="
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFPMVKSGSTS
"
sig_peptide 558..656
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
mat_peptide 657..3281
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/product="metabotropic glutamate receptor 8 isoform b"
misc_feature 687..2069
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Ligand-binding domain of the group III metabotropic
glutamate receptor; Region: PBP1_mGluR_groupIII; cd06376"
/db_xref="CDD:107371"
misc_feature order(768..770,1023..1025,1086..1094,1236..1238,
1482..1484,1758..1760)
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="ligand-binding site [chemical binding]; other site"
/db_xref="CDD:107371"
misc_feature 777..1991
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Receptor family ligand binding region; Region:
ANF_receptor; pfam01094"
/db_xref="CDD:201592"
misc_feature order(885..887,894..896,1038..1040,1047..1049,1116..1118,
1311..1313)
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="dimerization interface [polypeptide binding]; other
site"
/db_xref="CDD:107371"
misc_feature 2091..2243
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="Nine Cysteines Domain of family 3 GPCR; Region:
NCD3G; pfam07562"
/db_xref="CDD:191786"
misc_feature 2307..2381
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2334..3080
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/note="7 transmembrane sweet-taste receptor of 3 GCPR;
Region: 7tm_3; pfam00003"
/db_xref="CDD:200920"
misc_feature 2418..2480
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2499..2561
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2643..2705
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2796..2861
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 2901..2966
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
misc_feature 3012..3086
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O00222.2);
transmembrane region"
variation 586
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769194"
variation 619
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:769202"
STS 632..899
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN114198"
/db_xref="UniSTS:438993"
variation 914
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769200"
exon 1068..1284
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1285..1420
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1301
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:1131702"
variation 1321
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78266043"
variation 1351..1352
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:2234945"
variation 1351
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:17150343"
exon 1421..1575
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 1576..1713
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1642
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:78124913"
variation 1660
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:78947184"
exon 1714..1914
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 1732
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="g"
/db_xref="dbSNP:2234947"
variation 1845
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:75863532"
exon 1915..2051
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 2021
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:769198"
exon 2052..2987
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 2200
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="g"
/replace="t"
/db_xref="dbSNP:2234948"
STS 2229..2493
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111151"
/db_xref="UniSTS:435947"
STS 2467..2692
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111150"
/db_xref="UniSTS:435946"
variation 2579
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="c"
/db_xref="dbSNP:77222071"
STS 2685..2937
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN111149"
/db_xref="UniSTS:435945"
variation 2714
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="g"
/db_xref="dbSNP:769201"
variation 2860
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="a"
/replace="t"
/db_xref="dbSNP:1051433"
exon 2988..3289
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
exon 3290..3860
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/inference="alignment:Splign:1.39.8"
variation 3368
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/replace="c"
/replace="t"
/db_xref="dbSNP:712723"
STS 3386..3764
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="stSG612933"
/db_xref="UniSTS:451074"
STS 3474..3699
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
/standard_name="REN110736"
/db_xref="UniSTS:435532"
polyA_signal 3638..3643
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3658
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3781..3786
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_signal 3836..3841
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
polyA_site 3860
/gene="GRM8"
/gene_synonym="GLUR8; GPRC1H; mGlu8; MGLUR8"
ORIGIN
agtaaagaggttcagaaaagagggagactttacccggaactcccaaggcttggagatgtgatcccccaaaagtttagtcggcgaatgggagactgaagggtgacgggaagggggcaggcgcgctcggcgctctgactgggcgtgcggcggcaggattttaaagcgctctgcctcggatcgtctgccctgggtgacctcccggacctgccctggtggaatccggacttgccccgccgagatgacgaggaataattctgctacaaggctgatttcaaggacatgaattgttgacctcatcccaacatcagaacctcagatgttctaatttttgcaccattccaggcaagttgatcttataaggaaataaaattgaaccttaggggtctgatggaaattcactgtgacattcaaatcaagaaaacttgctaatgcccacagagccttttccccatgggccctgatggtagcctccagaaggtgcagcctcaggtggtgccctttcttctgtggcaagaataaactttgggtcttggattgcaataccacctgtggagaaaatggtatgcgagggaaagcgatcagcctcttgcccttgtttcttcctcttgaccgccaagttctactggatcctcacaatgatgcaaagaactcacagccaggagtatgcccattccatacgggtggatggggacattattttggggggtctcttccctgtccacgcaaagggagagagaggggtgccttgtggggagctgaagaaggaaaaggggattcacagactggaggccatgctttatgcaattgaccagattaacaaggaccctgatctcctttccaacatcactctgggtgtccgcatcctcgacacgtgctctagggacacctatgctttggagcagtctctaacattcgtgcaggcattaatagagaaagatgcttcggatgtgaagtgtgctaatggagatccacccattttcaccaagcccgacaagatttctggcgtcataggtgctgcagcaagctccgtgtccatcatggttgctaacattttaagactttttaagatacctcaaatcagctatgcatccacagccccagagctaagtgataacaccaggtatgactttttctctcgagtggttccgcctgactcctaccaagcccaagccatggtggacatcgtgacagcactgggatggaattatgtttcgacactggcttctgaggggaactatggtgagagcggtgtggaggccttcacccagatctcgagggagattggtggtgtttgcattgctcagtcacagaaaatcccacgtgaaccaagacctggagaatttgaaaaaattatcaaacgcctgctagaaacacctaatgctcgagcagtgattatgtttgccaatgaggatgacatcaggaggatattggaagcagcaaaaaaactaaaccaaagtgggcattttctctggattggctcagatagttggggatccaaaatagcacctgtctatcagcaagaggagattgcagaaggggctgtgacaattttgcccaaacgagcatcaattgatggatttgatcgatactttagaagccgaactcttgccaataatcgaagaaatgtgtggtttgcagaattctgggaggagaattttggctgcaagttaggatcacatgggaaaaggaacagtcatataaagaaatgcacagggctggagcgaattgctcgggattcatcttatgaacaggaaggaaaggtccaatttgtaattgatgctgtatattccatggcttacgccctgcacaatatgcacaaagatctctgccctggatacattggcctttgtccacgaatgagtaccattgatgggaaagagctacttggttatattcgggctgtaaattttaatggcagtgctggcactcctgtcacttttaatgaaaacggagatgctcctggacgttatgatatcttccagtatcaaataaccaacaaaagcacagagtacaaagtcatcggccactggaccaatcagcttcatctaaaagtggaagacatgcagtgggctcatagagaacatactcacccggcgtctgtctgcagcctgccgtgtaagccaggggagaggaagaaaacggtgaaaggggtcccttgctgctggcactgtgaacgctgtgaaggttacaactaccaggtggatgagctgtcctgtgaactttgccctctggatcagagacccaacatgaaccgcacaggctgccagcttatccccatcatcaaattggagtggcattctccctgggctgtggtgcctgtgtttgttgcaatattgggaatcatcgccaccacctttgtgatcgtgacctttgtccgctataatgacacacctatcgtgagggcttcaggacgcgaacttagttacgtgctcctaacggggatttttctctgttattcaatcacgtttttaatgattgcagcaccagatacaatcatatgctccttccgacgggtcttcctaggacttggcatgtgtttcagctatgcagcccttctgaccaaaacaaaccgtatccaccgaatatttgagcaggggaagaaatctgtcacagcgcccaagttcattagtccagcatctcagctggtgatcaccttcagcctcatctccgtccagctccttggagtgtttgtctggtttgttgtggatcccccccacatcatcattgactatggagagcagcggacactagatccagagaaggccaggggagtgctcaagtgtgacatttctgatctctcactcatttgttcacttggatacagtatcctcttgatggtcacttgtactgtttatgccattaaaacgagaggtgtcccagagactttcaatgaagccaaacctattggatttaccatgtataccacctgcatcatttggttagctttcatccccatcttttttggtacagcccagtcagcagaaaagatgtacatccagacaacaacacttactgtctccatgagtttaagtgcttcagtatctctgggcatgctctatatgcccaaggtttatattataatttttcatccagaacagaatgttcaaaaacgcaagaggagcttcaaggctgtggtgacagctgccaccatgcaaagcaaactgatccaaaaaggaaatgacagaccaaatggcgaggtgaaaagtgaactctgtgagagtcttgaaaccaacagtaagtcatctgtagagtttccgatggtcaagagcgggagcacttcctaatagatcttcctctaccaagacaacatatatcagttacagcaatcattcaatctgaaacagggaaatggcacaatctgaagagatgtggtatatgatcttaaatgatgaacatgagaccgcaaaaattcactcctggagatctccgtagactacaatcaatcaaatcaatagtcagtcttgtaaggaacaaaaattagccatgagccaaaagtatcaataaacggggagtgaagaaacccgttttatacaataaaaccaatgagtgtcaagctaaagtattgcttattcatgagcagttaaaacaaatcacaaaaggaaaactaatgttagctcgtgaaaaaaaatgctgttgaaataaataatgtctgatgttattcttgtatttttctgtgattgtgagaactcccgttcctgtcccacattgtttaacttgtataagacaatgagtctgtttcttgtaatggctgaccagattgaagccctgggttgtgctaaaaataaatgcaatgattgatgcatgcaattttttatacaaataatttatttctaataataaaggaatgttttgcaaatgttaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:2918 -> Molecular function: GO:0001642 [group III metabotropic glutamate receptor activity] evidence: IEA
GeneID:2918 -> Molecular function: GO:0004930 [G-protein coupled receptor activity] evidence: TAS
GeneID:2918 -> Molecular function: GO:0008066 [glutamate receptor activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007194 [negative regulation of adenylate cyclase activity] evidence: TAS
GeneID:2918 -> Biological process: GO:0007601 [visual perception] evidence: TAS
GeneID:2918 -> Biological process: GO:0007608 [sensory perception of smell] evidence: IEA
GeneID:2918 -> Biological process: GO:0030818 [negative regulation of cAMP biosynthetic process] evidence: IDA
GeneID:2918 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:2918 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
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