GGRNA Home | Help | Advanced search

2024-03-28 22:53:07, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001127184            1299 bp    mRNA    linear   PRI 15-JUL-2013
DEFINITION  Homo sapiens CASP8 and FADD-like apoptosis regulator (CFLAR),
            transcript variant 3, mRNA.
ACCESSION   NM_001127184
VERSION     NM_001127184.2  GI:321267565
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Wilkie-Grantham,R.P., Matsuzawa,S. and Reed,J.C.
  TITLE     Novel phosphorylation and ubiquitination sites regulate reactive
            oxygen species-dependent degradation of anti-apoptotic c-FLIP
            protein
  JOURNAL   J. Biol. Chem. 288 (18), 12777-12790 (2013)
   PUBMED   23519470
  REMARK    GeneRIF: novel ROS-dependent post-translational modifications of
            the c-FLIP protein that regulate its stability, thus impacting
            sensitivity of cancer cells to TRAIL.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Rao-Bindal,K., Rao,C.K., Yu,L. and Kleinerman,E.S.
  TITLE     Expression of c-FLIP in pulmonary metastases in osteosarcoma
            patients and human xenografts
  JOURNAL   Pediatr Blood Cancer 60 (4), 575-579 (2013)
   PUBMED   23255321
  REMARK    GeneRIF: c-FLIP may play an important role in the metastatic
            potential of osteosarcoma to the lung
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Silke,J. and Strasser,A.
  TITLE     The FLIP Side of Life
  JOURNAL   Sci Signal 6 (258), PE2 (2013)
   PUBMED   23322903
  REMARK    GeneRIF: Studies indicate that the anti-apoptotic protein c-FLIP is
            an important regulator of death receptor signaling, including
            TNFR1, Fas, DR4, and DR5.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Rasper,D.M., Vaillancourt,J.P., Hadano,S., Houtzager,V.M.,
            Seiden,I., Keen,S.L., Tawa,P., Xanthoudakis,S., Nasir,J.,
            Martindale,D., Koop,B.F., Peterson,E.P., Thornberry,N.A., Huang,J.,
            MacPherson,D.P., Black,S.C., Hornung,F., Lenardo,M.J., Hayden,M.R.,
            Roy,S. and Nicholson,D.W.
  TITLE     Cell death attenuation by 'Usurpin', a mammalian DED-caspase
            homologue that precludes caspase-8 recruitment and activation by
            the CD-95 (Fas, APO-1) receptor complex
  JOURNAL   Cell Death Differ. 5 (4), 271-288 (1998)
   PUBMED   10200473
REFERENCE   5  (bases 1 to 1299)
  AUTHORS   Goltsev,Y.V., Kovalenko,A.V., Arnold,E., Varfolomeev,E.E.,
            Brodianskii,V.M. and Wallach,D.
  TITLE     CASH, a novel caspase homologue with death effector domains
  JOURNAL   J. Biol. Chem. 272 (32), 19641-19644 (1997)
   PUBMED   9289491
REFERENCE   6  (bases 1 to 1299)
  AUTHORS   Srinivasula,S.M., Ahmad,M., Ottilie,S., Bullrich,F., Banks,S.,
            Wang,Y., Fernandes-Alnemri,T., Croce,C.M., Litwack,G.,
            Tomaselli,K.J., Armstrong,R.C. and Alnemri,E.S.
  TITLE     FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates
            Fas/TNFR1-induced apoptosis
  JOURNAL   J. Biol. Chem. 272 (30), 18542-18545 (1997)
   PUBMED   9228018
REFERENCE   7  (bases 1 to 1299)
  AUTHORS   Kim,T.W., Pettingell,W.H., Jung,Y.K., Kovacs,D.M. and Tanzi,R.E.
  TITLE     Alternative cleavage of Alzheimer-associated presenilins during
            apoptosis by a caspase-3 family protease
  JOURNAL   Science 277 (5324), 373-376 (1997)
   PUBMED   9219695
REFERENCE   8  (bases 1 to 1299)
  AUTHORS   Hu,S., Vincenz,C., Ni,J., Gentz,R. and Dixit,V.M.
  TITLE     I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and
            CD-95-induced apoptosis
  JOURNAL   J. Biol. Chem. 272 (28), 17255-17257 (1997)
   PUBMED   9211860
REFERENCE   9  (bases 1 to 1299)
  AUTHORS   Irmler,M., Thome,M., Hahne,M., Schneider,P., Hofmann,K.,
            Steiner,V., Bodmer,J.L., Schroter,M., Burns,K., Mattmann,C.,
            Rimoldi,D., French,L.E. and Tschopp,J.
  TITLE     Inhibition of death receptor signals by cellular FLIP
  JOURNAL   Nature 388 (6638), 190-195 (1997)
   PUBMED   9217161
REFERENCE   10 (bases 1 to 1299)
  AUTHORS   Shu,H.B., Halpin,D.R. and Goeddel,D.V.
  TITLE     Casper is a FADD- and caspase-related inducer of apoptosis
  JOURNAL   Immunity 6 (6), 751-763 (1997)
   PUBMED   9208847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK296036.1, Y14040.1 and
            AF005775.1.
            On Feb 3, 2011 this sequence version replaced gi:187608584.
            
            Summary: The protein encoded by this gene is a regulator of
            apoptosis and is structurally similar to caspase-8. However, the
            encoded protein lacks caspase activity and appears to be itself
            cleaved into two peptides by caspase-8. Several transcript variants
            encoding different isoforms have been found for this gene, and
            partial evidence for several more variants exists. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (3) represents use of an alternate
            coding exon that results in a shorter protein isoform (2) with a
            distinct C-terminus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y14040.1, BQ644010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025081, ERS025082 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AK296036.1         1-26
            27-404              Y14040.1           42-419
            405-891             Y14040.1           421-907
            892-1299            AF005775.1         427-834
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33-q34"
     gene            1..1299
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="CASP8 and FADD-like apoptosis regulator"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:1876"
                     /db_xref="MIM:603599"
     exon            1..328
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     variation       4
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:78384838"
     variation       31
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189589369"
     STS             58..253
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /standard_name="A008B37"
                     /db_xref="UniSTS:67797"
     variation       70
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:184055782"
     variation       324
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:370175319"
     exon            329..746
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     variation       357
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:192733942"
     variation       367..368
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace=""
                     /replace="agccctcagaaatgaagtt"
                     /db_xref="dbSNP:376356547"
     variation       417
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:10931931"
     variation       435
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184779247"
     misc_feature    451..453
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="upstream in-frame stop codon"
     variation       455..456
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:200933932"
     variation       456
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367710240"
     CDS             466..1131
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="isoform 2 is encoded by transcript variant 3;
                     inhibitor of FLICE; caspase-related inducer of apoptosis;
                     FADD-like anti-apoptotic molecule; usurpin beta; caspase
                     homolog; caspase-eight-related protein; MACH-related
                     inducer of toxicity; FADD-like antiapoptotic molecule 1;
                     cellular FLICE-like inhibitory protein; caspase-like
                     apoptosis regulatory protein"
                     /codon_start=1
                     /product="CASP8 and FADD-like apoptosis regulator isoform
                     2"
                     /protein_id="NP_001120656.1"
                     /db_xref="GI:187608585"
                     /db_xref="CCDS:CCDS46487.1"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:1876"
                     /db_xref="MIM:603599"
                     /translation="
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRMITPYAHCPDLKILGNCSM
"
     misc_feature    466..1050
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (O15519.1);
                     Region: Interaction with caspase-8"
     misc_feature    466..705
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="Death Effector Domain, repeat 1, of cellular
                     FLICE-Inhibitory Protein; Region: DED_c-FLIP_repeat1;
                     cd08337"
                     /db_xref="CDD:176748"
     misc_feature    order(508..513,523..525,532..537,541..546,634..636,
                     646..648)
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="DED1/DED2 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176748"
     misc_feature    order(514..516,655..657,661..663)
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="charge triad; other site"
                     /db_xref="CDD:176748"
     misc_feature    736..978
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="Death Effector Domain, repeat 2, of cellular
                     FLICE-Inhibitory Protein; Region: DED_c-FLIP_repeat2;
                     cd08340"
                     /db_xref="CDD:176751"
     misc_feature    order(736..738,745..750,754..759,769..771,853..855,
                     859..861,871..873)
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="DED1/DED2 interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176751"
     misc_feature    order(787..789,946..948,952..954)
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /note="charge triad; other site"
                     /db_xref="CDD:176751"
     variation       621
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149769889"
     variation       622
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371383444"
     variation       730
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:374815211"
     exon            747..852
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     variation       789
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369789091"
     variation       790
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61759466"
     variation       819
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145567470"
     variation       823
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:74654642"
     variation       825
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:148372596"
     variation       829
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150296080"
     variation       845
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146003529"
     exon            853..988
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     exon            989..1071
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     variation       1032
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:138647536"
     exon            1072..1298
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /inference="alignment:Splign:1.39.8"
     STS             1082..1230
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /standard_name="RH98318"
                     /db_xref="UniSTS:86750"
     STS             1130..1229
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /standard_name="D2S2141"
                     /db_xref="UniSTS:17406"
     STS             1137..1261
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /standard_name="WI-12098"
                     /db_xref="UniSTS:15976"
     variation       1199
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:184131473"
     polyA_signal    1275..1280
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
     polyA_site      1298
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; CLARP; FLAME; FLAME-1; FLAME1; FLIP;
                     I-FLICE; MRIT"
ORIGIN      
atactcagtcacacaagccatagcaggaaacagcgagcttgcagcctcaccgacgagtctcaactaaaagggactcccggagctaggggtggggactcggcctcacacagtgagtgccggctattggacttttgtccagtgacagctgagacaacaaggaccacgggaggaggtgtaggagagaagcgccgcgaacagcgatcgcccagcaccaagtccgcttccaggctttcggtttctttgcctccatcttgggtgcgccttcccggcgtctaggggagcgaaggctgaggtggcagcggcaggagagtccggccgcgacaggacgaactcccccactggaaaggattctgaaagaaatgaagtcagccctcagaaatgaagttgactgcctgctggctttctgttgactggcccggagctgtactgcaagacccttgtgagcttccctagtctaagagtaggatgtctgctgaagtcatccatcaggttgaagaagcacttgatacagatgagaaggagatgctgctctttttgtgccgggatgttgctatagatgtggttccacctaatgtcagggaccttctggatattttacgggaaagaggtaagctgtctgtcggggacttggctgaactgctctacagagtgaggcgatttgacctgctcaaacgtatcttgaagatggacagaaaagctgtggagacccacctgctcaggaaccctcaccttgtttcggactatagagtgctgatggcagagattggtgaggatttggataaatctgatgtgtcctcattaattttcctcatgaaggattacatgggccgaggcaagataagcaaggagaagagtttcttggaccttgtggttgagttggagaaactaaatctggttgccccagatcaactggatttattagaaaaatgcctaaagaacatccacagaatagacctgaagacaaaaatccagaagtacaagcagtctgttcaaggagcagggacaagttacaggaatgttctccaagcagcaatccaaaagagtctcaaggatccttcaaataacttcaggatgataacaccctatgcccattgtcctgatctgaaaattcttggaaattgttccatgtgattaacatggaactgcctctacttaatcattctgaatgattaaatcgtttcattttctaaatgtgttataatgtgtttagccctttcttgttgctgtatgtttagatgctttccaatcttttgttactactaataatgctataaaataaatatccttgtacttctttga
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:8837 -> Molecular function: GO:0002020 [protease binding] evidence: IPI
            GeneID:8837 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IEA
            GeneID:8837 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:8837 -> Molecular function: GO:0008047 [enzyme activator activity] evidence: IDA
            GeneID:8837 -> Biological process: GO:0006508 [proteolysis] evidence: IEA
            GeneID:8837 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:8837 -> Biological process: GO:0007519 [skeletal muscle tissue development] evidence: ISS
            GeneID:8837 -> Biological process: GO:0014732 [skeletal muscle atrophy] evidence: ISS
            GeneID:8837 -> Biological process: GO:0014842 [regulation of satellite cell proliferation] evidence: ISS
            GeneID:8837 -> Biological process: GO:0014866 [skeletal myofibril assembly] evidence: ISS
            GeneID:8837 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:8837 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:8837 -> Biological process: GO:0043085 [positive regulation of catalytic activity] evidence: IDA
            GeneID:8837 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
            GeneID:8837 -> Biological process: GO:0043403 [skeletal muscle tissue regeneration] evidence: ISS
            GeneID:8837 -> Biological process: GO:0051092 [positive regulation of NF-kappaB transcription factor activity] evidence: ISS
            GeneID:8837 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
            GeneID:8837 -> Biological process: GO:1901740 [negative regulation of myoblast fusion] evidence: ISS
            GeneID:8837 -> Biological process: GO:1902042 [negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] evidence: IMP
            GeneID:8837 -> Biological process: GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] evidence: IDA
            GeneID:8837 -> Biological process: GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] evidence: IMP
            GeneID:8837 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS
            GeneID:8837 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:8837 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:8837 -> Cellular component: GO:0031264 [death-inducing signaling complex] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.