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2024-03-28 21:33:51, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001126240            5131 bp    mRNA    linear   PRI 08-JUL-2013
DEFINITION  Homo sapiens tumor protein p73 (TP73), transcript variant 2, mRNA.
ACCESSION   NM_001126240
VERSION     NM_001126240.2  GI:323668322
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5131)
  AUTHORS   Zhang,J., Xu,E. and Chen,X.
  TITLE     TAp73 protein stability is controlled by histone deacetylase 1 via
            regulation of Hsp90 chaperone function
  JOURNAL   J. Biol. Chem. 288 (11), 7727-7737 (2013)
   PUBMED   23362263
  REMARK    GeneRIF: TAp73 protein stability is controlled by histone
            deacetylase 1 via regulation of Hsp90 chaperone function
REFERENCE   2  (bases 1 to 5131)
  AUTHORS   Wang,Y., Radhakrishnan,D., He,X., Peehl,D.M. and Eng,C.
  TITLE     Transcription factor KLLN inhibits tumor growth by AR suppression,
            induces apoptosis by TP53/TP73 stimulation in prostate carcinomas,
            and correlates with cellular differentiation
  JOURNAL   J. Clin. Endocrinol. Metab. 98 (3), E586-E594 (2013)
   PUBMED   23386643
  REMARK    GeneRIF: KLLN is a transcription factor directly regulating AR,
            TP53, and TP73 expression, with a role in prostate carcinogenesis.
REFERENCE   3  (bases 1 to 5131)
  AUTHORS   Jacobs,D.I., Hansen,J., Fu,A., Stevens,R.G., Tjonneland,A.,
            Vogel,U.B., Zheng,T. and Zhu,Y.
  TITLE     Methylation alterations at imprinted genes detected among long-term
            shiftworkers
  JOURNAL   Environ. Mol. Mutagen. 54 (2), 141-146 (2013)
   PUBMED   23193016
  REMARK    GeneRIF: The strongest evidence for altered methylation patterns in
            shiftworkers was observed for TP73 gene.
REFERENCE   4  (bases 1 to 5131)
  AUTHORS   Ethayathulla,A.S., Nguyen,H.T. and Viadiu,H.
  TITLE     Crystal structures of the DNA-binding domain tetramer of the p53
            tumor suppressor family member p73 bound to different full-site
            response elements
  JOURNAL   J. Biol. Chem. 288 (7), 4744-4754 (2013)
   PUBMED   23243311
  REMARK    GeneRIF: Crystal structures of the DNA-binding domain tetramer of
            the p53 tumor suppressor family member p73 bound to different
            full-site response elements
REFERENCE   5  (bases 1 to 5131)
  AUTHORS   Di,C.X., Yang,L.N., Zhang,H., An,L.Z., Zhang,X., Ma,X.F., Sun,C.,
            Wang,X.H., Yang,R., Wu,Z.H. and Si,J.
  TITLE     Effects of carbon-ion beam or X-ray irradiation on anti-apoptosis
            DeltaNp73 expression in HeLa cells
  JOURNAL   Gene 515 (1), 208-213 (2013)
   PUBMED   23228853
  REMARK    GeneRIF: there is a differential DeltaNp73 expression in response
            to different LET radiations, and down-regulated DeltaNp73
            expression might play a critical role in promoting cycle arrest and
            apoptosis in cancer cells.
REFERENCE   6  (bases 1 to 5131)
  AUTHORS   Mai,M., Qian,C., Yokomizo,A., Tindall,D.J., Bostwick,D.,
            Polychronakos,C., Smith,D.I. and Liu,W.
  TITLE     Loss of imprinting and allele switching of p73 in renal cell
            carcinoma
  JOURNAL   Oncogene 17 (13), 1739-1741 (1998)
   PUBMED   9796703
REFERENCE   7  (bases 1 to 5131)
  AUTHORS   Mai,M., Huang,H., Reed,C., Qian,C., Smith,J.S., Alderete,B.,
            Jenkins,R., Smith,D.I. and Liu,W.
  TITLE     Genomic organization and mutation analysis of p73 in
            oligodendrogliomas with chromosome 1 p-arm deletions
  JOURNAL   Genomics 51 (3), 359-363 (1998)
   PUBMED   9721206
REFERENCE   8  (bases 1 to 5131)
  AUTHORS   Nomoto,S., Haruki,N., Kondo,M., Konishi,H., Takahashi,T.,
            Takahashi,T. and Takahashi,T.
  TITLE     Search for mutations and examination of allelic expression
            imbalance of the p73 gene at 1p36.33 in human lung cancers
  JOURNAL   Cancer Res. 58 (7), 1380-1383 (1998)
   PUBMED   9537234
REFERENCE   9  (bases 1 to 5131)
  AUTHORS   Jost,C.A., Marin,M.C. and Kaelin,W.G. Jr.
  TITLE     p73 is a simian [correction of human] p53-related protein that can
            induce apoptosis
  JOURNAL   Nature 389 (6647), 191-194 (1997)
   PUBMED   9296498
  REMARK    Erratum:[Nature 1999 Jun 24;399(6738):817]
REFERENCE   10 (bases 1 to 5131)
  AUTHORS   Kaghad,M., Bonnet,H., Yang,A., Creancier,L., Biscan,J.C.,
            Valent,A., Minty,A., Chalon,P., Lelias,J.M., Dumont,X., Ferrara,P.,
            McKeon,F. and Caput,D.
  TITLE     Monoallelically expressed gene related to p53 at 1p36, a region
            frequently deleted in neuroblastoma and other human cancers
  JOURNAL   Cell 90 (4), 809-819 (1997)
   PUBMED   9288759
  REMARK    GeneRIF: TP73 gene is imprinted, with monoallelic expression likely
            from the maternal allele.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB055065.1, AL136528.11 and
            AI094238.1.
            On Feb 18, 2011 this sequence version replaced gi:187828901.
            
            Summary: This gene encodes a member of the p53 family of
            transcription factors involved in cellular responses to stress and
            development. It maps to a region on chromosome 1p36 that is
            frequently deleted in neuroblastoma and other tumors, and thought
            to contain multiple tumor suppressor genes. The demonstration that
            this gene is monoallelically expressed (likely from the maternal
            allele), supports the notion that it is a candidate gene for
            neuroblastoma. Many transcript variants resulting from alternative
            splicing and/or use of alternate promoters have been found for this
            gene, but the biological validity and the full-length nature of
            some variants have not been determined. [provided by RefSeq, Feb
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b,
            also known as deltaN p73 alpha) has a shorter and distinct
            N-terminus compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055065.1, AK304784.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 9288759
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-605               AB055065.1         1-605
            606-606             AL136528.11        47121-47121         c
            607-2211            AB055065.1         607-2211
            2212-5098           AL136528.11        33052-35938         c
            5099-5131           AI094238.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..5131
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.3"
     gene            1..5131
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="tumor protein p73"
                     /db_xref="GeneID:7161"
                     /db_xref="HGNC:12003"
                     /db_xref="MIM:601990"
     exon            1..273
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    148..150
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="upstream in-frame stop codon"
     CDS             235..1998
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="isoform b is encoded by transcript variant 2;
                     p53-related protein; p53-like transcription factor"
                     /codon_start=1
                     /product="tumor protein p73 isoform b"
                     /protein_id="NP_001119712.1"
                     /db_xref="GI:187828902"
                     /db_xref="CCDS:CCDS44049.1"
                     /db_xref="GeneID:7161"
                     /db_xref="HGNC:12003"
                     /db_xref="MIM:601990"
                     /translation="
MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
"
     misc_feature    466..1005
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="P53 DNA-binding domain; Region: P53; cd08367"
                     /db_xref="CDD:176262"
     misc_feature    order(667..669,676..678,859..861,871..873)
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="zinc binding site [ion binding]; other site"
                     /db_xref="CDD:176262"
     misc_feature    order(670..678,682..684)
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="dimerization site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:176262"
     misc_feature    order(862..864,868..870,889..891,964..966,970..978,
                     985..987)
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:176262"
     misc_feature    1123..1245
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="P53 tetramerisation motif; Region: P53_tetramer;
                     pfam07710"
                     /db_xref="CDD:149007"
     misc_feature    1540..1734
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="SAM domain (Sterile alpha motif); Region: SAM_2;
                     pfam07647"
                     /db_xref="CDD:203706"
     misc_feature    1546..1740
                     /gene="TP73"
                     /gene_synonym="P73"
                     /note="SAM domain of tumor-p73 proteins; Region:
                     SAM_tumor-p73; cd09571"
                     /db_xref="CDD:188970"
     exon            274..516
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            517..703
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            704..819
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            820..929
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     STS             851..1023
                     /gene="TP73"
                     /gene_synonym="P73"
                     /standard_name="MARC_17809-17810:1024936155:1"
                     /db_xref="UniSTS:268408"
     exon            930..1072
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1073..1161
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1162..1283
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1284..1432
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1433..1571
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1572..1665
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     exon            1666..5120
                     /gene="TP73"
                     /gene_synonym="P73"
                     /inference="alignment:Splign:1.39.8"
     STS             3386..3577
                     /gene="TP73"
                     /gene_synonym="P73"
                     /standard_name="D1S1310"
                     /db_xref="UniSTS:149507"
     STS             4847..4967
                     /gene="TP73"
                     /gene_synonym="P73"
                     /standard_name="SHGC-74137"
                     /db_xref="UniSTS:76612"
     variation       complement(4972)
                     /gene="TP73"
                     /gene_synonym="P73"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1047928"
     polyA_signal    5099..5104
                     /gene="TP73"
                     /gene_synonym="P73"
     polyA_site      5120
                     /gene="TP73"
                     /gene_synonym="P73"
ORIGIN      
ggattcagccagttgacagaactaagggagatgggaaaagcgaaaatgccaacaaacggcccgcatgttccccagcatcctcggctcctgcctcactagctgcggagcctctcccgctcggtccacgctgccgggcggccacgaccgtgacccttcccctcgggccgcccagatccatgcctcgtcccacgggacaccagttccctggcgtgtgcagaccccccggcgcctaccatgctgtacgtcggtgaccccgcacggcacctcgccacggcccagttcaatctgctgagcagcaccatggaccagatgagcagccgcgcggcctcggccagcccctacaccccagagcacgccgccagcgtgcccacccactcgccctacgcacaacccagctccaccttcgacaccatgtcgccggcgcctgtcatcccctccaacaccgactaccccggaccccaccactttgaggtcactttccagcagtccagcacggccaagtcagccacctggacgtactccccgctcttgaagaaactctactgccagatcgccaagacatgccccatccagatcaaggtgtccaccccgccacccccaggcaccgccatccgggccatgcctgtttacaagaaagcggagcacgtgaccgacgtcgtgaaacgctgccccaaccacgagctcgggagggacttcaacgaaggacagtctgctccagccagccacctcatccgcgtggaaggcaataatctctcgcagtatgtggatgaccctgtcaccggcaggcagagcgtcgtggtgccctatgagccaccacaggtggggacggaattcaccaccatcctgtacaacttcatgtgtaacagcagctgtgtagggggcatgaaccggcggcccatcctcatcatcatcaccctggagatgcgggatgggcaggtgctgggccgccggtcctttgagggccgcatctgcgcctgtcctggccgcgaccgaaaagctgatgaggaccactaccgggagcagcaggccctgaacgagagctccgccaagaacggggccgccagcaagcgtgccttcaagcagagcccccctgccgtccccgcccttggtgccggtgtgaagaagcggcggcatggagacgaggacacgtactaccttcaggtgcgaggccgggagaactttgagatcctgatgaagctgaaagagagcctggagctgatggagttggtgccgcagccactggtggactcctatcggcagcagcagcagctcctacagaggccgagtcacctacagcccccgtcctacgggccggtcctctcgcccatgaacaaggtgcacgggggcatgaacaagctgccctccgtcaaccagctggtgggccagcctcccccgcacagttcggcagctacacccaacctggggcccgtgggccccgggatgctcaacaaccatggccacgcagtgccagccaacggcgagatgagcagcagccacagcgcccagtccatggtctcggggtcccactgcactccgccacccccctaccacgccgaccccagcctcgtcagttttttaacaggattggggtgtccaaactgcatcgagtatttcacctcccaagggttacagagcatttaccacctgcagaacctgaccattgaggacctgggggccctgaagatccccgagcagtaccgcatgaccatctggcggggcctgcaggacctgaagcagggccacgactacagcaccgcgcagcagctgctccgctctagcaacgcggccaccatctccatcggcggctcaggggaactgcagcgccagcgggtcatggaggccgtgcacttccgcgtgcgccacaccatcaccatccccaaccgcggcggcccaggcggcggccctgacgagtgggcggacttcggcttcgacctgcccgactgcaaggcccgcaagcagcccatcaaggaggagttcacggaggccgagatccactgagggcctcgcctggctgcagcctgcgccaccgcccagagacccaagctgcctcccctctccttcctgtgtgtccaaaactgcctcaggaggcaggaccttcgggctgtgcccggggaaaggcaaggtccggcccatccccaggcacctcacaggccccaggaaaggcccagccaccgaagccgcctgtggacagcctgagtcacctgcagaaccttctggagctgccctagtgctgggcttgtggggcgggggctggcccactctcagccctgccactgccccggcgtgctccatggcaggcgtgggtggggaccgcagcgtcggctccgacttccaggcttcatcctagagactgtcatctcccaaccaggcgaggtccttccaaaggaaaggatcctctttgctgatggactgccaaaaagtattttgcgacatcttttggttctggatagtagtgagcagccaagtgactgtgtctgaaacaccagtgtattttcagggaatgtccctaactgcgtcttgcccgcgccgggggctggggactctctctgctggacttgggactggcctctgcccccagcacgctgtattctgcaggaccgcctccttcctgcccctaacaacaaccacagtgttgctgaaattggagaaaactggggagggcgcaaccccccccaggcgcggggaagcatgtggtaccgcctcagccagtgcccctcagcctggccacagtcgcctctcctcggggacccctcagcagaaagggacagcctgtccttagaggactggaaattgtcaatatttgataaaatgatacccttttctacatggtgggtcagcttttttttttttttttttaactttctttctcagcattctctttggagttcaacctagcgcccatgagccaggctgaggaagctgagtgagaagccaggtgggcgggacttgttcccaggaaggccgggtggggaggaagcctagagggaaccccaggaagggcaaatccaggcaaatctgcaggaatgctctgccatgggagcagctcctcccttgccacggccaccttctctagcactgcaaggtccacagggcattgctttcctttctaggcggtggcagtcagggaacagactgaggtaggtgtaggggggtctaggccttcgtggagcaccccagggagttagtaggccccggggagacagagtctgcacaggccctttctggggccacctccatccacgaggagcagcctgagccttggtggccgaaccttgaccgtcccggagcacagcttcagggcagggaaccggagcccctggggggcctcacgggtgtgacgaggcccttcattgcaggcaggtgggccaatgggagccctcacccacgcaagccgagacaccacccagagtgcaggctgcctggccccttctggcacggccagctccacaccccctgcctagggtatgtgtggtcctaagggctaggagcttcccctactaacatctcccagaaaaagcagttaagcccctcagggcacagcaaggttagacacagcccccatccccagatcaggactccatcttgctaagtggcatcaccgtcaccagcctccccttatttaaaagcagcgactggtgttgccgcaggtacctggtctacgaagacgcaggcatccctctcccaccgtccacctccccgggggccgctgacagcacagtcgcctgggtgcacgcttgtgggggcagcaggaacggggctgtcggctctcaggggatctggctgcagccagggcgagggcctggcccttccttccagctccttccggctccttccagctgaagggcaggaagctctggccgcttagcttctagggttccatctccctagaaaggtgcccacgcccagggcatcagtcagtagcggcagcagcagcagactcggggctttcccagggtggcgcagccaccccagctgcatgtcacctcagctctccatcttattgccattttgtagatgaggaagctgagaccagaaaggctaagacccatgccccaggcaccacacccatctcttgggggctgggcacctgctacccgaggccacctcctgaagcccccactcttcccccatgttccacttcaggagccgcgggggcccatcctgacacccggggttcctcagcccagcgcagatgtgcttcagttccagagggcttgttgatttgtttcttaggtacgttacctgtccaccctgagtccagtgaggctgtcccaagagcccctgtagtgtgctcctgggaagggctgggggggctgggggggctgggagaggcccaggggcagctgtcactggaaccccagccagatgtccaaggaagccggccagaacacggagcagccagatggccccagctgcacctgtctagggagcccatgcagcctccttgcactggagaagcagctgtgaaagtagacagagttgagacttcgccgtggtcaggagaaaatgcaaattcccaggaacaagaatcctttaagtgatatgtttttataaaactaaacaaatcaacaaataaatcttgaaggcggatggttttcccagcagtgcaggggttggagggaggctgctggcactcctggggccaagggggacaggcagtggtcctgagtctgctcagagaggcaaggcagaaggagctcgccaggcaggtcagctcacatctgtccaagtcgctctggtcagaaacagcgactctcccccattcccccagcgttcccaccaggcctgggctgctgggaagcccttgctgtacccaggagcccgacccgcagtatcctggcacagagccacttgtcactcagaacagtcagtgtctccaacgcacaaacatccactcctctgttaccagttaaagcactttaatgctttaaggtgaaaacgaaatcccatccgtgtttttcgtgtaagatcgtgcttctccgagcagtattaatggacgccctccaatgacataacaactgtttttggtaatgtaatcttgggaaaatgtgttatttttttagctgtgtttcagtggggatttttgtttttgtaacataataaagtgtatgttccaatgaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:7161 -> Molecular function: GO:0002039 [p53 binding] evidence: IBA
            GeneID:7161 -> Molecular function: GO:0003682 [chromatin binding] evidence: IBA
            GeneID:7161 -> Molecular function: GO:0003684 [damaged DNA binding] evidence: IBA
            GeneID:7161 -> Molecular function: GO:0003690 [double-stranded DNA binding] evidence: IBA
            GeneID:7161 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
            GeneID:7161 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:7161 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:7161 -> Molecular function: GO:0019901 [protein kinase binding] evidence: IPI
            GeneID:7161 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:7161 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IEA
            GeneID:7161 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IDA
            GeneID:7161 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
            GeneID:7161 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IBA
            GeneID:7161 -> Biological process: GO:0000187 [activation of MAPK activity] evidence: IEA
            GeneID:7161 -> Biological process: GO:0001822 [kidney development] evidence: IEA
            GeneID:7161 -> Biological process: GO:0001836 [release of cytochrome c from mitochondria] evidence: IEA
            GeneID:7161 -> Biological process: GO:0006298 [mismatch repair] evidence: TAS
            GeneID:7161 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
            GeneID:7161 -> Biological process: GO:0006954 [inflammatory response] evidence: IEA
            GeneID:7161 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IDA
            GeneID:7161 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IBA
            GeneID:7161 -> Biological process: GO:0007050 [cell cycle arrest] evidence: IEA
            GeneID:7161 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: TAS
            GeneID:7161 -> Biological process: GO:0009791 [post-embryonic development] evidence: IEA
            GeneID:7161 -> Biological process: GO:0010165 [response to X-ray] evidence: IBA
            GeneID:7161 -> Biological process: GO:0010243 [response to organonitrogen compound] evidence: IEA
            GeneID:7161 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IBA
            GeneID:7161 -> Biological process: GO:0021766 [hippocampus development] evidence: IEA
            GeneID:7161 -> Biological process: GO:0031571 [mitotic G1 DNA damage checkpoint] evidence: IBA
            GeneID:7161 -> Biological process: GO:0033326 [cerebrospinal fluid secretion] evidence: IEA
            GeneID:7161 -> Biological process: GO:0034644 [cellular response to UV] evidence: IBA
            GeneID:7161 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IBA
            GeneID:7161 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IDA
            GeneID:7161 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:7161 -> Biological process: GO:0043508 [negative regulation of JUN kinase activity] evidence: IBA
            GeneID:7161 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IBA
            GeneID:7161 -> Biological process: GO:0045665 [negative regulation of neuron differentiation] evidence: IEA
            GeneID:7161 -> Biological process: GO:0045793 [positive regulation of cell size] evidence: IEA
            GeneID:7161 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
            GeneID:7161 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
            GeneID:7161 -> Biological process: GO:0048546 [digestive tract morphogenesis] evidence: IEA
            GeneID:7161 -> Biological process: GO:0048666 [neuron development] evidence: IEA
            GeneID:7161 -> Biological process: GO:0048714 [positive regulation of oligodendrocyte differentiation] evidence: IEA
            GeneID:7161 -> Biological process: GO:0051262 [protein tetramerization] evidence: IEA
            GeneID:7161 -> Cellular component: GO:0000785 [chromatin] evidence: IBA
            GeneID:7161 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
            GeneID:7161 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IBA
            GeneID:7161 -> Cellular component: GO:0005829 [cytosol] evidence: IBA

by @meso_cacase at DBCLS
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