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2024-04-24 16:32:49, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001122821 2863 bp mRNA linear PRI 16-JUN-2013
DEFINITION Homo sapiens SET nuclear oncogene (SET), transcript variant 1,
mRNA.
ACCESSION NM_001122821
VERSION NM_001122821.1 GI:170763499
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2863)
AUTHORS Avet,C., Garrel,G., Denoyelle,C., Laverriere,J.N., Counis,R.,
Cohen-Tannoudji,J. and Simon,V.
TITLE SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
JOURNAL J. Biol. Chem. 288 (4), 2641-2654 (2013)
PUBMED 23233674
REMARK GeneRIF: SET protein interacts with intracellular domains of the
gonadotropin-releasing hormone receptor and differentially
regulates receptor signaling to cAMP and calcium in gonadotrope
cells
REFERENCE 2 (bases 1 to 2863)
AUTHORS Lam,B.D., Anthony,E.C. and Hordijk,P.L.
TITLE Cytoplasmic targeting of the proto-oncogene SET promotes cell
spreading and migration
JOURNAL FEBS Lett. 587 (2), 111-119 (2013)
PUBMED 23195690
REMARK GeneRIF: A SET mutant, lacking a nuclear localization signal,
SET(DeltaNLS), promotes cell spreading and motility. This was
accompanied by an increase in the number and frequency of membrane
ruffles.
REFERENCE 3 (bases 1 to 2863)
AUTHORS Almeida,L.O., Goto,R.N., Pestana,C.R., Uyemura,S.A., Gutkind,S.,
Curti,C. and Leopoldino,A.M.
TITLE SET overexpression decreases cell detoxification efficiency: ALDH2
and GSTP1 are downregulated, DDR is impaired and DNA damage
accumulates
JOURNAL FEBS J. 279 (24), 4615-4628 (2012)
PUBMED 23106910
REMARK GeneRIF: SET downregulated repair genes ATM, BRCA1 and CHEK2 and
upregulated TP53
REFERENCE 4 (bases 1 to 2863)
AUTHORS Kim,J.Y., Kim,K.B., Son,H.J., Chae,Y.C., Oh,S.T., Kim,D.W.,
Pak,J.H. and Seo,S.B.
TITLE H3K27 methylation and H3S28 phosphorylation-dependent
transcriptional regulation by INHAT subunit SET/TAF-Ibeta
JOURNAL FEBS Lett. 586 (19), 3159-3165 (2012)
PUBMED 22796192
REMARK GeneRIF: SET/TAF-Ibeta is sequentially recruited to the target gene
promoter ATF3 after the PRC2 complex via H3K27me recognition and
may offer additive effects in the repression of the target gene.
REFERENCE 5 (bases 1 to 2863)
AUTHORS Irie,A., Harada,K., Araki,N. and Nishimura,Y.
TITLE Phosphorylation of SET protein at Ser171 by protein kinase D2
diminishes its inhibitory effect on protein phosphatase 2A
JOURNAL PLoS ONE 7 (12), E51242 (2012)
PUBMED 23251465
REMARK GeneRIF: Recombinant SET with phosphorylation-mimic Ser171 to Glu
substitution reduced its inhibitory effects on PP2A phosphatase
activity compared with Ser171 to Ala substituted or wild-type SET
REFERENCE 6 (bases 1 to 2863)
AUTHORS Nagata,K., Kawase,H., Handa,H., Yano,K., Yamasaki,M., Ishimi,Y.,
Okuda,A., Kikuchi,A. and Matsumoto,K.
TITLE Replication factor encoded by a putative oncogene, set, associated
with myeloid leukemogenesis
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (10), 4279-4283 (1995)
PUBMED 7753797
REFERENCE 7 (bases 1 to 2863)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification of in vivo phosphorylation sites of SET, a nuclear
phosphoprotein encoded by the translocation breakpoint in acute
undifferentiated leukemia
JOURNAL FEBS Lett. 340 (3), 231-235 (1994)
PUBMED 8131851
REFERENCE 8 (bases 1 to 2863)
AUTHORS Vaesen,M., Barnikol-Watanabe,S., Gotz,H., Awni,L.A., Cole,T.,
Zimmermann,B., Kratzin,H.D. and Hilschmann,N.
TITLE Purification and characterization of two putative HLA class II
associated proteins: PHAPI and PHAPII
JOURNAL Biol. Chem. Hoppe-Seyler 375 (2), 113-126 (1994)
PUBMED 8192856
REFERENCE 9 (bases 1 to 2863)
AUTHORS Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
TITLE Identification and characterization of SET, a nuclear
phosphoprotein encoded by the translocation break point in acute
undifferentiated leukemia
JOURNAL J. Biol. Chem. 269 (3), 2258-2262 (1994)
PUBMED 8294483
REFERENCE 10 (bases 1 to 2863)
AUTHORS von Lindern,M., van Baal,S., Wiegant,J., Raap,A., Hagemeijer,A. and
Grosveld,G.
TITLE Can, a putative oncogene associated with myeloid leukemogenesis,
may be activated by fusion of its 3' half to different genes:
characterization of the set gene
JOURNAL Mol. Cell. Biol. 12 (8), 3346-3355 (1992)
PUBMED 1630450
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from CB129868.1, D45198.1,
BP343325.1, CN408133.1 and BQ774097.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The protein encoded by this gene inhibits acetylation of
nucleosomes, especially histone H4, by histone acetylases (HAT).
This inhibition is most likely accomplished by masking histone
lysines from being acetylated, and the consequence is to silence
HAT-dependent transcription. The encoded protein is part of a
complex localized to the endoplasmic reticulum but is found in the
nucleus and inhibits apoptosis following attack by cytotoxic T
lymphocytes. This protein can also enhance DNA replication of the
adenovirus genome. Several transcript variants encoding different
isoforms have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (1) encodes the longer isoform (1;
also known as isoform alpha).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: D45198.1, AK300794.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-406 CB129868.1 1-406
407-1207 D45198.1 190-990
1208-1648 BP343325.1 138-578
1649-2355 CN408133.1 50-756
2356-2863 BQ774097.1 1-508 c
FEATURES Location/Qualifiers
source 1..2863
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9q34"
gene 1..2863
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="SET nuclear oncogene"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
exon 1..353
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 121
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:376347261"
misc_feature 149..151
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="upstream in-frame stop codon"
variation 187
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:145061646"
CDS 242..1114
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="isoform 1 is encoded by transcript variant 1; SET
translocation (myeloid leukemia-associated); protein
phosphatase type 2A inhibitor; Template-Activating
Factor-I, chromatin remodelling factor; inhibitor of
granzyme A-activated DNase; HLA-DR-associated protein II;
inhibitor-2 of protein phosphatase-2A; phosphatase 2A
inhibitor I2PP2A"
/codon_start=1
/product="protein SET isoform 1"
/protein_id="NP_001116293.1"
/db_xref="GI:170763500"
/db_xref="CCDS:CCDS48037.1"
/db_xref="GeneID:6418"
/db_xref="HGNC:10760"
/db_xref="MIM:600960"
/translation="
MAPKRQSPLPPQKKKPRPPPALGPEETSASAGLPKKGEKEQQEAIEHIDEVQNEIDRLNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEEALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKWKSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQYYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGEDD
"
misc_feature 260..262
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q01105.3); phosphorylation site"
misc_feature 332..475
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q01105.3);
Region: Dimerization"
misc_feature 365..952
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="Nucleosome assembly protein (NAP); Region: NAP;
pfam00956"
/db_xref="CDD:201525"
misc_feature 413..943
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/note="(NAP-L) nucleosome assembly protein -L;
Provisional; Region: PTZ00007; cl08298"
/db_xref="CDD:186817"
misc_feature 476..916
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q01105.3);
Region: Earmuff domain"
misc_feature 635..637
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q01105.3); acetylation site"
misc_feature 689..691
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q01105.3); acetylation site"
misc_feature 755..757
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q01105.3); acetylation site"
misc_feature 1088..1093
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/experiment="experimental evidence, no additional details
recorded"
/note="Breakpoint for translocation to form SET-CAN
oncogene; propagated from UniProtKB/Swiss-Prot (Q01105.3);
other site"
variation 271
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:369353971"
variation 306
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:138894709"
variation 307
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:191311210"
exon 354..411
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
exon 412..554
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 478
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:372830096"
variation 505
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:148209973"
exon 555..658
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 580
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:62641744"
variation 596
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:141752935"
exon 659..772
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 673
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:146235252"
variation 677
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374932364"
variation 682
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375022413"
variation 709
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:369280257"
exon 773..943
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 786
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139428399"
variation 789
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:142648600"
variation 798
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:150832256"
variation 847
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:200600519"
variation 871
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:139252094"
variation 886
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:376525055"
variation 889
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:75427242"
variation 890
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:4836619"
exon 944..1090
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 964
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:142411393"
variation 973
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:150020269"
variation 982
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:145251942"
variation 985
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:368663030"
variation 1060
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:372294597"
variation 1067
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:71497404"
exon 1091..2846
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/inference="alignment:Splign:1.39.8"
variation 1099
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:201761796"
variation 1116
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:201084109"
variation 1141
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:374784143"
variation 1161
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:371016083"
variation 1185
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="t"
/db_xref="dbSNP:35778650"
variation 1205
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:77610267"
variation 1208..1209
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="c"
/db_xref="dbSNP:201363886"
variation 1217
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:10988092"
variation 1296
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988093"
variation 1426
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1061240"
variation 1443
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="g"
/db_xref="dbSNP:78124756"
variation 1475
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988094"
variation 1517
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988095"
variation 1519
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:10988096"
variation 1600
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:10988097"
variation 1607
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:139027346"
variation 1628
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:143324900"
variation 1661
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:60115664"
variation 1720
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:191018343"
variation 1777
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:369703905"
variation 1843
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:373337066"
variation 1875
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:184069752"
variation 2178
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:189098066"
variation 2233
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="g"
/db_xref="dbSNP:377534760"
STS 2240..2579
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="WI-7839"
/db_xref="UniSTS:5472"
variation 2244..2245
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="ct"
/db_xref="dbSNP:201161315"
variation 2368
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:375728256"
variation 2379..2380
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace=""
/replace="g"
/db_xref="dbSNP:34355767"
variation 2410
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="c"
/db_xref="dbSNP:1141306"
variation 2437
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="g"
/replace="t"
/db_xref="dbSNP:192423121"
STS 2449..2542
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/standard_name="RH69637"
/db_xref="UniSTS:84497"
variation 2728
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="a"
/replace="t"
/db_xref="dbSNP:11542566"
variation 2738
/gene="SET"
/gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; PHAPII;
TAF-I; TAF-IBETA"
/replace="c"
/replace="t"
/db_xref="dbSNP:183084664"
ORIGIN
gtgcccctgcagagcgaggcagagagcaactaaaagaaatttctcctgattggagggtgggtgggatgaggctgggggagggggccggggtgtgtgtcccactgtcatgtaaatatcccttccaggcagggcggctccagtgcagatttaagccgctggcacctggggcagtctcagtgttcagcctgcttccggacgggcgaggagactcgtggtctggttctgggacttccctaacagcatggcccctaaacgccagtctccactcccgcctcaaaagaagaaaccaagaccacctcctgctctgggaccggaggagacatcggcctctgcaggcttgccgaagaagggagaaaaagaacagcaagaagcgattgaacacattgatgaagtacaaaatgaaatagacagacttaatgaacaagccagtgaggagattttgaaagtagaacagaaatataacaaactccgccaaccattttttcagaagaggtcagaattgatcgccaaaatcccaaatttttgggtaacaacatttgtcaaccatccacaagtgtctgcactgcttggggaggaagatgaagaggcactgcattatttgaccagagttgaagtgacagaatttgaagatattaaatcaggttacagaatagatttttattttgatgaaaatccttactttgaaaataaagttctctccaaagaatttcatctgaatgagagtggtgatccatcttcgaagtccaccgaaatcaaatggaaatctggaaaggatttgacgaaacgttcgagtcaaacgcagaataaagccagcaggaagaggcagcatgaggaaccagagagcttctttacctggtttactgaccattctgatgcaggtgctgatgagttaggagaggtcatcaaagatgatatttggccaaacccattacagtactacttggttcccgatatggatgatgaagaaggagaaggagaagaagatgatgatgatgatgaagaggaggaaggattagaagatattgacgaagaaggggatgaggatgaaggtgaagaagatgaagatgatgatgaaggggaggaaggagaggaggatgaaggagaagatgactaaatagaacactgatggattccaaccttcctttttttaaattttctccagtccctgggagcaagttgcagtcttttttttttttttttttttttttccctcttgtgctcagtcgccctgttcttgaggtctcttttctctactccatggttctcaatttatttggggggaaataccttgagcagaatacaatgggaaaagagtctctacccctttctgttcgaagttcatttttatcccttcctgtctgaacaaaaactgtatggaatcaacaccaccgagctctgtgggaaaaaagaaaaacctgctcccttcgctctgctggaagctggagggtgctaggcccctgtgtagtagtgcatagaattctagcttttttcctcctttctctgtatattgggctcagagagtacactgtgtctctatgtgaatatggacagttagcatttaccaacatgtatctgtctactttctcttgtttaaaaaaagaaaaaaaaacttaaaaaaatggggttatagaaggtcagcaaagggtgggtttgagatgtttgggtgggttaagtgggcattttgacaacatggcttctcctttggcatgtttaattgtgatatttgacagacatccttgcagtttaagatgacacttttaaaataaattctctcctaatgatgacttgagccctgccactcaatgggagaatcagcagaacctgtaggatcttatttggaattgacattctctattgtaattttgttcctgtttatttttaaattttctttttgtttcactggaaaggaaagatgatgctcagttttaaacgttaaaagtgtacaagttgctttgttacaataaaactaaatgtgtacacaaaggatttgatgcttttctctcagcataggtatgcttactatgaccttccaagtttgacttgtataacatcactgtcaaactttgtcaccctaacttcgtattttttgatacgcactttgcaggatgacctcagggctatgtggattgagtaatgggatttgaatcaatgtattaatatctccatagctgggaaacgtgggttcaatttgccattggtttctgaaagtattcacatcatttgggataccagatagctcaatactctctgagtacattgtgcccttgatttttatctccaagtggcagtttttaaaattggccttttacctggatataaattaattgtgcctgccaccaccatccaacagacctggtgctctaatgccaagttatacacgggacagttgctggcatgtcttcattggctatataaaatgtggccaagaagataggctctcagtaagaagtctgatggtgagcagtaactgtccctgctttctggtataaagctctcaaatgtgaccatgtgaatctgggtgggataatggactcagctctgtctgctcaatgccattgtgcagagaagcaccctaatgcataagctttttaatgctgtaaaatatagtcgctgaaattaaatgccactttttcagaggtgaattaatggacagtctggtgaacttcaaaagctttttgatgtataaaacttgataaatggaactattccatcaataggcaaaagtgtaacaacctatctagatggatagtatgtaatttctgcacaggtctctgtttagtaaatacatcactgtataccgatcaggaatcttgctccaataaaggaacataaagattttttttggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:6418 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:6418 -> Molecular function: GO:0004864 [protein phosphatase inhibitor activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:6418 -> Molecular function: GO:0008601 [protein phosphatase type 2A regulator activity] evidence: TAS
GeneID:6418 -> Molecular function: GO:0042393 [histone binding] evidence: TAS
GeneID:6418 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:6418 -> Biological process: GO:0006334 [nucleosome assembly] evidence: IEA
GeneID:6418 -> Biological process: GO:0006337 [nucleosome disassembly] evidence: TAS
GeneID:6418 -> Biological process: GO:0006913 [nucleocytoplasmic transport] evidence: NAS
GeneID:6418 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:6418 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:6418 -> Biological process: GO:0035067 [negative regulation of histone acetylation] evidence: TAS
GeneID:6418 -> Biological process: GO:0043524 [negative regulation of neuron apoptotic process] evidence: IGI
GeneID:6418 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:6418 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005783 [endoplasmic reticulum] evidence: IDA
GeneID:6418 -> Cellular component: GO:0005829 [cytosol] evidence: IEA
GeneID:6418 -> Cellular component: GO:0043234 [protein complex] evidence: IDA
GeneID:6418 -> Cellular component: GO:0048471 [perinuclear region of cytoplasm] evidence: IDA
by
@meso_cacase at
DBCLS
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