Home |
Help |
Advanced search
2024-04-18 22:10:34, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001120 1969 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens major facilitator superfamily domain containing 10
(MFSD10), transcript variant 1, mRNA.
ACCESSION NM_001120
VERSION NM_001120.4 GI:225703101
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1969)
AUTHORS Ushijima,H., Hiasa,M., Namba,T., Hwang,H.J., Hoshino,T., Mima,S.,
Tsuchiya,T., Moriyama,Y. and Mizushima,T.
TITLE Expression and function of TETRAN, a new type of membrane
transporter
JOURNAL Biochem. Biophys. Res. Commun. 374 (2), 325-330 (2008)
PUBMED 18638446
REMARK GeneRIF: TETRAN is a novel human organic anion transporter, and
that it serves as a transporter for some NSAIDs and various other
organic anions at the final excretion step.
REFERENCE 2 (bases 1 to 1969)
AUTHORS Mima,S., Ushijima,H., Hwang,H.J., Tsutsumi,S., Makise,M.,
Yamaguchi,Y., Tsuchiya,T., Mizushima,H. and Mizushima,T.
TITLE Identification of the TPO1 gene in yeast, and its human orthologue
TETRAN, which cause resistance to NSAIDs
JOURNAL FEBS Lett. 581 (7), 1457-1463 (2007)
PUBMED 17362938
REMARK GeneRIF: A BLAST search identified the possible human orthologue of
Tpo1p, tetracycline transporter-like protein (TETRAN), whose
overexpression in cultured human cells caused resistance to some
NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs.
REFERENCE 3 (bases 1 to 1969)
AUTHORS Duyao,M.P., Taylor,S.A., Buckler,A.J., Ambrose,C.M., Lin,C.,
Groot,N., Church,D., Barnes,G., Wasmuth,J.J., Housman,D.E. et al.
TITLE A gene from chromosome 4p16.3 with similarity to a superfamily of
transporter proteins
JOURNAL Hum. Mol. Genet. 2 (6), 673-676 (1993)
PUBMED 8353488
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL390065.20, BI769550.1,
L11669.1, BC001502.2 and BC023537.2.
On Mar 27, 2009 this sequence version replaced gi:142384705.
Summary: This gene encodes a member of the major facilitator
superfamily of transporter proteins. The encoded protein likely
functions in efflux of organic anions, including the non-steroidal
anti-inflammatory drugs indomethacin and diclofenac. Alternatively
spliced transcript variants have been described. [provided by
RefSeq, Mar 2009].
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: L11669.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-115 AL390065.20 139005-139119
116-195 BI769550.1 114-193
196-346 L11669.1 2-152
347-391 BC001502.2 71-115
392-1952 L11669.1 198-1758
1953-1969 BC023537.2 1540-1556
FEATURES Location/Qualifiers
source 1..1969
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p16.3"
gene 1..1969
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="major facilitator superfamily domain containing 10"
/db_xref="GeneID:10227"
/db_xref="HGNC:16894"
/db_xref="MIM:610977"
exon 1..485
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
misc_feature 267..269
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="upstream in-frame stop codon"
CDS 315..1682
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="tetracycline transporter-like protein"
/codon_start=1
/product="major facilitator superfamily domain-containing
protein 10"
/protein_id="NP_001111.3"
/db_xref="GI:225703102"
/db_xref="CCDS:CCDS3365.1"
/db_xref="GeneID:10227"
/db_xref="HGNC:16894"
/db_xref="MIM:610977"
/translation="
MGWGGGGGCTPRPPIHQQPPERRVVTVVFLGLLLDLLAFTLLLPLLPGLLESHGRAHDPLYGSWQGGVDWFATAIGMPVEKRYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLGRRPVMLLCLMGVATSYAVWATSRSFAAFLASRLIGGISKGNVSLSTAIVADLGSPLARSQGMAVIGVAFSLGFTLGPMLGASLPLEMAPWFALLFAASDLLFIFCFLPETLPLEKRAPSIALGFRDAADLLSPLALLRFSAVARGQDPPSGDRLSSLRRLGLVYFLYLFLFSGLEYTLSFLTHQRFQFSSLQQGKMFFLIGLTMATIQGAYARRIHPGGEVAAVKRALLLLVPAFLLIGWGRSLPVLGLGLLLYSFAAAVVVPCLSSVVAGYGSPGQKGTVMGTLRSLGALARAAGPLVAASVYWLAGAQACFTTWSGLFLLPFFLLQKLSYPAQTLKAE
"
misc_feature 393..455
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 525..>908
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="The Major Facilitator Superfamily (MFS) is a large
and diverse group of secondary transporters that includes
uniporters, symporters, and antiporters. MFS proteins
facilitate the transport across cytoplasmic or internal
membranes of a variety of...; Region: MFS; cd06174"
/db_xref="CDD:119392"
misc_feature 567..>908
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/note="Major Facilitator Superfamily; Region: MFS_1;
pfam07690"
/db_xref="CDD:191813"
misc_feature 570..632
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 651..719
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 756..818
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 840..902
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 918..980
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1137..1199
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1242..1295
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1320..1382
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1389..1451
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
misc_feature 1575..1637
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14728.1);
transmembrane region"
exon 486..582
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 583..686
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
variation 599
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/replace="a"
/replace="c"
/db_xref="dbSNP:34745961"
exon 687..845
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 846..1007
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1008..1116
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1117..1228
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1229..1337
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1338..1428
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1429..1476
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1477..1566
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
exon 1567..1959
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/inference="alignment:Splign:1.39.8"
variation 1658
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
/replace="a"
/replace="g"
/db_xref="dbSNP:1034400"
polyA_signal 1932..1937
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
polyA_site 1959
/gene="MFSD10"
/gene_synonym="TETRAN; TETTRAN"
ORIGIN
gtgggaggcgcggccgtggggtggggtggggccaggtccgcgatgtgctcaccctggtctctcaggaccgttgcctttgcggctattttttgtgcaatccccgaagcctgcgtttcctgctgcctgggttcggggcgggggcatcgcgcaggccagaacggcccctgcgtccgtaggccagagcccctgccatcagcccctttagggtgctcgccggctgtcgggtgtgggggtatgccaggccccggaggactcggcttccccgctaacccgacccgccgcaccccacccaggccaggtcagagcagcccaccatgggatggggagggggtggaggctgcaccccgcgcccacccatccaccagcagccgccggagcgccgcgtggtcaccgttgtctttctcggcctcctgctggacctcctggccttcacgctgctgctgcccctgctgcccgggctgttggagagccacggccgtgcccacgaccccctctatggctcctggcagggcggggtggactggtttgccaccgccatcgggatgccagtggagaagaggtacaacagtgtcctgttcggaggtctcattggctcggcattctctgtcctgcagtttctgtgtgcgccactcactggggccacctctgactgcttggggaggcgcccggtgatgctgctgtgcctgatgggtgtggccacctcatatgcagtctgggccacctctcggagctttgcggccttcctggcctccaggctgattgggggcatcagcaaagggaacgtcagcctctccacggccatcgttgctgacctgggctcgcctctggcccgcagtcaaggcatggcggtcattggggtggccttctcactgggcttcaccctgggccctatgctcggagcctccctgcccctggaaatggcaccctggtttgccctgctcttcgcagcctccgacctgctgttcatcttctgcttcctgccagagacgctgcccctggagaaacgggcgccctctatcgccctggggttccgtgatgcggctgatctgctcagccccctggccctgctgcgcttctcggctgtcgctcgtggccaggacccaccctctggagacaggctcagcagcctgcgccgcctgggcctagtctacttcctctacctcttcctgttctcgggcctggagtacacgctgagcttcctcacacaccagcgcttccagttcagtagcctacagcaggggaagatgtttttcctcatcggcctcaccatggccaccatccagggtgcctatgcccggcggatccaccctggcggggaagttgctgccgtgaagcgggccctcctgctgctggtgcccgccttcctcctcatcggctggggacgttctctgcccgtgctgggcctggggctgctgctctactcctttgccgccgccgttgtggtgccctgcctgtcctccgtggtcgctggctatggctcaccagggcagaagggcacggtcatgggtacactgcgcagcctaggtgctctggccagggccgcggggcccctggtggccgcttcagtgtactggctggccggggcccaggcctgcttcaccacgtggtccgggctctttttgctccccttcttcctcctgcagaagctgagttacccggcacagacgctcaaggctgagtagctgagccactgtgcccaggctgtgggcaccaggcagagtgggagcctaggtcaggcccctgcccactgcctgacccccaccccccgccagtccagggagaccctgtgggtgggggccggcccctaagcaggaagctcaggcagctcctccagacttacttactccttcagtgactccgagctgcagcactccaaggctgtcagggcttctgtttgttttttaaactatgcaccaggtttctgatgatgaaataaagcacctgtttgttttataccaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10227 -> Molecular function: GO:0008493 [tetracycline transporter activity] evidence: TAS
GeneID:10227 -> Biological process: GO:0006810 [transport] evidence: TAS
GeneID:10227 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10227 -> Biological process: GO:0015904 [tetracycline transport] evidence: TAS
GeneID:10227 -> Biological process: GO:0055085 [transmembrane transport] evidence: IEA
GeneID:10227 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.