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2024-04-21 01:37:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001114982 2640 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens tumor protein p63 (TP63), transcript variant 6, mRNA.
ACCESSION NM_001114982
VERSION NM_001114982.1 GI:169234664
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2640)
AUTHORS Montariello,D., Troiano,A., Malanga,M., Calabro,V. and Quesada,P.
TITLE p63 involvement in poly(ADP-ribose) polymerase 1 signaling of
topoisomerase I-dependent DNA damage in carcinoma cells
JOURNAL Biochem. Pharmacol. 85 (7), 999-1006 (2013)
PUBMED 23376119
REMARK GeneRIF: p63 Is a new player of the PARP1-dependent signalling of
DNA damage
REFERENCE 2 (bases 1 to 2640)
AUTHORS Matin,R.N., Chikh,A., Chong,S.L., Mesher,D., Graf,M., Sanza',P.,
Senatore,V., Scatolini,M., Moretti,F., Leigh,I.M., Proby,C.M.,
Costanzo,A., Chiorino,G., Cerio,R., Harwood,C.A. and Bergamaschi,D.
TITLE p63 is an alternative p53 repressor in melanoma that confers
chemoresistance and a poor prognosis
JOURNAL J. Exp. Med. 210 (3), 581-603 (2013)
PUBMED 23420876
REMARK GeneRIF: data provide evidence of a physiological interaction
between p63 with p53 whereby translocation of p63 to the
mitochondria occurred through a codependent process with p53,
whereas accumulation of p53 in the nucleus was prevented by p63
REFERENCE 3 (bases 1 to 2640)
AUTHORS Ethayathulla,A.S., Nguyen,H.T. and Viadiu,H.
TITLE Crystal structures of the DNA-binding domain tetramer of the p53
tumor suppressor family member p73 bound to different full-site
response elements
JOURNAL J. Biol. Chem. 288 (7), 4744-4754 (2013)
PUBMED 23243311
REMARK GeneRIF: Crystal structures of the DNA-binding domain tetramer of
the p53 tumor suppressor family member p73 bound to different
full-site response elements
REFERENCE 4 (bases 1 to 2640)
AUTHORS Re,M., Magliulo,G., Ferrante,L., Zizzi,A., Santarelli,A.,
Stramazzotti,D., Lo Muzio,L., Goteri,G. and Rubini,C.
TITLE p63 expression in laryngeal squamous cell carcinoma is related to
tumor extension, histologic grade, lymph node involvement and
clinical stage
JOURNAL J. Biol. Regul. Homeost. Agents 27 (1), 121-129 (2013)
PUBMED 23489692
REMARK GeneRIF: Abnormal expression of p63 may be involved in the early
phases of laryngeal tumorigenesis.
REFERENCE 5 (bases 1 to 2640)
AUTHORS Yamaki,T., Suenaga,Y., Iuchi,T., Alagu,J., Takatori,A., Itami,M.,
Araki,A., Ohira,M., Inoue,M., Kageyama,H., Yokoi,S., Saeki,N. and
Nakagawara,A.
TITLE Temozolomide suppresses MYC via activation of TAp63 to inhibit
progression of human glioblastoma
JOURNAL Sci Rep 3, 1160 (2013)
PUBMED 23362460
REMARK GeneRIF: Therefore, our results suggest that the TAp63-mediated
transcriptional repression of MYC is a novel pathway regulating TMZ
efficacy in GBM.
REFERENCE 6 (bases 1 to 2640)
AUTHORS Osada,M., Ohba,M., Kawahara,C., Ishioka,C., Kanamaru,R., Katoh,I.,
Ikawa,Y., Nimura,Y., Nakagawara,A., Obinata,M. and Ikawa,S.
TITLE Cloning and functional analysis of human p51, which structurally
and functionally resembles p53
JOURNAL Nat. Med. 4 (7), 839-843 (1998)
PUBMED 9662378
REMARK Erratum:[Nat Med 1998 Sep;4(9):982]
REFERENCE 7 (bases 1 to 2640)
AUTHORS Trink,B., Okami,K., Wu,L., Sriuranpong,V., Jen,J. and Sidransky,D.
TITLE A new human p53 homologue
JOURNAL Nat. Med. 4 (7), 747-748 (1998)
PUBMED 9662346
REMARK Erratum:[Nat Med 1998 Sep;4(9):982]
REFERENCE 8 (bases 1 to 2640)
AUTHORS Zeng,X., Levine,A.J. and Lu,H.
TITLE Non-p53 p53RE binding protein, a human transcription factor
functionally analogous to P53
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (12), 6681-6686 (1998)
PUBMED 9618472
REFERENCE 9 (bases 1 to 2640)
AUTHORS Bian,J. and Sun,Y.
TITLE p53CP, a putative p53 competing protein that specifically binds to
the consensus p53 DNA binding sites: a third member of the p53
family?
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 94 (26), 14753-14758 (1997)
PUBMED 9405685
REFERENCE 10 (bases 1 to 2640)
AUTHORS Robinson,A., Gibbins,J., Rodriguez-Linares,B., Finan,P.M.,
Wilson,L., Kellie,S., Findell,P. and Watson,S.P.
TITLE Characterization of Grb2-binding proteins in human platelets
activated by Fc gamma RIIA cross-linking
JOURNAL Blood 88 (2), 522-530 (1996)
PUBMED 8695800
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC063939.15 and AF075429.1.
Summary: This gene encodes a member of the p53 family of
transcription factors. An animal model, p63 -/- mice, has been
useful in defining the role this protein plays in the development
and maintenance of stratified epithelial tissues. p63 -/- mice have
several developmental defects which include the lack of limbs and
other tissues, such as teeth and mammary glands, which develop as a
result of interactions between mesenchyme and epithelium. Mutations
in this gene are associated with ectodermal dysplasia, and cleft
lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4
(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT
syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary
syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both
alternative splicing and the use of alternative promoters results
in multiple transcript variants encoding different proteins. Many
transcripts encoding different proteins have been reported but the
biological validity and the full-length nature of these variants
have not been determined. [provided by RefSeq, Jul 2008].
Transcript Variant: This variant (6) differs in the 5' UTR and
coding region, and in the 3' UTR and coding region, compared to
variant 1. The resulting protein (isoform 6, also known as
deltaNp63gamma) is shorter and has distinct N- and C-termini,
compared to isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF075429.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025087 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-141 AC063939.15 10082-10222
142-1323 AF075429.1 1-1182
1324-2640 AC063939.15 100601-101917
FEATURES Location/Qualifiers
source 1..2640
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q28"
gene 1..2640
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="tumor protein p63"
/db_xref="GeneID:8626"
/db_xref="HGNC:15979"
/db_xref="MIM:603273"
exon 1..183
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 6
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="g"
/db_xref="dbSNP:116224653"
variation 36
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:191335786"
variation 42
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:77388546"
misc_feature 61..63
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="upstream in-frame stop codon"
variation 67..68
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="agag"
/db_xref="dbSNP:145588726"
variation 69..70
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="ag"
/replace="ca"
/db_xref="dbSNP:72592281"
variation 70..71
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="ag"
/replace="agag"
/db_xref="dbSNP:34201045"
variation 71..72
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="agag"
/db_xref="dbSNP:62702062"
variation 71
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201196077"
variation 73
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:202103123"
variation 75
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="g"
/replace="t"
/db_xref="dbSNP:200635680"
CDS 142..1323
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="isoform 6 is encoded by transcript variant 6; tumor
protein p53-competing protein; tumor protein 63; amplified
in squamous cell carcinoma; chronic ulcerative stomatitis
protein; transformation-related protein 63; tumor protein
p63 deltaN isoform delta; CUSP; keratinocyte transcription
factor KET"
/codon_start=1
/product="tumor protein 63 isoform 6"
/protein_id="NP_001108454.1"
/db_xref="GI:169234665"
/db_xref="CCDS:CCDS46980.1"
/db_xref="GeneID:8626"
/db_xref="HGNC:15979"
/db_xref="MIM:603273"
/translation="
MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKHLLSACFRNELVEPRRETPKQSDVFFRHSKPPNRSVYP
"
misc_feature 388..933
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="P53 DNA-binding domain; Region: P53; cd08367"
/db_xref="CDD:176262"
misc_feature order(589..591,598..600,781..783,793..795)
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="zinc binding site [ion binding]; other site"
/db_xref="CDD:176262"
misc_feature order(592..600,604..606)
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="dimerization site [polypeptide binding]; other
site"
/db_xref="CDD:176262"
misc_feature order(784..786,790..792,811..813,886..888,892..900,
907..909)
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:176262"
misc_feature 1033..1155
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/note="P53 tetramerisation motif; Region: P53_tetramer;
pfam07710"
/db_xref="CDD:149007"
STS 152..223
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/standard_name="Trp63"
/db_xref="UniSTS:526812"
variation 157
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="c"
/db_xref="dbSNP:113993963"
exon 184..438
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 220
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:111466227"
variation 225
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201774402"
variation 238
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:375508394"
variation 245
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:193287780"
variation 246
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:151335217"
variation 258
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:145730343"
variation 261
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201239102"
variation 291
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:200459305"
variation 303
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="g"
/db_xref="dbSNP:150028891"
variation 357
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146612442"
variation 363
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:141278696"
variation 377
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:113993965"
variation 378
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="g"
/db_xref="dbSNP:369833293"
variation 380
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201188464"
variation 417
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:200355416"
variation 426
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373262255"
exon 439..625
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 533
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:374833411"
variation 536
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:193921145"
STS 537..619
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/standard_name="PMC25851P1"
/db_xref="UniSTS:272288"
variation 537
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:61732782"
variation 547
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="g"
/db_xref="dbSNP:201466089"
variation 556
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908838"
variation 558
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:199727371"
variation 570
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:199686014"
variation 572
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:377757904"
variation 584
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201617537"
variation 586
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:121908835"
variation 587
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908836"
variation 609
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:371524635"
exon 626..741
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 656
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908849"
variation 668
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="c"
/db_xref="dbSNP:79939938"
variation 698
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="t"
/db_xref="dbSNP:190865056"
variation 718
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:33979049"
STS 740..824
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/standard_name="PMC25851P2"
/db_xref="UniSTS:272289"
exon 742..851
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 759
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:372807713"
variation 771
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:34119860"
variation 812
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908840"
variation 814
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:121908839"
exon 852..988
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 868
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="g"
/db_xref="dbSNP:113993966"
variation 869
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:113993967"
variation 887
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908841"
variation 892
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:121908837"
variation 903
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:370101210"
variation 911
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908844"
variation 913
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:121908847"
variation 921
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:34841666"
variation 942
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:148937466"
variation 953
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:147148566"
variation 961
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:201706554"
variation 969
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375593834"
variation 980
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:199807776"
variation 986
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:143591434"
exon 989..1071
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 989
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:148052765"
variation 1020
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:140374868"
exon 1072..1208
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 1101
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:188455234"
variation 1173
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:373897470"
variation 1180
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:200973739"
exon 1209..2640
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/inference="alignment:Splign:1.39.8"
variation 1246
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:375536822"
variation 1249
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:369826042"
variation 1250
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:202217271"
variation 1317
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:201416031"
variation 1331
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="t"
/db_xref="dbSNP:376426724"
variation 1362..1363
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="c"
/db_xref="dbSNP:148731783"
variation 1378..1379
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="gt"
/db_xref="dbSNP:147985284"
variation 1394
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:35477020"
variation 1401
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:35611733"
variation 1473
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:375382614"
variation 1482
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="g"
/replace="t"
/db_xref="dbSNP:35032687"
variation 1637
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="g"
/db_xref="dbSNP:373799956"
variation 1798
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="t"
/db_xref="dbSNP:185278845"
variation 1805
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:190782229"
variation 1868
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:34623470"
variation 1962
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="c"
/db_xref="dbSNP:141969530"
variation 1981
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:187062184"
variation 2084
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="a"
/db_xref="dbSNP:5855275"
variation 2130
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:371129754"
variation 2199
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:146081754"
variation 2247
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="a"
/replace="g"
/db_xref="dbSNP:191452119"
variation 2258
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:7645830"
variation 2326..2327
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="a"
/db_xref="dbSNP:11396460"
variation 2361..2365
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="taaaa"
/db_xref="dbSNP:200709718"
variation 2415..2416
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="t"
/db_xref="dbSNP:200234165"
variation 2416
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="t"
/db_xref="dbSNP:150573954"
variation 2549
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace=""
/replace="t"
/db_xref="dbSNP:35540680"
variation 2588
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
/replace="c"
/replace="t"
/db_xref="dbSNP:35857344"
polyA_signal 2618..2623
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
polyA_site 2640
/gene="TP63"
/gene_synonym="AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP;
OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4;
TP53CP; TP53L; TP73L"
ORIGIN
agagagagaaagagagagagggacttgagttctgttatcttcttaagtagattcatattgtaagggtctcggggtgggggggttggcaaaatcctggagccagaagaaaggacagcagcattgatcaatcttacagctaacatgttgtacctggaaaacaatgcccagactcaatttagtgagccacagtacacgaacctggggctcctgaacagcatggaccagcagattcagaacggctcctcgtccaccagtccctataacacagaccacgcgcagaacagcgtcacggcgccctcgccctacgcacagcccagctccaccttcgatgctctctctccatcacccgccatcccctccaacaccgactacccaggcccgcacagtttcgacgtgtccttccagcagtcgagcaccgccaagtcggccacctggacgtattccactgaactgaagaaactctactgccaaattgcaaagacatgccccatccagatcaaggtgatgaccccacctcctcagggagctgttatccgcgccatgcctgtctacaaaaaagctgagcacgtcacggaggtggtgaagcggtgccccaaccatgagctgagccgtgaattcaacgagggacagattgcccctcctagtcatttgattcgagtagaggggaacagccatgcccagtatgtagaagatcccatcacaggaagacagagtgtgctggtaccttatgagccaccccaggttggcactgaattcacgacagtcttgtacaatttcatgtgtaacagcagttgtgttggagggatgaaccgccgtccaattttaatcattgttactctggaaaccagagatgggcaagtcctgggccgacgctgctttgaggcccggatctgtgcttgcccaggaagagacaggaaggcggatgaagatagcatcagaaagcagcaagtttcggacagtacaaagaacggtgatggtacgaagcgcccgtttcgtcagaacacacatggtatccagatgacatccatcaagaaacgaagatccccagatgatgaactgttatacttaccagtgaggggccgtgagacttatgaaatgctgttgaagatcaaagagtccctggaactcatgcagtaccttcctcagcacacaattgaaacgtacaggcaacagcaacagcagcagcaccagcacttacttcagaaacatctcctttcagcctgcttcaggaatgagcttgtggagccccggagagaaactccaaaacaatctgacgtcttctttagacattccaagcccccaaaccgatcagtgtacccatagagccctatctctatattttaagtgtgtgtgttgtatttccatgtgtatatgtgagtgtgtgtgtgtgtatgtgtgtgcgtgtgtatctagccctcataaacaggacttgaagacactttggctcagagacccaactgctcaaaggcacaaagccactagtgagagaatcttttgaagggactcaaacctttacaagaaaggatgttttctgcagattttgtatccttagaccggccattggtgggtgaggaaccactgtgtttgtctgtgagctttctgttgtttcctgggagggaggggtcaggtggggaaaggggcattaagatgtttattggaacccttttctgtcttcttctgttgtttttctaaaattcacagggaagcttttgagcaggtctcaaacttaagatgtctttttaagaaaaggagaaaaaagttgttattgtctgtgcataagtaagttgtaggtgactgagagactcagtcagacccttttaatgctggtcatgtaataatattgcaagtagtaagaaacgaaggtgtcaagtgtactgctgggcagcgaggtgatcattaccaaaagtaatcaactttgtgggtggagagttctttgtgagaacttgcattatttgtgtcctcccctcatgtgtaggtagaacatttcttaatgctgtgtacctgcctctgccactgtatgttggcatctgttatgctaaagtttttcttgtacatgaaaccctggaagacctactacaaaaaaactgttgtttggcccccatagcaggtgaactcattttgtgcttttaatagaaagacaaatccaccccagtaatattgcccttacgtagttgtttaccattattcaaagctcaaaatagaatttgaagccctctcacaaaatctgtgattaatttgcttaattagagcttctatccctcaagcctacctaccataaaaccagccatattactgatactgttcagtgcatttagccaggagacttacgttttgagtaagtgagatccaagcagacgtgttaaaatcagcactcctggactggaaattaaagattgaaagggtagactacttttcttttttttactcaaaagtttagagaatctctgtttctttccattttaaaaacatattttaagataatagcataaagactttaaaaatgttcctcccctccatcttcccacacccagtcaccagcactgtattttctgtcaccaagacaatgatttcttgttattgaggctgttgcttttgtggatgtgtgattttaattttcaataaacttttgcatcttggttt
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:8626 -> Molecular function: GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] evidence: IEA
GeneID:8626 -> Molecular function: GO:0002039 [p53 binding] evidence: IBA
GeneID:8626 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:8626 -> Molecular function: GO:0003682 [chromatin binding] evidence: IBA
GeneID:8626 -> Molecular function: GO:0003682 [chromatin binding] evidence: IDA
GeneID:8626 -> Molecular function: GO:0003684 [damaged DNA binding] evidence: IBA
GeneID:8626 -> Molecular function: GO:0003690 [double-stranded DNA binding] evidence: IBA
GeneID:8626 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IBA
GeneID:8626 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:8626 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
GeneID:8626 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IBA
GeneID:8626 -> Molecular function: GO:0044212 [transcription regulatory region DNA binding] evidence: IEA
GeneID:8626 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:8626 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IBA
GeneID:8626 -> Biological process: GO:0001501 [skeletal system development] evidence: IEA
GeneID:8626 -> Biological process: GO:0001736 [establishment of planar polarity] evidence: IEA
GeneID:8626 -> Biological process: GO:0002053 [positive regulation of mesenchymal cell proliferation] evidence: IEA
GeneID:8626 -> Biological process: GO:0002064 [epithelial cell development] evidence: IEA
GeneID:8626 -> Biological process: GO:0006338 [chromatin remodeling] evidence: IEA
GeneID:8626 -> Biological process: GO:0006915 [apoptotic process] evidence: IDA
GeneID:8626 -> Biological process: GO:0006917 [induction of apoptosis] evidence: IEA
GeneID:8626 -> Biological process: GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] evidence: IBA
GeneID:8626 -> Biological process: GO:0007219 [Notch signaling pathway] evidence: IEA
GeneID:8626 -> Biological process: GO:0007499 [ectoderm and mesoderm interaction] evidence: IEA
GeneID:8626 -> Biological process: GO:0007569 [cell aging] evidence: IEA
GeneID:8626 -> Biological process: GO:0009954 [proximal/distal pattern formation] evidence: IEA
GeneID:8626 -> Biological process: GO:0010165 [response to X-ray] evidence: IBA
GeneID:8626 -> Biological process: GO:0010259 [multicellular organismal aging] evidence: IEA
GeneID:8626 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IBA
GeneID:8626 -> Biological process: GO:0010481 [epidermal cell division] evidence: IEA
GeneID:8626 -> Biological process: GO:0030216 [keratinocyte differentiation] evidence: IEA
GeneID:8626 -> Biological process: GO:0030326 [embryonic limb morphogenesis] evidence: IEA
GeneID:8626 -> Biological process: GO:0030859 [polarized epithelial cell differentiation] evidence: IEA
GeneID:8626 -> Biological process: GO:0031069 [hair follicle morphogenesis] evidence: IEA
GeneID:8626 -> Biological process: GO:0031571 [mitotic G1 DNA damage checkpoint] evidence: IBA
GeneID:8626 -> Biological process: GO:0034644 [cellular response to UV] evidence: IBA
GeneID:8626 -> Biological process: GO:0036342 [post-anal tail morphogenesis] evidence: IEA
GeneID:8626 -> Biological process: GO:0042475 [odontogenesis of dentin-containing tooth] evidence: IEA
GeneID:8626 -> Biological process: GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] evidence: IBA
GeneID:8626 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IEA
GeneID:8626 -> Biological process: GO:0043523 [regulation of neuron apoptotic process] evidence: IBA
GeneID:8626 -> Biological process: GO:0043616 [keratinocyte proliferation] evidence: IEA
GeneID:8626 -> Biological process: GO:0045617 [negative regulation of keratinocyte differentiation] evidence: IEA
GeneID:8626 -> Biological process: GO:0045669 [positive regulation of osteoblast differentiation] evidence: IMP
GeneID:8626 -> Biological process: GO:0045747 [positive regulation of Notch signaling pathway] evidence: IDA
GeneID:8626 -> Biological process: GO:0045892 [negative regulation of transcription, DNA-dependent] evidence: IDA
GeneID:8626 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:8626 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: NAS
GeneID:8626 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:8626 -> Biological process: GO:0048485 [sympathetic nervous system development] evidence: IEA
GeneID:8626 -> Biological process: GO:0048745 [smooth muscle tissue development] evidence: IEA
GeneID:8626 -> Biological process: GO:0048807 [female genitalia morphogenesis] evidence: IEA
GeneID:8626 -> Biological process: GO:0051289 [protein homotetramerization] evidence: IPI
GeneID:8626 -> Biological process: GO:0051402 [neuron apoptotic process] evidence: IEA
GeneID:8626 -> Biological process: GO:0060157 [urinary bladder development] evidence: IEA
GeneID:8626 -> Biological process: GO:0060197 [cloacal septation] evidence: IEA
GeneID:8626 -> Biological process: GO:0060513 [prostatic bud formation] evidence: IEA
GeneID:8626 -> Biological process: GO:0060529 [squamous basal epithelial stem cell differentiation involved in prostate gland acinus development] evidence: IEA
GeneID:8626 -> Biological process: GO:2000381 [negative regulation of mesoderm development] evidence: IEA
GeneID:8626 -> Cellular component: GO:0000785 [chromatin] evidence: IBA
GeneID:8626 -> Cellular component: GO:0000790 [nuclear chromatin] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
GeneID:8626 -> Cellular component: GO:0005654 [nucleoplasm] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IBA
GeneID:8626 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:8626 -> Cellular component: GO:0005829 [cytosol] evidence: IBA
GeneID:8626 -> Cellular component: GO:0030425 [dendrite] evidence: IBA
by
@meso_cacase at
DBCLS
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