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2024-04-20 16:43:38, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001114122 4174 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 1,
mRNA.
ACCESSION NM_001114122
VERSION NM_001114122.2 GI:349501056
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4174)
AUTHORS Cheng,Y.C., Lin,T.Y. and Shieh,S.Y.
TITLE Candidate tumor suppressor BTG3 maintains genomic stability by
promoting Lys63-linked ubiquitination and activation of the
checkpoint kinase CHK1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (15), 5993-5998 (2013)
PUBMED 23533280
REMARK GeneRIF: BTG3-dependent CHK1 ubiquitination contributes to its
chromatin localization and activation and a defect in this
regulation may increase genome instability and promote
tumorigenesis
REFERENCE 2 (bases 1 to 4174)
AUTHORS Wang,W.J., Wu,S.P., Liu,J.B., Shi,Y.S., Huang,X., Zhang,Q.B. and
Yao,K.T.
TITLE MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem
cell-like population of nasopharyngeal carcinoma cells
JOURNAL Cancer Res. 73 (3), 1219-1231 (2013)
PUBMED 23269272
REMARK GeneRIF: MYC regulation of CHK1 and CHK2 promotes radioresistance
in a stem cell-like population of nasopharyngeal carcinoma cells.
REFERENCE 3 (bases 1 to 4174)
AUTHORS Huh,J. and Piwnica-Worms,H.
TITLE CRL4(CDT2) targets CHK1 for PCNA-independent destruction
JOURNAL Mol. Cell. Biol. 33 (2), 213-226 (2013)
PUBMED 23109433
REMARK GeneRIF: CRL4 is a major regulator of CHK1 stability. CRL4CDT2
targets CHK1 for ubiquitination in the nucleoplasm, and for
PCNA-independent degradation. CHK1 is required for G2 arrest in
CDT2-depleted cells.
REFERENCE 4 (bases 1 to 4174)
AUTHORS Okita,N., Yoshimura,M., Watanabe,K., Minato,S., Kudo,Y., Higami,Y.
and Tanuma,S.
TITLE CHK1 cleavage in programmed cell death is intricately regulated by
both caspase and non-caspase family proteases
JOURNAL Biochim. Biophys. Acta 1830 (1), 2204-2213 (2013)
PUBMED 23085068
REMARK GeneRIF: CASP and non-CASP family proteases intricately regulate
cleavage for up-regulation of CHK1 kinase activity during PCD.
REFERENCE 5 (bases 1 to 4174)
AUTHORS Kumar,G., Breen,E.J. and Ranganathan,S.
TITLE Identification of ovarian cancer associated genes using an
integrated approach in a Boolean framework
JOURNAL BMC Syst Biol 7, 12 (2013)
PUBMED 23383610
REMARK GeneRIF: IRAK1, CHEK1 and BUB1 may play an important role in
ovarian cancer.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4174)
AUTHORS Ouyang,B., Li,W., Pan,H., Meadows,J., Hoffmann,I. and Dai,W.
TITLE The physical association and phosphorylation of Cdc25C protein
phosphatase by Prk
JOURNAL Oncogene 18 (44), 6029-6036 (1999)
PUBMED 10557092
REFERENCE 7 (bases 1 to 4174)
AUTHORS Giaccia,A.J. and Kastan,M.B.
TITLE The complexity of p53 modulation: emerging patterns from divergent
signals
JOURNAL Genes Dev. 12 (19), 2973-2983 (1998)
PUBMED 9765199
REMARK Review article
REFERENCE 8 (bases 1 to 4174)
AUTHORS Flaggs,G., Plug,A.W., Dunks,K.M., Mundt,K.E., Ford,J.C.,
Quiggle,M.R., Taylor,E.M., Westphal,C.H., Ashley,T., Hoekstra,M.F.
and Carr,A.M.
TITLE Atm-dependent interactions of a mammalian chk1 homolog with meiotic
chromosomes
JOURNAL Curr. Biol. 7 (12), 977-986 (1997)
PUBMED 9382850
REFERENCE 9 (bases 1 to 4174)
AUTHORS Peng,C.Y., Graves,P.R., Thoma,R.S., Wu,Z., Shaw,A.S. and
Piwnica-Worms,H.
TITLE Mitotic and G2 checkpoint control: regulation of 14-3-3 protein
binding by phosphorylation of Cdc25C on serine-216
JOURNAL Science 277 (5331), 1501-1505 (1997)
PUBMED 9278512
REFERENCE 10 (bases 1 to 4174)
AUTHORS Sanchez,Y., Wong,C., Thoma,R.S., Richman,R., Wu,Z.,
Piwnica-Worms,H. and Elledge,S.J.
TITLE Conservation of the Chk1 checkpoint pathway in mammals: linkage of
DNA damage to Cdk regulation through Cdc25
JOURNAL Science 277 (5331), 1497-1501 (1997)
PUBMED 9278511
REMARK GeneRIF: Biochemical studies suggest the functional interactions of
this protein with cell cycle regulators. Cdc25A, Cdc25B, and Cdc25C
can be phosphoryalted by this protein.
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX419129.2, AW149126.1,
CA868104.1, AK300082.1, DA567616.1, BC004202.2, CA441277.1,
BG191840.1, BM455102.1, BX506561.1, BX114781.1, AI750792.1 and
AA224205.1.
On Oct 4, 2011 this sequence version replaced gi:166295195.
Summary: The protein encoded by this gene belongs to the Ser/Thr
protein kinase family. It is required for checkpoint mediated cell
cycle arrest in response to DNA damage or the presence of
unreplicated DNA. This protein acts to integrate signals from ATM
and ATR, two cell cycle proteins involved in DNA damage responses,
that also associate with chromatin in meiotic prophase I.
Phosphorylation of CDC25A protein phosphatase by this protein is
required for cells to delay cell cycle progression in response to
double-strand DNA breaks. Several alternatively spliced transcript
variants have been found for this gene. [provided by RefSeq, Oct
2011].
Transcript Variant: This variant (1) represents the predominant
transcript, and encodes isoform 1. Variant 1-3 encode the same
isoform.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF016582.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025085 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-85 BX419129.2 648-732 c
86-431 AW149126.1 82-427
432-744 CA868104.1 1-313 c
745-802 AK300082.1 155-212
803-838 DA567616.1 37-72
839-2307 BC004202.2 1-1469
2308-2308 CA441277.1 463-463 c
2309-2355 BC004202.2 1471-1517
2356-2742 BG191840.1 126-512
2743-3001 BM455102.1 369-627
3002-3273 BX506561.1 253-524
3274-3750 BX114781.1 281-757
3751-4143 AI750792.1 9-401 c
4144-4174 AA224205.1 1-31 c
FEATURES Location/Qualifiers
source 1..4174
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q24.2"
gene 1..4174
/gene="CHEK1"
/gene_synonym="CHK1"
/note="checkpoint kinase 1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
exon 1..877
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 14
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:61612408"
variation 48
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:61451117"
STS 129..258
/gene="CHEK1"
/gene_synonym="CHK1"
/standard_name="RH92593"
/db_xref="UniSTS:88954"
variation 157..159
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="aaa"
/db_xref="dbSNP:71715502"
variation 162..163
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="a"
/db_xref="dbSNP:34798120"
variation 179..180
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="g"
/db_xref="dbSNP:3216096"
variation 181..182
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="c"
/db_xref="dbSNP:28365794"
variation 181
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:1057733"
variation 181
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="cc"
/replace="t"
/db_xref="dbSNP:66498879"
variation 182
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:2298482"
variation 205
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192831922"
variation 234
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:558351"
variation 336
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144289861"
variation 339
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:147779069"
variation 344
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:139443875"
variation 384
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112740384"
variation 465
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184405894"
variation 491
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:555752"
misc_feature 643..645
/gene="CHEK1"
/gene_synonym="CHK1"
/note="upstream in-frame stop codon"
variation 645
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:116191495"
variation 689
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73616024"
variation 707
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:112362212"
variation 710
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:77183579"
variation 716
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:76045215"
exon 878..962
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 880
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371037025"
CDS 898..2328
/gene="CHEK1"
/gene_synonym="CHK1"
/EC_number="2.7.11.1"
/note="isoform 1 is encoded by transcript variant 1;
Checkpoint, S. pombe, homolog of, 1;
serine/threonine-protein kinase Chk1; CHK1 checkpoint
homolog; checkpoint kinase-1; cell cycle checkpoint
kinase; Chk1-S"
/codon_start=1
/product="serine/threonine-protein kinase Chk1 isoform 1"
/protein_id="NP_001107594.1"
/db_xref="GI:166295196"
/db_xref="CCDS:CCDS8459.1"
/db_xref="GeneID:1111"
/db_xref="HGNC:1925"
/db_xref="MIM:603078"
/translation="
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
"
misc_feature 898..1692
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14757.2);
Region: Interaction with CLSPN (By similarity)"
misc_feature 922..1689
/gene="CHEK1"
/gene_synonym="CHK1"
/note="Serine/Threonine protein kinases, catalytic domain;
Region: S_TKc; smart00220"
/db_xref="CDD:197582"
misc_feature 940..1683
/gene="CHEK1"
/gene_synonym="CHK1"
/note="Catalytic domain of Protein Kinases; Region: PKc;
cd00180"
/db_xref="CDD:173623"
misc_feature order(940..954,964..966,1003..1005,1009..1011,1099..1101,
1147..1158,1168..1170,1174..1176,1285..1287,1291..1293,
1297..1302,1306..1308,1339..1341,1348..1350,1402..1413)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(940..954,964..966,1003..1005,1009..1011,1099..1101,
1147..1158,1168..1170,1285..1287,1291..1293,1297..1302,
1306..1308,1339..1341)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(952..954,1168..1170,1174..1176,1285..1287,
1291..1293,1297..1299,1348..1350,1402..1413)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(1336..1356,1402..1413)
/gene="CHEK1"
/gene_synonym="CHK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1753..1755
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1783..1785
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1798..1800
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(O14757.2); phosphorylation site"
misc_feature 1846..1848
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (O14757.2); phosphorylation site"
misc_feature 1930..1932
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine, by ATM and ATR; propagated from
UniProtKB/Swiss-Prot (O14757.2); phosphorylation site"
misc_feature 2068..2325
/gene="CHEK1"
/gene_synonym="CHK1"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (O14757.2);
Region: Autoinhibitory region"
variation 907
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201459198"
variation 931
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:200520758"
variation 936
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144523921"
exon 963..1186
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1013
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367942205"
variation 1056
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372546907"
variation 1059
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112291840"
variation 1098
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148040708"
variation 1102
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375481689"
variation 1109
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141665265"
variation 1137
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371045906"
exon 1187..1251
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1251
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375305289"
exon 1252..1321
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1260
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368957964"
variation 1273
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:112275638"
variation 1284
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:114850047"
variation 1312
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:371765740"
exon 1322..1510
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1329
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113468080"
variation 1363
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:140276570"
variation 1364
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:3731410"
variation 1375
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:369248914"
variation 1395
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373714183"
variation 1421
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:75583143"
variation 1482
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:200960815"
variation 1503
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:190137928"
variation 1504
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:376741119"
exon 1511..1615
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1545
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:377704459"
variation 1565
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:35817404"
variation 1575
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370350660"
exon 1616..1711
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1648
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201395400"
variation 1657
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11553952"
variation 1669
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201385540"
exon 1712..1820
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1737
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:111852956"
variation 1774
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147323405"
variation 1809
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:182542971"
exon 1821..1998
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 1831
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34097480"
variation 1842
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371546941"
variation 1875
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:2847422"
variation 1897
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:139936669"
variation 1929
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375729370"
variation 1933
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199535573"
variation 1939
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:374866866"
variation 1951
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149667923"
variation 1971
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111415405"
variation 1980
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200239581"
exon 1999..2130
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 2004
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375980825"
variation 2007
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:77764256"
variation 2034
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369650833"
variation 2049
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192063586"
variation 2067
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372751798"
variation 2085
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374032447"
variation 2105
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:115991933"
variation 2106
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:149857578"
variation 2114
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:145794689"
exon 2131..2232
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 2137
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148568641"
variation 2157
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:141332865"
variation 2159
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370268372"
exon 2233..4155
/gene="CHEK1"
/gene_synonym="CHK1"
/inference="alignment:Splign:1.39.8"
variation 2293
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146590504"
variation 2308
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:506504"
variation 2331
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373998065"
variation 2350
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:375887872"
variation 2389
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:9282658"
variation 2423
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148807246"
variation 2464
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373169887"
variation 2495
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:184393295"
variation 2654
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142447277"
variation 2700..2701
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:141464656"
variation 2701..2702
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:113628894"
variation 2701
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:199723723"
variation 2702..2703
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tttc"
/db_xref="dbSNP:72531173"
variation 2703..2704
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:3731480"
variation 2704..2705
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="tctt"
/db_xref="dbSNP:35167388"
variation 2704
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:201914580"
polyA_signal 2732..2737
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2751
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:190098261"
polyA_site 2753
/gene="CHEK1"
/gene_synonym="CHK1"
variation 2774
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:181773130"
variation 2852
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:184932784"
variation 3071
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:113311223"
variation 3110
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189829306"
variation 3166
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151312608"
variation 3249
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140546391"
variation 3273
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144047942"
variation 3274
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:567889"
variation 3276
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368655022"
variation 3332
/gene="CHEK1"
/gene_synonym="CHK1"
/replace=""
/replace="t"
/db_xref="dbSNP:34215005"
variation 3345
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146445217"
variation 3440
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370171293"
variation 3448
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:140816182"
variation 3809
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144623058"
variation 3823
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370678835"
variation 3887
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:11220176"
STS 3912..4018
/gene="CHEK1"
/gene_synonym="CHK1"
/standard_name="A006U05"
/db_xref="UniSTS:17547"
STS 3926..4049
/gene="CHEK1"
/gene_synonym="CHK1"
/standard_name="RH36540"
/db_xref="UniSTS:25497"
variation 4018
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:138368921"
variation 4078
/gene="CHEK1"
/gene_synonym="CHK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:180885007"
polyA_signal 4126..4131
/gene="CHEK1"
/gene_synonym="CHK1"
polyA_site 4155
/gene="CHEK1"
/gene_synonym="CHK1"
ORIGIN
cttttaaatttgcgttgtaagatttattttggctctccccgcctgttctttgcacattaaaaatgaaaaagtttgtagaactaagctaagcagatggtcttcctgcaaaaagaccgggctgaagtaaagcattgttttggagctggttcacagaaaaaaggcaaaactggttatcctgacttcaagctccaacataaactgctcgctttctccgggaaacttgccccgccacacacacttgactgcgtggccagttctttcgaagcctctcgctcccaacacggagttcctcccatttcttcacagtcggctctcagcagctgctgctggtttctcggctccagcaccacgagtaccgcactctgaggtttacaaagcactctgcttcaccgactgtgatcctcacagtcctgtccggtggcctcacgcaggtggcggtgcagcctttcaggcccagagcggccaggagcgaagcccgcagccccgcctggaagcgcagcgcggtcggtcgcgcgcccctgaggcttggaggcctgggcttcccccagcagcgctcgagcaccgcccagtcgagcctcacaccggatgccacttcatatttgggcccagagctcaattcgcgccgatgcggtccgccgtccttaaatctcttcagccaggatctctccccgactgcaaagcagccctgggcgggagcggcaacatctccacgtcacccttttggagccgccgacattcagaggggcaggacacgggaacgcgcgctgtcttgctttacggcgcgggtgcgcgagtttgcggcagcgtgacgccctcaagttttggcgggaaaagcgctgcatttggattcctgcagtggtgggcaaaggacagtccgccgaggtgctcggtggagtcatggcagtgccctttgtggaagactgggacttggtgcaaaccctgggagaaggtgcctatggagaagttcaacttgctgtgaatagagtaactgaagaagcagtcgcagtgaagattgtagatatgaagcgtgccgtagactgtccagaaaatattaagaaagagatctgtatcaataaaatgctaaatcatgaaaatgtagtaaaattctatggtcacaggagagaaggcaatatccaatatttatttctggagtactgtagtggaggagagctttttgacagaatagagccagacataggcatgcctgaaccagatgctcagagattcttccatcaactcatggcaggggtggtttatctgcatggtattggaataactcacagggatattaaaccagaaaatcttctgttggatgaaagggataacctcaaaatctcagactttggcttggcaacagtatttcggtataataatcgtgagcgtttgttgaacaagatgtgtggtactttaccatatgttgctccagaacttctgaagagaagagaatttcatgcagaaccagttgatgtttggtcctgtggaatagtacttactgcaatgctcgctggagaattgccatgggaccaacccagtgacagctgtcaggagtattctgactggaaagaaaaaaaaacatacctcaacccttggaaaaaaatcgattctgctcctctagctctgctgcataaaatcttagttgagaatccatcagcaagaattaccattccagacatcaaaaaagatagatggtacaacaaacccctcaagaaaggggcaaaaaggccccgagtcacttcaggtggtgtgtcagagtctcccagtggattttctaagcacattcaatccaatttggacttctctccagtaaacagtgcttctagtgaagaaaatgtgaagtactccagttctcagccagaaccccgcacaggtctttccttatgggataccagcccctcatacattgataaattggtacaagggatcagcttttcccagcccacatgtcctgatcatatgcttttgaatagtcagttacttggcaccccaggatcctcacagaacccctggcagcggttggtcaaaagaatgacacgattctttaccaaattggatgcagacaaatcttatcaatgcctgaaagagacttgtgagaagttgggctatcaatggaagaaaagttgtatgaatcaggttactatatcaacaactgataggagaaacaataaactcattttcaaagtgaatttgttagaaatggatgataaaatattggttgacttccggctttctaagggtgatggattggagttcaagagacacttcctgaagattaaagggaagctgattgatattgtgagcagccagaagatttggcttcctgccacatgatcggaccatcggctctggggaatcctggtgaatatagtgctgctatgttgacattattcttcctagagaagattatcctgtcctgcaaactgcaaatagtagttcctgaagtgttcacttccctgtttatccaaacatcttccaatttattttgtttgttcggcatacaaataatacctatatcttaattgtaagcaaaactttggggaaaggatgaatagaattcatttgattatttcttcatgtgtgtttagtatctgaatttgaaactcatctggtggaaaccaagtttcaggggacatgagttttccagcttttatacacacgtatctcatttttatcaaaacattttgtttaattcaaaaagtacatattccatgttgatttaattctaagatgaaccaataaagacataattcttgtgacttttggacagtagatttatcagtctgtgaagcgaagccagcttcaaaacatatccccaagatttgtacttatattttcaaaagggcctggccagttatataaacctgtttttgaattataatgattaattaaaattgcaagtaggtgttttttccagtgtagttagtaaaatacttgtattttacagtgttgcataaactctagtgcttaactaactttactctaaaaattactgttgaacatcttaaatatttttctatattttctactttcatagccatattttaaccttttcaacttactggtgaccaagcttttaggtgataaagaataaaagagggaagggaagagtaaggaagctataagaaaaatagatctgattctttgttcctttacctgttagacttacaaaaagtttgtttttctaataaaatttgtatcaactttggggcatattaggttgaggccttggctcctgcctgtagtcccagctacttaggaggctgagagaggaggatcgcgtgaacctggaagtttgaggctgtagtgagctatgattgcaccagtgcactccagcttggatgacagagtaagaccctacctctaataaaaatttttaaaattgtaaaacattataaaattaatcagttattttaatctgaagccaagaacatgtagaatgttatgattagagtttatcacatattaatgtatactggcaaattgtgttactggagtatacccataggaggaataaattcaaacctgttttatttatttgaacctatttacggtatgcttaagaattgaatcagtataaattctcaaatatgggagaaattttgttcttgagaattatctgagtcattaatatttttcaaaaacagctctcactgacttgaacctcttctgtaagctctaaccttttacctgctttacatttccacttgaatgtctagtaggcatctcttgaccaaaaacagcttttgattcctgttctccaacctgttcctctcctagttttctccatctcagaaatgttacttcctctgcaaagtctttccctgacttatctaaaataataacctcctctgtttgctgtgggaatttgtatagaatggtgggaaaatttcaagtttcatatttggattagctctgacatttatttatctgaacactggtaattgcctcagtaaagacactgataataagtaccttttagagttattttaatctttaatgctttaatgtgtaggaagagtatagtgtcctgttttgcacagaaaggcattctgtaaataataagttgccttaattttcctgtaatgttcattatattgttgtgggaaggtatttactcctattattaaaaataaaaatgtgtaaaatttactacctgaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:1111 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:1111 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:1111 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
GeneID:1111 -> Molecular function: GO:0035402 [histone kinase activity (H3-T11 specific)] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IDA
GeneID:1111 -> Biological process: GO:0000077 [DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0000086 [G2/M transition of mitotic cell cycle] evidence: IEA
GeneID:1111 -> Biological process: GO:0006260 [DNA replication] evidence: TAS
GeneID:1111 -> Biological process: GO:0006281 [DNA repair] evidence: IMP
GeneID:1111 -> Biological process: GO:0006974 [response to DNA damage stimulus] evidence: IMP
GeneID:1111 -> Biological process: GO:0006975 [DNA damage induced protein phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0010569 [regulation of double-strand break repair via homologous recombination] evidence: IDA
GeneID:1111 -> Biological process: GO:0010767 [regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage] evidence: ISS
GeneID:1111 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: IDA
GeneID:1111 -> Biological process: GO:0031572 [G2 DNA damage checkpoint] evidence: IMP
GeneID:1111 -> Biological process: GO:0033261 [regulation of S phase] evidence: IEA
GeneID:1111 -> Biological process: GO:0042127 [regulation of cell proliferation] evidence: IEA
GeneID:1111 -> Biological process: GO:0045839 [negative regulation of mitosis] evidence: IDA
GeneID:1111 -> Biological process: GO:0046602 [regulation of mitotic centrosome separation] evidence: IDA
GeneID:1111 -> Biological process: GO:0048096 [chromatin-mediated maintenance of transcription] evidence: ISS
GeneID:1111 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:1111 -> Biological process: GO:0071313 [cellular response to caffeine] evidence: IEA
GeneID:1111 -> Biological process: GO:0090399 [replicative senescence] evidence: NAS
GeneID:1111 -> Biological process: GO:2000615 [regulation of histone H3-K9 acetylation] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000781 [chromosome, telomeric region] evidence: IDA
GeneID:1111 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:1111 -> Cellular component: GO:0000794 [condensed nuclear chromosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:1111 -> Cellular component: GO:0005657 [replication fork] evidence: IEA
GeneID:1111 -> Cellular component: GO:0005813 [centrosome] evidence: IDA
GeneID:1111 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001107594 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.