LOCUS       NM_001111319            2708 bp    mRNA    linear   PRI 23-MAR-2013
DEFINITION  Homo sapiens claudin 22 (CLDN22), mRNA.
ACCESSION   NM_001111319 XM_001723535 XM_926796 XM_940253
VERSION     NM_001111319.1  GI:162417972
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2708)
  AUTHORS   Lal-Nag,M. and Morin,P.J.
  TITLE     The claudins
  JOURNAL   Genome Biol. 10 (8), 235 (2009)
   PUBMED   19706201
  REMARK    Review article
REFERENCE   2  (bases 1 to 2708)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim. Biophys. Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   3  (bases 1 to 2708)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
REFERENCE   4  (bases 1 to 2708)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     CLDN23 gene, frequently down-regulated in intestinal-type gastric
            cancer, is a novel member of CLAUDIN gene family
  JOURNAL   Int. J. Mol. Med. 11 (6), 683-689 (2003)
   PUBMED   12736707
  REMARK    GeneRIF: CLDN21, clustered with CLDN22 at human chromosome 4q35.1,
            is a four-transmembrane protein with WWCC motif, defined by
            W-X(17-22)-W-X(2)-C-X(8-10)-C.
REFERENCE   5  (bases 1 to 2708)
  AUTHORS   Gonzalez-Mariscal,L., Betanzos,A., Nava,P. and Jaramillo,B.E.
  TITLE     Tight junction proteins
  JOURNAL   Prog. Biophys. Mol. Biol. 81 (1), 1-44 (2003)
   PUBMED   12475568
  REMARK    Review article
REFERENCE   6  (bases 1 to 2708)
  AUTHORS   Tsukita,S. and Furuse,M.
  TITLE     Claudin-based barrier in simple and stratified cellular sheets
  JOURNAL   Curr. Opin. Cell Biol. 14 (5), 531-536 (2002)
   PUBMED   12231346
  REMARK    Review article
REFERENCE   7  (bases 1 to 2708)
  AUTHORS   Tsukita,S., Furuse,M. and Itoh,M.
  TITLE     Multifunctional strands in tight junctions
  JOURNAL   Nat. Rev. Mol. Cell Biol. 2 (4), 285-293 (2001)
   PUBMED   11283726
  REMARK    Review article
REFERENCE   8  (bases 1 to 2708)
  AUTHORS   Heiskala,M., Peterson,P.A. and Yang,Y.
  TITLE     The roles of claudin superfamily proteins in paracellular transport
  JOURNAL   Traffic 2 (2), 93-98 (2001)
   PUBMED   11247307
  REMARK    Review article
REFERENCE   9  (bases 1 to 2708)
  AUTHORS   Kniesel,U. and Wolburg,H.
  TITLE     Tight junctions of the blood-brain barrier
  JOURNAL   Cell. Mol. Neurobiol. 20 (1), 57-76 (2000)
   PUBMED   10690502
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093844.3.
            On or before Mar 29, 2008 this sequence version replaced
            gi:169166859, gi:169166378, gi:169167177.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. This gene is intronless and overlaps the 3'
            UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
            [provided by RefSeq, Aug 2010].
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2708              AC093844.3         110375-113082       c
FEATURES             Location/Qualifiers
     source          1..2708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..2708
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="claudin 22"
                     /db_xref="GeneID:53842"
                     /db_xref="HGNC:2044"
     exon            1..2708
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    <1..597
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST BG566150 (NID:g13573803)"
     misc_feature    <1..371
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AW195363 (NID:g6474439) xn37d11.x1"
     misc_feature    <1..219
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST BG938816 (NID:g14338188) cn28e07.y1"
     misc_feature    <1..144
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST D62422 (NID:g966198)"
     misc_feature    <1..17
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AL120932 (NID:g5926933)"
     misc_feature    31..453
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AW237273 (NID:g6569662) xm69c02.x1"
     misc_feature    88..225
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AL120932 (NID:g5926933)"
     misc_feature    154..763
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST BE890365 (NID:g10348610)"
     misc_feature    166..575
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AW294579 (NID:g6701215)"
     misc_feature    407..681
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST BF439878 (NID:g11452395)"
     variation       443
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373911861"
     misc_feature    536..538
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="upstream in-frame stop codon"
     CDS             557..1219
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /codon_start=1
                     /product="claudin-22"
                     /protein_id="NP_001104789.1"
                     /db_xref="GI:162417973"
                     /db_xref="CCDS:CCDS43286.1"
                     /db_xref="GeneID:53842"
                     /db_xref="HGNC:2044"
                     /translation="

MALVFRTVAQLAGVSLSLLGWVLSCLTNYLPHWKNLNLDLNEMENWTMGLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRILMFLSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLLILGGILSWASGVTALVPVSWVAHKTVQEFWDENVPDFVPRWEFGEALFLGWFAGLSLLLGGCLLHCAACSSHAPLASGHYAVAQTQDHHQELETRNTNLKH

"
     misc_feature    587..646
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N7P3.3);
                     transmembrane region"
     misc_feature    <701..1066
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl15797"
                     /db_xref="CDD:210197"
     misc_feature    800..862
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N7P3.3);
                     transmembrane region"
     misc_feature    908..970
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N7P3.3);
                     transmembrane region"
     misc_feature    1049..1111
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8N7P3.3);
                     transmembrane region"
     misc_feature    632..1168
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AI806011 (NID:g5392577) te53b07.x1"
     misc_feature    675
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST D62422 (NID:g966198)"
     misc_feature    879..1591
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST BG114978 (NID:g12608484)"
     STS             2126..2317
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /standard_name="RH36596"
                     /db_xref="UniSTS:33607"
     misc_feature    2163..2708
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /note="match to EST AW589643 (NID:g7276761) hg21b06.x1"
     STS             2291..2415
                     /gene="CLDN22"
                     /gene_synonym="CLDN21"
                     /standard_name="SHGC-59360"
                     /db_xref="UniSTS:37895"
ORIGIN      

ctgataagattgatttatttggttaagaaatacttttcttaaacctatttttaaaaaataacactcagtattaccataacatgcacatttgaaatgtgagaactataagagatgaaaatctgacaggtgcagttagtgaaacacaaagcaggaggagttgaaccaaaaccatcagttaaacattttgcatttagacttaattctttgttagaaaggttgggaataacatgaaagccattttaaccttgacaatgaaaggagattatcacttaattatatttcagtgacaaactgctttctgtcaaatccagcccacaggacacaaacacaatcttggccacaccttggcattactggttggcggcattatttccctatccttttgtgaaacccattcaacatggaatcaaacaatagcaactctggcaagaatcctcctatatacacaatgaagaaatatttctgagtttcataagttataacacaagtgtcacacttcttttcacagcaaccgaagggcaggagttagtttggctaaagctctcaggacattataatggctttagtatttagaactgtagctcaactagctggagtttcattatctttgctgggatgggttttatcctgtcttacaaactacctgccacactggaagaacctcaacctggacttaaatgaaatggaaaactggaccatgggactctggcaaacctgtgtcatccaagaggaagtggggatgcaatgcaaggactttgactccttcctggctttgcctgctgaactcagggtctccaggatcttaatgtttctgtcaaatgggctgggatttctgggcctgctggtctctgggtttggcctggactgtttgagaattggagagagtcagagagatctcaagaggcgactgctgatcctgggaggaattctgtcctgggcctcgggagtcacagccctggttcccgtctcttgggttgcccacaagacggttcaggagttctgggatgagaacgtcccagactttgtccccaggtgggagtttggggaggccctgtttctgggctggtttgctggactttctcttctgctaggagggtgtctgctccactgtgcagcctgctccagccacgctcccctagcttcgggccactacgcagtggcacaaacacaagatcatcatcaagaactggagacgagaaacaccaacctgaaacactaagccagaaaggacaagcgtctgctgttcaggagacgcttgctcaacactggatttggtaggatgtcccgctctagtcatctcactgtgcttttgatttttgaaaatgcatcttttcctgtggctattaaactatagtttctttccaagactggtaaaccatttttatcttctagtctgagaccaaaatcaatcaagactgaatagtaatgacacccattactgtggatgagttttctcaattttaaaatagcgattgcacagaagtggtaaataaaacattaatctctatgtatctttgaaggtattattcatatggagcggaatcatttggcaaatcatttacttatttcaggtgtttaagataacctagtataataagcctgaggtcttgttgcatatttatttaaaatgcatgacgtcttattatataaaataattactagctctttagaagcttcagaggtgaaaggtgtagacacatcatctccttctgaatcagagacctcagtgtctctatggaacctttttcaaaaggcagccacattcagtcacgccttctatactgtcagaggcaggagggcgatcttgggttttggatgattcaagtagactctgccacacaaacgtgcttctgcatcctgtgttctgtatttcacgggcagcgtttctggcttcccaggcactgagcagcctgtggggggcacggcagggcaggactggggtgtgtgggtagataacctcctgggacggctgcctctctgtggagcacactgccagcccaggcgcagcgaccacagagcacatattctggagcccttcattttatttgctcaatgaaaatacttcgtccttttttatcagcaatacatatagttccaacaagaactattcatcacaaactgccagcctggggatttcttcatgaaatattttgtatttgcttggtacatggttcaaggaaactcttgtgtttgtgccaatcagggaaataaactgaacaataaacgacactgaaatagagtattaggcaatatgtagctttgtttttgcttttttttttaaaaaaaaccactgaatttttttccacccacaaacacatggaaagtgcagaaaccagttaatctatgtgatgtatttgcatacgtttacaaacaagacaaattaaaacagaaacatgttcagaatttaacctgattaaatattaagttcagtcctgagcttttgatatttaagacaatatagataaagcaatagcaaaaaattttaatttatttgatttgcatgctacagagatttagctaaactttgttcatttggctagcaatattctttttgtacctgtaacacttaagattctgatatacaaaattgtaataatatactgataattcaaacttgagaactaaatattacattctttttaccctgtgcgaataaattctaccttttaaaaatagtatttataatattaaaattcatatttgtccat

//

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:53842 -> Molecular function: GO:0005198 [structural molecule activity] evidence: IEA
            GeneID:53842 -> Molecular function: GO:0042802 [identical protein binding] evidence: ISS
            GeneID:53842 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: ISS
            GeneID:53842 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
            GeneID:53842 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
            GeneID:53842 -> Biological process: GO:0070830 [tight junction assembly] evidence: TAS
            GeneID:53842 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:53842 -> Cellular component: GO:0005923 [tight junction] evidence: ISS
            GeneID:53842 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA