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2024-03-30 00:32:37, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001102667            1159 bp    mRNA    linear   PRI 08-JUN-2013
DEFINITION  Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 4
            (PSMA4), transcript variant 2, mRNA.
ACCESSION   NM_001102667
VERSION     NM_001102667.1  GI:156713441
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Wang,J., Bansal,A.T., Martin,M., Germer,S., Benayed,R., Essioux,L.,
            Lee,J.S., Begovich,A., Hemmings,A., Kenwright,A., Taylor,K.E.,
            Upmanyu,R., Cutler,P., Harari,O., Marchini,J., Criswell,L.A. and
            Platt,A.
  TITLE     Genome-wide association analysis implicates the involvement of
            eight loci with response to tocilizumab for the treatment of
            rheumatoid arthritis
  JOURNAL   Pharmacogenomics J. 13 (3), 235-241 (2013)
   PUBMED   22491018
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Hansen,H.M., Xiao,Y., Rice,T., Bracci,P.M., Wrensch,M.R.,
            Sison,J.D., Chang,J.S., Smirnov,I.V., Patoka,J., Seldin,M.F.,
            Quesenberry,C.P., Kelsey,K.T. and Wiencke,J.K.
  TITLE     Fine mapping of chromosome 15q25.1 lung cancer susceptibility in
            African-Americans
  JOURNAL   Hum. Mol. Genet. 19 (18), 3652-3661 (2010)
   PUBMED   20587604
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Amos,C.I., Gorlov,I.P., Dong,Q., Wu,X., Zhang,H., Lu,E.Y.,
            Scheet,P., Greisinger,A.J., Mills,G.B. and Spitz,M.R.
  TITLE     Nicotinic acetylcholine receptor region on chromosome 15q25 and
            lung cancer risk among African Americans: a case-control study
  JOURNAL   J. Natl. Cancer Inst. 102 (15), 1199-1205 (2010)
   PUBMED   20554942
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int. J. Mol. Med. 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am. J. Hypertens. 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Castano,J.G., Mahillo,E., Arizti,P. and Arribas,J.
  TITLE     Phosphorylation of C8 and C9 subunits of the multicatalytic
            proteinase by casein kinase II and identification of the C8
            phosphorylation sites by direct mutagenesis
  JOURNAL   Biochemistry 35 (12), 3782-3789 (1996)
   PUBMED   8619999
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B.
  TITLE     Human proteasome subunits from 2-dimensional gels identified by
            partial sequencing
  JOURNAL   Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994)
   PUBMED   7811265
  REMARK    Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID:
            7864893]
REFERENCE   8  (bases 1 to 1159)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   9  (bases 1 to 1159)
  AUTHORS   Arribas,J., Arizti,P. and Castano,J.G.
  TITLE     Antibodies against the C2 COOH-terminal region discriminate the
            active and latent forms of the multicatalytic proteinase complex
  JOURNAL   J. Biol. Chem. 269 (17), 12858-12864 (1994)
   PUBMED   8175701
REFERENCE   10 (bases 1 to 1159)
  AUTHORS   Tamura,T., Lee,D.H., Osaka,F., Fujiwara,T., Shin,S., Chung,C.H.,
            Tanaka,K. and Ichihara,A.
  TITLE     Molecular cloning and sequence analysis of cDNAs for five major
            subunits of human proteasomes (multi-catalytic proteinase
            complexes)
  JOURNAL   Biochim. Biophys. Acta 1089 (1), 95-102 (1991)
   PUBMED   2025653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG528289.1, BU930105.1, BG616186.1 and CD365826.1.
            
            Summary: The proteasome is a multicatalytic proteinase complex with
            a highly ordered ring-shaped 20S core structure. The core structure
            is composed of 4 rings of 28 non-identical subunits; 2 rings are
            composed of 7 alpha subunits and 2 rings are composed of 7 beta
            subunits. Proteasomes are distributed throughout eukaryotic cells
            at a high concentration and cleave peptides in an
            ATP/ubiquitin-dependent process in a non-lysosomal pathway. An
            essential function of a modified proteasome, the immunoproteasome,
            is the processing of class I MHC peptides. This gene encodes a
            member of the peptidase T1A family, that is a 20S core alpha
            subunit. Three alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses a different splice site
            in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode
            the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG682177.1, BG616186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BG528289.1         2-33
            33-589              BU930105.1         1-557
            590-723             BG616186.1         547-680
            724-1159            CD365826.1         1-436               c
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..1159
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="proteasome (prosome, macropain) subunit, alpha
                     type, 4"
                     /db_xref="GeneID:5685"
                     /db_xref="HGNC:9533"
                     /db_xref="MIM:176846"
     exon            1..59
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       3
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:151040409"
     variation       9
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:75609110"
     variation       46
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:3813571"
     variation       55
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371585497"
     exon            60..85
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       60
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375114621"
     misc_feature    68..70
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="upstream in-frame stop codon"
     variation       70
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:200532673"
     CDS             83..868
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /EC_number="3.4.25.1"
                     /note="isoform 1 is encoded by transcript variant 2;
                     proteasome component C9; proteasome subunit HC9;
                     proteasome subunit L; macropain subunit C9; multicatalytic
                     endopeptidase complex subunit C9; proteasome subunit alpha
                     type-4"
                     /codon_start=1
                     /product="proteasome subunit alpha type-4 isoform 1"
                     /protein_id="NP_001096137.1"
                     /db_xref="GI:156713442"
                     /db_xref="CCDS:CCDS10303.1"
                     /db_xref="GeneID:5685"
                     /db_xref="HGNC:9533"
                     /db_xref="MIM:176846"
                     /translation="
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK
"
     misc_feature    83..793
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="proteasome subunit alpha; Provisional; Region:
                     PTZ00246"
                     /db_xref="CDD:173491"
     misc_feature    89..730
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="proteasome_alpha_type_4. The 20S proteasome,
                     multisubunit proteolytic complex, is the central enzyme of
                     nonlysosomal protein degradation in both the cytosol and
                     nucleus. It is composed of 28 subunits arranged as four
                     homoheptameric rings that stack on...; Region:
                     proteasome_alpha_type_4; cd03752"
                     /db_xref="CDD:239721"
     misc_feature    order(101..112,116..121,125..130,140..142,149..151,
                     158..163,170..172,194..196,239..241,245..250,320..328,
                     332..337,428..430,437..439,446..451,458..472,524..526,
                     539..544,548..550,554..559,563..565)
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="alpha subunit interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:239721"
     misc_feature    119..121
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P25789.1); phosphorylation site"
     misc_feature    order(176..178,224..226,230..232,272..274,578..580)
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /note="active site"
                     /db_xref="CDD:239721"
     misc_feature    305..307
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P25789.1); phosphorylation site"
     misc_feature    461..463
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P25789.1); acetylation site"
     misc_feature    608..610
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P25789.1); acetylation site"
     exon            86..128
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       88
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:368498566"
     variation       100
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17588"
     variation       105
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551783"
     variation       110
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551787"
     exon            129..291
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       175
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:11551784"
     variation       197
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:11551779"
     variation       199
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551776"
     variation       230
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149336836"
     variation       238
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:368528101"
     variation       268
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551775"
     variation       269
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17352537"
     variation       287
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:143441800"
     exon            292..369
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       293
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:75116593"
     variation       301
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:183640841"
     variation       315
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551781"
     variation       322
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11551786"
     variation       348
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551782"
     variation       367
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200102081"
     exon            370..458
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       420
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147984456"
     variation       421
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:11551774"
     exon            459..589
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       485
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373384097"
     variation       550
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377378619"
     variation       586
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370716397"
     variation       587
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:147172987"
     exon            590..713
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     variation       592
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:140433184"
     exon            714..1144
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /inference="alignment:Splign:1.39.8"
     STS             765..902
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /standard_name="G62016"
                     /db_xref="UniSTS:139094"
     variation       789
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:147521961"
     variation       802
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8053"
     variation       831
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113098925"
     variation       839
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1065640"
     variation       851
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201574707"
     variation       893
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370714227"
     STS             899..1015
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /standard_name="WI-9202"
                     /db_xref="UniSTS:30996"
     variation       901
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111842716"
     STS             921..1079
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /standard_name="D15S636E"
                     /db_xref="UniSTS:58748"
     variation       929
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113789828"
     variation       935
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1052035"
     variation       967
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:111362317"
     variation       970..971
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace=""
                     /replace="g"
                     /db_xref="dbSNP:35919397"
     variation       1003
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369831856"
     variation       1049
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143345504"
     variation       1063
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1052040"
     variation       1069
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3206623"
     variation       1086
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:113738721"
     variation       1137
                     /gene="PSMA4"
                     /gene_synonym="HC9; HsT17706; PSC9"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371007026"
ORIGIN      
cccgccccaacccagcggttctgcgcatgcgcgggggccatattagcagcggttattcggaactatataaagttcagaaaacatgtctcgaagatatgactccaggaccactatattttctccagaaggtcgcttataccaagttgaatatgccatggaagctattggacatgcaggcacctgtttgggaattttagcaaatgatggtgttttgcttgcagcagagagacgcaacatccacaagcttcttgatgaagtctttttttctgaaaaaatttataaactcaatgaggacatggcttgcagtgtggcaggcataacttctgatgctaatgttctgactaatgaactaaggctcattgctcaaaggtatttattacagtatcaggagccaataccttgtgagcagttggttacagcgctgtgtgatatcaaacaagcttatacacaatttggaggaaaacgtccctttggtgtttcattgctgtacattggctgggataagcactatggctttcagctctatcagagtgaccctagtggaaattacgggggatggaaggccacatgcattggaaataatagcgctgcagctgtgtcaatgttgaaacaagactataaagaaggagaaatgaccttgaagtcagcacttgctttagctatcaaagtactaaataagaccatggatgttagtaaactctctgctgaaaaagtggaaattgcaacactaacaagagagaatggaaagacagtaatcagagttctcaaacaaaaagaagtggagcagttgatcaaaaaacatgaggaagaagaagccaaagctgagcgtgagaagaaagaaaaagaacagaaagaaaaggataaatagaatcagagattttattactcatttggggcaccatttcagtgtaaaagcagtcctactcttccacactaggaaggctttactttttttaactggtgcagtgggaaaataggacattacatactgaattgggtccttgtcatttctgtccaattgaatactttattgtaacgatgatggttacccttcatggacgtcttaatcttccacacacatcccctttttttggaataaaatttggaaaatggaaatgaaggaataaattctctgtagcagtaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5685 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA
            GeneID:5685 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5685 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS
            GeneID:5685 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS
            GeneID:5685 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
            GeneID:5685 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS
            GeneID:5685 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS
            GeneID:5685 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS
            GeneID:5685 -> Biological process: GO:0010467 [gene expression] evidence: TAS
            GeneID:5685 -> Biological process: GO:0016032 [viral process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
            GeneID:5685 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS
            GeneID:5685 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:5685 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5685 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5685 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS
            GeneID:5685 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS
            GeneID:5685 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: ISS
            GeneID:5685 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5685 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5685 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS
            GeneID:5685 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001096137 -> EC 3.4.25.1

by @meso_cacase at DBCLS
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