2024-03-30 00:32:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001102667 1159 bp mRNA linear PRI 08-JUN-2013 DEFINITION Homo sapiens proteasome (prosome, macropain) subunit, alpha type, 4 (PSMA4), transcript variant 2, mRNA. ACCESSION NM_001102667 VERSION NM_001102667.1 GI:156713441 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1159) AUTHORS Wang,J., Bansal,A.T., Martin,M., Germer,S., Benayed,R., Essioux,L., Lee,J.S., Begovich,A., Hemmings,A., Kenwright,A., Taylor,K.E., Upmanyu,R., Cutler,P., Harari,O., Marchini,J., Criswell,L.A. and Platt,A. TITLE Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis JOURNAL Pharmacogenomics J. 13 (3), 235-241 (2013) PUBMED 22491018 REFERENCE 2 (bases 1 to 1159) AUTHORS Hansen,H.M., Xiao,Y., Rice,T., Bracci,P.M., Wrensch,M.R., Sison,J.D., Chang,J.S., Smirnov,I.V., Patoka,J., Seldin,M.F., Quesenberry,C.P., Kelsey,K.T. and Wiencke,J.K. TITLE Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans JOURNAL Hum. Mol. Genet. 19 (18), 3652-3661 (2010) PUBMED 20587604 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (bases 1 to 1159) AUTHORS Amos,C.I., Gorlov,I.P., Dong,Q., Wu,X., Zhang,H., Lu,E.Y., Scheet,P., Greisinger,A.J., Mills,G.B. and Spitz,M.R. TITLE Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study JOURNAL J. Natl. Cancer Inst. 102 (15), 1199-1205 (2010) PUBMED 20554942 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 4 (bases 1 to 1159) AUTHORS Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N., Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y. TITLE Association of genetic variants with hemorrhagic stroke in Japanese individuals JOURNAL Int. J. Mol. Med. 25 (4), 649-656 (2010) PUBMED 20198315 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 5 (bases 1 to 1159) AUTHORS Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N., Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y. TITLE Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals JOURNAL Am. J. Hypertens. 23 (1), 70-77 (2010) PUBMED 19851296 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 6 (bases 1 to 1159) AUTHORS Castano,J.G., Mahillo,E., Arizti,P. and Arribas,J. TITLE Phosphorylation of C8 and C9 subunits of the multicatalytic proteinase by casein kinase II and identification of the C8 phosphorylation sites by direct mutagenesis JOURNAL Biochemistry 35 (12), 3782-3789 (1996) PUBMED 8619999 REFERENCE 7 (bases 1 to 1159) AUTHORS Kristensen,P., Johnsen,A.H., Uerkvitz,W., Tanaka,K. and Hendil,K.B. TITLE Human proteasome subunits from 2-dimensional gels identified by partial sequencing JOURNAL Biochem. Biophys. Res. Commun. 205 (3), 1785-1789 (1994) PUBMED 7811265 REMARK Erratum:[Biochem Biophys Res Commun. 1995 Feb 27;207(3):1059. PMID: 7864893] REFERENCE 8 (bases 1 to 1159) AUTHORS Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N., Yokoyama-Kobayashi,M. and Aoki,T. TITLE Construction of a human full-length cDNA bank JOURNAL Gene 150 (2), 243-250 (1994) PUBMED 7821789 REFERENCE 9 (bases 1 to 1159) AUTHORS Arribas,J., Arizti,P. and Castano,J.G. TITLE Antibodies against the C2 COOH-terminal region discriminate the active and latent forms of the multicatalytic proteinase complex JOURNAL J. Biol. Chem. 269 (17), 12858-12864 (1994) PUBMED 8175701 REFERENCE 10 (bases 1 to 1159) AUTHORS Tamura,T., Lee,D.H., Osaka,F., Fujiwara,T., Shin,S., Chung,C.H., Tanaka,K. and Ichihara,A. TITLE Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes) JOURNAL Biochim. Biophys. Acta 1089 (1), 95-102 (1991) PUBMED 2025653 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BG528289.1, BU930105.1, BG616186.1 and CD365826.1. Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG682177.1, BG616186.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025088 [ECO:0000348] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-32 BG528289.1 2-33 33-589 BU930105.1 1-557 590-723 BG616186.1 547-680 724-1159 CD365826.1 1-436 c FEATURES Location/Qualifiers source 1..1159 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="15" /map="15q25.1" gene 1..1159 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="proteasome (prosome, macropain) subunit, alpha type, 4" /db_xref="GeneID:5685" /db_xref="HGNC:9533" /db_xref="MIM:176846" exon 1..59 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 3 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:151040409" variation 9 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /db_xref="dbSNP:75609110" variation 46 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /db_xref="dbSNP:3813571" variation 55 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:371585497" exon 60..85 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 60 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:375114621" misc_feature 68..70 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="upstream in-frame stop codon" variation 70 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /db_xref="dbSNP:200532673" CDS 83..868 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /EC_number="3.4.25.1" /note="isoform 1 is encoded by transcript variant 2; proteasome component C9; proteasome subunit HC9; proteasome subunit L; macropain subunit C9; multicatalytic endopeptidase complex subunit C9; proteasome subunit alpha type-4" /codon_start=1 /product="proteasome subunit alpha type-4 isoform 1" /protein_id="NP_001096137.1" /db_xref="GI:156713442" /db_xref="CCDS:CCDS10303.1" /db_xref="GeneID:5685" /db_xref="HGNC:9533" /db_xref="MIM:176846" /translation="
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK
" misc_feature 83..793 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="proteasome subunit alpha; Provisional; Region: PTZ00246" /db_xref="CDD:173491" misc_feature 89..730 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="proteasome_alpha_type_4. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on...; Region: proteasome_alpha_type_4; cd03752" /db_xref="CDD:239721" misc_feature order(101..112,116..121,125..130,140..142,149..151, 158..163,170..172,194..196,239..241,245..250,320..328, 332..337,428..430,437..439,446..451,458..472,524..526, 539..544,548..550,554..559,563..565) /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="alpha subunit interaction site [polypeptide binding]; other site" /db_xref="CDD:239721" misc_feature 119..121 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P25789.1); phosphorylation site" misc_feature order(176..178,224..226,230..232,272..274,578..580) /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /note="active site" /db_xref="CDD:239721" misc_feature 305..307 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /experiment="experimental evidence, no additional details recorded" /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot (P25789.1); phosphorylation site" misc_feature 461..463 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P25789.1); acetylation site" misc_feature 608..610 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /experiment="experimental evidence, no additional details recorded" /note="N6-acetyllysine; propagated from UniProtKB/Swiss-Prot (P25789.1); acetylation site" exon 86..128 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 88 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="g" /replace="t" /db_xref="dbSNP:368498566" variation 100 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:17588" variation 105 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551783" variation 110 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551787" exon 129..291 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 175 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /db_xref="dbSNP:11551784" variation 197 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="g" /db_xref="dbSNP:11551779" variation 199 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551776" variation 230 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:149336836" variation 238 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="c" /db_xref="dbSNP:368528101" variation 268 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:11551775" variation 269 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:17352537" variation 287 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:143441800" exon 292..369 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 293 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="g" /replace="t" /db_xref="dbSNP:75116593" variation 301 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="g" /replace="t" /db_xref="dbSNP:183640841" variation 315 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551781" variation 322 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:11551786" variation 348 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551782" variation 367 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:200102081" exon 370..458 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 420 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:147984456" variation 421 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:11551774" exon 459..589 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 485 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="g" /db_xref="dbSNP:373384097" variation 550 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:377378619" variation 586 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:370716397" variation 587 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:147172987" exon 590..713 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" variation 592 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:140433184" exon 714..1144 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /inference="alignment:Splign:1.39.8" STS 765..902 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /standard_name="G62016" /db_xref="UniSTS:139094" variation 789 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="g" /replace="t" /db_xref="dbSNP:147521961" variation 802 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:8053" variation 831 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:113098925" variation 839 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:1065640" variation 851 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:201574707" variation 893 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="g" /db_xref="dbSNP:370714227" STS 899..1015 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /standard_name="WI-9202" /db_xref="UniSTS:30996" variation 901 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:111842716" STS 921..1079 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /standard_name="D15S636E" /db_xref="UniSTS:58748" variation 929 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:113789828" variation 935 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:1052035" variation 967 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:111362317" variation 970..971 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="" /replace="g" /db_xref="dbSNP:35919397" variation 1003 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="t" /db_xref="dbSNP:369831856" variation 1049 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="c" /replace="g" /db_xref="dbSNP:143345504" variation 1063 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:1052040" variation 1069 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:3206623" variation 1086 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="" /replace="t" /db_xref="dbSNP:113738721" variation 1137 /gene="PSMA4" /gene_synonym="HC9; HsT17706; PSC9" /replace="a" /replace="g" /db_xref="dbSNP:371007026" ORIGIN
cccgccccaacccagcggttctgcgcatgcgcgggggccatattagcagcggttattcggaactatataaagttcagaaaacatgtctcgaagatatgactccaggaccactatattttctccagaaggtcgcttataccaagttgaatatgccatggaagctattggacatgcaggcacctgtttgggaattttagcaaatgatggtgttttgcttgcagcagagagacgcaacatccacaagcttcttgatgaagtctttttttctgaaaaaatttataaactcaatgaggacatggcttgcagtgtggcaggcataacttctgatgctaatgttctgactaatgaactaaggctcattgctcaaaggtatttattacagtatcaggagccaataccttgtgagcagttggttacagcgctgtgtgatatcaaacaagcttatacacaatttggaggaaaacgtccctttggtgtttcattgctgtacattggctgggataagcactatggctttcagctctatcagagtgaccctagtggaaattacgggggatggaaggccacatgcattggaaataatagcgctgcagctgtgtcaatgttgaaacaagactataaagaaggagaaatgaccttgaagtcagcacttgctttagctatcaaagtactaaataagaccatggatgttagtaaactctctgctgaaaaagtggaaattgcaacactaacaagagagaatggaaagacagtaatcagagttctcaaacaaaaagaagtggagcagttgatcaaaaaacatgaggaagaagaagccaaagctgagcgtgagaagaaagaaaaagaacagaaagaaaaggataaatagaatcagagattttattactcatttggggcaccatttcagtgtaaaagcagtcctactcttccacactaggaaggctttactttttttaactggtgcagtgggaaaataggacattacatactgaattgggtccttgtcatttctgtccaattgaatactttattgtaacgatgatggttacccttcatggacgtcttaatcttccacacacatcccctttttttggaataaaatttggaaaatggaaatgaaggaataaattctctgtagcagtaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:5685 -> Molecular function: GO:0004298 [threonine-type endopeptidase activity] evidence: IEA GeneID:5685 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:5685 -> Biological process: GO:0000082 [G1/S transition of mitotic cell cycle] evidence: TAS GeneID:5685 -> Biological process: GO:0000209 [protein polyubiquitination] evidence: TAS GeneID:5685 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS GeneID:5685 -> Biological process: GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] evidence: TAS GeneID:5685 -> Biological process: GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] evidence: TAS GeneID:5685 -> Biological process: GO:0006521 [regulation of cellular amino acid metabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:5685 -> Biological process: GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] evidence: TAS GeneID:5685 -> Biological process: GO:0010467 [gene expression] evidence: TAS GeneID:5685 -> Biological process: GO:0016032 [viral process] evidence: TAS GeneID:5685 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:5685 -> Biological process: GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0034641 [cellular nitrogen compound metabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] evidence: TAS GeneID:5685 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: TAS GeneID:5685 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:5685 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS GeneID:5685 -> Biological process: GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5685 -> Biological process: GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5685 -> Biological process: GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle] evidence: TAS GeneID:5685 -> Cellular component: GO:0000502 [proteasome complex] evidence: TAS GeneID:5685 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: ISS GeneID:5685 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS GeneID:5685 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:5685 -> Cellular component: GO:0005839 [proteasome core complex] evidence: ISS GeneID:5685 -> Cellular component: GO:0019773 [proteasome core complex, alpha-subunit complex] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001096137 -> EC 3.4.25.1
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