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2024-04-20 02:55:20, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001100399 7190 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens PDS5, regulator of cohesion maintenance, homolog A (S.
cerevisiae) (PDS5A), transcript variant 1, mRNA.
ACCESSION NM_001100399
VERSION NM_001100399.1 GI:155030215
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7190)
AUTHORS Capalbo,G., Muller-Kuller,T., Ottmann,O.G., Hoelzer,D. and
Scheuring,U.J.
TITLE HIV-1 infection suppresses expression of host cell cycle-associated
gene PDS5A
JOURNAL Intervirology 55 (4), 263-275 (2012)
PUBMED 21865657
REMARK GeneRIF: The data show a downregulation of proliferation-associated
host gene PDS5A and suggest a role of PDS5A in HIV-1-induced
cellular pathogenesis but not viral replication.
REFERENCE 2 (bases 1 to 7190)
AUTHORS Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
TITLE Full-length transcriptome analysis of human retina-derived cell
lines ARPE-19 and Y79 using the vector-capping method
JOURNAL Invest. Ophthalmol. Vis. Sci. 52 (9), 6662-6670 (2011)
PUBMED 21697133
REMARK Publication Status: Online-Only
REFERENCE 3 (bases 1 to 7190)
AUTHORS Hagemann,C., Weigelin,B., Schommer,S., Schulze,M., Al-Jomah,N.,
Anacker,J., Gerngras,S., Kuhnel,S., Kessler,A.F., Polat,B.,
Ernestus,R.I., Patel,R. and Vince,G.H.
TITLE The cohesin-interacting protein, precocious dissociation of sisters
5A/sister chromatid cohesion protein 112, is up-regulated in human
astrocytic tumors
JOURNAL Int. J. Mol. Med. 27 (1), 39-51 (2011)
PUBMED 21069257
REMARK GeneRIF: Data show that the siRNA-mediated knockdown of Pds5A
affects sister chromatid cohesion but does not influence mitotic
checkpoint function or the proliferation and survival of
glioblastoma multiforme cells.
REFERENCE 4 (bases 1 to 7190)
AUTHORS Terret,M.E., Sherwood,R., Rahman,S., Qin,J. and Jallepalli,P.V.
TITLE Cohesin acetylation speeds the replication fork
JOURNAL Nature 462 (7270), 231-234 (2009)
PUBMED 19907496
REFERENCE 5 (bases 1 to 7190)
AUTHORS Zhang,H., Liu,Y., Wang,Y., Li,G., Luo,Z., Jiang,Pf., Li,F., Wang,S.
and Deng,K.
TITLE [Analysis of deafness gene mutations by gene chip and its clinical
significance]
JOURNAL Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23 (22), 1032-1035
(2009)
PUBMED 20359100
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 6 (bases 1 to 7190)
AUTHORS Losada,A., Yokochi,T. and Hirano,T.
TITLE Functional contribution of Pds5 to cohesin-mediated cohesion in
human cells and Xenopus egg extracts
JOURNAL J. Cell. Sci. 118 (PT 10), 2133-2141 (2005)
PUBMED 15855230
REFERENCE 7 (bases 1 to 7190)
AUTHORS Rankin,S., Ayad,N.G. and Kirschner,M.W.
TITLE Sororin, a substrate of the anaphase-promoting complex, is required
for sister chromatid cohesion in vertebrates
JOURNAL Mol. Cell 18 (2), 185-200 (2005)
PUBMED 15837422
REMARK Erratum:[Mol Cell. 2005 May 27;18(5):609]
REFERENCE 8 (bases 1 to 7190)
AUTHORS Kumar,D., Sakabe,I., Patel,S., Zhang,Y., Ahmad,I., Gehan,E.A.,
Whiteside,T.L. and Kasid,U.
TITLE SCC-112, a novel cell cycle-regulated molecule, exhibits reduced
expression in human renal carcinomas
JOURNAL Gene 328, 187-196 (2004)
PUBMED 15019998
REMARK GeneRIF: Findings suggest that the SCC-112 gene expression is
likely to be associated with normal cell growth and proliferation.
REFERENCE 9 (bases 1 to 7190)
AUTHORS Gregson,H.C., Schmiesing,J.A., Kim,J.S., Kobayashi,T., Zhou,S. and
Yokomori,K.
TITLE A potential role for human cohesin in mitotic spindle aster
assembly
JOURNAL J. Biol. Chem. 276 (50), 47575-47582 (2001)
PUBMED 11590136
REFERENCE 10 (bases 1 to 7190)
AUTHORS Sumara,I., Vorlaufer,E., Gieffers,C., Peters,B.H. and Peters,J.M.
TITLE Characterization of vertebrate cohesin complexes and their
regulation in prophase
JOURNAL J. Cell Biol. 151 (4), 749-762 (2000)
PUBMED 11076961
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC041361.1, AC098591.4 and
BC114218.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The protein encoded by this gene binds to the cohesin
complex and associates with chromatin through most of the cell
cycle. The encoded protein may play a role in regulating sister
chromatid cohesion during mitosis. Two transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq, May 2010].
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC114218.1, AB621803.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-92 BC041361.1 5-96
93-93 AC098591.4 27340-27340 c
94-316 BC041361.1 98-320
317-5067 BC114218.1 13-4763
5068-7190 BC114218.1 4765-6887
FEATURES Location/Qualifiers
source 1..7190
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="4"
/map="4p14"
gene 1..7190
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/note="PDS5, regulator of cohesion maintenance, homolog A
(S. cerevisiae)"
/db_xref="GeneID:23244"
/db_xref="HGNC:29088"
/db_xref="MIM:613200"
exon 1..500
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 501..678
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
misc_feature 508..510
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/note="upstream in-frame stop codon"
CDS 541..4554
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/note="isoform 1 is encoded by transcript variant 1;
sister chromatid cohesion protein PDS5 homolog A; sister
chromatid cohesion protein 112; cell
proliferation-inducing gene 54 protein"
/codon_start=1
/product="sister chromatid cohesion protein PDS5 homolog A
isoform 1"
/protein_id="NP_001093869.1"
/db_xref="GI:155030216"
/db_xref="CCDS:CCDS47045.1"
/db_xref="GeneID:23244"
/db_xref="HGNC:29088"
/db_xref="MIM:613200"
/translation="
MDFTAQPKPATALCGVVSADGKIAYPPGVKEITDKITTDEMIKRLKMVVKTFMDMDQDSEDEKQQYLPLALHLASEFFLRNPNKDVRLLVACCLADIFRIYAPEAPYTSHDKLKDIFLFITRQLKGLEDTKSPQFNRYFYLLENLAWVKSYNICFELEDCNEIFIQLFRTLFSVINNSHNKKVQMHMLDLMSSIIMEGDGVTQELLDSILINLIPAHKNLNKQSFDLAKVLLKRTVQTIEACIANFFNQVLVLGRSSVSDLSEHVFDLIQELFAIDPHLLLSVMPQLEFKLKSNDGEERLAVVRLLAKLFGSKDSDLATQNRPLWQCFLGRFNDIHVPVRLESVKFASHCLMNHPDLAKDLTEYLKVRSHDPEEAIRHDVIVTIITAAKRDLALVNDQLLGFVRERTLDKRWRVRKEAMMGLAQLYKKYCLHGEAGKEAAEKVSWIKDKLLHIYYQNSIDDKLLVEKIFAQYLVPHNLETEERMKCLYYLYASLDPNAVKALNEMWKCQNMLRSHVRELLDLHKQPTSEANCSAMFGKLMTIAKNLPDPGKAQDFVKKFNQVLGDDEKLRSQLELLISPTCSCKQADICVREIARKLANPKQPTNPFLEMVKFLLERIAPVHIDSEAISALVKLMNKSIEGTADDEEEGVSPDTAIRSGLELLKVLSFTHPTSFHSAETYESLLQCLRMEDDKVAEAAIQIFRNTGHKIETDLPQIRSTLIPILHQKAKRGTPHQAKQAVHCIHAIFTNKEVQLAQIFEPLSRSLNADVPEQLITPLVSLGHISMLAPDQFASPMKSVVANFIVKDLLMNDRSTGEKNGKLWSPDEEVSPEVLAKVQAIKLLVRWLLGMKNNQSKSANSTLRLLSAMLVSEGDLTEQKRISKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAGAENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAERQIDLQR
"
misc_feature 1717..1827
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q29RF7.1);
Region: HEAT"
misc_feature 3976..3978
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q29RF7.1); acetylation site"
misc_feature 4123..4125
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q29RF7.1); phosphorylation site"
misc_feature 4162..4164
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (Q29RF7.1); phosphorylation site"
misc_feature 4171..4173
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q29RF7.1); acetylation site"
misc_feature 4408..4410
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine; propagated from
UniProtKB/Swiss-Prot (Q29RF7.1); acetylation site"
misc_feature 4453..4455
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q29RF7.1); phosphorylation site"
exon 679..882
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 883..969
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 970..1067
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1068..1194
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1195..1275
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1276..1416
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1417..1532
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1533..1627
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1628..1773
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1774..1925
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 1926..2039
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2040..2121
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2122..2170
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2171..2310
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2311..2426
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2427..2532
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2533..2693
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2694..2817
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2818..2976
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 2977..3045
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3046..3182
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3183..3306
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3307..3511
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3512..3626
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3627..3759
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3760..3879
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3880..3942
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 3943..4088
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 4089..4197
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 4198..4550
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
exon 4551..7176
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/inference="alignment:Splign:1.39.8"
polyA_signal 5214..5219
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
polyA_site 5237
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
STS 5375..5566
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/standard_name="SHGC-59611"
/db_xref="UniSTS:21735"
STS 5463..5590
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/standard_name="STS-H01326"
/db_xref="UniSTS:27352"
variation 5660
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/replace="a"
/replace="c"
/db_xref="dbSNP:1046817"
polyA_signal 5702..5707
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
polyA_site 5722
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
variation 5783
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/replace="c"
/replace="t"
/db_xref="dbSNP:11538741"
polyA_signal 6606..6611
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
polyA_site 6637
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
STS 6919..7098
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/standard_name="RH128590"
/db_xref="UniSTS:211898"
STS 7035..7163
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
/standard_name="WI-15044"
/db_xref="UniSTS:40536"
polyA_signal 7152..7157
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
polyA_site 7176
/gene="PDS5A"
/gene_synonym="PIG54; SCC-112; SCC112"
ORIGIN
ggccggcggaggaaggggagggagcgaggagcgcgcgctgctctcgcgtgctctcgcgccgctcgcgtgaccggccggtgtgtgcgcgaggccccggctcccggggcacggacggccgggcgcgcgcctctgcgaggggcgtccgggtccgagtcggcggtccgggccggcgcgaggtgcgtgcgggcgggccgcgggggtcccggacggacacaagcgcacacactcccggaggagccttcgaggctgctcttcctcggccagacggagagcggcactgtctccccgcccagcgctcactcgccccgcgtctccccccgcggcggctgctcctcctcggcaccgccagccccagcgccgctcccgggcgggcgggcggcggcggcggcggcggcgggacccgcggagccgctttgtgtgcagcccgactaggggcggcggcgcaaccacctgacagaggcccgggcgctcgatgcaccttccgcccgcatgaggaggagaggccggtagaggactgtgaaccaaaagttgtcccccaggatggacttcaccgcgcagcccaagcctgccactgccctctgtggcgtcgtgagtgccgacgggaagatcgcttaccctccgggggtaaaagagatcaccgacaagatcaccacggacgagatgatcaaacgcctgaagatggtagtgaaaacctttatggatatggatcaggactcagaagatgaaaaacagcagtatctcccactagccttgcatcttgcatctgaattcttcctcaggaaccccaataaagatgtgcgtctccttgtagcatgttgtttggctgatatctttcgtatctatgccccagaagctccatatacttcccatgataaacttaaggacatatttttgtttattaccagacaattaaaaggtttggaggatacaaagagtccacagtttaatagatacttttatttattagagaatttagcttgggttaaatcatataacatctgctttgaattggaagattgcaatgaaatttttattcagctttttagaactctcttctcagtgatcaacaatagccacaataagaaggtacaaatgcacatgctagatttgatgagttctatcatcatggaaggtgatggagttactcaagaattattggactccattcttattaacctcattcctgcacataagaacttaaataaacagtcctttgaccttgcaaaagtgctattgaaaagaacagtccagactattgaggcatgcattgctaattttttcaatcaagtcctggtgctgggaagatcatcagtaagtgatttgtcagaacatgtatttgatctgattcaggaactttttgctatagatcctcatttattattatccgtcatgccacagcttgaattcaaactaaagagcaatgatggagaagagcgattagctgttgttcgacttctagctaaattgtttggctccaaagattctgatttggcaacacagaatcgtcctctttggcaatgttttcttggacgatttaatgatattcatgttcctgtgagattagaaagtgtgaaatttgccagtcattgtttaatgaatcacccagatttagcgaaggatctcacagaatatttaaaggttagatcacatgatccagaagaagctattcgtcatgatgtcattgttactataataacagctgccaagagggacctggccttagtaaatgatcagctgcttggctttgtaagggaaagaacactggataaacggtggcgagtaagaaaagaagctatgatgggtctggctcagctttataagaaatactgtcttcatggtgaagcaggaaaggaagctgcagagaaagtcagctggataaaggacaaacttctgcatatttattatcagaacagcattgacgacaaactgttggtagagaaaatctttgctcagtatcttgtcccccacaacctggaaacagaagagagaatgaaatgcttatattacttatatgctagtttggatccaaatgctgtaaaagctctcaacgaaatgtggaagtgtcagaacatgcttcggagccatgtacgcgaactattggatttgcacaagcagcctacatcagaggctaactgttctgccatgtttggaaaactgatgaccatagcaaagaatttgcctgaccccgggaaagcacaagattttgtgaagaaatttaaccaggttctcggcgatgatgagaaacttcggtctcagttggagttattaattagcccaacctgttcttgcaaacaagcagatatttgtgtgagagaaatagcccggaaacttgcaaatcctaagcaaccaacaaatccttttctagagatggtcaaatttctgttggaaagaatcgcacctgtgcacattgattcagaagccataagtgcactagtgaaattgatgaataagtcaatagaggggacagcagatgatgaagaggagggtgtaagtccagatacagctatccgttcaggacttgaacttcttaaggttctgtcttttacacatcctacctcgttccactctgcagagacatatgagtccttgttacagtgcctaagaatggaggatgacaaggtagcagaagctgctattcaaatttttagaaatacaggtcacaaaatagaaacagaccttccccagatacgatcgaccttaattcccattttacatcaaaaagcaaagaggggtactccacaccaagcaaaacaggctgtgcactgtatacacgccatattcacaaataaagaagtccagcttgcacagatttttgagccactcagtaggagtctgaatgctgatgtgccagaacaacttataactccattagtttcattgggccacatttctatgttagcaccagatcagtttgcttccccaatgaaatctgtagtagcaaattttattgtgaaagatctgctaatgaatgacaggtcaacaggtgaaaagaatggaaaactgtggtctccagatgaagaggtttcccctgaagtactagcaaaggtacaggcaattaaacttctggtaaggtggctgttgggtatgaaaaacaaccagtctaaatctgccaattcaacccttcggttattatcagcgatgttggttagtgagggtgacctgacagagcaaaagaggatcagtaaatctgatatgtctcgcttgcgattagctgctggtagtgccataatgaagcttgctcaggaaccttgttaccatgaaattattaccccagaacagtttcagctctgtgcacttgttattaatgatgagtgttaccaagtaaggcagatatttgctcagaagctgcataaggcacttgtgaagttactgctcccattggagtatatggcgatctttgccttgtgtgccaaagatcctgtgaaggagagaagagcacacgcacgacaatgtttactgaaaaatatcagtatacgcagggaatacattaagcagaatcctatggctactgagaaattattatcactgttgcctgaatatgtagttccatacatgattcacctgctagcccatgatccagattttacaagatcacaagatgttgatcagcttcgtgatatcaaagagtgcctatggttcatgcttgaagttttaatgacaaagaatgaaaacaatagccatgcctttatgaagaagatggcagagaacatcaagttaaccagagatgcccagtctccagatgaatccaagacaaatgaaaaactgtatacagtatgtgatgtggctctctgtgttataaatagtaaaagtgctttgtgcaatgcagattcaccaaaggacccagtcctcccaatgaaattttttacacaacctgaaaaggacttctgtaacgataagagttatatttcagaagagacaagagtacttctgttaacaggaaagccaaagcctgctggagtactaggtgcagtaaataagcctttatcagcaacgggaaggaaaccctatgttagaagcactggcactgagactggaagcaatattaatgtaaattcagagctgaacccttcaaccggaaatcgatcaagggaacagagttcagaggcagcagaaactggagttagtgaaaatgaagagaaccctgtgaggattatttcagtcacacctgtaaagaatattgacccagtaaagaataaggaaattaattctgatcaggctacccagggcaacatcagcagtgaccgaggaaagaaaagaacagtaacagcagctggtgcagagaatatccaacaaaaaacagatgagaaagtagatgaatcgggacctcccgccccttccaaacccaggagaggacgtcgacccaagtctgaatctcagggcaatgctaccaaaaatgatgatctaaataaacctattaacaagggaaggaagagagctgcagtgggtcaggagagccctgggggtttggaagcaggtaatgccaaagcacccaaactgcaagatttagccaaaaaggcagcaccagcagaaagacaaattgacttacaaaggtaaaaatgcatttgcaaagggagaaaatgaaggccaaacagaagcaggctccagcttctgcaaaaacttggattcacaaatgtccctgaacagaaaatgaagctcacttcagaacacacactctctgccttgaaaactaaagagactattacttccttttcacatgaccacaagtcctctgatggaaatgtacagcagaaactcttgagagagaggctaaaagcaactctgttctcccccttcccctagacttttcttacgaaaagtcaataattaagcaaattgcttaacacttggttccagttcctgcctatctggagtttaaatgcgtaatacaccattaatttccacgctgcagtttttattttaaagaaagtaacaagatgtctttacactgacactgaaaattcatccattttagagccaggaattcccatgttacacaggaaaaaatagaagtctactgaattaattttttaaaagaaaagagatcagattaaatatttctttgtttttccttttggaaacttttatgtataattctttctgcctgcctacttttctgcaaaaatgagatgtacagatttcggttccctgctatgaaaagtgatgtggtagcaattttataaatgttgctttctgatttttatcagagtgagaaaattaaaattattgatttgcaagtagtaaacagttcatattttgatttcccctcattttagtttaatataatttgcaataaatgtacatattgttgtttgtttcataaagcatatcactttaaaatggtttttactcctgtgattatgttggaatatttggaattttaaaggagtaaagactgtccagcatttggttttataatgtttgtcaccagatttttattaatgtaaaaaaaatcaatttttaaaaaatagttggactttggcagcttttaaggaaagttggaggtgttttaggattgctatcaattttcagcattgtgctatttggaaataagtgttttgcttttgtctgatggtctgggctcatttttatgtttattttagaaaactgttgcatcaatatattatgtttcttggcattgttcagcataggtaatgtgtgcactttatgtgtacacataatcatatttaagttttttgcataaaataaatgcttctagatgtcatggcagtctttttaatctttttatcatatgctttcttgtgaattttttcatgttaaagagctaaagtcataacatgattacagtcaactctccattatctatataaaatagtgactaagcctcaggtttttaattttgtgataacaaaataacgaaggcatgtaagacctgattctggaggaacatgaaatttgtcttttctcatgtccagagttctatcctgcccccactgtccactgtagggtcatccgcaaagccctagcagaatgtgctcactccatttccttacacgtttctagcatgggtcagaggaaacaacatttgtgttataacttcgtcttgataggctgtagtgtacatgggatgtaaaacaaacaagtgtatcaaaggtggatgattctgttagagtgaagtttgagagtaaatgtcacttacgtttctcatagataatcaagagttggctgtgtattgactgaaagatgggtaattattttaaatatgcatttacacacatttaggtatcagaagatgcttagggaacaatggataccaatgatagaaaatgatacctttacaggggcagaaaaatccccactcttccttattgcctcttcagaaccctttagaaagtataaaatattgcctccaacatgctgaaaaagagtatctatgcataagtatcagagaagtccctcaagcaatcagtaggtgtgttctatttagagagagtttaaagttctcttagcatcagacaacttgattcctaaggtttccagtgtgtcaccaacaaaaagtgcattgatagggacctttgtctcttcctccctttgattaattgcccggcatcacagtttactagattaccaagtgttacatcatattaaataaaatgtagcagaaccatctgcatcaatatattcctgtttagatttttgcaggagagaagttaaaaggatttgctccttgtatgatgtaagtggcccaccccaattttgtaacatgatgcaagtgtctggcactaagggaagcaagagtagggttgtggaaagaccaagctgatggggagggacttgtttacgggaatttttttagttttccttttcaaaggaaaacattaaaatcccttaggaatttggtattcacatctcagagaactacaacacaaaagtgcagacttatatttgagaattaatgttaaccctttgtgtctagtttgaagcttcttgtatttgtctaaaacaacaagccagaattttgtatctcctttgataaaaagtgtgtataatgtaaagtagttttgcatattcttgtgctgcacatgggctgaatttttaaattttttttaaaaacttgaagcagaaccttgtaatttgtgtaaatgacaagtgtaaaatcctaccataaaatgctaaaaatatgcactgtttcaaataaaaccaagaaatgcagcattaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23244 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23244 -> Biological process: GO:0000278 [mitotic cell cycle] evidence: TAS
GeneID:23244 -> Biological process: GO:0000910 [cytokinesis] evidence: TAS
GeneID:23244 -> Biological process: GO:0007067 [mitosis] evidence: IEA
GeneID:23244 -> Biological process: GO:0008156 [negative regulation of DNA replication] evidence: IMP
GeneID:23244 -> Cellular component: GO:0000775 [chromosome, centromeric region] evidence: TAS
GeneID:23244 -> Cellular component: GO:0000785 [chromatin] evidence: IDA
GeneID:23244 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:23244 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
GeneID:23244 -> Cellular component: GO:0005694 [chromosome] evidence: TAS
GeneID:23244 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:23244 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:23244 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
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