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2024-04-19 08:31:36, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001099431 883 bp mRNA linear PRI 19-MAY-2013
DEFINITION Homo sapiens C-type lectin domain family 1, member B (CLEC1B),
transcript variant 2, mRNA.
ACCESSION NM_001099431
VERSION NM_001099431.1 GI:153252047
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 883)
AUTHORS Manne,B.K., Getz,T.M., Hughes,C.E., Alshehri,O., Dangelmaier,C.,
Naik,U.P., Watson,S.P. and Kunapuli,S.P.
TITLE Fucoidan is a novel platelet agonist for the C-type lectin-like
receptor 2 (CLEC-2)
JOURNAL J. Biol. Chem. 288 (11), 7717-7726 (2013)
PUBMED 23341451
REMARK GeneRIF: fucoidan is a novel CLEC-2 receptor agonist that activates
platelets through a SFK-dependent signaling pathway
REFERENCE 2 (bases 1 to 883)
AUTHORS Hughes,C.E., Sinha,U., Pandey,A., Eble,J.A., O'Callaghan,C.A. and
Watson,S.P.
TITLE Critical Role for an acidic amino acid region in platelet signaling
by the HemITAM (hemi-immunoreceptor tyrosine-based activation
motif) containing receptor CLEC-2 (C-type lectin receptor-2)
JOURNAL J. Biol. Chem. 288 (7), 5127-5135 (2013)
PUBMED 23264619
REMARK GeneRIF: Dimerization of two phosphorylated CLEC-2 molecules leads
to recruitment of the tyrosine kinase Syk via its tandem SH2
domains and initiation of a downstream signaling cascade
REFERENCE 3 (bases 1 to 883)
AUTHORS Parguina,A.F., Alonso,J., Rosa,I., Velez,P., Gonzalez-Lopez,M.J.,
Guitian,E., Ebble,J.A., Loza,M.I. and Garcia,A.
TITLE A detailed proteomic analysis of rhodocytin-activated platelets
reveals novel clues on the CLEC-2 signalosome: implications for
CLEC-2 signaling regulation
JOURNAL Blood 120 (26), E117-E126 (2012)
PUBMED 23053573
REMARK GeneRIF: A differential proteomic analysis of basal and
rhodocytin-activated platelets with the aim of providing novel
clues on CLEC-2 signaling regulation.
REFERENCE 4 (bases 1 to 883)
AUTHORS Wang,L., Ren,S., Zhu,H., Zhang,D., Hao,Y., Ruan,Y., Zhou,L.,
Lee,C., Qiu,L., Yun,X. and Xie,J.
TITLE Structural and functional conservation of CLEC-2 with the
species-specific regulation of transcript expression in evolution
JOURNAL Glycoconj. J. 29 (5-6), 335-345 (2012)
PUBMED 22740230
REMARK GeneRIF: The glycosylation sites (N120 and N134) are necessary for
the surface expression of CLEC-2.
REFERENCE 5 (bases 1 to 883)
AUTHORS Fei,M., Zhou,L., Xie,J., Ruan,Y., Xu,J., He,S., Shen,H., Hu,Y.,
Ren,S. and Ruan,C.
TITLE The production of soluble C-type lectin-like receptor 2 is a
regulated process
JOURNAL Glycoconj. J. 29 (5-6), 315-321 (2012)
PUBMED 22736279
REMARK GeneRIF: Shedding of CLEC-2 from the cell surface may reflect
increased expression of this membrane protein and serve as a marker
of disease activity.
REFERENCE 6 (bases 1 to 883)
AUTHORS Chaipan,C., Soilleux,E.J., Simpson,P., Hofmann,H., Gramberg,T.,
Marzi,A., Geier,M., Stewart,E.A., Eisemann,J., Steinkasserer,A.,
Suzuki-Inoue,K., Fuller,G.L., Pearce,A.C., Watson,S.P., Hoxie,J.A.,
Baribaud,F. and Pohlmann,S.
TITLE DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1
capture by platelets
JOURNAL J. Virol. 80 (18), 8951-8960 (2006)
PUBMED 16940507
REMARK GeneRIF: platelets capture and transfer infectious HIV-1 via
DC-SIGN and CLEC-2, thereby possibly facilitating HIV-1
dissemination in infected patients
REFERENCE 7 (bases 1 to 883)
AUTHORS Suzuki-Inoue,K., Fuller,G.L., Garcia,A., Eble,J.A., Pohlmann,S.,
Inoue,O., Gartner,T.K., Hughan,S.C., Pearce,A.C., Laing,G.D.,
Theakston,R.D., Schweighoffer,E., Zitzmann,N., Morita,T.,
Tybulewicz,V.L., Ozaki,Y. and Watson,S.P.
TITLE A novel Syk-dependent mechanism of platelet activation by the
C-type lectin receptor CLEC-2
JOURNAL Blood 107 (2), 542-549 (2006)
PUBMED 16174766
REFERENCE 8 (bases 1 to 883)
AUTHORS Watson,A.A. and O'Callaghan,C.A.
TITLE Crystallization and X-ray diffraction analysis of human CLEC-2
JOURNAL Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (PT 12),
1094-1096 (2005)
PUBMED 16511244
REMARK GeneRIF: X-ray diffraction analysis of human CLEC-2
REFERENCE 9 (bases 1 to 883)
AUTHORS Sobanov,Y., Bernreiter,A., Derdak,S., Mechtcheriakova,D.,
Schweighofer,B., Duchler,M., Kalthoff,F. and Hofer,E.
TITLE A novel cluster of lectin-like receptor genes expressed in
monocytic, dendritic and endothelial cells maps close to the NK
receptor genes in the human NK gene complex
JOURNAL Eur. J. Immunol. 31 (12), 3493-3503 (2001)
PUBMED 11745369
REFERENCE 10 (bases 1 to 883)
AUTHORS Colonna,M., Samaridis,J. and Angman,L.
TITLE Molecular characterization of two novel C-type lectin-like
receptors, one of which is selectively expressed in human dendritic
cells
JOURNAL Eur. J. Immunol. 30 (2), 697-704 (2000)
PUBMED 10671229
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC029554.1, AC091814.10 and AY358599.1.
Summary: Natural killer (NK) cells express multiple
calcium-dependent (C-type) lectin-like receptors, such as CD94
(KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact
with major histocompatibility complex class I molecules and either
inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a
C-type lectin-like receptor expressed in myeloid cells and NK cells
(Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan
2011].
Transcript Variant: This variant (2) lacks an alternate in-frame
exon in the 5' coding region, compared to variant 1, resulting in a
shorter protein (isoform b), compared to isoform a.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BX647321.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-137 BC029554.1 71-207
138-257 BC029554.1 209-328
258-258 AC091814.10 11405-11405
259-291 BC029554.1 330-362
292-292 AC091814.10 13196-13196
293-883 AY358599.1 373-963
FEATURES Location/Qualifiers
source 1..883
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13.2"
gene 1..883
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/note="C-type lectin domain family 1, member B"
/db_xref="GeneID:51266"
/db_xref="HGNC:24356"
/db_xref="MIM:606783"
exon 1..264
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/inference="alignment:Splign:1.39.8"
misc_feature 135..137
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/note="upstream in-frame stop codon"
CDS 201..791
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/note="isoform b is encoded by transcript variant 2;
C-type lectin-like receptor-2; CLEC-2; C-type lectin-like
receptor 2"
/codon_start=1
/product="C-type lectin domain family 1 member B isoform
b"
/protein_id="NP_001092901.1"
/db_xref="GI:153252048"
/db_xref="CCDS:CCDS41751.1"
/db_xref="GeneID:51266"
/db_xref="HGNC:24356"
/db_xref="MIM:606783"
/translation="
MQDEDGYITLNIKTRKPALISAVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP
"
misc_feature 405..755
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/note="C-type lectin-like domain (CTLD) of the type found
in natural killer cell receptors (NKRs); Region:
CLECT_NK_receptors_like; cd03593"
/db_xref="CDD:153063"
misc_feature order(567..569,651..653,705..707,711..716)
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/note="ligand binding surface [chemical binding]; other
site"
/db_xref="CDD:153063"
variation 258
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/replace="a"
/replace="g"
/db_xref="dbSNP:612593"
exon 265..384
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/inference="alignment:Splign:1.39.8"
variation 292
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/replace="a"
/replace="g"
/db_xref="dbSNP:583903"
exon 385..539
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/inference="alignment:Splign:1.39.8"
exon 540..646
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/inference="alignment:Splign:1.39.8"
exon 647..873
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/inference="alignment:Splign:1.39.8"
variation 802
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
/replace="a"
/replace="t"
/db_xref="dbSNP:15635"
polyA_signal 837..842
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
polyA_site 859
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
polyA_site 873
/gene="CLEC1B"
/gene_synonym="1810061I13Rik; CLEC2; CLEC2B; PRO1384;
QDED721"
ORIGIN
gtccatgtatctctgagcagctatgaagaagcttcctggaaaacaataagcaaaggaaaacaaatgtgtcccatctcacatggttctaccctactaaagacaggaagatcataaactgacagatactgaaattgtaaagttggaaactacattttgcaaagtcattgaactctgagctcagttgcagtactcgggaagccatgcaggatgaagatggatacatcaccttaaatattaaaactcggaaaccagctctcatctccgctgtcatgcagcgcaattacctacaaggtgagaatgaaaatcgcacaggaactctgcaacaattagcaaagcgcttctgtcaatatgtggtaaaacaatcagaactaaagggcactttcaaaggtcataaatgcagcccctgtgacacaaactggagatattatggagatagctgctatgggttcttcaggcacaacttaacatgggaagagagtaagcagtactgcactgacatgaatgctactctcctgaagattgacaaccggaacattgtggagtacatcaaagccaggactcatttaattcgttgggtcggattatctcgccagaagtcgaatgaggtctggaagtgggaggatggctcggttatctcagaaaatatgtttgagtttttggaagatggaaaaggaaatatgaattgtgcttattttcataatgggaaaatgcaccctaccttctgtgagaacaaacattatttaatgtgtgagaggaaggctggcatgaccaaggtggaccaactaccttaatgcaaagaggtggacaggataacacagataagggctttattgtacaataaaagatatgtatgaatgcatcagtagctgaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:51266 -> Molecular function: GO:0004888 [transmembrane signaling receptor activity] evidence: TAS
GeneID:51266 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:51266 -> Molecular function: GO:0030246 [carbohydrate binding] evidence: IEA
GeneID:51266 -> Biological process: GO:0006952 [defense response] evidence: TAS
GeneID:51266 -> Biological process: GO:0007166 [cell surface receptor signaling pathway] evidence: TAS
GeneID:51266 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: IEA
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@meso_cacase at
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