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2019-03-25 15:14:40, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001098814            4219 bp    mRNA    linear   PRI 15-JUN-2013
DEFINITION  Homo sapiens sarcalumenin (SRL), mRNA.
ACCESSION   NM_001098814 XM_064152 XM_942054
VERSION     NM_001098814.1  GI:149363671
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4219)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS ONE 7 (12), E51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 4219)
  AUTHORS   Lanfranchi,G., Muraro,T., Caldara,F., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Toppo,S., Trevisan,S., Scarso,S. and Valle,G.
  TITLE     Identification of 4370 expressed sequence tags from a
            3'-end-specific cDNA library of human skeletal muscle by DNA
            sequencing and filter hybridization
  JOURNAL   Genome Res. 6 (1), 35-42 (1996)
   PUBMED   8681137
REFERENCE   3  (bases 1 to 4219)
  AUTHORS   Leberer,E., Charuk,J.H., Green,N.M. and MacLennan,D.H.
  TITLE     Molecular cloning and expression of cDNA encoding a lumenal calcium
            binding glycoprotein from sarcoplasmic reticulum
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 86 (16), 6047-6051 (1989)
   PUBMED   2762314
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB149163.1, AL831973.2, AK056588.1, AL832361.1, DA563862.1 and
            F26773.1.
            On or before Jun 26, 2007 this sequence version replaced
            gi:113425877, gi:113426305.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056588.1, AL831973.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DB149163.1         1-28
            29-459              AL831973.2         1-431
            460-483             AK056588.1         460-483
            484-566             DB149163.1         484-566
            567-1259            AL831973.2         539-1231
            1260-1573           AL832361.1         2632-2945
            1574-2487           AL831973.2         1547-2460
            2488-2681           AL832361.1         3860-4053
            2682-2936           DA563862.1         307-561
            2937-3092           AL831973.2         2910-3065
            3093-3762           AK056588.1         1437-2106
            3763-4211           AL831973.2         3736-4184
            4212-4219           F26773.1           322-329
FEATURES             Location/Qualifiers
     source          1..4219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..4219
                     /gene="SRL"
                     /note="sarcalumenin"
                     /db_xref="GeneID:6345"
                     /db_xref="HGNC:11295"
                     /db_xref="MIM:604992"
     exon            1..74
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     CDS             14..1435
                     /gene="SRL"
                     /codon_start=1
                     /product="sarcalumenin precursor"
                     /protein_id="NP_001092284.1"
                     /db_xref="GI:149363672"
                     /db_xref="CCDS:CCDS42113.1"
                     /db_xref="GeneID:6345"
                     /db_xref="HGNC:11295"
                     /db_xref="MIM:604992"
                     /translation="
MRALVLLGCLLASLLFSGQAEETEDANEEAPLRDRSHIEKTLMLNEDKPSDDYSAVLQRLRKIYHSSIKPLEQSYKYNELRQHEITDGEITSKPMVLFLGPWSVGKSTMINYLLGLENTRYQLYTGAEPTTSEFTVLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLIGIEVPHKLLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEMLFRQLKGRESQIRIILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQEYKPDTHQELFLQEEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFKDIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISSFKLLSQQCSYMGGCFLEKIERAITQELPGLLGSLGLGKNPGALNCDKTGCSETPKNRYRKH
"
     sig_peptide     14..73
                     /gene="SRL"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    296..1021
                     /gene="SRL"
                     /note="Eps15 homology domain (EHD), C-terminal domain;
                     Region: EHD; cd09913"
                     /db_xref="CDD:206740"
     misc_feature    299..784
                     /gene="SRL"
                     /note="Dynamin family; Region: Dynamin_N; pfam00350"
                     /db_xref="CDD:201172"
     misc_feature    311..334
                     /gene="SRL"
                     /note="G1 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(326..337,581..583,779..781,785..787,887..895)
                     /gene="SRL"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206740"
     misc_feature    404..406
                     /gene="SRL"
                     /note="G2 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    416..424
                     /gene="SRL"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206740"
     misc_feature    581..592
                     /gene="SRL"
                     /note="G3 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    order(587..592,668..673)
                     /gene="SRL"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206740"
     misc_feature    776..787
                     /gene="SRL"
                     /note="G4 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    854..856
                     /gene="SRL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
                     /citation=[3]
     misc_feature    887..895
                     /gene="SRL"
                     /note="G5 box; other site"
                     /db_xref="CDD:206740"
     misc_feature    1178..1180
                     /gene="SRL"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="glycosylation site"
                     /citation=[3]
     exon            75..176
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     exon            177..272
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     exon            273..389
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     exon            390..623
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     exon            624..4214
                     /gene="SRL"
                     /inference="alignment:Splign:1.39.8"
     STS             846..1493
                     /gene="SRL"
                     /standard_name="SRL__5315"
                     /db_xref="UniSTS:463911"
     variation       1490
                     /gene="SRL"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:251787"
     STS             2063..2149
                     /gene="SRL"
                     /standard_name="D8S2279"
                     /db_xref="UniSTS:473907"
     variation       2378
                     /gene="SRL"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:200621667"
     variation       2682
                     /gene="SRL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2240668"
     variation       3798
                     /gene="SRL"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369466725"
     STS             3955..4077
                     /gene="SRL"
                     /standard_name="RH102371"
                     /db_xref="UniSTS:96705"
     polyA_signal    4191..4196
                     /gene="SRL"
ORIGIN      
cttggcagtcaccatgagggcgctggtcctgctcggctgcctcctggcctcgctcctgttctcaggacaagcagaagagacggaggatgcaaatgaagaagccccattgagggaccgctcccacatcgagaagaccctcatgctgaatgaggacaagccatccgatgactactctgcggtgctgcagcggcttcggaagatctaccactcatccatcaagcctctggagcagtcctacaagtacaatgagctccggcagcatgagatcacagatggagagattacctccaagcccatggtactgttcctgggaccgtggagtgttggtaaatctaccatgataaactacctccttgggctggaaaatactcgctatcagctctatacaggcgctgaacccaccacctctgagttcacggtcctcatgcatgggcctaagctgaaaaccatcgagggcatcgtcatggctgctgacagcgcccgttccttctcaccccttgagaagtttggccagaatttcctagagaagctgattggcattgaggttccccacaaacttctggagagggtcacttttgtggatacaccaggcatcatcgagaaccgcaagcagcaagaaagaggctaccccttcaacgacgtgtgccagtggttcatcgacagagctgacctcatctttgtcgtctttgacccaacaaagctggatgtgggtctagagctggagatgctcttccgccagttgaaggggcgtgaatcccagataaggatcatcctgaacaaggctgacaatctggccacccaaatgctcatgcgggtttacggggccctcttctggagcttggcccctctcatcaatgtcacagagcccccaagggtttacgtcagctccttctggccacaagagtataagccggacacccatcaggaactgttcctccaagaagagatctccctcctagaagacctgaatcaggtgatcgagaacagactggagaacaagattgccttcatccgccagcacgccatccgggtccgcatccacgccctcctggttgaccgctacctgcagacttacaaggacaaaatgaccttcttcagtgatggagaactggtctttaaggacattgtggaagatcccgataaattctacatcttcaagaccatcctggcaaagaccaatgtcagcaaatttgaccttcccaaccgcgaggcctataaggacttcttcggcatcaatcccatttccagtttcaaactgctctcccagcagtgctcctacatgggaggttgctttctggagaagattgagcgggccatcactcaggagcttccgggcctcctgggtagcctcgggctcgggaagaatccaggtgctctcaactgtgacaaaacagggtgtagcgaaacaccaaaaaatcgctacaggaagcactaggtggtggagcggtccttgggttcctgttggtgaatcagcttgtgtcctaactgtctgagaggtcctggtttattaaccctttgagccacactggcaggaattattacacagtggagagttgggagttcattgaggccaggggtcggggcaggtgtgtgggtctagggaggagagtggaaactgtgaattcctgtgtgcttgtcttgttgcttcaatgaggaggcctgattgaggcaagtcagcctccacctgcttttcctgggtcctgtcttggaaggacagagagcagctaaattctagtgtatcttaaatcagtgagggtcaaataagctaaaagcagctgaaattcctttgttccctgtgagctgggaaaacagcgaaggcctgagtcgtagagattgtcaggtccattttggcttctttccacacccacagtctcgcgtttgttccccagccctcggctgcctcttaactttgggttgactttcaacagtgaatagtctcttgggtctgaatatacctgggtttgtttttgtgtttttgagacggagtctcgctctgtcggccaggttggagtgcagtggtgcaatctcagctcactgcaacctccccctcctgggttcaagcgattctcctgcctcagcctcctgagtagctgagattataggcctaccaccatgcccagccaatttttgtatttttagtagaaacgggacttcaccatgttgcccaggctggcctcgaactcctgacctcaagtgatccacccgcctcggcctcccaaagtgctgggattacaggcatgagctgccgcacccggcctccacctgggttttgagccaatcccccggacttgctcctggtttcctcaaggggtggggcagtggtttaggacactcgacaactaagaacaggagttcccaggaaggacaaggatctgcctcccccactgccacttctctgatgtgttcctcaaagctggctcgagggctcgatcccttcatcggacccaggaggggactggttggtgtatccaggtaatttactcttggaagtgactgtagtgaaggtcgtggaagggctcagagggttaattggtttgcagtgcgtctttgtctattgcatgtcttggaaaactcagatcccaaaggcgctgggtttcagagaggacagtggagaccttgctccttttccttaggccgccagtctctcaaatttcagaggaggctgtttccacaactcccctgtggaaacacttggcagcggagttgctcctttgcagtttccacaccatggcttttcctttcctttcttctccattccctgatgcatcaacacttacttggagcaatttcctaggagtcagaaccagcaccagccactcggtgtcggtggccaccaaggcttaacattgaccttcccgcctgaccttgatgcagatgtccactgaacacaccgcaggaaagccagggccttcaataccaataagtgtgaatatgtgtgtatgttgtccaagagagattagggagatcacatagactctagggagtagagaacttgtaacagtcttgcaaggctagcatgcacggctccacagcaggtggtggggagcagaggggcaggacctgcagggaagaagcagcctttggatggtgaaatgtgcatggtgcacagtctgtgcatgcccaggagacccagcccgggctgcctcgaggggctcctttgtacacagccagccgcttctcttgggaacaagctgtcctgggggccttacccacgaggcaggagtcaggatgcaccagctcagcaccaggaagtcatcctggacccaggacagtggaaaggcaggcagagggagaggcactctgaggtcaggcagggtaagccagttggcagtcaggttaggtctatgaggagaacctcgagttaggaattcccggttctcagaattgttatcactctggtgcatgctgtcacaggggccgttgcgtttggctttgtggagggcctggacccttccacaagaacacccgaggttccagggcactcaggacaatgtttccaaggaacgagtcgaccaggaaagaacagtgagttctgcaaggggcatccacggagcctgtgataggggctgatgagatggaatctgtcctggacttttcttctcattaaccaccctccgcaaaccccagaacccctcgcctcatctctgtactgtctgccctcttgggggatgggccctcccactttcccctgcctgctcctccatgctgtgagctgctttggcagatctgtttttctgtgtagtcaggggaaaaacaaaaaaagatgcacaactgtgtgggcattgtcatagctgttggtgtcaccactgctttgggggaaatggctgggatgaggctaatacattcatgcaatatttatattttcagggggctgcgttatcagcatgctctccctgccttgggcttttctttccgtcatgttttccttttcgtgttccttctctgatttctcttgtctctgctgctcacaggcctgcccatcagtcagtacagatactcagtgtctggtttctggccagctccgtggagggggctttaagcagaattctgactctttggggtgggggattaggaactgggggaaacttaatgatccagagattcccccaagaggagtgtctggaaggatctgtgcctggacagtggcagaacctttccagtgttcttttggttctgatttcatcagtctcaataaagttccgatctctctttaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:6345 -> Molecular function: GO:0003924 [GTPase activity] evidence: IEA
            GeneID:6345 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
            GeneID:6345 -> Cellular component: GO:0033018 [sarcoplasmic reticulum lumen] evidence: IEA

by @meso_cacase at DBCLS
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