2024-04-19 21:29:16, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001098520 1509 bp mRNA linear PRI 15-JUL-2013 DEFINITION Homo sapiens HIV-1 Tat interactive protein 2, 30kDa (HTATIP2), transcript variant 1, mRNA. ACCESSION NM_001098520 VERSION NM_001098520.1 GI:148728165 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1509) AUTHORS Li,A., Zhang,C., Gao,S., Chen,F., Yang,C., Luo,R. and Xiao,H. TITLE TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice JOURNAL Oncogene 32 (18), 2273-2281 (2013) PUBMED 22733137 REMARK GeneRIF: TIP30 acts as a crucial regulator in suppressing cytoplasmic and nuclear EGFR signaling in the lung.TIP30 functions as a tumor suppressor to inhibit EGFR cytoplasmic and nuclear signaling and suppress adenocarcinogenesis in the lung. REFERENCE 2 (bases 1 to 1509) AUTHORS Huang,Q.D., Hu,X.Q., Wan,L., Gao,G.H., Zheng,S.R., You,J. and Guo,G.L. TITLE [Clinical significance of CC3/TIP30 expression in breast carcinoma and its correlation with HER-2/neu] JOURNAL Zhonghua Wai Ke Za Zhi 50 (1), 57-61 (2012) PUBMED 22490293 REMARK GeneRIF: The loss of CC3/TIP30 is related to occurrence and development in breast cancer, suggesting early onset of metastasis and recurrence. REFERENCE 3 (bases 1 to 1509) AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K., Gibbs,R.A. and Butte,N.F. TITLE Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population JOURNAL PLoS ONE 7 (12), E51954 (2012) PUBMED 23251661 REFERENCE 4 (bases 1 to 1509) AUTHORS Liu,D.C. and Yang,Z.L. TITLE Clinicopathologic significance of minichromosome maintenance protein 2 and Tat-interacting protein 30 expression in benign and malignant lesions of the gallbladder JOURNAL Hum. Pathol. 42 (11), 1676-1683 (2011) PUBMED 21543106 REMARK GeneRIF: overexpression of MCM2 or loss of expression of Tat-interacting protein 30 is closely related to carcinogenesis, progression, biological behavior, and prognosis of gallbladder adenocarcinoma. REFERENCE 5 (bases 1 to 1509) AUTHORS Zhang,C., Li,A., Gao,S., Zhang,X. and Xiao,H. TITLE The TIP30 protein complex, arachidonic acid and coenzyme A are required for vesicle membrane fusion JOURNAL PLoS ONE 6 (6), E21233 (2011) PUBMED 21731680 REMARK GeneRIF: The TIP30 complex facilitates biological membrane fusion through modification of phosphatidic acid on membranes. REFERENCE 6 (bases 1 to 1509) AUTHORS Xiao,H., Palhan,V., Yang,Y. and Roeder,R.G. TITLE TIP30 has an intrinsic kinase activity required for up-regulation of a subset of apoptotic genes JOURNAL EMBO J. 19 (5), 956-963 (2000) PUBMED 10698937 REFERENCE 7 (bases 1 to 1509) AUTHORS Whitman,S., Wang,X., Shalaby,R. and Shtivelman,E. TITLE Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis JOURNAL Mol. Cell. Biol. 20 (2), 583-593 (2000) PUBMED 10611237 REFERENCE 8 (bases 1 to 1509) AUTHORS Baker,M.E. TITLE TIP30, a cofactor for HIV-1 Tat-activated transcription, is homologous to short-chain dehydrogenases/reductases JOURNAL Curr. Biol. 9 (13), R471 (1999) PUBMED 10395547 REFERENCE 9 (bases 1 to 1509) AUTHORS Xiao,H., Tao,Y., Greenblatt,J. and Roeder,R.G. TITLE A cofactor, TIP30, specifically enhances HIV-1 Tat-activated transcription JOURNAL Proc. Natl. Acad. Sci. U.S.A. 95 (5), 2146-2151 (1998) PUBMED 9482853 REFERENCE 10 (bases 1 to 1509) AUTHORS Shtivelman,E. TITLE A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma JOURNAL Oncogene 14 (18), 2167-2173 (1997) PUBMED 9174052 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP382529.1, AK222969.1 and BC015358.2. Transcript Variant: This variant (1) encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002439.2, BU538361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns ERS025081, ERS025082 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-528 BP382529.1 1-528 529-1474 AK222969.1 413-1358 1475-1509 BC015358.2 1381-1415 FEATURES Location/Qualifiers source 1..1509 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="11" /map="11p15.1" gene 1..1509 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /note="HIV-1 Tat interactive protein 2, 30kDa" /db_xref="GeneID:10553" /db_xref="HGNC:16637" /db_xref="MIM:605628" exon 1..170 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 33..34 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="" /replace="c" /db_xref="dbSNP:375714821" variation 35 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /db_xref="dbSNP:182333117" CDS 70..900 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /EC_number="1.1.1.-" /note="isoform a precursor is encoded by transcript variant 1; short chain dehydrogenase/reductase family 44U, member 1; Tat-interacting protein (30kD); oxidoreductase HTATIP2; HIV-1 TAT-interactive protein 2; 30 kDa HIV-1 TAT-interacting protein" /codon_start=1 /product="oxidoreductase HTATIP2 isoform a precursor" /protein_id="NP_001091990.1" /db_xref="GI:148728166" /db_xref="CCDS:CCDS44553.1" /db_xref="GeneID:10553" /db_xref="HGNC:16637" /db_xref="MIM:605628" /translation="
MAGPAALSAAAAAALAAALLLLRREDPGPGAGPSMAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEEAYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAKAGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPGEWLVRKFFGSLPDSWASGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSLKP
" sig_peptide 70..123 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="COORDINATES: ab initio prediction:SignalP:4.0" misc_feature 226..864 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /note="CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250" /db_xref="CDD:187560" misc_feature 238..>681 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /note="NADH(P)-binding; Region: NAD_binding_10; pfam13460" /db_xref="CDD:205638" misc_feature order(244..246,250..261,325..330,385..387,442..453, 490..492,502..504,559..567,598..600,610..612,670..681) /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /note="NAD binding site [chemical binding]; other site" /db_xref="CDD:187560" misc_feature order(493..495,565..567,598..600,610..612) /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /note="active site" /db_xref="CDD:187560" exon 171..366 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 176 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:369625277" variation 261 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:191533610" variation 280 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:202128953" variation 296 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:200846453" variation 315 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:145143466" variation 319 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:200473579" variation 330 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="g" /db_xref="dbSNP:145549108" exon 367..474 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 405 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:112368564" variation 413 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:144136689" variation 424 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:146530848" variation 429 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:77126933" variation 430 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:14273" variation 436 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:140788394" variation 445 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:377269888" variation 467 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="g" /db_xref="dbSNP:143928186" variation 468 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:200863409" variation 473 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:148194087" exon 475..612 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 503 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:140080675" variation 507 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:140165037" variation 532 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="g" /db_xref="dbSNP:181081777" variation 553 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:377524639" variation 561 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:150327548" variation 575 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /db_xref="dbSNP:370929399" variation 582 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:141995111" exon 613..674 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 628 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:138879906" variation 652 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:376468659" variation 655 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:370076424" exon 675..1478 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /inference="alignment:Splign:1.39.8" variation 678 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:143261552" variation 730 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:1051776" variation 751..752 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="" /replace="c" /db_xref="dbSNP:35285540" variation 762 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:3824886" variation 767 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /db_xref="dbSNP:79296772" variation 774 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /replace="g" /db_xref="dbSNP:142077207" variation 787 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:144100738" variation 792 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:373986235" variation 852 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="g" /db_xref="dbSNP:187804828" variation 856 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="g" /db_xref="dbSNP:14222" variation 864 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:200003351" variation 879 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:202065100" variation 898 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="" /replace="t" /db_xref="dbSNP:370774686" variation 906 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /replace="g" /replace="t" /db_xref="dbSNP:3781679" variation 1036 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:372324685" variation 1089 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:191247504" variation 1172 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="c" /db_xref="dbSNP:183794581" variation 1210 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:375554086" variation 1284 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:16906210" variation 1317 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="a" /replace="g" /db_xref="dbSNP:369175509" STS 1319..1458 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /standard_name="G29234" /db_xref="UniSTS:63559" variation 1363 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="g" /replace="t" /db_xref="dbSNP:188466553" variation 1403 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" /replace="c" /replace="t" /db_xref="dbSNP:77228546" polyA_signal 1447..1452 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" polyA_signal 1455..1460 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" polyA_site 1478 /gene="HTATIP2" /gene_synonym="CC3; SDR44U1; TIP30" ORIGIN
aagccgggtaggcgctgtctccgtcgcctccaacccccccggtccgaccagggaaggtgggatgctctgatggccgggcctgcggcgctgagcgcggcggcggcggctgctctggcggccgccctgctcctgctgcgtcgtgaggacccggggccgggggctggccccagcatggccgaaacagaagccctgtcgaagcttcgggaagacttcaggatgcagaataaatccgtctttattttgggcgccagcggagaaaccggcagagtgctcttaaaggaaatcctggagcagggcctgttttccaaagtcacgctcattggccggaggaagctcaccttcgacgaggaagcttataaaaatgtgaatcaagaagtggtggactttgaaaagttggatgactacgcctctgcctttcaaggtcatgatgttggattctgttgcctgggtaccaccagagggaaagctggggcggagggatttgttcgtgttgaccgagattatgtgctgaagtctgcagagctggcaaaagctggagggtgcaaacatttcaacttgctatcctctaaaggagctgataaatcaagcaattttttatatctacaagttaagggagaagtagaagccaaggttgaagaattaaaatttgatcgttactctgtatttaggcctggagttctgttatgtgataggcaagaatctcgcccaggtgaatggctggttagaaagttctttggctccttaccagactcttgggccagtgggcattctgtgcctgtggtgaccgtggttagagcaatgctgaacaatgtggtgagaccaagagacaagcagatggaactgctggagaacaaggccatccatgacctggggaaagcgcatggctctctcaagccatgaccacattggagaaatggtttttattgtcaaccttaacacccatcaccaaatcggtaatttcagggtctaaaaaaagtcagcatgttttaactttgttgttttactatcctcaggcatccattccaatcaagaaatgatggtgctctgcatcagtggttcagagcctggttatacatatagatcactcagggagctttggaaaaataaagatttgtcagccctatctcaaacttgaatcaaaatttctggggtgtgggcacaataatctgtaattttctttgtttatacttcccctgatgccactggttccgatgccactggctggggggcctgctttgaaatgcttgtctgcagagtcacagcagccatgaaaaccttatgaccgtgcaaatgagctctgctctaaaattgttgacattcatgtctctgagttacaaaagtgctaattcactacatgtaattgtgtaagtaaacattgtgcctttactacttctttatgtaatagaagttatatacctaagcttatataatacatggggaggattaaataaaggaataaagatgaatggacaactcctaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
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ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:10553 -> Molecular function: GO:0003713 [transcription coactivator activity] evidence: TAS GeneID:10553 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:10553 -> Molecular function: GO:0016491 [oxidoreductase activity] evidence: IEA GeneID:10553 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA GeneID:10553 -> Biological process: GO:0006357 [regulation of transcription from RNA polymerase II promoter] evidence: TAS GeneID:10553 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA GeneID:10553 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:10553 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA GeneID:10553 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: TAS GeneID:10553 -> Biological process: GO:0045765 [regulation of angiogenesis] evidence: IDA GeneID:10553 -> Biological process: GO:0051170 [nuclear import] evidence: IDA GeneID:10553 -> Cellular component: GO:0005634 [nucleus] evidence: TAS GeneID:10553 -> Cellular component: GO:0005635 [nuclear envelope] evidence: IDA GeneID:10553 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001091990 -> EC 1.1.1.-
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