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2024-04-20 13:08:08, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001098517 4240 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens cell adhesion molecule 1 (CADM1), transcript variant
2, mRNA.
ACCESSION NM_001098517
VERSION NM_001098517.1 GI:148664210
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4240)
AUTHORS Lee,E., Lee,B.B., Ko,E., Kim,Y., Han,J., Shim,Y.M., Park,J. and
Kim,D.H.
TITLE Cohypermethylation of p14 in combination with CADM1 or DCC as a
recurrence-related prognostic indicator in stage I esophageal
squamous cell carcinoma
JOURNAL Cancer 119 (9), 1752-1760 (2013)
PUBMED 23310950
REMARK GeneRIF: results suggested that cohypermethylation of p14 in
combination with DCC and/or CADM1 may be an independent prognostic
factor for recurrence in patients with stage I ESCC
REFERENCE 2 (bases 1 to 4240)
AUTHORS Minami,A., Shimono,Y., Mizutani,K., Nobutani,K., Momose,K.,
Azuma,T. and Takai,Y.
TITLE Reduction of the ST6 beta-galactosamide alpha-2,6-sialyltransferase
1 (ST6GAL1)-catalyzed sialylation of nectin-like molecule 2/cell
adhesion molecule 1 and enhancement of ErbB2/ErbB3 signaling by
microRNA-199a
JOURNAL J. Biol. Chem. 288 (17), 11845-11853 (2013)
PUBMED 23504322
REMARK GeneRIF: the suppressive role of Necl-2 in the HRG-induced
ErbB2/ErbB3 signaling is regulated by miR-199a at least through the
reduction of the ST6GAL1-catalyzed sialylation of Necl-2
REFERENCE 3 (bases 1 to 4240)
AUTHORS Miao,X., Yang,Z.L., Xiong,L., Zou,Q., Yuan,Y., Li,J., Liang,L.,
Chen,M. and Chen,S.
TITLE Nectin-2 and DDX3 are biomarkers for metastasis and poor prognosis
of squamous cell/adenosquamous carcinomas and adenocarcinoma of
gallbladder
JOURNAL Int J Clin Exp Pathol 6 (2), 179-190 (2013)
PUBMED 23330003
REMARK GeneRIF: Positive Nectin-2 and DDx3 expression is closely
correlated with clinical, pathological, and biological behaviors as
well as poor-prognosis of gallbladder cancer.
REFERENCE 4 (bases 1 to 4240)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 5 (bases 1 to 4240)
AUTHORS Snellenberg,S., De Strooper,L.M., Hesselink,A.T., Meijer,C.J.,
Snijders,P.J., Heideman,D.A. and Steenbergen,R.D.
TITLE Development of a multiplex methylation-specific PCR as candidate
triage test for women with an HPV-positive cervical scrape
JOURNAL BMC Cancer 12, 551 (2012)
PUBMED 23176198
REMARK GeneRIF: Data indicate that DNA methylation status of multiple
genes CADM1, MAL and hsa-miR-124-2 was analyzed in human
papillomavirus (hrHPV)-positive cervical scrape.
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4240)
AUTHORS Masuda,M., Yageta,M., Fukuhara,H., Kuramochi,M., Maruyama,T.,
Nomoto,A. and Murakami,Y.
TITLE The tumor suppressor protein TSLC1 is involved in cell-cell
adhesion
JOURNAL J. Biol. Chem. 277 (34), 31014-31019 (2002)
PUBMED 12050160
REMARK GeneRIF: TSLC1 mediates intracellular adhesion through homophilic
interactions in a Ca(2+)/Mg(2+)-independent manner
REFERENCE 7 (bases 1 to 4240)
AUTHORS Allinen,M., Peri,L., Kujala,S., Lahti-Domenici,J., Outila,K.,
Karppinen,S.M., Launonen,V. and Winqvist,R.
TITLE Analysis of 11q21-24 loss of heterozygosity candidate target genes
in breast cancer: indications of TSLC1 promoter hypermethylation
JOURNAL Genes Chromosomes Cancer 34 (4), 384-389 (2002)
PUBMED 12112527
REMARK GeneRIF: The TSLC1 promoter region has many methylated cytosines in
the CpG islands in chromosome 11q LOH in breast cancer.
REFERENCE 8 (bases 1 to 4240)
AUTHORS Fukuhara,H., Kuramochi,M., Fukami,T., Kasahara,K., Furuhata,M.,
Nobukuni,T., Maruyama,T., Isogai,K., Sekiya,T., Shuin,T.,
Kitamura,T., Reeves,R.H. and Murakami,Y.
TITLE Promoter methylation of TSLC1 and tumor suppression by its gene
product in human prostate cancer
JOURNAL Jpn. J. Cancer Res. 93 (6), 605-609 (2002)
PUBMED 12079507
REMARK GeneRIF: alteration of TSLC1 is involved in prostate cancer
REFERENCE 9 (bases 1 to 4240)
AUTHORS Kuramochi,M., Fukuhara,H., Nobukuni,T., Kanbe,T., Maruyama,T.,
Ghosh,H.P., Pletcher,M., Isomura,M., Onizuka,M., Kitamura,T.,
Sekiya,T., Reeves,R.H. and Murakami,Y.
TITLE TSLC1 is a tumor-suppressor gene in human non-small-cell lung
cancer
JOURNAL Nat. Genet. 27 (4), 427-430 (2001)
PUBMED 11279526
REFERENCE 10 (bases 1 to 4240)
AUTHORS Gomyo,H., Arai,Y., Tanigami,A., Murakami,Y., Hattori,M., Hosoda,F.,
Arai,K., Aikawa,Y., Tsuda,H., Hirohashi,S., Asakawa,S., Shimizu,N.,
Soeda,E., Sakaki,Y. and Ohki,M.
TITLE A 2-Mb sequence-ready contig map and a novel immunoglobulin
superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
JOURNAL Genomics 62 (2), 139-146 (1999)
PUBMED 10610705
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BI915307.1, BC125103.1, BM309987.1, AF132811.1, CA777709.1 and
CA447277.1.
Transcript Variant: This variant (2) lacks an alternate in-frame
segment in the 3' coding region, compared to variant 1. The
resulting protein (isoform 2) is shorter than isoform 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC125102.1, AK315245.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025082, ERS025083 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-126 BI915307.1 1-126
127-2471 BC125103.1 1-2345
2472-2879 BM309987.1 90-497
2880-3551 AF132811.1 2841-3512
3552-4043 CA777709.1 240-731
4044-4240 CA447277.1 1-197 c
FEATURES Location/Qualifiers
source 1..4240
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q23.2"
gene 1..4240
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="cell adhesion molecule 1"
/db_xref="GeneID:23705"
/db_xref="HGNC:5951"
/db_xref="MIM:605686"
exon 1..253
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
misc_feature 70..72
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="upstream in-frame stop codon"
CDS 130..1374
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="isoform 2 precursor is encoded by transcript
variant 2; tumor suppressor in lung cancer 1; nectin-like
protein 2; immunoglobulin superfamily, member 4;
nectin-like 2; immunoglobulin superfamily, member 4D
variant 2; TSLC1/Nectin-like 2/IGSF4; TSLC-1; synaptic
cell adhesion molecule; immunoglobulin superfamily member
4; spermatogenic immunoglobulin superfamily; truncated
CADM1 protein"
/codon_start=1
/product="cell adhesion molecule 1 isoform 2 precursor"
/protein_id="NP_001091987.1"
/db_xref="GI:148664211"
/db_xref="CCDS:CCDS53711.1"
/db_xref="GeneID:23705"
/db_xref="HGNC:5951"
/db_xref="MIM:605686"
/translation="
MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDSRAGEEGSIRAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
"
sig_peptide 130..261
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
misc_feature 265..549
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="First (N-terminal) immunoglobulin (Ig)-like domain
of nectin-like molecule 2 (also known as cell adhesion
molecule 1 (CADM1)); Region: Ig1_Necl-2; cd05881"
/db_xref="CDD:143289"
misc_feature 274..555
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="Immunoglobulin V-set domain; Region: V-set;
pfam07686"
/db_xref="CDD:203725"
misc_feature order(343..345,352..354,367..372,376..378,394..396,
400..402,508..510)
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="putative dimer interface [polypeptide binding];
other site"
/db_xref="CDD:143289"
misc_feature 610..855
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="Second immunoglobulin (Ig)-like domain of
nectin-like molecule 2 (also known as cell adhesion
molecule 1 (CADM1)); Region: Ig2_Necl-2; cd05883"
/db_xref="CDD:143291"
misc_feature 883..1119
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/note="Immunoglobulin; Region: IG; smart00409"
/db_xref="CDD:197707"
exon 254..400
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 401..553
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 554..691
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 692..850
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 851..950
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 951..1123
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 1124..1255
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
exon 1256..4223
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/inference="alignment:Splign:1.39.8"
variation 1674
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/replace="c"
/replace="g"
/db_xref="dbSNP:1048876"
STS 2528..2677
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="SHGC-31226"
/db_xref="UniSTS:25823"
STS 3389..3521
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="D11S4693"
/db_xref="UniSTS:3134"
variation 3566
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/replace="a"
/replace="c"
/db_xref="dbSNP:3210211"
STS 3651..3722
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="D11S2038"
/db_xref="UniSTS:18715"
variation 3718
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/replace="g"
/replace="t"
/db_xref="dbSNP:1048932"
STS 3859..4115
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="WI-20930"
/db_xref="UniSTS:49301"
STS 4001..4134
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="RH47303"
/db_xref="UniSTS:8346"
STS 4011..4134
/gene="CADM1"
/gene_synonym="BL2; IGSF4; IGSF4A; Necl-2; NECL2; RA175;
sgIGSF; ST17; sTSLC-1; SYNCAM; synCAM1; TSLC1"
/standard_name="RH47150"
/db_xref="UniSTS:56845"
ORIGIN
ggttgggctcgcggcgctgtgattggtctgcccggactccgcctccagcgcatgtcattagcatctcattagctgtccgctcgggctccggaggcagccaacgccgccagtctgaggcaggtgcccgacatggcgagtgtagtgctgccgagcggatcccagtgtgcggcggcagcggcggcggcggcgcctcccgggctccggctccggcttctgctgttgctcttctccgccgcggcactgatccccacaggtgatgggcagaatctgtttacgaaagacgtgacagtgatcgagggagaggttgcgaccatcagttgccaagtcaataagagtgacgactctgtgattcagctactgaatcccaacaggcagaccatttatttcagggacttcaggcctttgaaggacagcaggtttcagttgctgaatttttctagcagtgaactcaaagtatcattgacaaacgtctcaatttctgatgaaggaagatacttttgccagctctataccgatcccccacaggaaagttacaccaccatcacagtcctggtcccaccacgtaatctgatgatcgatatccagaaagacactgcggtggaaggtgaggagattgaagtcaactgcactgctatggccagcaagccagccacgactatcaggtggttcaaagggaacacagagctaaaaggcaaatcggaggtggaagagtggtcagacatgtacactgtgaccagtcagctgatgctgaaggtgcacaaggaggacgatggggtcccagtgatctgccaggtggagcaccctgcggtcactggaaacctgcagacccagcggtatctagaagtacagtataagcctcaagtgcacattcagatgacttatcctctacaaggcttaacccgggaaggggacgcgcttgagttaacatgtgaagccatcgggaagccccagcctgtgatggtaacttgggtgagagtcgatgatgaaatgcctcaacacgccgtactgtctgggcccaacctgttcatcaataacctaaacaaaacagataatggtacataccgctgtgaagcttcaaacatagtggggaaagctcactcggattatatgctgtatgtatacgattcccgagcaggtgaagaaggctcgatcagggcagtggatcatgccgtgatcggtggcgtcgtggcggtggtggtgttcgccatgctgtgcttgctcatcattctggggcgctattttgccagacataaaggtacatacttcactcatgaagccaaaggagccgatgacgcagcagacgcagacacagctataatcaatgcagaaggaggacagaacaactccgaagaaaagaaagagtacttcatctagatcagcctttttgtttcaatgaggtgtccaactggccctatttagatgataaagagacagtgatattggaacttgcgagaaattcgtgtgtttttttatgaatgggtggaaaggtgtgagactgggaaggcttgggatttgctgtgtaaaaaaaaaaaaaatgttctttggaaagtacactctgctgtttgacacctcttttttcgtttgtttgtttgtttaatttttatttcttcctaccaagtcaaacttggatacttggatttagtttcagtagattgcagaaaattctgtgccttgttttttgtttgtttgttgcgttcctttcttttccccctttgtgcacatttatttcctccctctaccccaatttcggattttttccaaaatctcccattttggaatttgcctgctgggattccttagactcttttccttcccttttctgttctagttttttacttttgtttatttttatggtaactgctttctgttccaaattcagtttcataaaaggagaaccagcacagcttagatttcatagttcagaatttagtgtatccataatgcattcttctctgttgtcgtaaagatttgggtgaacaaacaatgaaaactctttgctgctgcccatgtttcaaatacttagagcagtgaagactagaaaattagactgtgattcagaaaatgttctgtttgctgtggaactacattactgtacagggttatctgcaagtgaggtgtgtcacaatgagattgaatttcactgtctttaattctgtatctgtagacggctcagtatagataccctacgctgtccagaaaggtttggggcagaaaggactcctcctttttccatgccctaaacagacctgacaggtgaggtctgttccttttatataagtggacaaattttgagttgccacaggaggggaagtagggaggggggaaatacagttctgctctggttgtttctgttccaaatgattccatccacctttcccaatcggccttacttctcactaatttgtaggaaaaagcaagttcgtctgttgtgcgaatgactgaatgggacagagttgatttttttttttttttcctttgtgcttagttaggaaggcagtaggatgtggcctgcatgtactgtatattacagatatttgtcatgctgggatttccaactcgaatctgtgtgaaactttcattccttcagatttggcttgacaaaggcaggaggtacaaaagaagggctggtattgttctcacactggtctgctgtcgctctcagttctcgataggtcagagcagaggtggaaaaacagcatgtacggattttcagttacttaatcaaaactcaaatgtgagtgtttttatctttttacctttcatacactagccttggcctctttcctcagccttaagaaccatctgccaaaaattactgatcctcgcatgatggcagccatagtgcatagctactaaaatcagtgaccttgaacatatcttagatggggagcctcgggaaaaggtagaggagtcacgttaccatttacatgttttaaagaaagaagtgtggggattttcactgaaacgtctaggaaatctagaagtagtcctgaaggacagaaactaaactcttaccatatgtttggtaagactccagactccagctaacagtccctatggaaagatggcatcaaaaaagatagatctatatatatatataaatatatattctattacattttcagtgagtaattttggattttgcaaggtgcatttttactattgttacattatgtggaaaacttatgctgatttatttaagggggaaaaagtgtcaactctttgttatttgaaaacatgtttatttttcttgtctttattttaacctttgatagaaccattgcaatatgggggccttttgggaacggactggtatgtaaaagaaaatccattatcgagcagcattttatttacccctcccctatccctaggcacttaaccaagacaaaaagccacaatgaacatccctttttcaatgaattttataatctgcagctctattccgagcccttagcacccattccgaccatagtataatcatatcaaagggtgagaatcatttagcatgttgttgaaaggttttttttcagttgttctttttagaaaaaaagaaaaacaaaaacaaaaacaaaaaaaaaaaatcacaccattgctcacagaattggcatctcatttttgggacctcccatctttctgttttgaaaagtgtacagtagtgcagtgttcctgatgtaactttatggcttacaatgttgacatgtctcaggttcatgtgttgcgattggtgttttccgtctcaggtagattgcaaagtgtaggccccacacattggaaaaaataataataaaacaaagcaaaaacaggaaattatggattttagttgtatattggtttatgtattttttcttaagtatacagtgcactgtttgaaatgtattgttgagtattactttgtacaggttgatcactttttttagagtgaagaaagaacaaacttgttttttgtgttttttaaaggaatataaaataatgaaggatgtataattgatgccaaataagcttgttctttagtcacaccgacgtcttatttttccctttaggccagttctgtttttaaggtgtacatggacaatgttacagtgtaagaaactccatatccatatgttcccattcgcattttgtattggttcatgtataccatttttacaaaaaaaaaaagaaaaaaaagaagtactataaaatatctgtcttcttaataaaaaaaaattaatgttacaaagtgaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:23705 -> Molecular function: GO:0005102 [receptor binding] evidence: IPI
GeneID:23705 -> Molecular function: GO:0005102 [receptor binding] evidence: ISS
GeneID:23705 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:23705 -> Molecular function: GO:0008022 [protein C-terminus binding] evidence: ISS
GeneID:23705 -> Molecular function: GO:0030165 [PDZ domain binding] evidence: ISS
GeneID:23705 -> Molecular function: GO:0042803 [protein homodimerization activity] evidence: ISS
GeneID:23705 -> Molecular function: GO:0050839 [cell adhesion molecule binding] evidence: IEA
GeneID:23705 -> Biological process: GO:0001889 [liver development] evidence: IEA
GeneID:23705 -> Biological process: GO:0001913 [T cell mediated cytotoxicity] evidence: IDA
GeneID:23705 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:23705 -> Biological process: GO:0007156 [homophilic cell adhesion] evidence: ISS
GeneID:23705 -> Biological process: GO:0007157 [heterophilic cell-cell adhesion] evidence: ISS
GeneID:23705 -> Biological process: GO:0007283 [spermatogenesis] evidence: IEA
GeneID:23705 -> Biological process: GO:0007416 [synapse assembly] evidence: IEA
GeneID:23705 -> Biological process: GO:0007420 [brain development] evidence: IEA
GeneID:23705 -> Biological process: GO:0008037 [cell recognition] evidence: IDA
GeneID:23705 -> Biological process: GO:0008037 [cell recognition] evidence: ISS
GeneID:23705 -> Biological process: GO:0009826 [unidimensional cell growth] evidence: IEA
GeneID:23705 -> Biological process: GO:0016338 [calcium-independent cell-cell adhesion] evidence: IEA
GeneID:23705 -> Biological process: GO:0030154 [cell differentiation] evidence: IEA
GeneID:23705 -> Biological process: GO:0034329 [cell junction assembly] evidence: TAS
GeneID:23705 -> Biological process: GO:0034332 [adherens junction organization] evidence: TAS
GeneID:23705 -> Biological process: GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] evidence: IDA
GeneID:23705 -> Biological process: GO:0042271 [susceptibility to natural killer cell mediated cytotoxicity] evidence: ISS
GeneID:23705 -> Biological process: GO:0045216 [cell-cell junction organization] evidence: TAS
GeneID:23705 -> Biological process: GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] evidence: IDA
GeneID:23705 -> Biological process: GO:0045954 [positive regulation of natural killer cell mediated cytotoxicity] evidence: ISS
GeneID:23705 -> Biological process: GO:0050715 [positive regulation of cytokine secretion] evidence: IDA
GeneID:23705 -> Biological process: GO:0050798 [activated T cell proliferation] evidence: IDA
GeneID:23705 -> Biological process: GO:0051606 [detection of stimulus] evidence: IDA
GeneID:23705 -> Biological process: GO:0051606 [detection of stimulus] evidence: ISS
GeneID:23705 -> Biological process: GO:0060348 [bone development] evidence: IEA
GeneID:23705 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:23705 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:23705 -> Cellular component: GO:0005911 [cell-cell junction] evidence: ISS
GeneID:23705 -> Cellular component: GO:0008021 [synaptic vesicle] evidence: IEA
GeneID:23705 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
GeneID:23705 -> Cellular component: GO:0016323 [basolateral plasma membrane] evidence: ISS
GeneID:23705 -> Cellular component: GO:0030424 [axon] evidence: IEA
GeneID:23705 -> Cellular component: GO:0030425 [dendrite] evidence: IEA
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