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2024-04-19 17:01:23, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001098202 3071 bp mRNA linear PRI 09-JUN-2013
DEFINITION Homo sapiens hypermethylated in cancer 1 (HIC1), transcript variant
2, mRNA.
ACCESSION NM_001098202
VERSION NM_001098202.1 GI:148237269
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3071)
AUTHORS Dehennaut,V., Loison,I., Dubuissez,M., Nassour,J., Abbadie,C. and
Leprince,D.
TITLE DNA double-strand breaks lead to activation of hypermethylated in
cancer 1 (HIC1) by SUMOylation to regulate DNA repair
JOURNAL J. Biol. Chem. 288 (15), 10254-10264 (2013)
PUBMED 23417673
REMARK GeneRIF: epigenetic HIC1 inactivation, which is an early step in
tumorigenesis, could contribute to the accumulation of DNA
mutations through impaired DNA repair and thus favor tumorigenesis.
REFERENCE 2 (bases 1 to 3071)
AUTHORS Dehennaut,V., Loison,I., Boulay,G., Van Rechem,C. and Leprince,D.
TITLE Identification of p21 (CIP1/WAF1) as a direct target gene of HIC1
(Hypermethylated In Cancer 1)
JOURNAL Biochem. Biophys. Res. Commun. 430 (1), 49-53 (2013)
PUBMED 23178572
REMARK GeneRIF: these results further demonstrate that HIC1 is a key
player in the regulation of the DNA damage response.
REFERENCE 3 (bases 1 to 3071)
AUTHORS Svedlund,J., Koskinen Edblom,S., Marquez,V.E., Akerstrom,G.,
Bjorklund,P. and Westin,G.
TITLE Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene
epigenetically deregulated in hyperparathyroid tumors by histone H3
lysine modification
JOURNAL J. Clin. Endocrinol. Metab. 97 (7), E1307-E1315 (2012)
PUBMED 22544915
REMARK GeneRIF: A growth-regulatory role of HIC1 in the parathyroid glands
and perturbed expression of HIC1 may represent an early event
during tumor development.
REFERENCE 4 (bases 1 to 3071)
AUTHORS Dehennaut,V., Loison,I., Pinte,S. and Leprince,D.
TITLE Molecular dissection of the interaction between HIC1 and SIRT1
JOURNAL Biochem. Biophys. Res. Commun. 421 (2), 384-388 (2012)
PUBMED 22510409
REMARK GeneRIF: these results demonstrate that the activating acetylation
to SUMOylation switch of HIC1 is favored by genotoxic stresses to
regulate the DNA damage response.
REFERENCE 5 (bases 1 to 3071)
AUTHORS Eggers,H., Steffens,S., Grosshennig,A., Becker,J.U.,
Hennenlotter,J., Stenzl,A., Merseburger,A.S., Kuczyk,M.A. and
Serth,J.
TITLE Prognostic and diagnostic relevance of hypermethylated in cancer 1
(HIC1) CpG island methylation in renal cell carcinoma
JOURNAL Int. J. Oncol. 40 (5), 1650-1658 (2012)
PUBMED 22327210
REMARK GeneRIF: Identify HIC1 hypermethylation in renal cell carcinoma as
an independent predictor of reduced recurrence-free survival.
REFERENCE 6 (bases 1 to 3071)
AUTHORS Guerardel,C., Deltour,S., Pinte,S., Monte,D., Begue,A., Godwin,A.K.
and Leprince,D.
TITLE Identification in the human candidate tumor suppressor gene HIC-1
of a new major alternative TATA-less promoter positively regulated
by p53
JOURNAL J. Biol. Chem. 276 (5), 3078-3089 (2001)
PUBMED 11073960
REMARK GeneRIF: A new major alternative promoter of HIC1 (HIC-1) is
conserved in the murine locus and positively regulated by TP53.
REFERENCE 7 (bases 1 to 3071)
AUTHORS Deltour,S., Guerardel,C. and Leprince,D.
TITLE Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a
general mechanism for BTB/POZ transcriptional repressors: the case
of HIC-1 and gammaFBP-B
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (26), 14831-14836 (1999)
PUBMED 10611298
REMARK GeneRIF: HIC-1 (HIC1) is a transcriptional repressor. However, in
contrast to other BTB/POZ transcriptional repressors ( such as BCL6
or PLZF) it fails to recruit SMRT/NCoR-mSin3A/HDAC complexes via
its BTB/POZ domain.
REFERENCE 8 (bases 1 to 3071)
AUTHORS Deltour,S., Guerardel,C., Stehelin,D. and Leprince,D.
TITLE The carboxy-terminal end of the candidate tumor suppressor gene
HIC-1 is phylogenetically conserved
JOURNAL Biochim. Biophys. Acta 1443 (1-2), 230-232 (1998)
PUBMED 9838134
REFERENCE 9 (bases 1 to 3071)
AUTHORS Fujii,H., Biel,M.A., Zhou,W., Weitzman,S.A., Baylin,S.B. and
Gabrielson,E.
TITLE Methylation of the HIC-1 candidate tumor suppressor gene in human
breast cancer
JOURNAL Oncogene 16 (16), 2159-2164 (1998)
PUBMED 9572497
REFERENCE 10 (bases 1 to 3071)
AUTHORS Wales,M.M., Biel,M.A., el Deiry,W., Nelkin,B.D., Issa,J.P.,
Cavenee,W.K., Kuerbitz,S.J. and Baylin,S.B.
TITLE p53 activates expression of HIC-1, a new candidate tumour
suppressor gene on 17p13.3
JOURNAL Nat. Med. 1 (6), 570-577 (1995)
PUBMED 7585125
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC090617.16 and BQ004706.1.
Summary: This gene functions as a growth regulatory and tumor
repressor gene. Hypermethylation or deletion of the region of this
gene have been associated with tumors and the contiguous-gene
syndrome, Miller-Dieker syndrome. Alternative splicing of this gene
results in multiple transcript variants. [provided by RefSeq, Sep
2010].
Transcript Variant: This variant (2) contains an alternate in-frame
exon in the 5' coding region and uses a downstream start codon,
compared to variant 1. Isoform 2 has a shorter N-terminus, compared
to isoform 1.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data because no single transcript was available
for the full length of the gene. The extent of this transcript is
supported by transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: single sample supports all introns ERS025083,
ERS025084 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-37 AC090617.16 170768-170804 c
38-2663 AC090617.16 167818-170443 c
2664-3071 BQ004706.1 1-408 c
FEATURES Location/Qualifiers
source 1..3071
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.3"
gene 1..3071
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="hypermethylated in cancer 1"
/db_xref="GeneID:3090"
/db_xref="HGNC:4909"
/db_xref="MIM:603825"
CDS 1..2202
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="isoform 2 is encoded by transcript variant 2; zinc
finger and BTB domain-containing protein 29"
/codon_start=1
/product="hypermethylated in cancer 1 protein isoform 2"
/protein_id="NP_001091672.1"
/db_xref="GI:148237270"
/db_xref="CCDS:CCDS42229.1"
/db_xref="GeneID:3090"
/db_xref="HGNC:4909"
/db_xref="MIM:603825"
/translation="
MTFPEADILLKSGECAGQTMLDTMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLADGAEAAAAAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCHLRGGGGGGGGYAPYGRPGRGLRAATPVIQACYPSPVGPPPPPAAEPPSGPEAAVNTHCAELYASGPGPAAALCASERRCSPLCGLDLSKKSPPGSAAPERPLAERELPPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKLEEAAPPSDPFRGGSGSPGPEPPGRPDGPSLLYRWMKHEPGLGSYGDELGRERGSPSERCEERGGDAAVSPGGPPLGLAPPPRYPGSLDGPGAGGDGDDYKSSSEETGSSEDPSPPGGHLEGYPCPHLAYGEPESFGDNLYVCIPCGKGFPSSEQLNAHVEAHVEEEEALYGRAEAAEVAAGAAGLGPPFGGGGDKVAGAPGGLGELLRPYRCASCDKSYKDPATLRQHEKTHWLTRPYPCTICGKKFTQRGTMTRHMRSHLGLKPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISHMKMHAVGGAAGAAGALAGLGGLPGVPGPDGKGKLDFPEGVFAVARLTAEQLSLKQQDKAAAAELLAQTTHFLHDPKVALESLYPLAKFTAELGLSPDKAAEVLSQGAHLAAGPDGRTIDRFSPT
"
misc_feature 121..450
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="BTB/POZ domain; Region: BTB; pfam00651"
/db_xref="CDD:201372"
misc_feature 460..945
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14526.5);
Region: Mediates HDAC-dependent transcriptional
repression"
misc_feature 721..741
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q14526.5);
Region: Interaction with CTBP1"
misc_feature 997..999
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/experiment="experimental evidence, no additional details
recorded"
/note="N6-acetyllysine, alternate; propagated from
UniProtKB/Swiss-Prot (Q14526.5); acetylation site"
misc_feature 1603..1671
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc finger, C2H2 type; Region: zf-C2H2; cl15478"
/db_xref="CDD:210117"
misc_feature 1648..1722
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
misc_feature 1681..>1827
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="FOG: Zn-finger [General function prediction only];
Region: COG5048"
/db_xref="CDD:34653"
misc_feature 1732..1806
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/note="Zinc-finger double domain; Region: zf-H2C2_2;
pfam13465"
/db_xref="CDD:205643"
exon 1..37
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/inference="alignment:Splign:1.39.8"
variation 20
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="t"
/db_xref="dbSNP:375835534"
variation 27
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:201780325"
variation 34
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:377629449"
variation 35
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:376178946"
exon 38..3054
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/inference="alignment:Splign:1.39.8"
variation 52
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:369608521"
STS 54..304
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="Hic1"
/db_xref="UniSTS:498503"
variation 102
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:202126573"
STS 127..319
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54864"
/db_xref="UniSTS:164094"
variation 150
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/replace="t"
/db_xref="dbSNP:201428525"
variation 167
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:200866682"
STS 234..569
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54865"
/db_xref="UniSTS:164095"
variation 265
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:375891653"
variation 345
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:143756173"
variation 396
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:372719892"
variation 450
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:147657937"
STS 498..750
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54866"
/db_xref="UniSTS:164096"
STS 701..1014
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54867"
/db_xref="UniSTS:164097"
variation 937..938
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="g"
/db_xref="dbSNP:150364074"
STS 969..1210
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54868"
/db_xref="UniSTS:164098"
variation 1012
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:373870177"
variation 1047
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:77393586"
variation 1108
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:182733310"
STS 1136..1337
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54869"
/db_xref="UniSTS:164099"
variation 1180
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:373366887"
variation 1200
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:370995439"
variation 1209
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:375461568"
variation 1251
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:377067216"
STS 1275..1565
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54752"
/db_xref="UniSTS:164100"
variation 1287
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:115113418"
variation 1296
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:199689510"
variation 1356
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:373778061"
variation 1389
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="g"
/replace="t"
/db_xref="dbSNP:371242587"
variation 1402
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:202115526"
variation 1426
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:201599490"
variation 1431
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:371253281"
variation 1445
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="g"
/replace="t"
/db_xref="dbSNP:371934522"
variation 1454
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="c"
/db_xref="dbSNP:34263875"
variation 1466
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376477815"
variation 1468
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:370020453"
variation 1473
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201813917"
variation 1482
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:375775546"
STS 1489..1698
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54870"
/db_xref="UniSTS:164101"
variation 1539
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201380957"
variation 1548
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:373038310"
variation 1563
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376846488"
variation 1593
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:369179545"
variation 1608
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:75796056"
STS 1634..1817
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54871"
/db_xref="UniSTS:164089"
variation 1665
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:371173480"
variation 1711
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:373992938"
variation 1740
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:376884773"
STS 1759..2006
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54872"
/db_xref="UniSTS:164090"
variation 1794
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:370184800"
variation 1858
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:199947545"
variation 1936
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:188260013"
variation 1961
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:200496232"
variation 1996
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:373603534"
variation 2025
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="g"
/db_xref="dbSNP:202155372"
STS 2059..2316
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54874"
/db_xref="UniSTS:164092"
variation 2139
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:374377797"
variation 2173
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:1063317"
variation 2205
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:201398249"
STS 2276..2468
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="G54875"
/db_xref="UniSTS:164093"
variation 2303
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:374245376"
variation 2367
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:377630513"
variation 2467
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:72634003"
variation 2655
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="g"
/db_xref="dbSNP:111245437"
variation 2676
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:114468879"
variation 2756
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace=""
/replace="t"
/db_xref="dbSNP:3215740"
STS 2815..2948
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/standard_name="RH78924"
/db_xref="UniSTS:61512"
variation 2831
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="t"
/db_xref="dbSNP:34644105"
variation 2849
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:73976190"
variation 2884
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:369296924"
variation 2979
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="c"
/replace="t"
/db_xref="dbSNP:116213695"
variation 3022
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
/replace="a"
/replace="c"
/db_xref="dbSNP:146467608"
polyA_signal 3035..3040
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
polyA_site 3054
/gene="HIC1"
/gene_synonym="hic-1; ZBTB29; ZNF901"
ORIGIN
atgacttttcctgaagcggacattttacttaaatcgggagagtgtgctgggcagacgatgctggacacgatggaggcgcccggccactccaggcagctgctgctgcagctcaacaaccagcgcaccaagggcttcttgtgcgacgtgatcatcgtggtgcagaacgccctcttccgcgcgcacaagaacgtgctggcggccagcagcgcctacctcaagtccctggtggtgcatgacaacctgctcaacctggaccatgacatggtgagcccggccgtgttccgcctggtgctggacttcatctacaccggccgcctggctgacggcgcagaggcggctgcggccgcggccgtggccccgggggctgagccgagcctgggcgccgtgctggccgccgccagctacctgcagatccccgacctcgtggcgctgtgcaagaaacgcctcaagcgccacggcaagtactgccacctgcggggcggcggcggcggcggcggcggctacgcgccctatggtcggccgggccggggcctgcgggccgccacgccggtcatccaggcctgctacccgtccccagtcgggcctccgccgccgcctgccgcggagccgccctcgggcccagaggccgcggtcaacacgcactgcgccgagctgtacgcgtcgggacccggcccggccgccgcactctgtgcctcggagcgccgctgctcccctctttgtggcctggacctgtccaagaagagcccgccgggctccgcggcgccagagcggccgctggctgagcgcgagctgcccccgcgcccggacagccctcccagcgccggccccgccgcctacaaggagccgcctctcgccctgccgtcgctgccgccgctgcccttccagaagctggaggaggccgcaccgccttccgacccatttcgcggcggcagcggcagcccgggacccgagccccccggccgccccgacgggcctagtctcctctatcgctggatgaagcacgagccgggcctgggtagctatggcgacgagctgggccgggagcgcggctcccccagcgagcgctgcgaagagcgtggtggggacgcggccgtctcgcccggggggcccccgctcggcctggcgccgccgccgcgctaccctggcagcctggacgggcccggcgcgggcggcgacggcgacgactacaagagcagcagcgaggagaccggtagcagcgaggaccccagcccgcctggcggccacctcgagggctacccatgcccgcacctggcctatggcgagcccgagagcttcggtgacaacctgtacgtgtgcattccgtgcggcaagggcttccccagctctgagcagctgaacgcgcacgtggaggctcacgtggaggaggaggaagcgctgtacggcagggccgaggcggccgaagtggccgctggggccgccggcctagggcccccttttggaggcggcggggacaaggtcgccggggctccgggtggcctgggagagctgctgcggccctaccgctgcgcgtcgtgcgacaagagctacaaggacccggccacgctgcggcagcacgagaagacgcactggctgacccggccctacccatgcaccatctgcgggaagaagttcacgcagcgtgggaccatgacgcgccacatgcgcagccacctgggcctcaagcccttcgcgtgcgacgcgtgcggcatgcggttcacgcgccagtaccgcctcacggagcacatgcgcatccactcgggcgagaagccctacgagtgccaggtgtgcggcggcaagttcgcacagcaacgcaacctcatcagccacatgaagatgcacgccgtggggggcgcggccggcgcggccggggcgctggcgggcttgggggggctccccggcgtccccggccccgacggcaagggcaagctcgacttccccgagggcgtctttgctgtggctcgcctcacggccgagcagctgagcctgaagcagcaggacaaggcggccgcggccgagctgctggcgcagaccacgcacttcctgcacgaccccaaggtggcgctggagagcctctacccgctggccaagttcacggccgagctgggcctcagccccgacaaggcggccgaggtgctgagccagggcgctcacctggcggccgggcccgacggccggaccatcgaccgtttctctcccacctagagcgcccctcgccagcccgctctgtcgctgctgcgcggccctggcccgcaccccagggagcggcgggggcggcgcgcagggcccactgtgcccgggacaaccgcagcgtcgccacagtggcggctccacctctcggcggcctcacctggcctcactgcttcgtgccttagctcgggggtcgggggagaaccccgggacgggggtgggatggggtaagggaaatttatatttttgatatcagctttgaccaaaggagaccccaggcccctcccgcctcttcctgtggttcgtcggccccctcccccggctccgcgctgctcttagagggggaggggtgtcactgtcggggcactcctagccctacctccggcccttgcgaccacacccattctcactgtgaatctccccgctggggtcggagcgtcgggcagagttggggagtggggaggggactgagccggccggagggccccccgcacccccgctcccacccaccccgggactgataatgtgaagttcctcattttgcacaagtggcactagccccagggccaacccttccttcctcagtcaccaagggcggggagttctggagtcggaaggcgaagagcctaccaccaggtctcccactcccgcggtgccctcccttcccttccctgcggccccggaccatatttattgcatgcgccccggcggccccccatcccgagcccaggctgggctgggctggaacgcggtctctttagctccctcctcttcgtttgtatatttcctaccttgtacacaggctcttccagagccgcttccattttctatactcgaaccaaacagcaataaagcagtaaccaaggaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:3090 -> Molecular function: GO:0003677 [DNA binding] evidence: NAS
GeneID:3090 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: IDA
GeneID:3090 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:3090 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:3090 -> Molecular function: GO:0042826 [histone deacetylase binding] evidence: IDA
GeneID:3090 -> Molecular function: GO:0043565 [sequence-specific DNA binding] evidence: IDA
GeneID:3090 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:3090 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: IDA
GeneID:3090 -> Biological process: GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:3090 -> Biological process: GO:0006351 [transcription, DNA-dependent] evidence: IEA
GeneID:3090 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: TAS
GeneID:3090 -> Biological process: GO:0007275 [multicellular organismal development] evidence: NAS
GeneID:3090 -> Biological process: GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] evidence: IDA
GeneID:3090 -> Biological process: GO:0016055 [Wnt receptor signaling pathway] evidence: IEA
GeneID:3090 -> Biological process: GO:0030178 [negative regulation of Wnt receptor signaling pathway] evidence: IDA
GeneID:3090 -> Biological process: GO:0043517 [positive regulation of DNA damage response, signal transduction by p53 class mediator] evidence: ISS
GeneID:3090 -> Cellular component: GO:0000785 [chromatin] evidence: ISS
GeneID:3090 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:3090 -> Cellular component: GO:0005634 [nucleus] evidence: NAS
GeneID:3090 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA
GeneID:3090 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
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DBCLS
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