GGRNA Home | Help | Advanced search

2024-03-28 21:29:27, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001083613            1019 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens transmembrane protein 219 (TMEM219), transcript
            variant 1, mRNA.
ACCESSION   NM_001083613
VERSION     NM_001083613.1  GI:134288872
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1019)
  AUTHORS   Ingermann,A.R., Yang,Y.F., Han,J., Mikami,A., Garza,A.E.,
            Mohanraj,L., Fan,L., Idowu,M., Ware,J.L., Kim,H.S., Lee,D.Y. and
            Oh,Y.
  TITLE     Identification of a novel cell death receptor mediating
            IGFBP-3-induced anti-tumor effects in breast and prostate cancer
  JOURNAL   J. Biol. Chem. 285 (39), 30233-30246 (2010)
   PUBMED   20353938
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB506492.1, BC050051.1 and CF453990.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM915430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025083 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               DB506492.1         1-316
            317-995             BC050051.1         344-1022
            996-1019            CF453990.1         939-962
FEATURES             Location/Qualifiers
     source          1..1019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1019
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /note="transmembrane protein 219"
                     /db_xref="GeneID:124446"
                     /db_xref="HGNC:25201"
     exon            1..103
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    63..65
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /note="upstream in-frame stop codon"
     exon            104..305
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     variation       116
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370073098"
     variation       126
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:372738520"
     variation       127
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375055627"
     CDS             141..863
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /note="insulin-like growth factor binding protein-3
                     receptor; insulin-like growth factor-binding protein 3
                     receptor"
                     /codon_start=1
                     /product="insulin-like growth factor-binding protein 3
                     receptor precursor"
                     /protein_id="NP_001077082.1"
                     /db_xref="GI:134288873"
                     /db_xref="CCDS:CCDS42145.1"
                     /db_xref="GeneID:124446"
                     /db_xref="HGNC:25201"
                     /translation="
MGNCQAGHNLHLCLAHHPPLVCATLILLLLGLSGLGLGSFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSRLLVLGSFLLLFCGLLCCVTAMCFHPRRESHWSRTRL
"
     sig_peptide     141..254
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Potential; propagated from UniProtKB/Swiss-Prot
                     (Q86XT9.1)"
     mat_peptide     255..860
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /product="Insulin-like growth factor-binding protein 3
                     receptor"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XT9.1)"
     misc_feature    753..815
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q86XT9.1);
                     transmembrane region"
     variation       187
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:369197997"
     variation       201
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200171423"
     variation       214
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372519753"
     variation       215
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:377178738"
     variation       222
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139432501"
     variation       286
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201972818"
     exon            306..495
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     variation       306
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:373561978"
     variation       312
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368041333"
     variation       332
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:76571198"
     variation       366
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375867009"
     variation       370
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368235524"
     variation       382
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:199601574"
     variation       395
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369756545"
     variation       422
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371821689"
     variation       428
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369362636"
     variation       486
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200245582"
     exon            496..725
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     variation       522
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201405792"
     variation       547
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:187590348"
     variation       560
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:202215099"
     variation       580
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:79505862"
     variation       592
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370745884"
     variation       606
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:367905774"
     variation       627
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:372393686"
     variation       642
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200066942"
     variation       653
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201280263"
     variation       681
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:201255291"
     variation       715
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:190481775"
     variation       724
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371222070"
     exon            726..896
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     variation       753
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:199948804"
     variation       758
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:143774804"
     variation       826
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377452886"
     variation       828
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370014475"
     variation       847
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370371593"
     variation       856
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373005070"
     variation       857
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200253644"
     variation       865
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201304055"
     variation       870
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:377568882"
     variation       872
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:370475830"
     variation       874
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:375365347"
     variation       882
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373060298"
     variation       883
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368295355"
     exon            897..999
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /inference="alignment:Splign:1.39.8"
     variation       990
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:35204406"
     variation       999
                     /gene="TMEM219"
                     /gene_synonym="IGFBP-3R"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:55743682"
ORIGIN      
gaggaggagggtcggggacggaagcgcagagcacggaccccgccccctcgcggccccgctcgtgacgtcgcggggggcgccggcctccgcccggccccgagggcaggctctccccggaggctcagccccctctgctccccatgggcaactgccaggcagggcacaacctgcacctgtgtctggcccaccacccacctctggtctgtgccactttgatcctgctgctccttggcctctctggcctgggccttggcagcttcctcctcacccacaggactggcctgcgcagccctgacatcccccaggactgggtctcttttttgagatcttttggccagctgaccctgtgtcccaggaatgggacagtcacagggaagtggcgagggtctcacgtcgtgggcttgctgaccaccttgaacttcggagacggtccagacaggaacaagacccggacattccaggccacagtcctgggaagtcagatgggattgaaaggatcttctgcaggacaactggtccttatcacagccagggtgaccacagaaaggactgcaggaacctgcctatattttagtgctgttccaggaatcctaccctccagccagccacccatatcctgctcagaggagggggctggaaatgccaccctgagccctagaatgggtgaggaatgtgttagtgtctggagccatgaaggccttgtgctgaccaagctgctcacctcggaggagctggctctgtgtggctccaggctgctggtcttgggctccttcctgcttctcttctgtggccttctctgctgtgtcactgctatgtgcttccacccgcgccgggagtcccactggtctagaacccggctctgagggcactggcctagttcccgacttgtttctcaggtgtgaatcaacttcttgggccttggctctgagttggaaaaggttttagaaaaagtgaagagctggaatgtgggggaaaataaaaagcttttttgcccagtggaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:124446 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:124446 -> Cellular component: GO:0005886 [plasma membrane] evidence: IEA
            GeneID:124446 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.