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2020-10-26 18:23:49, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001081640           13416 bp    mRNA    linear   PRI 01-JUL-2013
DEFINITION  Homo sapiens protein kinase, DNA-activated, catalytic polypeptide
            (PRKDC), transcript variant 2, mRNA.
ACCESSION   NM_001081640
VERSION     NM_001081640.1  GI:126032349
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13416)
  AUTHORS   Davis,A.J., Lee,K.J. and Chen,D.J.
  TITLE     The N-terminal region of the DNA-dependent protein kinase catalytic
            subunit is required for its DNA double-stranded break-mediated
            activation
  JOURNAL   J. Biol. Chem. 288 (10), 7037-7046 (2013)
   PUBMED   23322783
  REMARK    GeneRIF: Results show the N-terminal region mediates the
            interaction between DNA-PKcs and the Ku70/Ku80-DNA complex and is
            required for its DNA double-stranded breaks (DSBs)-induced
            enzymatic activity.
REFERENCE   2  (bases 1 to 13416)
  AUTHORS   Munoz,D.P., Kawahara,M. and Yannone,S.M.
  TITLE     An autonomous chromatin/DNA-PK mechanism for localized DNA damage
            signaling in mammalian cells
  JOURNAL   Nucleic Acids Res. 41 (5), 2894-2906 (2013)
   PUBMED   23325849
  REMARK    GeneRIF: Allosteric regulation of DNA-PK by DNA termini protruding
            from chromatin constitutes an autonomous mechanism for
            break-localized protein phosphorylation that generates sub-nuclear
            foci.
REFERENCE   3  (bases 1 to 13416)
  AUTHORS   Zhang,J., Wu,X.H. and Gan,Y.
  TITLE     Current evidence on the relationship between three polymorphisms in
            the XRCC7 gene and cancer risk
  JOURNAL   Mol. Biol. Rep. 40 (1), 81-86 (2013)
   PUBMED   23108991
  REMARK    GeneRIF: XRCC7 rs7003908 polymorphism may contribute to cancer
            susceptibility for prostate cancer, which is recommended to be
            included in future large-sample studies and functional assays.
REFERENCE   4  (bases 1 to 13416)
  AUTHORS   Pyun,B.J., Seo,H.R., Lee,H.J., Jin,Y.B., Kim,E.J., Kim,N.H.,
            Kim,H.S., Nam,H.W., Yook,J.I. and Lee,Y.S.
  TITLE     Mutual regulation between DNA-PKcs and Snail1 leads to increased
            genomic instability and aggressive tumor characteristics
  JOURNAL   Cell Death Dis 4, E517 (2013)
   PUBMED   23449453
  REMARK    GeneRIF: DNA-PKcs phosphorylates snail1 at ser100 led to increased
            snail 1 stability and inhibited the kinase activity of DNA-Pkcs.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13416)
  AUTHORS   Rahimi,M., Fayaz,S., Fard-Esfahani,A., Modarressi,M.H., Akrami,S.M.
            and Fard-Esfahani,P.
  TITLE     The role of Ile3434Thr XRCC7 gene polymorphism in differentiated
            thyroid cancer risk in an Iranian population
  JOURNAL   Iran. Biomed. J. 16 (4), 218-222 (2012)
   PUBMED   23183621
  REMARK    GeneRIF: Allele 3434Thr in XRCC7 gene might be associated with
            differentiated thyroid cancer risk.
REFERENCE   6  (bases 1 to 13416)
  AUTHORS   Poltoratsky,V.P., Shi,X., York,J.D., Lieber,M.R. and Carter,T.H.
  TITLE     Human DNA-activated protein kinase (DNA-PK) is homologous to
            phosphatidylinositol kinases
  JOURNAL   J. Immunol. 155 (10), 4529-4533 (1995)
   PUBMED   7594449
REFERENCE   7  (bases 1 to 13416)
  AUTHORS   Sipley,J.D., Menninger,J.C., Hartley,K.O., Ward,D.C., Jackson,S.P.
            and Anderson,C.W.
  TITLE     Gene for the catalytic subunit of the human DNA-activated protein
            kinase maps to the site of the XRCC7 gene on chromosome 8
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 92 (16), 7515-7519 (1995)
   PUBMED   7638222
REFERENCE   8  (bases 1 to 13416)
  AUTHORS   Iijima,S., Teraoka,H., Date,T. and Tsukada,K.
  TITLE     DNA-activated protein kinase in Raji Burkitt's lymphoma cells.
            Phosphorylation of c-Myc oncoprotein
  JOURNAL   Eur. J. Biochem. 206 (2), 595-603 (1992)
   PUBMED   1597196
REFERENCE   9  (bases 1 to 13416)
  AUTHORS   Carter,T., Vancurova,I., Sun,I., Lou,W. and DeLeon,S.
  TITLE     A DNA-activated protein kinase from HeLa cell nuclei
  JOURNAL   Mol. Cell. Biol. 10 (12), 6460-6471 (1990)
   PUBMED   2247066
REFERENCE   10 (bases 1 to 13416)
  AUTHORS   Lees-Miller,S.P. and Anderson,C.W.
  TITLE     The human double-stranded DNA-activated protein kinase
            phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two
            NH2-terminal threonine residues
  JOURNAL   J. Biol. Chem. 264 (29), 17275-17280 (1989)
   PUBMED   2507541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U47077.5 and U34994.3.
            
            Summary: This gene encodes the catalytic subunit of the
            DNA-dependent protein kinase (DNA-PK). It functions with the
            Ku70/Ku80 heterodimer protein in DNA double strand break repair and
            recombination. The protein encoded is a member of the
            PI3/PI4-kinase family.[provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region, compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U34994.3 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11453             U47077.5           1-11453
            11454-12409         U34994.3           11449-12404
            12410-13416         U47077.5           12503-13509
FEATURES             Location/Qualifiers
     source          1..13416
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11"
     gene            1..13416
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="protein kinase, DNA-activated, catalytic
                     polypeptide"
                     /db_xref="GeneID:5591"
                     /db_xref="HGNC:9413"
                     /db_xref="MIM:600899"
     exon            1..211
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     CDS             58..12351
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DNA-dependent protein kinase catalytic subunit;
                     hyper-radiosensitivity of murine scid mutation,
                     complementing 1; p460; DNA-PK catalytic subunit"
                     /codon_start=1
                     /product="DNA-dependent protein kinase catalytic subunit
                     isoform 2"
                     /protein_id="NP_001075109.1"
                     /db_xref="GI:126032350"
                     /db_xref="GeneID:5591"
                     /db_xref="HGNC:9413"
                     /db_xref="MIM:600899"
                     /translation="
MAGSGAGVRCSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFVRKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALDLLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEMINNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIFNFVLKAIRPQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIIRNVDSNNKELSIAIRGYGLFAGPCKVINAKDVDFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSFPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPKGPESESEDHRASGEVRTGKWKVPTYKDYVDLFRHLLSSDQMMDSILADEAFFSVNSSSESLNHLLYDEFVKSVLKIVEKLDLTLEIQTVGEQENGDEAPGVWMIPTSDPAANLHPAKPKDFSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKIKYFEGVSPKSLKHSPEDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSALSDETKNNWEVSALSRAAQKGFNKVVLKHLKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLTVTSSDEMMKSYVAWDREKRLSFAVPFREMKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFGTGAAGNRTSPQEGERYNYSKCTVVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIAPGDERQCLPSLDLSCKQLASGLLELAFAFGGLCERLVSLLLNPAVLSTASLGSSQGSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFTSLTGGSLEELRRVLEQLIVAHFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRIARRGSCVTQVGLLESVYEMFRKDDPRLSFTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNESTFDTQITKKMGYYKILDVMYSRLPKDDVHAKESKINQVFHGSCITEGNELTKTLIKLCYDAFTENMAGENQLLERRRLYHCAAYNCAISVICCVFNELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAANGDSDGPSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQRDPTVHDDVLELEMDELNRHECMAPLTALVKHMHRSLGPPQGEEDSVPRDLPSWMKFLHGKLGNPIVPLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAASENNGGEGIHYMVVEIVATILSWTGLATPTGVPKDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDPESETDNDSQEIFKLAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTPMFVETQASQGTLQTRTQEGSLSARWPVAGQIRATQQQHDFTLTQTADGRSSFDWLTGSSTDPLVDHTSPSSDSLLFAHKRSERLQRAPLKSVGPDFGKKRLGLPGDEVDNKVKGAAGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELAKLYRSIGEYDVLRGIFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANALSSEPACLAEIEEDKARRILELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCGPAAGVIDAYMTLADFCDQQLRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRMKLSDFNDITNMLLLKMNKDSKPPGNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSSDPRAPPCEYKDWLTKMSGKHDVGAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALRAFRSDPGLLTNTMDVFVKEPSFDWKNFEQKMLKKGGSWIQEINVAEKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWM
"
     misc_feature    406..408
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    919..1026
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: HEAT 1"
     misc_feature    2539..2541
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    2734..2736
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P78527.3); phosphorylation site"
     misc_feature    3067..3177
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: HEAT 2"
     misc_feature    3682..3684
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    4564..4671
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: Interaction with C1D"
     misc_feature    4564..4671
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: Leucine-zipper"
     misc_feature    5224..5325
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: TPR 1"
     misc_feature    5500..6687
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="NUC194 domain; Region: NUC194; pfam08163"
                     /db_xref="CDD:203865"
     misc_feature    5965..5967
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    6115..6120
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Cleavage, by caspase-3 (Probable); propagated from
                     UniProtKB/Swiss-Prot (P78527.3); cleavage site"
     misc_feature    6832..6834
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    7363..9693
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (P78527.3);
                     Region: KIP-binding"
     misc_feature    7882..7884
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
     misc_feature    7891..7893
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
     misc_feature    7891..7893
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    7969..7971
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
     misc_feature    7969..7971
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    7996..7998
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphothreonine, by autocatalysis; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); phosphorylation site"
     misc_feature    7996..7998
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8080..8082
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8086..8088
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    8284..8286
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    9124..10467
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="FAT domain; Region: FAT; pfam02259"
                     /db_xref="CDD:202179"
     misc_feature    9670..9672
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P78527.3); phosphorylation site"
     misc_feature    9670..9672
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
     misc_feature    9778..9780
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    9835..9837
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    10918..10920
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    10969..10971
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    10981..10983
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="N6-acetyllysine; propagated from
                     UniProtKB/Swiss-Prot (P78527.3); acetylation site"
     misc_feature    11212..12009
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="DNA-dependent protein kinase (DNA-PK), catalytic
                     domain; The DNA-PK catalytic domain subfamily is part of a
                     larger superfamily that includes the catalytic domains of
                     other kinases such as the typical
                     serine/threonine/tyrosine protein kinases (PKs); Region:
                     PIKKc_DNA-PK; cd05172"
                     /db_xref="CDD:119432"
     misc_feature    order(11242..11244,11248..11256,11260..11262,11308..11310,
                     11314..11316,11323..11325,11428..11430,11539..11550,
                     11563..11565,11743..11745,11749..11751,11782..11787)
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:119432"
     misc_feature    11305..12015
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="Phosphoinositide 3-kinase, catalytic domain;
                     Region: PI3Kc; smart00146"
                     /db_xref="CDD:197542"
     misc_feature    11719..11745
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="catalytic loop [active]"
                     /db_xref="CDD:119432"
     misc_feature    order(11785..11817,11821..11856)
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:119432"
     misc_feature    12040..12042
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (P78527.3); phosphorylation site"
     misc_feature    12253..12348
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /note="FATC domain; Region: FATC; pfam02260"
                     /db_xref="CDD:202180"
     variation       73
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8177999"
     exon            212..288
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            289..381
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            382..456
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            457..565
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            566..678
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            679..778
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            779..834
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            835..865
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            866..1023
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1024..1170
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       1056
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178017"
     exon            1171..1335
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1336..1504
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1505..1554
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1555..1680
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     STS             1566..1645
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /standard_name="PMC84245P1"
                     /db_xref="UniSTS:273442"
     exon            1681..1833
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            1834..1949
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       1848
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178032"
     variation       1871
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:8178033"
     exon            1950..2109
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       1968
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:45438803"
     variation       2097
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178040"
     exon            2110..2196
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       2140
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178046"
     exon            2197..2316
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2317..2476
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2477..2583
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2584..2674
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2675..2838
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2839..2991
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            2992..3099
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            3100..3326
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       3269
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178070"
     exon            3327..3421
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            3422..3521
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            3522..3655
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            3656..3904
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       3816
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178087"
     variation       3891
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178088"
     exon            3905..4128
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       3998
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8178090"
     exon            4129..4337
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            4338..4470
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            4471..4629
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            4630..4833
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       4820
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:8178104"
     exon            4834..5019
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       4866
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:8178106"
     exon            5020..5124
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            5125..5292
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            5293..5420
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       5310
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178120"
     exon            5421..5628
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       5622
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178122"
     exon            5629..5807
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            5808..5976
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            5977..6042
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6043..6115
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6116..6264
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       6198
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178141"
     exon            6265..6402
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       6341
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178147"
     exon            6403..6522
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6523..6666
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6667..6818
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6819..6950
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            6951..7062
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            7063..7187
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            7188..7337
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            7338..7511
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            7512..7610
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            7611..7818
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       7704
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:4425755"
     exon            7819..8008
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            8009..8209
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       8161
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178178"
     exon            8210..8322
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            8323..8454
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            8455..8634
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            8635..8840
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       8752
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:4278157"
     exon            8841..8979
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            8980..9168
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       9102
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201065627"
     variation       9103
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:202148492"
     exon            9169..9393
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            9394..9502
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            9503..9614
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       9503
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178208"
     exon            9615..9804
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       9658
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178216"
     exon            9805..9979
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            9980..10173
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            10174..10354
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       10179
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178224"
     variation       10268
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178225"
     exon            10355..10515
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       10433
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178228"
     exon            10516..10727
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       10683
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178231"
     exon            10728..10815
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       10741
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:8178232"
     exon            10816..10959
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            10960..11164
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       11133
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178235"
     variation       11163
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178236"
     exon            11165..11232
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            11233..11453
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            11454..11543
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       11471
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178245"
     exon            11544..11615
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            11616..11817
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       11730
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178247"
     variation       11758
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178248"
     variation       11769
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178249"
     exon            11818..12006
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            12007..12146
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     exon            12147..13416
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /inference="alignment:Splign:1.39.8"
     variation       12188
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2515637"
     STS             12408..12614
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /standard_name="G29848"
                     /db_xref="UniSTS:40531"
     variation       12542
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178268"
     variation       12644
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1804610"
     variation       12693
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178269"
     variation       12882
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:8178270"
     variation       12986
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:8178271"
     STS             13272..13371
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /standard_name="D8S1353E"
                     /db_xref="UniSTS:151168"
     STS             13273..13377
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
                     /standard_name="EST197660"
                     /db_xref="UniSTS:10824"
     polyA_signal    13394..13399
                     /gene="PRKDC"
                     /gene_synonym="DNA-PKcs; DNAPK; DNPK1; HYRC; HYRC1; p350;
                     XRCC7"
ORIGIN      
ggggcatttccgggtccgggccgagcgggcgcacgcgcgggagcgggactcggcggcatggcgggctccggagccggtgtgcgttgctccctgctgcggctgcaggagaccttgtccgctgcggaccgctgcggtgctgccctggccggtcatcaactgatccgcggcctggggcaggaatgcgtcctgagcagcagccccgcggtgctggcattacagacatctttagttttttccagagatttcggtttgcttgtatttgtccggaagtcactcaacagtattgaatttcgtgaatgtagagaagaaatcctaaagtttttatgtattttcttagaaaaaatgggccagaagatcgcaccttactctgttgaaattaagaacacttgtaccagtgtttatacaaaagatagagctgctaaatgtaaaattccagccctggaccttcttattaagttacttcagacttttagaagttctagactcatggatgaatttaaaattggagaattatttagtaaattctatggagaacttgcattgaaaaaaaaaataccagatacagttttagaaaaagtatatgagctcctaggattattgggtgaagttcatcctagtgagatgataaataatgcagaaaacctgttccgcgcttttctgggtgaacttaagacccagatgacatcagcagtaagagagcccaaactacctgttctggcaggatgtctgaaggggttgtcctcacttctgtgcaacttcactaagtccatggaagaagatccccagacttcaagggagatttttaattttgtactaaaggcaattcgtcctcagattgatctgaagagatatgctgtgccctcagctggcttgcgcctatttgccctgcatgcatctcagtttagcacctgccttctggacaactacgtgtctctatttgaagtcttgttaaagtggtgtgcccacacaaatgtagaattgaaaaaagctgcactttcagccctggaatcctttctgaaacaggtttctaatatggtggcgaaaaatgcagaaatgcataaaaataaactgcagtactttatggagcagttttatggaatcatcagaaatgtggattcgaacaacaaggagttatctattgctatccgtggatatggactttttgcaggaccgtgcaaggttataaacgcaaaagatgttgacttcatgtacgttgagctcattcagcgctgcaagcagatgttcctcacccagacagacactggtgacgaccgtgtttatcagatgccaagcttcctccagtctgttgcaagcgtcttgctgtaccttgacacagttcctgaggtgtatactccagttctggagcacctcgtggtgatgcagatagacagtttcccacagtacagtccaaaaatgcagctggtgtgttgcagagccatagtgaaggtgttcctagctttggcagcaaaagggccagttctcaggaattgcattagtactgtggtgcatcagggtttaatcagaatatgttctaaaccagtggtccttccaaagggccctgagtctgaatctgaagaccaccgtgcttcaggggaagtcagaactggcaaatggaaggtgcccacatacaaagactacgtggatctcttcagacatctcctgagctctgaccagatgatggattctattttagcagatgaagcatttttctctgtgaattcctccagtgaaagtctgaatcatttactttatgatgaatttgtaaaatccgttttgaagattgttgagaaattggatcttacacttgaaatacagactgttggggaacaagagaatggagatgaggcgcctggtgtttggatgatcccaacttcagatccagcggctaacttgcatccagctaaacctaaagatttttcggctttcattaacctggtggaattttgcagagagattctccctgagaaacaagcagaattttttgaaccatgggtgtactcattttcatatgaattaattttgcaatctacaaggttgcccctcatcagtggtttctacaaattgctttctattacagtaagaaatgccaagaaaataaaatatttcgagggagttagtccaaagagtctgaaacactctcctgaagacccagaaaagtattcttgctttgctttatttgtgaaatttggcaaagaggtggcagttaaaatgaagcagtacaaagatgaacttttggcctcttgtttgacctttcttctgtccttgccacacaacatcattgaactcgatgttagagcctacgttcctgcactgcagatggctttcaaactgggcctgagctatacccccttggcagaagtaggcctgaatgctctagaagaatggtcaatttatattgacagacatgtaatgcagccttattacaaagacattctcccctgcctggatggatacctgaagacttcagccttgtcagatgagaccaagaataactgggaagtgtcagctctttctcgggctgcccagaaaggatttaataaagtggtgttaaagcatctgaagaagacaaagaacctttcatcaaacgaagcaatatccttagaagaaataagaattagagtagtacaaatgcttggatctctaggaggacaaataaacaaaaatcttctgacagtcacgtcctcagatgagatgatgaagagctatgtggcctgggacagagagaagcggctgagctttgcagtgccctttagagagatgaaacctgtcattttcctggatgtgttcctgcctcgagtcacagaattagcgctcacagccagtgacagacaaactaaagttgcagcctgtgaacttttacatagcatggttatgtttatgttgggcaaagccacgcagatgccagaagggggacagggagccccacccatgtaccagctctataagcggacgtttcctgtgctgcttcgacttgcgtgtgatgttgatcaggtgacaaggcaactgtatgagccactagttatgcagctgattcactggttcactaacaacaagaaatttgaaagtcaggatactgttgccttactagaagctatattggatggaattgtggaccctgttgacagtactttaagagatttttgtggtcggtgtattcgagaattccttaaatggtccattaagcaaataacaccacagcagcaggagaagagtccagtaaacaccaaatcgcttttcaagcgactttatagccttgcgcttcaccccaatgctttcaagaggctgggagcatcacttgcctttaataatatctacagggaattcagggaagaagagtctctggtggaacagtttgtgtttgaagccttggtgatatacatggagagtctggccttagcacatgcagatgagaagtccttaggtacaattcaacagtgttgtgatgccattgatcacctatgccgcatcattgaaaagaagcatgtttctttaaataaagcaaagaaacgacgtttgccgcgaggatttccaccttccgcatcattgtgtttattggatctggtcaagtggcttttagctcattgtgggaggccccagacagaatgtcgacacaaatccattgaactcttttataaattcgttcctttattgccaggcaacagatcccctaatttgtggctgaaagatgttctcaaggaagaaggtgtctcttttctcatcaacacctttgaggggggtggctgtggccagccctcgggcatcctggcccagcccaccctcttgtaccttcgggggccattcagcctgcaggccacgctatgctggctggacctgctcctggccgcgttggagtgctacaacacgttcattggcgagagaactgtaggagcgctccaggtcctaggtactgaagcccagtcttcacttttgaaagcagtggctttcttcttagaaagcattgccatgcatgacattatagcagcagaaaagtgctttggcactggggcagcaggtaacagaacaagcccacaagagggagaaaggtacaactacagcaaatgcaccgttgtggtccggattatggagtttaccacgactctgctaaacacctccccggaaggatggaagctcctgaagaaggacttgtgtaatacacacctgatgagagtcctggtgcagacgctgtgtgagcccgcaagcataggtttcaacatcggagacgtccaggttatggctcatcttcctgatgtttgtgtgaatctgatgaaagctctaaagatgtccccatacaaagatatcctagagacccatctgagagagaaaataacagcacagagcattgaggagctttgtgccgtcaacttgtatggccctgacgcgcaagtggacaggagcaggctggctgctgttgtgtctgcctgtaaacagcttcacagagctgggcttctgcataatatattaccgtctcagtccacagatttgcatcattctgttggcacagaacttctttccctggtttataaaggcattgcccctggagatgagagacagtgtctgccttctctagacctcagttgtaagcagctggccagcggacttctggagttagcctttgcttttggaggactgtgtgagcgccttgtgagtcttctcctgaacccagcggtgctgtccacggcgtccttgggcagctcacagggcagcgtcatccacttctcccatggggagtatttctatagcttgttctcagaaacgatcaacacggaattattgaaaaatctggatcttgctgtattggagctcatgcagtcttcagtggataataccaaaatggtgagtgccgttttgaacggcatgttagaccagagcttcagggagcgagcaaaccagaaacaccaaggactgaaacttgcgactacaattctgcaacactggaagaagtgtgattcatggtgggccaaagattcccctctcgaaactaaaatggcagtgctggccttactggcaaaaattttacagattgattcatctgtatcttttaatacaagtcatggttcattccctgaagtctttacaacatatattagtctacttgctgacacaaagctggatctacatttaaagggccaagctgtcactcttcttccattcttcaccagcctcactggaggcagtctggaggaacttagacgtgttctggagcagctcatcgttgctcacttccccatgcagtccagggaatttcctccaggaactccgcggttcaataattatgtggactgcatgaaaaagtttctagatgcattggaattatctcaaagccctatgttgttggaattgatgacagaagttctttgtcgggaacagcagcatgtcatggaagaattatttcaatccagtttcaggaggattgccagaaggggttcatgtgtcacacaagtaggccttctggaaagcgtgtatgaaatgttcaggaaggatgacccccgcctaagtttcacacgccagtcctttgtggaccgctccctcctcactctgctgtggcactgtagcctggatgctttgagagaattcttcagcacaattgtggtggatgccattgatgtgttgaagtccaggtttacaaagctaaatgaatctacctttgatactcaaatcaccaagaagatgggctactataagattctagacgtgatgtattctcgccttcccaaagatgatgttcatgctaaggaatcaaaaattaatcaagttttccatggctcgtgtattacagaaggaaatgaacttacaaagacattgattaaattgtgctacgatgcatttacagagaacatggcaggagagaatcagctgctggagaggagaagactttaccattgtgcagcatacaactgcgccatatctgtcatctgctgtgtcttcaatgagttaaaattttaccaaggttttctgtttagtgaaaaaccagaaaagaacttgcttatttttgaaaatctgatcgacctgaagcgccgctataattttcctgtagaagttgaggttcctatggaaagaaagaaaaagtacattgaaattaggaaagaagccagagaagcagcaaatggggattcagatggtccttcctatatgtcttccctgtcatatttggcagacagtaccctgagtgaggaaatgagtcaatttgatttctcaaccggagttcagagctattcatacagctcccaagaccctagacctgccactggtcgttttcggagacgggagcagcgggaccccacggtgcatgatgatgtgctggagctggagatggacgagctcaatcggcatgagtgcatggcgcccctgacggccctggtcaagcacatgcacagaagcctgggcccgcctcaaggagaagaggattcagtgccaagagatcttccttcttggatgaaattcctccatggcaaactgggaaatccaatagtaccattaaatatccgtctcttcttagccaagcttgttattaatacagaagaggtctttcgcccttacgcgaagcactggcttagccccttgctgcagctggctgcttctgaaaacaatggaggagaaggaattcactacatggtggttgagatagtggccactattctttcatggacaggcttggccactccaacaggggtccctaaagatgaagtgttagcaaatcgattgcttaatttcctaatgaaacatgtctttcatccaaaaagagctgtgtttagacacaaccttgaaattataaagacccttgtcgagtgctggaaggattgtttatccatcccttataggttaatatttgaaaagttttccggtaaagatcctaattctaaagacaactcagtagggattcaattgctaggcatcgtgatggccaatgacctgcctccctatgacccacagtgtggcatccagagtagcgaatacttccaggctttggtgaataatatgtcctttgtaagatataaagaagtgtatgccgctgcagcagaagttctaggacttatacttcgatatgttatggagagaaaaaacatactggaggagtctctgtgtgaactggttgcgaaacaattgaagcaacatcagaatactatggaggacaagtttattgtgtgcttgaacaaagtgaccaagagcttccctcctcttgcagacaggttcatgaatgctgtgttctttctgctgccaaaatttcatggagtgttgaaaacactctgtctggaggtggtactttgtcgtgtggagggaatgacagagctgtacttccagttaaagagcaaggacttcgttcaagtcatgagacatagagatgatgaaagacaaaaagtatgtttggacataatttataagatgatgccaaagttaaaaccagtagaactccgagaacttctgaaccccgttgtggaattcgtttcccatccttctacaacatgtagggaacaaatgtataatattctcatgtggattcatgataattacagagatccagaaagtgagacagataatgactcccaggaaatatttaagttggcaaaagatgtgctgattcaaggattgatcgatgagaaccctggacttcaattaattattcgaaatttctggagccatgaaactaggttaccttcaaataccttggaccggttgctggcactaaattccttatattctcctaagatagaagtgcactttttaagtttagcaacaaattttctgctcgaaatgaccagcatgagcccagattatccaaaccccatgttcgagcatcctctgtcagaatgcgaatttcaggaatataccattgattctgattggcgtttccgaagtactgttctcactccgatgtttgtggagacccaggcctcccagggcactctccagacccgtacccaggaagggtccctctcagctcgctggccagtggcagggcagataagggccacccagcagcagcatgacttcacactgacacagactgcagatggaagaagctcatttgattggctgaccgggagcagcactgacccgctggtcgaccacaccagtccctcatctgactccttgctgtttgcccacaagaggagtgaaaggttacagagagcacccttgaagtcagtggggcctgattttgggaaaaaaaggctgggccttccaggggacgaggtggataacaaagtgaaaggtgcggccggccggacggacctactacgactgcgcagacggtttatgagggaccaggagaagctcagtttgatgtatgccagaaaaggcgttgctgagcaaaaacgagagaaggaaatcaagagtgagttaaaaatgaagcaggatgcccaggtcgttctgtacagaagctaccggcacggagaccttcctgacattcagatcaagcacagcagcctcatcaccccgttacaggccgtggcccagagggacccaataattgcaaaacagctctttagcagcttgttttctggaattttgaaagagatggataaatttaagacactgtctgaaaaaaacaacatcactcaaaagttgcttcaagacttcaatcgttttcttaataccaccttctctttctttccaccctttgtctcttgtattcaggacattagctgtcagcacgcagccctgctgagcctcgacccagcggctgttagcgctggttgcctggccagcctacagcagcccgtgggcatccgcctgctagaggaggctctgctccgcctgctgcctgctgagctgcctgccaagcgagtccgtgggaaggcccgcctccctcctgatgtcctcagatgggtggagcttgctaagctgtatagatcaattggagaatacgacgtcctccgtgggatttttaccagtgagataggaacaaagcaaatcactcagagtgcattattagcagaagccagaagtgattattctgaagctgctaagcagtatgatgaggctctcaataaacaagactgggtagatggtgagcccacagaagccgagaaggatttttgggaacttgcatcccttgactgttacaaccaccttgctgagtggaaatcacttgaatactgttctacagccagtatagacagtgagaaccccccagacctaaataaaatctggagtgaaccattttatcaggaaacatatctaccttacatgatccgcagcaagctgaagctgctgctccagggagaggctgaccagtccctgctgacatttattgacaaagctatgcacggggagctccagaaggcgattctagagcttcattacagtcaagagctgagtctgctttacctcctgcaagatgatgttgacagagccaaatattacattcaaaatggcattcagagttttatgcagaattattctagtattgatgtcctcttacaccaaagtagactcaccaaattgcagtctgtacaggctttaacagaaattcaggagttcatcagctttataagcaaacaaggcaatttatcatctcaagttccccttaagagacttctgaacacctggacaaacagatatccagatgctaaaatggacccaatgaacatctgggatgacatcatcacaaatcgatgtttctttctcagcaaaatagaggagaagcttacccctcttccagaagataatagtatgaatgtggatcaagatggagaccccagtgacaggatggaagtgcaagagcaggaagaagatatcagctccctgatcaggagttgcaagttttccatgaaaatgaagatgatagacagtgcccggaagcagaacaatttctcacttgctatgaaactactgaaggagctgcataaagagtcaaaaaccagagacgattggctggtgagctgggtgcagagctactgccgcctgagccactgccggagccggtcccagggctgctctgagcaggtgctcactgtgctgaaaacagtctctttgttggatgagaacaacgtgtcaagct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//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:5591 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
            GeneID:5591 -> Molecular function: GO:0004672 [protein kinase activity] evidence: TAS
            GeneID:5591 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
            GeneID:5591 -> Molecular function: GO:0004677 [DNA-dependent protein kinase activity] evidence: IDA
            GeneID:5591 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:5591 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:5591 -> Molecular function: GO:0008134 [transcription factor binding] evidence: IPI
            GeneID:5591 -> Molecular function: GO:0019899 [enzyme binding] evidence: IEA
            GeneID:5591 -> Biological process: GO:0000723 [telomere maintenance] evidence: IEA
            GeneID:5591 -> Biological process: GO:0001756 [somitogenesis] evidence: IEA
            GeneID:5591 -> Biological process: GO:0002326 [B cell lineage commitment] evidence: IEA
            GeneID:5591 -> Biological process: GO:0002328 [pro-B cell differentiation] evidence: IEA
            GeneID:5591 -> Biological process: GO:0002360 [T cell lineage commitment] evidence: IEA
            GeneID:5591 -> Biological process: GO:0006281 [DNA repair] evidence: TAS
            GeneID:5591 -> Biological process: GO:0006302 [double-strand break repair] evidence: TAS
            GeneID:5591 -> Biological process: GO:0006303 [double-strand break repair via nonhomologous end joining] evidence: TAS
            GeneID:5591 -> Biological process: GO:0006464 [cellular protein modification process] evidence: TAS
            GeneID:5591 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
            GeneID:5591 -> Biological process: GO:0007420 [brain development] evidence: IEA
            GeneID:5591 -> Biological process: GO:0007507 [heart development] evidence: IEA
            GeneID:5591 -> Biological process: GO:0010332 [response to gamma radiation] evidence: IEA
            GeneID:5591 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: IDA
            GeneID:5591 -> Biological process: GO:0031648 [protein destabilization] evidence: IEA
            GeneID:5591 -> Biological process: GO:0032481 [positive regulation of type I interferon production] evidence: TAS
            GeneID:5591 -> Biological process: GO:0032869 [cellular response to insulin stimulus] evidence: IMP
            GeneID:5591 -> Biological process: GO:0033077 [T cell differentiation in thymus] evidence: IEA
            GeneID:5591 -> Biological process: GO:0033152 [immunoglobulin V(D)J recombination] evidence: IEA
            GeneID:5591 -> Biological process: GO:0033153 [T cell receptor V(D)J recombination] evidence: IEA
            GeneID:5591 -> Biological process: GO:0035234 [germ cell programmed cell death] evidence: IEA
            GeneID:5591 -> Biological process: GO:0043065 [positive regulation of apoptotic process] evidence: IEA
            GeneID:5591 -> Biological process: GO:0045087 [innate immune response] evidence: TAS
            GeneID:5591 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
            GeneID:5591 -> Cellular component: GO:0005654 [nucleoplasm] evidence: TAS
            GeneID:5591 -> Cellular component: GO:0005667 [transcription factor complex] evidence: IDA
            GeneID:5591 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
            GeneID:5591 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
            GeneID:5591 -> Cellular component: GO:0005958 [DNA-dependent protein kinase-DNA ligase 4 complex] evidence: IDA
            GeneID:5591 -> Cellular component: GO:0070419 [nonhomologous end joining complex] evidence: IDA
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001075109 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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