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2024-04-26 05:35:46, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001080532 3303 bp mRNA linear PRI 18-APR-2013
DEFINITION Homo sapiens transmembrane channel-like 3 (TMC3), mRNA.
ACCESSION NM_001080532 XM_930010
VERSION NM_001080532.1 GI:122937501
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3303)
AUTHORS Zody,M.C., Garber,M., Sharpe,T., Young,S.K., Rowen,L., O'Neill,K.,
Whittaker,C.A., Kamal,M., Chang,J.L., Cuomo,C.A., Dewar,K.,
FitzGerald,M.G., Kodira,C.D., Madan,A., Qin,S., Yang,X., Abbasi,N.,
Abouelleil,A., Arachchi,H.M., Baradarani,L., Birditt,B., Bloom,S.,
Bloom,T., Borowsky,M.L., Burke,J., Butler,J., Cook,A.,
DeArellano,K., DeCaprio,D., Dorris,L. III, Dors,M., Eichler,E.E.,
Engels,R., Fahey,J., Fleetwood,P., Friedman,C., Gearin,G.,
Hall,J.L., Hensley,G., Johnson,E., Jones,C., Kamat,A., Kaur,A.,
Locke,D.P., Madan,A., Munson,G., Jaffe,D.B., Lui,A., Macdonald,P.,
Mauceli,E., Naylor,J.W., Nesbitt,R., Nicol,R., O'Leary,S.B.,
Ratcliffe,A., Rounsley,S., She,X., Sneddon,K.M., Stewart,S.,
Sougnez,C., Stone,S.M., Topham,K., Vincent,D., Wang,S.,
Zimmer,A.R., Birren,B.W., Hood,L., Lander,E.S. and Nusbaum,C.
TITLE Analysis of the DNA sequence and duplication history of human
chromosome 15
JOURNAL Nature 440 (7084), 671-675 (2006)
PUBMED 16572171
REFERENCE 2 (bases 1 to 3303)
AUTHORS Kurima,K., Yang,Y., Sorber,K. and Griffith,A.J.
TITLE Characterization of the transmembrane channel-like (TMC) gene
family: functional clues from hearing loss and epidermodysplasia
verruciformis
JOURNAL Genomics 82 (3), 300-308 (2003)
PUBMED 12906855
REFERENCE 3 (bases 1 to 3303)
AUTHORS Keresztes,G., Mutai,H. and Heller,S.
TITLE TMC and EVER genes belong to a larger novel family, the TMC gene
family encoding transmembrane proteins
JOURNAL BMC Genomics 4 (1), 24 (2003)
PUBMED 12812529
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from AC103858.2.
On Jan 18, 2007 this sequence version replaced gi:89038496.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
##Evidence-Data-START##
Transcript exon combination :: BC132679.1 [ECO:0000332]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-89 AC103858.2 189658-189746 c
90-236 AC103858.2 188260-188406 c
237-312 AC103858.2 183922-183997 c
313-394 AC103858.2 177889-177970 c
395-501 AC103858.2 175034-175140 c
502-600 AC103858.2 174071-174169 c
601-743 AC103858.2 173818-173960 c
744-891 AC103858.2 172116-172263 c
892-935 AC103858.2 171394-171437 c
936-1083 AC103858.2 167363-167510 c
1084-1193 AC103858.2 165127-165236 c
1194-1272 AC103858.2 162034-162112 c
1273-1518 AC103858.2 160435-160680 c
1519-1647 AC103858.2 159586-159714 c
1648-1715 AC103858.2 158947-159014 c
1716-1844 AC103858.2 157059-157187 c
1845-1955 AC103858.2 155063-155173 c
1956-2081 AC103858.2 154324-154449 c
2082-2160 AC103858.2 153515-153593 c
2161-2203 AC103858.2 152278-152320 c
2204-2459 AC103858.2 150389-150644 c
2460-3303 AC103858.2 148088-148931 c
FEATURES Location/Qualifiers
source 1..3303
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="15"
/map="15q25.1"
gene 1..3303
/gene="TMC3"
/note="transmembrane channel-like 3"
/db_xref="GeneID:342125"
/db_xref="HGNC:22995"
CDS 1..3303
/gene="TMC3"
/codon_start=1
/product="transmembrane channel-like protein 3"
/protein_id="NP_001074001.1"
/db_xref="GI:122937502"
/db_xref="CCDS:CCDS45324.1"
/db_xref="GeneID:342125"
/db_xref="HGNC:22995"
/translation="
MKTSKASQRYRGIRRNASQCYLYQESLLLSNLDDSFSADETGDSNDPEQIFQNIQFQKDLMANIRCRPWTMGQKLRALRQAKNIVLKFEGRLTRTRGYQAAGAELWRKFARLACNFVVIFIPWEMRIKKIESHFGSGVASYFIFLRWLFGINIVLTIMTGAFIVIPELIAGQPFGSTARKTIPKEQVSSAQDLDTVWSLGGYLQYSVLFYGYYGRERKIGRAGYRLPLAYFLVGMAVFAYSFIILLKKMAKNSRTSLASASNENYTFCWRVFCAWDYLIGNPEAAESKTAAIVNSIREAILEEQEKKKSKNLAVTICLRIIANILVLLSLAGSIYLIYFVVDRSQKLEQSKKELTLWEKNEVSVVVSLVTMIAPSAFDLIAALEMYHPRTTLRFQLARVLVLYLGNLYSLIIALLDKVNSMSIEEMATKNNTSHWIDSTTFFATRTAPEEEKWSTSRPGMGLRRNNTWALEETSISAYTMPLIKANKTSLHTQSPQDQCWETYVGQEMLKLSIIDMLFTVASILLIDFFRGLFVRYLSDYWCWDLESKFPEYGEFKIAENVLHLVYNQGMIWMGAFFSPCLPAFNVLKLIGLMYLRSWAVLTCNVPHQQVFRASRSNNFYLAMLLFMLFLCMLPTIFAIVRYKPSLNCGPFSGQEKIYDIVSETIEKDFPVWFGSVVGHISSPVVILPAVLLLFMLIYYLQSIARSLKLSNHQLKMQIQNARSEDKKKVAQMVEARIQTQEESTKKLPNDSDLTSQLSSAHSGTPQNNGNVAHFDSGSSKSGRIETVAQSMPQSPRPGDRAPSSPLPGVPKSRLEHETNRYLHGLCASTSDLHRNRSRTPMTFTTHIEDVHSEPLFRKDFQQINPPHRGPQASTLLAQGPRPHAPRYYVINECDSYKKKHLNVWPERHFKIDASGDIVELYPRNVRQYASRVPRQPPSPQLSEEEEETPSRDWIKRSLPPRSLIDLRRAPHFYIGERSESQTRDPEHQGRVHYKSWNEDFEGHLERPAYVPRKPRSRNFQYPQPPLKPRGKPRFEPSLTESDSVSAASSSDQQNSSADQYLQVTHSQGRFPRSVGQPSRRKAKSGQELTVDLDDLICSDV
"
misc_feature 445..507
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 577..639
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 676..738
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 958..1020
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 1084..1146
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 1180..1242
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 1495..1842
/gene="TMC3"
/note="TMC domain; Region: TMC; pfam07810"
/db_xref="CDD:149077"
misc_feature 1525..1587
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 1708..1770
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 1855..1917
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
misc_feature 2038..2100
/gene="TMC3"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q7Z5M5.3);
transmembrane region"
exon 1..89
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 90..236
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 237..312
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 313..394
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 395..501
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 502..600
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 601..743
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 744..891
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 892..935
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 936..1083
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1084..1193
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1194..1272
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1273..1518
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1519..1647
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1648..1715
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1716..1844
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
variation 1743
/gene="TMC3"
/replace="a"
/replace="c"
/db_xref="dbSNP:4073140"
exon 1845..1955
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 1956..2081
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 2082..2160
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 2161..2203
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 2204..2459
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
exon 2460..3303
/gene="TMC3"
/inference="alignment:Splign:1.39.8"
variation 3194
/gene="TMC3"
/replace="a"
/replace="c"
/db_xref="dbSNP:201301937"
ORIGIN
atgaaaacctcgaaggcatcccagcgctatagaggcatccggagaaatgccagccagtgctacctctaccaggaatctctgctgctcagcaacttggatgacagctttagtgctgatgaaacaggggacagcaatgatccggaacaaatcttccagaatatacagttccagaaagatctcatggcaaacattcgctgcagaccctggactatgggacagaagctgagggcattgagacaagcgaagaacattgtgctgaagtttgaagggaggctgaccaggacccgaggctaccaagcagcaggtgcagagctctggcggaaatttgctcgtctcgcctgtaactttgtggtcatcttcattccctgggaaatgaggataaagaaaatcgagagtcattttggatctggcgttgcctcctatttcatattcttgagatggttatttggaattaatattgtgctcaccattatgacaggtgcttttattgtcattccagagctgattgcaggccagccctttggaagcacagccaggaagaccatccccaaggagcaggtttcgtctgcccaagacctggacaccgtctggtctctggggggctacctccagtactctgtcctcttctacggatattacggcagggagaggaagatcgggagagctggctaccggctgcccttggcgtatttcctagtggggatggcagtgtttgcttacagcttcatcattcttttaaaaaagatggctaagaactcccgcacgagtcttgccagtgcttccaatgaaaactataccttctgctggcgggtgttctgtgcctgggattacctcattggaaacccagaggctgcagagagcaaaacagctgccatagtgaacagcatcagggaagctatattggaagaacaggagaaaaagaaaagcaaaaacctggcagtgaccatctgcctgaggattattgccaacatcctggtgcttctctcactggctgggagcatttatctcatctactttgtggtggaccggtcccagaagctggagcagtcgaagaaggagctgacactttgggaaaagaatgaggtcagtgtggtggtctccctcgtcaccatgatagcaccatcagcctttgacctcattgctgccttagagatgtaccaccccaggaccacgctgcgcttccagcttgcaagggtccttgtgctgtatttgggaaatctctacagcctgatcattgctctcctggacaaagttaacagcatgagcattgaggaaatggctaccaaaaataacacaagtcattggatagattccaccaccttctttgcaaccaggacagcccctgaagaagagaaatggtccacatctcggcctggaatggggctcaggagaaacaacacatgggccttggaagagaccagcatttcagcttataccatgcctcttataaaggccaacaagactagcctccacactcagagtccacaagaccagtgctgggagacatacgttggtcaggagatgctgaagctctccatcattgacatgctcttcaccgtggcgagcattctgctcatagacttcttccgaggacttttcgtgcggtacttaagtgactactggtgttgggatctggagagcaagtttcctgaatatggagaattcaaaatagctgagaatgtgctacatttagtctacaaccaaggaatgatttggatgggggccttcttctccccatgtctcccagcgttcaacgttctcaaactcattgggctcatgtacctgagaagctgggctgtgctgacctgcaatgtgccccaccagcaagtatttcgagcctcaagatccaacaacttctacttggcaatgctcctgtttatgctgtttctgtgcatgctgccaaccatttttgctattgtccgatacaagccatctctaaactgtgggccattcagtggacaagagaaaatttatgacattgtgtcagaaacgattgagaaagactttcctgtgtggtttggctccgtggttggacacatcagtagccccgtggtcatcctgcccgcagtactcctgcttttcatgctcatctattatctccagagcatcgcacggtctctaaagctcagcaaccaccagctcaaaatgcagatccaaaacgcaagatcagaggataagaaaaaggttgcccagatggtagaagcccgaatccagacccaggaagaaagcaccaagaagcttccaaacgacagtgatcttaccagccagctgtcctcagcgcactcgggcacaccccaaaacaacggcaacgtggcccattttgactcagggagcagcaagagtggcaggatagagacagtcgcacagtccatgccccagagcccgaggccaggggacagggctcctagctcacctctccctggggtccccaaatccaggctagagcatgaaactaacaggtatctgcacggtctgtgtgcaagcaccagtgaccttcacaggaacagatcgcgcacacctatgacatttacaacgcacatcgaagatgtacactcagaacctcttttccgaaaagactttcagcaaatcaaccctcctcaccgtggaccacaggcctcgactttgctggcacagggtcccaggccccacgcccccagatactatgtcattaatgaatgtgactcttacaagaaaaaacatctaaatgtctggccagaaagacatttcaagatagatgcttcaggtgacattgtggagctgtaccccaggaacgtgcgacaatatgcatcccgggtcccccgccagcctccctccccacagctgagtgaagaagaggaggagacgccaagcagagattggatcaaacggtctcttcccccacgctccctgatagacctccgtcgggctcctcatttttatattggggagaggtccgaaagtcagacccgggatcccgagcaccaggggagggtgcactacaagtcgtggaatgaagattttgagggtcaccttgagaggccagcctatgtgcccagaaagccacgatcccggaatttccaatacccacagccccctctgaagcccagagggaagcccaggttcgagccatccctcacggaatctgactccgtgtcggcagcatccagcagtgaccagcagaacagcagcgctgaccagtacctgcaggtcacccacagccagggcaggttcccgaggtccgtgggccagcccagcaggaggaaggccaagtcggggcaggagctgaccgtggatctggatgacttgatttgttcagatgtctag
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:342125 -> Biological process: GO:0006811 [ion transport] evidence: IEA
GeneID:342125 -> Cellular component: GO:0016021 [integral to membrane] evidence: IEA
by
@meso_cacase at
DBCLS
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