GGRNA Home | Help | Advanced search

2020-10-26 18:53:57, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001080467            9520 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens myosin VB (MYO5B), mRNA.
ACCESSION   NM_001080467 XM_371116
VERSION     NM_001080467.2  GI:239915992
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9520)
  AUTHORS   Gidon,A., Bardin,S., Cinquin,B., Boulanger,J., Waharte,F.,
            Heliot,L., de la Salle,H., Hanau,D., Kervrann,C., Goud,B. and
            Salamero,J.
  TITLE     A Rab11A/myosin Vb/Rab11-FIP2 complex frames two late recycling
            steps of langerin from the ERC to the plasma membrane
  JOURNAL   Traffic 13 (6), 815-833 (2012)
   PUBMED   22420646
  REMARK    GeneRIF: Rab11A/myosin Vb/Rab11-FIP2 complex frames two late
            recycling steps of langerin from the ERC to the plasma membrane
REFERENCE   2  (bases 1 to 9520)
  AUTHORS   Dong,W., Chen,X., Chen,P., Yue,D., Zhu,L. and Fan,Q.
  TITLE     Inactivation of MYO5B promotes invasion and motility in gastric
            cancer cells
  JOURNAL   Dig. Dis. Sci. 57 (5), 1247-1252 (2012)
   PUBMED   22134786
  REMARK    GeneRIF: Inactivation of MYO5B by siRNA against MYO5B can promote
            cell proliferation, invasion and motility.The expression of MYO5B
            was downregulated in gastric cancer and inactivation of MYO5B may
            contribute to tumorigenesis.
REFERENCE   3  (bases 1 to 9520)
  AUTHORS   Golachowska,M.R., van Dael,C.M., Keuning,H., Karrenbeld,A.,
            Hoekstra,D., Gijsbers,C.F., Benninga,M.A., Rings,E.H. and van
            Ijzendoorn,S.C.
  TITLE     MYO5B mutations in patients with microvillus inclusion disease
            presenting with transient renal Fanconi syndrome
  JOURNAL   J. Pediatr. Gastroenterol. Nutr. 54 (4), 491-498 (2012)
   PUBMED   22441677
  REMARK    GeneRIF: MYO5B mutations have divergent effects on the apical
            membrane system in kidney and intestinal epithelial cells.
REFERENCE   4  (bases 1 to 9520)
  AUTHORS   Szperl,A.M., Golachowska,M.R., Bruinenberg,M., Prekeris,R.,
            Thunnissen,A.M., Karrenbeld,A., Dijkstra,G., Hoekstra,D.,
            Mercer,D., Ksiazyk,J., Wijmenga,C., Wapenaar,M.C., Rings,E.H. and
            van IJzendoorn,S.C.
  TITLE     Functional characterization of mutations in the myosin Vb gene
            associated with microvillus inclusion disease
  JOURNAL   J. Pediatr. Gastroenterol. Nutr. 52 (3), 307-313 (2011)
   PUBMED   21206382
  REMARK    GeneRIF: Our functional analysis indicates that MYO5B mutations can
            be correlated with an aberrant subcellular distribution of the
            myosin Vb protein, and apical recycling endosomes...
REFERENCE   5  (bases 1 to 9520)
  AUTHORS   Roland,J.T., Bryant,D.M., Datta,A., Itzen,A., Mostov,K.E. and
            Goldenring,J.R.
  TITLE     Rab GTPase-Myo5B complexes control membrane recycling and
            epithelial polarization
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 108 (7), 2789-2794 (2011)
   PUBMED   21282656
  REMARK    GeneRIF: In polarized epithelial cyst cultures, Myo5B was required
            for apical membrane trafficking and de novo lumen formation,
            dependent on association with both Rab8a and Rab11a.
REFERENCE   6  (bases 1 to 9520)
  AUTHORS   Lapierre,L.A., Kumar,R., Hales,C.M., Navarre,J., Bhartur,S.G.,
            Burnette,J.O., Provance,D.W. Jr., Mercer,J.A., Bahler,M. and
            Goldenring,J.R.
  TITLE     Myosin vb is associated with plasma membrane recycling systems
  JOURNAL   Mol. Biol. Cell 12 (6), 1843-1857 (2001)
   PUBMED   11408590
  REMARK    GeneRIF: Dominant negative approach suggests MYO5B plays a role in
            plasma membrane recycling (through early endosomes).
REFERENCE   7  (bases 1 to 9520)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   8  (bases 1 to 9520)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C. R. Acad. Sci. III, Sci. Vie 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   9  (bases 1 to 9520)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. PMID:
            7972138]
REFERENCE   10 (bases 1 to 9520)
  AUTHORS   Huang,W.M., Reed-Fourquet,L., Wu,E. and Wu,J.Y.
  TITLE     Molecular cloning and amino acid sequence of brain L-glutamate
            decarboxylase
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 87 (21), 8491-8495 (1990)
   PUBMED   2236059
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC032511.2, AY274809.1,
            AB290160.1, AK025336.1, BX641287.1, DA350416.1 and Z38208.1.
            This sequence is a reference standard in the RefSeqGene project.
            On Jun 13, 2009 this sequence version replaced gi:122937344.
            
            Summary: The protein encoded by this gene, together with other
            proteins, may be involved in plasma membrane recycling. Mutations
            in this gene are associated with microvillous inclusion disease.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290160.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025081, ERS025082 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-663               BC032511.2         1-663
            664-2193            AY274809.1         724-2253
            2194-3453           AB290160.1         2011-3270
            3454-4232           AK025336.1         597-1375
            4233-6799           AB290160.1         4053-6619
            6800-6879           BX641287.1         17-96
            6880-7755           AB290160.1         6700-7575
            7756-8106           DA350416.1         223-573
            8107-9490           AB290160.1         7927-9310
            9491-9520           Z38208.1           1-30                c
FEATURES             Location/Qualifiers
     source          1..9520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21"
     gene            1..9520
                     /gene="MYO5B"
                     /note="myosin VB"
                     /db_xref="GeneID:4645"
                     /db_xref="HGNC:7603"
                     /db_xref="MIM:606540"
     exon            1..315
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    235..237
                     /gene="MYO5B"
                     /note="upstream in-frame stop codon"
     CDS             289..5835
                     /gene="MYO5B"
                     /note="myosin-Vb; MYO5B variant protein"
                     /codon_start=1
                     /product="unconventional myosin-Vb"
                     /protein_id="NP_001073936.1"
                     /db_xref="GI:122937345"
                     /db_xref="CCDS:CCDS42436.1"
                     /db_xref="GeneID:4645"
                     /db_xref="HGNC:7603"
                     /db_xref="MIM:606540"
                     /translation="
MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLEDETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYCRGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYRQVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAEHLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQSPGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDEKEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEMTIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVFLKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVLILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDWGYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQDLEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLSGTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSNTCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAEGVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVMCDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGRNLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNEFEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNLEFLNEV
"
     misc_feature    478..2568
                     /gene="MYO5B"
                     /note="Myosin. Large ATPases; Region: MYSc; smart00242"
                     /db_xref="CDD:197599"
     misc_feature    496..2568
                     /gene="MYO5B"
                     /note="Myosin motor domain, type V myosins. Myosins V
                     transport a variety of intracellular cargo processively
                     along actin filaments, such as membraneous organelles and
                     mRNA. This catalytic (head) domain has ATPase activity and
                     belongs to the larger group of...; Region: MYSc_type_V;
                     cd01380"
                     /db_xref="CDD:30102"
     misc_feature    order(619..630,634..639,781..804)
                     /gene="MYO5B"
                     /note="ATP-binding site [chemical binding]; other site"
                     /db_xref="CDD:30102"
     misc_feature    937..951
                     /gene="MYO5B"
                     /note="switch I region; other site"
                     /db_xref="CDD:30102"
     misc_feature    1603..1626
                     /gene="MYO5B"
                     /note="switch II region; other site"
                     /db_xref="CDD:30102"
     misc_feature    order(1687..1722,1729..1758)
                     /gene="MYO5B"
                     /note="relay loop; other site"
                     /db_xref="CDD:30102"
     misc_feature    2206..2274
                     /gene="MYO5B"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ULV0.3);
                     Region: Actin-binding (Potential)"
     misc_feature    2326..2370
                     /gene="MYO5B"
                     /note="SH1 helix; other site"
                     /db_xref="CDD:30102"
     misc_feature    order(2365..2370,2377..2379,2395..2397,2404..2409,
                     2416..2418,2503..2505,2512..2514,2518..2523,2527..2535,
                     2545..2547,2554..2562)
                     /gene="MYO5B"
                     /note="converter subdomain; other site"
                     /db_xref="CDD:30102"
     misc_feature    2866..2931
                     /gene="MYO5B"
                     /note="Calmodulin-binding motif; Region: IQ; smart00015"
                     /db_xref="CDD:197470"
     misc_feature    2983..3393
                     /gene="MYO5B"
                     /note="TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2;
                     pfam07926"
                     /db_xref="CDD:149160"
     misc_feature    4624..4626
                     /gene="MYO5B"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
                     (Q9ULV0.3); phosphorylation site"
     misc_feature    5326..5643
                     /gene="MYO5B"
                     /note="DIL domain; Region: DIL; pfam01843"
                     /db_xref="CDD:202006"
     exon            316..426
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            427..598
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            599..743
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       664
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1815930"
     exon            744..900
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            901..1044
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1045..1126
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1127..1234
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1235..1344
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1345..1610
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1611..1692
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1693..1833
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1834..1956
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            1957..2040
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            2041..2193
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       2081
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:75107667"
     exon            2194..2291
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       2256
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1627232"
     exon            2292..2378
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       2331
                     /gene="MYO5B"
                     /replace="c"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:2969930"
     variation       2343
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2721078"
     exon            2379..2490
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            2491..2702
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            2703..2859
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            2860..3099
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            3100..3333
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       3113
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2277716"
     exon            3334..3418
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            3419..3564
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       3518
                     /gene="MYO5B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:596220"
     exon            3565..3684
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            3685..3825
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            3826..3891
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       3879
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3826579"
     exon            3892..4131
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4132..4232
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4233..4310
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       4250
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1942418"
     exon            4311..4509
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       4374
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2969924"
     exon            4510..4603
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4604..4747
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4748..4899
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4900..4989
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            4990..5140
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            5141..5426
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            5427..5601
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       5556
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1058514"
     exon            5602..5682
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     exon            5683..9520
                     /gene="MYO5B"
                     /inference="alignment:Splign:1.39.8"
     variation       5736
                     /gene="MYO5B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1058527"
     variation       5761
                     /gene="MYO5B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1058532"
     variation       5784
                     /gene="MYO5B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1058536"
     variation       5802
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058541"
     variation       5817
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058543"
     variation       5839
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1058544"
     STS             5840..5979
                     /gene="MYO5B"
                     /standard_name="RH17962"
                     /db_xref="UniSTS:56574"
     variation       5859
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1058548"
     variation       5875
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058550"
     variation       5879
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058551"
     variation       5891
                     /gene="MYO5B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1058553"
     variation       5999
                     /gene="MYO5B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:3208550"
     variation       6001
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:1058554"
     variation       6015
                     /gene="MYO5B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:1058556"
     polyA_signal    6026..6031
                     /gene="MYO5B"
     polyA_site      6049
                     /gene="MYO5B"
     variation       6143
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:555879"
     variation       7020
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199681294"
     variation       7421
                     /gene="MYO5B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1787518"
     variation       8299
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371402939"
     variation       8330
                     /gene="MYO5B"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:377526532"
     variation       8501
                     /gene="MYO5B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:373899751"
     variation       8635
                     /gene="MYO5B"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:1046477"
     variation       9135
                     /gene="MYO5B"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367570644"
     variation       9167
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199830730"
     variation       9186
                     /gene="MYO5B"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:369420591"
     STS             9266..9518
                     /gene="MYO5B"
                     /standard_name="D18S1018"
                     /db_xref="UniSTS:21508"
     STS             9301..9399
                     /gene="MYO5B"
                     /standard_name="D18S1061"
                     /db_xref="UniSTS:154108"
     variation       9341
                     /gene="MYO5B"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199813194"
     polyA_signal    9474..9479
                     /gene="MYO5B"
     polyA_site      9493
                     /gene="MYO5B"
ORIGIN      
gcctcctccccacacctgggaggggagtggtgcggcgcggcctcctcccccggcgctcgcaactcctgtccggccgtagctgcgccgccgcggcgggagtaaaggtcgcgccgccgggagcgagccggccgcggcgcctgcgggaagccggcggggcaggtcggagaagagcgagaagatcgagaaactccaggccagcccgggaacatggcgccaggcgggccagccgcggactgagagccgcggggcagccaggagccggggcccgagccccgcccggcccgggccatgtcggtgggcgagctctacagccagtgcacaagggtctggatccctgaccctgatgaggtatggcgctcagctgagttaaccaaggactacaaagaaggagacaagagcctacagctcagactggaggatgaaacgattctggaatacccaattgatgtacaacgcaaccagctgcccttcttacggaatccagatatcttggtgggagaaaatgacctgactgcccttagctatcttcatgagcctgcagttttgcataatttgaaggtccgtttcctggagtccaaccatatctacacttactgtggtatcgtacttgttgccattaatccttatgaacagttgccaatctatggacaagatgtcatctatacctacagtggccaaaacatgggagacatggacccccacatctttgctgtggcagaagaagcctacaagcagatggccagagatgagaagaatcagtccatcatagtcagtggggagtctggagccgggaagacggtatcagccaagtatgccatgcgctatttcgccaccgttggtggctcggccagtgaaaccaacatcgaagagaaggtgctggcatccagtcccatcatggaggccattggaaatgccaagaccacccgcaatgacaacagcagccgttttggcaagtacatccagattggctttgacaaaaggtaccacatcatcggggccaacatgaggacttacctcttggagaagtccagagtggtcttccaggcagatgatgagaggaattaccacatcttttaccagctctgtgctgctgccggtcttccagaatttaaagagcttgcactaacaagtgcagaggactttttctatacatcacagggaggagacacttccatcgagggtgtggacgatgctgaggactttgagaagactcgacaagccttcacactcctcggagtgaaagagtcccatcagatgagcatttttaagataattgcttctatcttgcaccttggaagtgtggcgattcaggctgagcgtgatggtgattcctgtagtatatcaccccaggatgtatacctaagcaacttctgccgactgctaggggtggagcacagtcagatggagcactggctgtgtcatcgcaagctggtcaccacctcggagacctacgtcaagaccatgtccctgcagcaggtgatcaatgcgcgcaacgccctggcgaagcacatctatgcccagttgttcggctggattgtggagcacatcaacaaggccctgcacacctccctcaagcagcactccttcatcggggtcctggacatctatgggtttgagacatttgaggtaaacagctttgagcagttctgtatcaactatgcaaatgaaaagctccagcagcagttcaactcgcatgttttcaaactggagcaagaagaatacatgaaggaacagatcccttggaccctgattgatttttatgataaccaaccttgtatcgacctcattgaagccaagctgggtatcttggacctgttggatgaagaatgtaaggtccccaaaggaactgaccagaactgggctcagaagctctatgaccggcactccagcagccagcacttccagaagccccgcatgtccaacacggccttcatcatcgtccactttgcagacaaggtggagtacctctctgatggttttctggagaaaaacagagacacggtgtatgaagagcagatcaatatcctgaaggccagcaagttcccactagtggctgacttgtttcatgatgacaaggaccctgttcctgccaccacccctgggaaggggtcatcttcgaagatcagcgtccgttctgccagaccccccatgaaagtctccaacaaggagcacaagaaaaccgttggccaccagttccgtacctccctgcatctgctcatggagaccctgaatgccacgacacctcactatgtccgctgcatcaagcccaacgatgagaagctcccctttcactttgacccaaagagagcagtgcagcaactcagagcctgcggggtgttggagacgattcgaatcagtgcagctggctacccatccaggtgggcctaccatgactttttcaaccggtatcgggtgctggtcaagaagagagagctcgccaacacagacaaaaaggccatctgcaggtctgtcctggagaacctcatcaaggaccccgacaagttccagtttggccgcaccaagatcttctttcgagcaggccaggtggcctacctggagaagctgcgggctgacaagttccggacagccaccatcatgatccagaaaactgtccggggatggctgcagaaggtgaaatatcacaggctgaagggggctaccttaaccctgcagaggtactgccggggacacctggcccgcaggctggctgagcacctgcggaggatcagagcggctgtggtgctccagaaacattaccgcatgcagagggcccgccaggcctaccagagggtccgcagagctgccgttgttatccaggccttcacccgggccatgtttgtgcggagaacctaccgccaggtcctcatggagcacaaggccaccaccatccagaagcacgtgcggggctggatggcacgcaggcacttccagcggctgcgggatgcagccattgtcatccagtgtgccttccggatgctcaaggccaggcgggagctgaaggccctcaggattgaggcccgctcagcagagcatctgaaacgtctcaacgtgggcatggagaacaaggtggtccagctgcagcggaagatcgatgagcagaacaaagagttcaagacactttcagagcagttgtccgtgaccacctcaacatacaccatggaggtagagcggctgaagaaggagctggtgcactaccagcagagcccaggtgaggacaccagcctcaggctgcaggaggaggtggagagcctgcgcacagagctgcagagggcccactcggagcgcaagatcttggaggacgcccacagcagggagaaagatgagctgaggaagcgagttgcagacctggagcaagaaaatgctctcttgaaagatgagaaagaacagctcaacaaccaaatcctgtgccagtctaaagatgaatttgcccagaactctgtgaaggaaaatctcatgaagaaagaactggaggaggagcgatcccggtaccagaaccttgtgaaggaatattcacagttggagcagagatacgacaaccttcgggatgaaatgaccatcataaagcaaactccaggtcataggcggaacccatcaaaccaaagtagcttagaatctgactccaattacccctccatctccacatctgagatcggagacactgaggatgccctccagcaggtggaggaaattggcctggagaaggcagccatggacatgacggtcttcctgaagctgcagaagagagtacgggagctggagcaggagaggaaaaagctgcaagtgcagctggagaagagagaacagcaggacagcaagaaagtccaggcggaaccaccacagactgacatagatttggacccgaatgcagatctggcctacaatagtctgaagaggcaagagctggagtcagagaacaaaaagctgaagaatgacctgaatgagctgaggaaagccgtggccgaccaagccacgcagaataactccagccacggctccccagatagctacagcctcctgctgaaccagctcaagctggcccacgaggagctcgaggtgcgcaaggaggaggtgctcatcctcaggacccagatcgtgagcgccgaccagcggcgactcgccggcaggaacgcggagccgaacattaatgccagatcaagttggcctaacagtgaaaagcatgttgaccaggaggatgccattgaggcctatcacggggtctgccagacaaacagcaagactgaggattggggatatttaaatgaagatggagaactcggcttggcctaccaaggcctaaagcaagttgccaggctgctggaggctcagctgcaggcccagagcctggagcatgaggaggaggtggagcatctcaaggctcagctcgaggccctgaaggaggagatggacaaacagcagcagaccttctgccagacgctactgctctccccagaggcccaggtggaattcggcgttcagcaggaaatatcccggctgaccaacgagaatctggaccttaaagaactggtagaaaagctggaaaagaatgagaggaagctcaaaaagcaactgaagatttacatgaagaaagcccaggacctagaagctgcccaggcattggcccagagtgagaggaagcgccatgagctcaacaggcaggtcacggtccagcggaaagagaaggatttccagggcatgctggagtaccacaaagaggacgaggccctcctcatccggaacctggtgacagacttgaagccccagatgctgtcgggcacagtgccctgtctccccgcctacatcctctacatgtgcatccggcacgcggactacaccaacgacgatctcaaggtgcactccctgctgacctccaccatcaacggcattaagaaagtcctgaaaaagcacaatgatgactttgagatgacgtcattctggttatccaacacctgccgccttcttcactgtctgaagcagtacagcggggatgagggcttcatgactcagaacactgcaaagcagaatgaacactgtcttaagaattttgacctcaccgaataccgtcaggtgctgagtgacctttccattcagatctaccagcagctcattaaaattgccgagggcgtgttacagccgatgatagtttctgccatgttggaaaatgagagcattcagggtctatctggtgtgaagcccaccggctaccggaagcgctcctccagcatggcagatggggataactcatactgcctggaagctatcatccgccagatgaatgcctttcatacagtcatgtgtgaccagggcttggaccctgagatcatcctgcaggtattcaaacagctcttctacatgatcaacgcagtgactcttaacaacctgctcttgcggaaggacgtctgctcttggagcacaggcatgcaactcaggtacaatataagtcagcttgaggagtggcttcggggaagaaaccttcaccagagtggagcagttcagaccatggaacctctgatccaagcagcccagctcctgcaattaaagaagaaaacccaggaggacgcagaggctatctgctccctgtgtacctccctcagcacccagcagattgtcaaaattttaaacctttatactcccctgaatgaatttgaagaacgggtaacagtggcctttatacgaacaatccaggcacaactacaagagcggaatgaccctcagcaactgctattagatgccaagcacatgtttcctgttttgtttccatttaatccatcttctctaaccatggactcaatccacatcccagcgtgtctcaatctggaattcctcaatgaagtctgaagatgcatgtttccagcattagtttgattcccaatgtgagcaagaaggaagtatatacagtaaagtaaattcaaggatctgttaaatctggtaaaagtagatcaaatcagagattgacagcctgtggagggtgctgaactatacagaattagacacaactatgtcattattttttgtacctactgctcagaataaaaacacttgaaatatggaagattttaagtttgatttcagtccaacacatatacataatttatagacaccaagcagtccccatagacatataaaaggtgtcaattctataaaacgaagctgcctagttttgatctttgcatagaactagagaatgtccaaattaaaataccaaatatatataagtcacataaattgccttcaaagggctttaacaaataatggtactaataaccatgataatggcatatactgacatttcccaaagtttgcaaaccataggtgtggttgagtttgtggtgagatgttttaagaacaaaaatatggggatgagacttctgagaaatattcccaaaatattttttaatggctgattatacacagacagtggtgtaactgacctccagaccagacattttgagtactggtttctgaagcaaaattagaagtgccagtcctcagtgtgctcaaacgcttttgtgttatcttgatttaatggaagagattattaaaatgctgctatcccaaactccaagtgagaaagatggaaaaatattttgtttctgatgctagtccatacactttccaagtcccacaaaactttcacaaaaatgtatataagctaaatattagaaacggataacaaacttgttttatttatagatgtaaaaaccaaacaagtcaatatgaaagcttttaatctcttaataccattaagcttccagtaagagcatcacataatgctctactgttccagaaaccaaatagtaaaacaaactaaagttcgcacatcagatcatctgaaaaaccttcaaaaataatcagttcagggatattatacaaaagtttgggttttttttttttaagagaataaaatggcttaggtcaactttcccttttcaggttattttcaacgtttttcaaatttagcacacaaaaaattgtaaatatctctcccacaaaataaggattttaaaaaagtaattcagtaatataacaggcttagatgtttgctgctcttagaattttttttaacttgtttttggtttcttcaaaagcaagcattcaattggaaacccatattctttccacacttttttttactgtcttttctgtatttcttgatagcagtatgctgttcccataagaaaaaaatggtatttgcaaatcatggaagaacagcctctgtattacattgagaaaataagatttatccatgaattggaagtagaacagcctgccttcaccctcttttactcaaccacccaacttaaaaggctcttggaaacacagcacactccacgctaccttctgcactgtgcccttagagcacagcttcctcagttgttctctgcatctcctggggcttaggccagtcttagcctgggttaaggctgctgacattgtgttccaatcagttgtcatgggcattatcccctctacatccacattaaacatgccggcttctcttgggcatcggcagagctgtgcctttttctttcagttacagttacataatcactgacgtccatgacacttacccatggatccatgtgctgacttcatttagaaggccaatctaaaacaactgggtttgtggctacctctttaaagttgtttgtgaaggataatttgttttttaatgcactttagtttgaaagtgagtctcttatgtaaggaccatccttaaaagaccaaaaatgccttgttagagtgttaaggagttttgacatgcagtggttccacaaacacagtggcttactatccttatacactgtcttataccatcattctctccatctctcttggtcactactctctgctgtcactggttaatcactaggtgccaagagcttactgaataaaagcttggcaattagaataaatggggagggaaggaccttatgaatagtccatttagcctaagaaatggcagatttagttcttctcttccaaaagataaaggtatatcctggaattgtacttaaaacttacagatgactaacaaatatatactttatatgtagttaatatttagatctgtcttatttaatacttggaggctagaagaagcatctttaggggaactatataatcttttgttagcattttctctgcattttaaaaaatcatttcaattcaaacatttatcagtgtcatgaaatcagtaatgactctttaacaattcaggtttgaactctgcattagatgtctctttaattttttaatatttaaaatttagttgacatttttttcaccaggtgcctttagcggttactaagataactgacatcagttgtttctctgaaataagtgttgctgtgggaataattttaatgttcaaggtgatatcatgggggagttttgtcttttaaaacattagaagcattttaaatattaagaatcaaatatttatagatcaaaacttgtgttttaagtattatacgggacctgtttacttatagtaaatgtgaatgtacacatgagttgttgctgaagctgacaagcatattacatacatgcattttccctgtgccctcatagttgcagttagagttccagtacctgtaggctcacctgggaggcagattagacccaaaggtagatgtttttcccctttccatgaagcatgtcagtgggagttgcttcctttgatttccctagtactaaattttaaggcttttgtaaaaacaaaacaaaactaggagcttggaacagttaaaaatcaacactgctaccatcaattcatcaaatatttacttagagctttcatacattaagattccagtaaccaataaattagaattcatttcttctgcataaagtaaattttcatacacttgacctactaagacagcaagggtgtcctaaattgaggcatttgtataatgcctgcataactaaatggtcactaaaatgggacagcatggggcaagaccttgtagttcttcacagaatatttgtggtcagtttctccaattaatttgctgcatgagccaaataaccataattcactttttatacccactggtgccataattagagaattagagggtgtagacagaggttaatgccaatgagaaacacaggacagggttttttttattataaaggtcattagatacaaaagattgtttttcaaaaaatttctaattctaacaaaggggatcaatcagaaatgaaactaagctactttctaaagtgacactgtatcagaataatccagatttgaatataacattttgccaccaactgacatttagatgaaggactgcctctctgaaagagttcagatcatattcaggggtgaatccaacaccatggaagaaagactactgatgaaaatattttcccactttgcacaaatctgtaaactacacctttgtttatagaaaaatgcttgtaatagtcactgtaatatttagctgtggataaaaatttgtggaaataaatacttttgaataaagaggtgtgccaaatctaaatgaaattt
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:4645 -> Molecular function: GO:0000146 [microfilament motor activity] evidence: TAS
            GeneID:4645 -> Molecular function: GO:0003779 [actin binding] evidence: IEA
            GeneID:4645 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:4645 -> Molecular function: GO:0005516 [calmodulin binding] evidence: IEA
            GeneID:4645 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:4645 -> Molecular function: GO:0017137 [Rab GTPase binding] evidence: IPI
            GeneID:4645 -> Biological process: GO:0006833 [water transport] evidence: TAS
            GeneID:4645 -> Biological process: GO:0015031 [protein transport] evidence: IEA
            GeneID:4645 -> Biological process: GO:0016192 [vesicle-mediated transport] evidence: IMP
            GeneID:4645 -> Biological process: GO:0055085 [transmembrane transport] evidence: TAS
            GeneID:4645 -> Cellular component: GO:0016459 [myosin complex] evidence: IEA
            GeneID:4645 -> Cellular component: GO:0030659 [cytoplasmic vesicle membrane] evidence: TAS
            GeneID:4645 -> Cellular component: GO:0043234 [protein complex] evidence: IDA

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 2.1 Japan License.