2024-04-21 01:20:53, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001080124 2750 bp mRNA linear PRI 09-JUN-2013 DEFINITION Homo sapiens caspase 8, apoptosis-related cysteine peptidase (CASP8), transcript variant F, mRNA. ACCESSION NM_001080124 VERSION NM_001080124.1 GI:122056473 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2750) AUTHORS Hong,S., Kim,H.Y., Kim,J., Ha,H.T., Kim,Y.M., Bae,E., Kim,T.H., Lee,K.C. and Kim,S.J. TITLE Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis JOURNAL J. Biol. Chem. 288 (5), 3560-3570 (2013) PUBMED 23255602 REMARK GeneRIF: Smad7 was able to activate the caspase 8 promoter through recruitment of the interferon regulatory factor 1 (IRF1) transcription factor to the interferon-stimulated response element (ISRE) site. REFERENCE 2 (bases 1 to 2750) AUTHORS Apelbaum,A., Yarden,G., Warszawski,S., Harari,D. and Schreiber,G. TITLE Type I interferons induce apoptosis by balancing cFLIP and caspase-8 independent of death ligands JOURNAL Mol. Cell. Biol. 33 (4), 800-814 (2013) PUBMED 23230268 REMARK GeneRIF: Apoptosis-related genes such as the caspase-8, FLIP, and DR5 genes specifically interfere with interferon-induced apoptosis. REFERENCE 3 (bases 1 to 2750) AUTHORS Erdman,V.V., Nasibullin,T.R., Tuktarova,I.A. and Mustafina,O.E. TITLE [Association of polymorphic markers of CASP8, BCL2 and BAX genes with aging and longevity] JOURNAL Adv Gerontol 25 (3), 398-404 (2012) PUBMED 23289213 REMARK GeneRIF: An increase of genotype frequency of BCL2*C/*C and decrease of genotype frequency of CASP8*I/*D was observed in male of senile age REFERENCE 4 (bases 1 to 2750) AUTHORS Li,S.X., Chai,L., Cai,Z.G., Jin,L.J., Chen,Y., Wu,H.R. and Sun,Z. TITLE Expression of survivin and caspase 3 in oral squamous cell carcinoma and peritumoral tissue JOURNAL Asian Pac. J. Cancer Prev. 13 (10), 5027-5031 (2012) PUBMED 23244104 REMARK GeneRIF: Low expression of caspase 3 is associated with oral squamous cell carcinoma and peritumoral tissue. REFERENCE 5 (bases 1 to 2750) AUTHORS Kominami,K., Nagai,T., Sawasaki,T., Tsujimura,Y., Yashima,K., Sunaga,Y., Tsuchimochi,M., Nishimura,J., Chiba,K., Nakabayashi,J., Koyamada,K., Endo,Y., Yokota,H., Miyawaki,A., Manabe,N. and Sakamaki,K. TITLE In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis JOURNAL PLoS ONE 7 (11), E50218 (2012) PUBMED 23185580 REMARK GeneRIF: Focal activation of CASP8 is sufficient to propagate apoptotic signals through death receptors. REFERENCE 6 (bases 1 to 2750) AUTHORS Breckenridge,D.G., Nguyen,M., Kuppig,S., Reth,M. and Shore,G.C. TITLE The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum JOURNAL Proc. Natl. Acad. Sci. U.S.A. 99 (7), 4331-4336 (2002) PUBMED 11917123 REFERENCE 7 (bases 1 to 2750) AUTHORS Fernandes-Alnemri,T., Takahashi,A., Armstrong,R., Krebs,J., Fritz,L., Tomaselli,K.J., Wang,L., Yu,Z., Croce,C.M., Salveson,G. et al. TITLE Mch3, a novel human apoptotic cysteine protease highly related to CPP32 JOURNAL Cancer Res. 55 (24), 6045-6052 (1995) PUBMED 8521391 REFERENCE 8 (bases 1 to 2750) AUTHORS Fernandes-Alnemri,T., Litwack,G. and Alnemri,E.S. TITLE CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme JOURNAL J. Biol. Chem. 269 (49), 30761-30764 (1994) PUBMED 7983002 REFERENCE 9 (bases 1 to 2750) AUTHORS DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and Calos,M.P. TITLE Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system JOURNAL Mol. Cell. Biol. 7 (1), 379-387 (1987) PUBMED 3031469 REFERENCE 10 (bases 1 to 2750) AUTHORS Clements,G.B., Klein,G. and Povey,S. TITLE Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA JOURNAL Int. J. Cancer 16 (1), 125-133 (1975) PUBMED 170210 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA420056.1, AF422927.1, AC007256.5 and AI351872.1. Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (F) includes different segments in the 5' UTR and lacks an alternate in-frame segment in the coding region, compared to variant G. Variants C and F both encode isoform C, which is shorter than isoform G. Isoform C has also been labelled as Alpha-2 or MCH5-beta. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: X98173.1, AF009620.1 [ECO:0000331] ##Evidence-Data-END## COMPLETENESS: full length. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-20 DA420056.1 1-20 21-1251 AF422927.1 9-1239 1252-1494 AC007256.5 132153-132395 c 1495-2475 AC007256.5 130031-131011 c 2476-2750 AI351872.1 1-275 c FEATURES Location/Qualifiers source 1..2750 /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="2" /map="2q33-q34" gene 1..2750 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="caspase 8, apoptosis-related cysteine peptidase" /db_xref="GeneID:841" /db_xref="HGNC:1509" /db_xref="MIM:601763" exon 1..112 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" exon 113..209 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" misc_feature 206..208 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="upstream in-frame stop codon" exon 210..540 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 224 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="c" /db_xref="dbSNP:200484909" CDS 236..1630 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /EC_number="3.4.22.61" /note="isoform C precursor is encoded by transcript variant F; caspase 8, apoptosis-related cysteine protease; FADD-homologous ICE/CED-3-like protease; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; FADD-like ICE; apoptotic protease Mch-5; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog" /codon_start=1 /product="caspase-8 isoform C precursor" /protein_id="NP_001073593.1" /db_xref="GI:122056474" /db_xref="CCDS:CCDS2343.1" /db_xref="GeneID:841" /db_xref="HGNC:1509" /db_xref="MIM:601763" /translation="
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
" misc_feature 242..487 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="Death effector domain, repeat 1, of Caspase-8; Region: DED_Caspase_8_repeat1; cd08333" /db_xref="CDD:176745" misc_feature order(281..286,296..298,305..310,314..319,425..427, 437..439) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="putative DED1/DED2 interface [polypeptide binding]; other site" /db_xref="CDD:176745" misc_feature order(287..289,446..448,452..454) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="charge triad; other site" /db_xref="CDD:176745" misc_feature 527..775 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633" /db_xref="CDD:209876" mat_peptide 839..1159 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /product="caspase-8 isoform C subunit p18" misc_feature 845..847 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /experiment="experimental evidence, no additional details recorded" /note="phosphorylation site" misc_feature 863..1621 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cd00032" /db_xref="CDD:28914" misc_feature order(968..970,1142..1144,1262..1264,1283..1285, 1418..1435,1445..1450) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="substrate pocket [chemical binding]; other site" /db_xref="CDD:28914" misc_feature order(1139..1141,1268..1270) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="active site" /db_xref="CDD:28914" misc_feature order(1286..1288,1373..1378,1397..1399,1406..1408, 1415..1417,1484..1486,1511..1513,1529..1531,1571..1573, 1586..1591,1595..1597,1604..1609) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="dimer interface [polypeptide binding]; other site" /db_xref="CDD:28914" misc_feature order(1289..1291,1370..1372) /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /note="proteolytic cleavage site; other site" /db_xref="CDD:28914" mat_peptide 1343..1627 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /product="caspase-8 isoform C subunit p10" STS 236..481 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="RH70951" /db_xref="UniSTS:19740" variation 319 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368413113" variation 334 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="g" /replace="t" /db_xref="dbSNP:138862018" variation 394 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:200261147" variation 409 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:374717331" variation 492 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:61995876" variation 497 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:374010917" variation 537 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:376330981" exon 541..646 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 574 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:17860422" variation 605 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:373203074" variation 622 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368684291" variation 634 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:150515363" exon 647..785 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 666 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:142688117" variation 667 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:149933993" variation 678 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:148697064" variation 687 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:367807709" variation 730 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:201525799" exon 786..850 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 830 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="g" /replace="t" /db_xref="dbSNP:146816437" variation 845 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /replace="t" /db_xref="dbSNP:35976359" exon 851..992 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 869 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:143410219" variation 932 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:17860424" variation 957 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:112383550" variation 979 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:35142591" exon 993..1494 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 1005 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:139337151" variation 1033 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="c" /db_xref="dbSNP:199934929" variation 1042 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:138030956" variation 1043 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:1045485" variation 1081 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860426" variation 1082 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:146286958" STS 1084..1463 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="PMC230316P2" /db_xref="UniSTS:272180" variation 1102 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:139361998" variation 1109 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:148960588" variation 1150 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045487" variation 1162 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:368087314" variation 1171 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:372973743" variation 1238 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:202185417" variation 1276 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:377204617" variation 1327 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:369704935" variation 1359 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:373673288" variation 1371..1372 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="c" /db_xref="dbSNP:34208389" variation 1372 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:190041873" variation 1374 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="t" /db_xref="dbSNP:150243843" exon 1495..2747 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /inference="alignment:Splign:1.39.8" variation 1682 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:34857899" variation 1690 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:13425113" STS 1693..1795 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="D11S2921" /db_xref="UniSTS:152074" STS 1700..1789 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="PMC156606P1" /db_xref="UniSTS:271408" variation 1701 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:41309822" variation 1713 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860428" variation 1728 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:36155452" variation 1729 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:13425383" variation 1737 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:184368293" variation 1745 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:370257689" variation 1752 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:3185378" variation 1776 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:201516518" variation 1796 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:35474602" variation 1805 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:2141331" STS 1912..2330 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="GDB:631813" /db_xref="UniSTS:158430" variation 1946 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:35419671" variation 2041 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="g" /db_xref="dbSNP:17860432" variation 2059 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:17860433" variation 2094 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:1045494" variation 2108 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045495" variation 2221 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:187758494" variation 2293 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:193117251" variation 2305 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:368491883" variation 2336 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="c" /replace="t" /db_xref="dbSNP:11551927" variation 2385 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:145519245" STS 2388..2533 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /standard_name="RH78960" /db_xref="UniSTS:4072" variation 2404 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1128421" variation 2419 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1128423" variation 2421 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:1045501" variation 2442..2443 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="aa" /db_xref="dbSNP:71769639" variation 2451 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="t" /db_xref="dbSNP:34552705" variation 2475 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="t" /db_xref="dbSNP:13113" variation 2503 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="a" /replace="g" /db_xref="dbSNP:371966481" variation 2556..2557 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="at" /db_xref="dbSNP:34461625" variation 2557..2558 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" /replace="" /replace="at" /db_xref="dbSNP:373026882" polyA_signal 2724..2729 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" polyA_site 2745 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" polyA_site 2747 /gene="CASP8" /gene_synonym="ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5" ORIGIN
gtgctctgagtttttggtttctgtttcaccttgtgtctgagctggtctgaaggctggttgttcagactgagcttcctgcctgcctgtaccccgccaacagcttcagaagaaggagcagcccctgggtgcgtccactttctgggcacgtgaggttgggccttggccgcctgagcccttgagttggtcacttgaaccttgggaatattgagattatattctcctgccttttaaaaagatggacttcagcagaaatctttatgatattggggaacaactggacagtgaagatctggcctccctcaagttcctgagcctggactacattccgcaaaggaagcaagaacccatcaaggatgccttgatgttattccagagactccaggaaaagagaatgttggaggaaagcaatctgtccttcctgaaggagctgctcttccgaattaatagactggatttgctgattacctacctaaacactagaaaggaggagatggaaagggaacttcagacaccaggcagggctcaaatttctgcctacagggtcatgctctatcagatttcagaagaagtgagcagatcagaattgaggtcttttaagtttcttttgcaagaggaaatctccaaatgcaaactggatgatgacatgaacctgctggatattttcatagagatggagaagagggtcatcctgggagaaggaaagttggacatcctgaaaagagtctgtgcccaaatcaacaagagcctgctgaagataatcaacgactatgaagaattcagcaaaggggaggagttgtgtggggtaatgacaatctcggactctccaagagaacaggatagtgaatcacagactttggacaaagtttaccaaatgaaaagcaaacctcggggatactgtctgatcatcaacaatcacaattttgcaaaagcacgggagaaagtgcccaaacttcacagcattagggacaggaatggaacacacttggatgcaggggctttgaccacgacctttgaagagcttcattttgagatcaagccccacgatgactgcacagtagagcaaatctatgagattttgaaaatctaccaactcatggaccacagtaacatggactgcttcatctgctgtatcctctcccatggagacaagggcatcatctatggcactgatggacaggaggcccccatctatgagctgacatctcagttcactggtttgaagtgcccttcccttgctggaaaacccaaagtgttttttattcaggcttgtcagggggataactaccagaaaggtatacctgttgagactgattcagaggagcaaccctatttagaaatggatttatcatcacctcaaacgagatatatcccggatgaggctgactttctgctggggatggccactgtgaataactgtgtttcctaccgaaaccctgcagagggaacctggtacatccagtcactttgccagagcctgagagagcgatgtcctcgaggcgatgatattctcaccatcctgactgaagtgaactatgaagtaagcaacaaggatgacaagaaaaacatggggaaacagatgcctcagcctactttcacactaagaaaaaaacttgtcttcccttctgattgatggtgctattttgtttgttttgttttgttttgtttttttgagacagaatctcgctctgtcgcccaggctggagtgcagtggcgtgatctcggctcaccgcaagctccgcctcccgggttcaggccattctcctgcctcagcctcccgagtagctgggactacaggggcccgccaccacacctggctaattttttaaaaatatttttagtagagacagggtttcactgtgttagccagggtggtcttgatctcctgacctcgtgatccacccacctcggcctcccaaagtgctgggattacaggcgtgagccaccgcgcctggccgatggtactatttagatataacactatgtttatttactaattttctagattttctactttattaattgttttgcacttttttataagagctaaagttaaataggatattaacaacaataacactgtctcctttctcttatgcttaaggctttgggaatgtttttagctggtggcaataaataccagacacgtacaaaatccagctatgaatatagagggcttatgattcagattgttatctatcaactataagcccactgttaatattctattaactttaattctctttcaaagctaaattccacactaccacattaaaaaaattagaaagtagccacgtatggtggctcatgtctataatcccagcactttgggaggttgaggtgggaggattgcttgaacccaagaggtcaaggctgcagtgagccatgttcacaccgctgcactcaagcttgggtgacagaacaagaccccgtctcaaaaaaaattttttttttaataaaacaaaatttgtttgaaatcttttaaaaattcaaatgatttttacaagttttaaataagctctccccaaacttgctttatgccttcttattgcttttatgatatatatatgcttggctaactatatttgctttttgctaacaatgctctggggtctttttatgcatttgcatttgctctttcatctctgcttggattattttaaatcattaggaattaagttatctttaaaatttaagtatcttttttcaaaaacattttttaatagaataaaatataatttgatcttattaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726): GeneID:841 -> Molecular function: GO:0002020 [protease binding] evidence: IPI GeneID:841 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: IDA GeneID:841 -> Molecular function: GO:0004197 [cysteine-type endopeptidase activity] evidence: TAS GeneID:841 -> Molecular function: GO:0005164 [tumor necrosis factor receptor binding] evidence: IEA GeneID:841 -> Molecular function: GO:0005515 [protein binding] evidence: IPI GeneID:841 -> Molecular function: GO:0008234 [cysteine-type peptidase activity] evidence: TAS GeneID:841 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI GeneID:841 -> Biological process: GO:0001525 [angiogenesis] evidence: IEA GeneID:841 -> Biological process: GO:0001841 [neural tube formation] evidence: IEA GeneID:841 -> Biological process: GO:0002224 [toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0002756 [MyD88-independent toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0006508 [proteolysis] evidence: IDA GeneID:841 -> Biological process: GO:0006915 [apoptotic process] evidence: IGI GeneID:841 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS GeneID:841 -> Biological process: GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] evidence: TAS GeneID:841 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS GeneID:841 -> Biological process: GO:0007507 [heart development] evidence: IEA GeneID:841 -> Biological process: GO:0009409 [response to cold] evidence: IEA GeneID:841 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA GeneID:841 -> Biological process: GO:0030225 [macrophage differentiation] evidence: IEA GeneID:841 -> Biological process: GO:0032025 [response to cobalt ion] evidence: IEA GeneID:841 -> Biological process: GO:0032355 [response to estradiol stimulus] evidence: IEA GeneID:841 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA GeneID:841 -> Biological process: GO:0034138 [toll-like receptor 3 signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0034142 [toll-like receptor 4 signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0034612 [response to tumor necrosis factor] evidence: IMP GeneID:841 -> Biological process: GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP GeneID:841 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:841 -> Biological process: GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IMP GeneID:841 -> Biological process: GO:0045087 [innate immune response] evidence: TAS GeneID:841 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA GeneID:841 -> Biological process: GO:0045651 [positive regulation of macrophage differentiation] evidence: IMP GeneID:841 -> Biological process: GO:0045862 [positive regulation of proteolysis] evidence: IDA GeneID:841 -> Biological process: GO:0046677 [response to antibiotic] evidence: IEA GeneID:841 -> Biological process: GO:0051291 [protein heterooligomerization] evidence: IEA GeneID:841 -> Biological process: GO:0051603 [proteolysis involved in cellular protein catabolic process] evidence: IMP GeneID:841 -> Biological process: GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP GeneID:841 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: IMP GeneID:841 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0097191 [extrinsic apoptotic signaling pathway] evidence: IDA GeneID:841 -> Biological process: GO:0097193 [intrinsic apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:0097202 [activation of cysteine-type endopeptidase activity] evidence: IDA GeneID:841 -> Biological process: GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway] evidence: TAS GeneID:841 -> Biological process: GO:2001239 [regulation of extrinsic apoptotic signaling pathway in absence of ligand] evidence: TAS GeneID:841 -> Cellular component: GO:0005634 [nucleus] evidence: IDA GeneID:841 -> Cellular component: GO:0005730 [nucleolus] evidence: IDA GeneID:841 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA GeneID:841 -> Cellular component: GO:0005739 [mitochondrion] evidence: IDA GeneID:841 -> Cellular component: GO:0005741 [mitochondrial outer membrane] evidence: TAS GeneID:841 -> Cellular component: GO:0005813 [centrosome] evidence: IDA GeneID:841 -> Cellular component: GO:0005829 [cytosol] evidence: TAS GeneID:841 -> Cellular component: GO:0005856 [cytoskeleton] evidence: TAS GeneID:841 -> Cellular component: GO:0030690 [Noc1p-Noc2p complex] evidence: IEA GeneID:841 -> Cellular component: GO:0031264 [death-inducing signaling complex] evidence: IDA GeneID:841 -> Cellular component: GO:0031265 [CD95 death-inducing signaling complex] evidence: IEA GeneID:841 -> Cellular component: GO:0043005 [neuron projection] evidence: IEA GeneID:841 -> Cellular component: GO:0044297 [cell body] evidence: IEA GeneID:841 -> Cellular component: GO:0045121 [membrane raft] evidence: IEA ANNOTATIONS from NCBI Entrez Gene (20130726): NP_001073593 -> EC 3.4.22.61
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