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2024-04-20 09:00:37, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001079559 5156 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens heterogeneous nuclear ribonucleoprotein U-like 2
(HNRNPUL2), mRNA.
ACCESSION NM_001079559 XM_001128651 XM_495877
VERSION NM_001079559.2 GI:325910854
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5156)
AUTHORS Polo,S.E., Blackford,A.N., Chapman,J.R., Baskcomb,L., Gravel,S.,
Rusch,A., Thomas,A., Blundred,R., Smith,P., Kzhyshkowska,J.,
Dobner,T., Taylor,A.M., Turnell,A.S., Stewart,G.S., Grand,R.J. and
Jackson,S.P.
TITLE Regulation of DNA-end resection by hnRNPU-like proteins promotes
DNA double-strand break signaling and repair
JOURNAL Mol. Cell 45 (4), 505-516 (2012)
PUBMED 22365830
REMARK GeneRIF: hnRNPUL1 and -2 function downstream of MRN and
CtBP-interacting protein (CtIP) to promote recruitment of the BLM
helicase to DNA breaks.
REFERENCE 2 (bases 1 to 5156)
AUTHORS Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
TITLE A probability-based approach for high-throughput protein
phosphorylation analysis and site localization
JOURNAL Nat. Biotechnol. 24 (10), 1285-1292 (2006)
PUBMED 16964243
REFERENCE 3 (bases 1 to 5156)
AUTHORS Fackelmayer,F.O. and Richter,A.
TITLE Purification of two isoforms of hnRNP-U and characterization of
their nucleic acid binding activity
JOURNAL Biochemistry 33 (34), 10416-10422 (1994)
PUBMED 8068679
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC029105.1, DQ470474.1, AP001458.6 and AI992017.1.
On Mar 11, 2011 this sequence version replaced gi:118601080.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
##Evidence-Data-START##
Transcript exon combination :: DQ470474.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025081, ERS025082 [ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-36 BC029105.1 88-123
37-3024 DQ470474.1 1-2988
3025-5142 AP001458.6 119897-122014 c
5143-5156 AI992017.1 1-14 c
FEATURES Location/Qualifiers
source 1..5156
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11q12.3"
gene 1..5156
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/note="heterogeneous nuclear ribonucleoprotein U-like 2"
/db_xref="GeneID:221092"
/db_xref="HGNC:25451"
exon 1..767
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
CDS 230..2473
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/note="scaffold-attachment factor A2"
/codon_start=1
/product="heterogeneous nuclear ribonucleoprotein U-like
protein 2"
/protein_id="NP_001073027.1"
/db_xref="GI:118601081"
/db_xref="CCDS:CCDS41659.1"
/db_xref="GeneID:221092"
/db_xref="HGNC:25451"
/translation="
MEVKRLKVTELRSELQRRGLDSRGLKVDLAQRLQEALDAEMLEDEAGGGGAGPGGACKAEPRPVAASGGGPGGDEEEDEEEEEEDEEALLEDEDEEPPPAQALGQAAQPPPEPPEAAAMEAAAEPDASEKPAEATAGSGGVNGGEEQGLGKREEDEPEERSGDETPGSEVPGDKAAEEQGDDQDSEKSKPAGSDGERRGVKRQRDEKDEHGRAYYEFREEAYHSRSKSPLPPEEEAKDEEEDQTLVNLDTYTSDLHFQVSKDRYGGQPLFSEKFPTLWSGARSTYGVTKGKVCFEAKVTQNLPMKEGCTEVSLLRVGWSVDFSRPQLGEDEFSYGFDGRGLKAENGQFEEFGQTFGENDVIGCFANFETEEVELSFSKNGEDLGVAFWISKDSLADRALLPHVLCKNCVVELNFGQKEEPFFPPPEEFVFIHAVPVEERVRTAVPPKTIEECEVILMVGLPGSGKTQWALKYAKENPEKRYNVLGAETVLNQMRMKGLEEPEMDPKSRDLLVQQASQCLSKLVQIASRTKRNFILDQCNVYNSGQRRKLLLFKTFSRKVVVVVPNEEDWKKRLELRKEVEGDDVPESIMLEMKANFSLPEKCDYMDEVTYGELEKEEAQPIVTKYKEEARKLLPPSEKRTNRRNNRNKRNRQNRSRGQGYVGGQRRGYDNRAYGQQYWGQPGNRGGYRNFYDRYRGDYDRFYGRDYEYNRYRDYYRQYNRDWQSYYYHHPQDRDRYYRNYYGYQGYR
"
misc_feature 236..331
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/note="Putative DNA-binding (bihelical) motif predicted to
be involved in chromosomal organisation; Region: SAP;
smart00513"
/db_xref="CDD:128789"
misc_feature 911..913
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(Q1KMD3.1); phosphorylation site"
misc_feature 1094..1480
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/note="SPRY domain; Region: SPRY; pfam00622"
/db_xref="CDD:201350"
misc_feature 1589..2026
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/note="AAA domain; Region: AAA_33; pfam13671"
/db_xref="CDD:205848"
exon 768..903
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 904..980
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 981..1120
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1121..1211
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1212..1324
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1325..1588
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1589..1711
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1712..1840
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 1841..2009
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 2010..2210
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
exon 2211..2284
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
variation 2234
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:755246"
exon 2285..2392
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
variation 2353
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="a"
/replace="c"
/db_xref="dbSNP:200711214"
exon 2393..5147
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/inference="alignment:Splign:1.39.8"
variation 2908
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="c"
/replace="t"
/db_xref="dbSNP:746610"
variation 2977
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="a"
/replace="g"
/db_xref="dbSNP:894464"
variation 4686
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2845670"
STS 4699..4827
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/standard_name="D11S2291E"
/db_xref="UniSTS:30592"
variation 4928
/gene="HNRNPUL2"
/gene_synonym="HNRPUL2; SAF-A2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1046323"
ORIGIN
tgttttgggctccgtgagccgaaagggggaggggagacgaaggagaagcaaacactgcgcagcgggaccgtgcgcggcctccgctcctgcgtgcgtgcgctcgctcgcgcgggctcagtgctggcgcgtgaggcggaggcgggcggcggcggcggcgcctgcgcggtcggactcggtcgacggttcgcaggggaggaggcggcgggaggcggaggaggcggcggcggcgatggaggtgaagcggctgaaagtgaccgagctgcggtcggagctgcagcggcggggcctggactcgcgcggcctcaaggtggatctggcgcagcggctgcaggaggcgctggacgccgagatgctcgaggacgaggccggcggcggcggggccgggcccggcggggcctgcaaggcggagcctcggcctgtggccgcgtcgggcggcggcccgggcggggacgaggaggaggacgaagaggaggaggaggaggacgaggaggcgctgcttgaggacgaggacgaggagccaccccctgctcaagccttgggtcaggccgcgcagccgccgccggagcccccggaggcggcagccatggaggccgcggccgagccagatgcttccgagaagccggcggaggccacggccgggtcaggcggggtaaatggtggcgaagagcagggcctcggcaagagggaggaagacgaacccgaggagcggagcggggacgagacgccgggatccgaggtgccgggtgacaaggccgccgaggaacagggagatgaccaggatagtgaaaagtcaaaaccagcaggctcagatggtgagcggcggggggtaaagagacagcgggatgagaaggatgaacatggccgagcttactatgaattccgagaggaggcttaccacagccgctcaaagtctccactgcctcctgaagaagaggcaaaagatgaggaggaggatcaaactcttgtgaacctggacacgtatacctcggatctgcattttcaagtgagcaaagaccgctatggagggcagccacttttctcagagaagttccccaccctttggtctggggcaaggagtacttacggagtgacaaagggaaaagtctgctttgaggcaaaggtaacccagaatctcccaatgaaagaaggctgcacagaggtctctctccttcgagttgggtggtctgttgatttttcccgtccacagcttggtgaagatgaattctcttacggtttcgatggacgaggactcaaggcagaaaatggacaatttgaggaatttggccagacttttggggagaatgatgttattggctgctttgctaattttgagactgaagaagtagaactttccttctccaagaatggagaagacctaggtgtggcattctggatcagcaaggattccctggcagaccgggcccttctaccccatgtcctctgcaaaaattgtgttgtagaattaaacttcggtcagaaggaggagcccttcttcccaccaccagaagagtttgtgttcattcatgctgtgcctgttgaggagcgtgtacgcactgcagtccctcccaagaccatagaggaatgtgaggtgattctgatggtgggactacccggatctggaaagacccagtgggcactgaaatatgcaaaagaaaaccctgagaaaagatacaatgtcctgggagctgagactgtgctcaatcaaatgaggatgaagggtctcgaggagccagagatggaccccaaaagccgagaccttttagttcagcaagcctcccagtgccttagtaagctggtccagattgcttcccggacaaagaggaactttattcttgatcagtgtaatgtgtacaattctggccaacggcggaagctattgctgttcaagaccttctctcggaaagtggtggtggttgtccctaatgaggaagattggaagaagaggctggagttgaggaaggaagtagagggagatgatgtgcctgaatctataatgctggagatgaaagccaacttctctttgcctgaaaaatgcgactatatggatgaggtgacatatggggagctggagaaggaggaagctcagcccattgtcactaagtacaaggaggaggcaaggaagcttctgcccccctccgagaagcggacaaatcgccgaaacaaccgaaacaagcgtaaccggcagaaccgaagccggggccaaggctatgtgggcgggcagcgccgaggctacgacaaccgggcctacgggcagcagtactgggggcagcctggaaacagagggggttaccgtaatttctatgatcgatacaggggagactatgatcgattttacgggcgagattatgagtacaacagatacagagactattacagacaatacaatcgggattggcagagttactactaccaccacccccaggacagagaccgatactacaggaattactacgggtaccaagggtatcggtgaagcccctgccatggtcacctgtcagccatgaagctgaatctctgggggtgccaggcacccccgcaaaacacaaccaaggaaaacaggggctgtcggggtggggctgagctgccggggaggggtggtggggggggagggtgctcaagcaggggtgggggaggggggaggtggaaacaaacaacaaaactgtacattttttttaaagtttgttgaaaagaatattgtcttattctataaaacatttcaaacctagttagagatttgtaatcaaaaaacatttgcgcagaaagcagcacttagggctgcctgttctataccctacagtcagacaggaaaagaactgaaaatggcacccttctgacattctgaggcagctggactggcagccaagtaaaggagagtgatgaggtggtgtggggagggtggggaggcagcgcgagggtgctctccacagcaggtaggagcaggcaggagtggggacagagggagagcttgtgactgggacagtgaaaataaacgattggctcttatcaatcacttgcaccaactaaccgtttgtattttctttaccgacctttcccttttgggatatgtggtctggtgggctgggaggcttacagtgtcccaactctccattttcctgtgcctttgtgctgtttggctgaggcatggagactgccagtgggtggttctattttacaggattcccaggccaagaaagcctggggactgtccttgatggcagagcagaatagcctgccccttctatagacccattgattaattcctgtaaaatcttggggagaatgggattgcagccctcagcctaaagattgtgatttgccagtctctagtctctgtcttccaaggttgagagaggtgggaggtctctgaaatcatccctgttagagtgtctgtcctcttacagtgcgagagaaggaacgtttctcagggtttcagctcacacgaaaacacagcaggattcttttcactgcagcgggatatgtatataggtgaatcctgtggtgtgggctcacaggcccaggtgctgagaatagcaactagcaactattttctacagtgtggagggctcgtgccctgctggtttttttgatacacaggtagagaatgaatagaagaggggagggtggtgggggggggtgggaggcagctcagtggggctgctgaaccttgggaagagtgtgagtgtgaacgtgtgtaaatgtgcgtgtgaaagggagcaccccttcccgacttctagaaacaaaattccttttggggcgctttccctgtgtgtccccagagaggcctctagccaggagccttcagttgggatagtttcatttgtgactttaccaataccctcccagttcttgatagacagctgtaggttgctgggttcaagaatatgggtgggatatggaatgctctttcaatgtctagcttcagttttcattcatcctcctgctcagcactgtcagccaagagcttactcagcagacaccacatactgcagcagttcctagtgagaaaatctgtgccactagaaaatgcttcacttccatttcctcacctgggcagttctctgtttaaaattgtgggctgatttggtcttcctctcctcctcccactgttactgccctgcagcccttgttcaggtgtacagacccttattctggcctctagtgtccttgtctgtcatgacacacccttccgcccaaatacctctgaccccaaggctggaatggggctggtaggagataagtttgcttactcatagtcatgtcctttctcttggcacctgcttccctgcggtgtcctcaaatggatttctgtgtggcagtggagtgattgcatgaatttttctgtaacacattaactttgtattattattaagggagtttgagaaagctttgcttataatgtcaaggcaaggaggtaaaaactggagcccaaagaaattcccttagggcaagattatgttataatagaaaattgaatttcctgaggcagtggctgccaccccttttcagatgtttagtcctgcaaatagcatctttcttgtagtctgtgacatggatggggatgctagggcccttaggggcaaggggactaaactaaatcaagttgagtttttttccagcaggggttaggggaggtactcgctgttgatatttgacactagaaagtaatcttttttacaaaactgtttttctaggtgggtggaaagtgaaactgccacatccttgttggtttagtccaagagatcatttgcaacaacagtagatgtccgggttttgtttctgtctttttattatgaaaaactatgttaagggggaaaatgtggattatggtaaccagaggaatccctagccttgttttccttagaagacttgtttagtgttttatcagacgtctgttgtagttgtagacaggaaagcttgtgagaaaaacaccacatggagcctgtaaatgtttttgcacaacctgtaaagcattcttggaagtggccagtaaaaaggggttttaccatttaaaaaaaaaatgtaactgtgtcattgtttacatctgtaactttttcctcccctgttctcattacaccattctggcgaaaatgtaggcaaagtagcttccagttttagaataaataaccatttggattgaattcaccctaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:221092 -> Molecular function: GO:0003676 [nucleic acid binding] evidence: IEA
GeneID:221092 -> Biological process: GO:0008150 [biological_process] evidence: ND
GeneID:221092 -> Cellular component: GO:0005634 [nucleus] evidence: ISS
by
@meso_cacase at
DBCLS
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