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2024-03-29 09:56:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001077663            3636 bp    mRNA    linear   PRI 07-JUL-2013
DEFINITION  Homo sapiens upregulator of cell proliferation (URGCP), transcript
            variant 3, mRNA.
ACCESSION   NM_001077663
VERSION     NM_001077663.1  GI:117968327
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3636)
  AUTHORS   Dodurga,Y., Yonguc,G.N., Avci,C.B., Bagci,G., Gunduz,C. and
            Satiroglu-Tufan,N.L.
  TITLE     Investigation of microRNA expression changes in HepG2 cell line in
            presence of URG4/URGCP and in absence of URG4/URGCP suppressed by
            RNA interference
  JOURNAL   Mol. Biol. Rep. 39 (12), 11119-11124 (2012)
   PUBMED   23053999
  REMARK    GeneRIF: microRNA profiles were analyzedin HepG2 cells in presence
            or absence of URG4/URGCP gene using RNA interference.
REFERENCE   2  (bases 1 to 3636)
  AUTHORS   Dodurga,Y., Avci,C.B., Susluer,S.Y., Satiroglu Tufan,N.L. and
            Gunduz,C.
  TITLE     The expression of URGCP gene in prostate cancer cell lines:
            correlation with rapamycin
  JOURNAL   Mol. Biol. Rep. 39 (12), 10173-10177 (2012)
   PUBMED   23007575
  REMARK    GeneRIF: Rapamycin diminishes URGCP gene expression in DU145 and
            PC3 cells, but increases expression in LNCaP cells.
REFERENCE   3  (bases 1 to 3636)
  AUTHORS   Xie,C., Song,L.B., Wu,J.H., Li,J., Yun,J.P., Lai,J.M., Xie,D.Y.,
            Lin,B.L., Yuan,Y.F., Li,M. and Gao,Z.L.
  TITLE     Upregulator of cell proliferation predicts poor prognosis in
            hepatocellular carcinoma and contributes to hepatocarcinogenesis by
            downregulating FOXO3a
  JOURNAL   PLoS ONE 7 (7), E40607 (2012)
   PUBMED   22815774
  REMARK    GeneRIF: The effects of URGCP/URG4-overexpression or -knockdown on
            expression of cell cycle regulators and transcriptional activity of
            FOXO3a, were examined.
REFERENCE   4  (bases 1 to 3636)
  AUTHORS   Oymak,Y., Dodurga,Y., Turedi,A., Yaman,Y., Ozek,G., Carti,O.,
            Gunes,B.T., Erbudak,E., Berber,E., Avci,C.B. and Vergin,C.
  TITLE     Higher expression of the novel gene upregulated gene 4 in two acute
            lymphoblastic leukemia patients with poor prednisolone response
  JOURNAL   Acta Haematol. 128 (2), 73-76 (2012)
   PUBMED   22677619
  REMARK    GeneRIF: higher expression of URG4 in our 2 patients suggests that
            URG4 might be involved in leukemogenesis
REFERENCE   5  (bases 1 to 3636)
  AUTHORS   Satiroglu-Tufan,N.L., Dodurga,Y., Gok,D., Cetinkaya,A. and
            Feitelson,M.A.
  TITLE     RNA interference-mediated URG4 gene silencing diminishes cyclin D1
            mRNA expression in HepG2 cells
  JOURNAL   Genet. Mol. Res. 9 (3), 1557-1567 (2010)
   PUBMED   20714998
  REMARK    GeneRIF: The data suggest that URG4 may play an important role in
            the development of hepatocellular carcinoma by partially regulating
            the expression of cyclin D1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3636)
  AUTHORS   Huang,J., Zhu,B., Lu,L., Lian,Z., Wang,Y., Yang,X.,
            Satiroglu-Tufan,N.L., Liu,J. and Luo,Z.
  TITLE     The expression of novel gene URG4 in osteosarcoma: correlation with
            patients' prognosis
  JOURNAL   Pathology 41 (2), 149-154 (2009)
   PUBMED   18972316
  REMARK    GeneRIF: URG4 may play important roles in the development of
            osteosarcoma, and might be a useful molecular marker for predicting
            the prognosis of osteosarcoma.
REFERENCE   7  (bases 1 to 3636)
  AUTHORS   Song,J., Xie,H., Lian,Z., Yang,G., Du,R., Du,Y., Zou,X., Jin,H.,
            Gao,J., Liu,J. and Fan,D.
  TITLE     Enhanced cell survival of gastric cancer cells by a novel gene URG4
  JOURNAL   Neoplasia 8 (12), 995-1002 (2006)
   PUBMED   17217616
  REMARK    GeneRIF: URG4 plays an important role in the development of human
            gastric cancer by regulating the expression of cyclin D1.
REFERENCE   8  (bases 1 to 3636)
  AUTHORS   Tsang,H.T., Connell,J.W., Brown,S.E., Thompson,A., Reid,E. and
            Sanderson,C.M.
  TITLE     A systematic analysis of human CHMP protein interactions:
            additional MIT domain-containing proteins bind to multiple
            components of the human ESCRT III complex
  JOURNAL   Genomics 88 (3), 333-346 (2006)
   PUBMED   16730941
REFERENCE   9  (bases 1 to 3636)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   10 (bases 1 to 3636)
  AUTHORS   Tufan,N.L., Lian,Z., Liu,J., Pan,J., Arbuthnot,P., Kew,M.,
            Clayton,M.M., Zhu,M. and Feitelson,M.A.
  TITLE     Hepatitis Bx antigen stimulates expression of a novel cellular
            gene, URG4, that promotes hepatocellular growth and survival
  JOURNAL   Neoplasia 4 (4), 355-368 (2002)
   PUBMED   12082552
  REMARK    GeneRIF: URG4 may be a natural effector of HBxAg that contributes
            importantly to multistep hepatocarcinogenesis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA240479.1, DA316326.1, AK026185.1, DR421788.1, AK000661.1 and
            AL833744.1.
            
            Summary: URG4 is upregulated in the presence of hepatitis B virus
            (HBV)-encoded X antigen (HBxAg) and may contribute to the
            development of hepatocellular carcinoma by promoting hepatocellular
            growth and survival (Tufan et al., 2002 [PubMed
            12082552]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (3) represents the more frequently
            occurring transcript and it encodes the longest protein (isoform
            3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA313524.1, BX648505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025082, ERS025085 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA240479.1         1-7
            8-555               DA316326.1         1-548
            556-1844            AK026185.1         170-1458
            1845-2380           DR421788.1         130-665
            2381-3607           AK000661.1         525-1751
            3608-3636           AL833744.1         2148-2176
FEATURES             Location/Qualifiers
     source          1..3636
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3636
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="upregulator of cell proliferation"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:30890"
                     /db_xref="MIM:610337"
     exon            1..71
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     CDS             58..2853
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     up-regulated gene 4; HBxAg up-regulated gene 4 protein;
                     HBV X protein up-regulated gene 4 protein; up-regulator of
                     cell proliferation"
                     /codon_start=1
                     /product="up-regulator of cell proliferation isoform 3"
                     /protein_id="NP_001071131.1"
                     /db_xref="GI:117968328"
                     /db_xref="CCDS:CCDS47578.1"
                     /db_xref="GeneID:55665"
                     /db_xref="HGNC:30890"
                     /db_xref="MIM:610337"
                     /translation="
MASPGIEVELLGKGHSDLGEVAPEIKASERRTAVAIADLEWREMEGDDCEFRYGDGTNEAQDNDFPTVERSRLQEMLSLLGLETYQVQKLSLQDSLQISFDSMKNWAPQVPKDLPWNFLRKLQALNADARNTTMVLDVLPDARPVEKESQMEEEIIYWDPADDLAADIYSFSELPTPDTPVNPLDLLCALLLSSDSFLQQEIALKMALCQFALPLVLPDSENHYHTFLLWAMRGIVRTWWSQPPRGMGSFREDSVVLSRAPAFAFVRMDVSSNSKSQLLNAVLSPGHRQWDCFWHRDLNLGTNAREISDGLVEISWFFPSGREDLDIFPEPVAFLNLRGDIGSHWLQFKLLTEISSAVFILTDNISKKEYKLLYSMKESTTKYYFILSPYRGKRNTNLRFLNKLIPVLKIDHSHVLVKVSSTDSDSFVKRIRAIVGNVLRAPCRRVSVEDMAHAARKLGLKVDEDCEECQKAKDRMERITRKIKDSDAYRRDELRLQGDPWRKAAQVEKEFCQLQWAVDPPEKHRAELRRRLLELRMQQNGHDPSSGVQEFISGISSPSLSEKQYFLRWMEWGLARVAQPRLRQPPETLLTLRPKHGGTTDVGEPLWPEPLGVEHFLREMGQFYEAESCLVEAGRLPAGQRRFAHFPGLASELLLTGLPLELIDGSTLSMPVRWVTGLLKELHVRLERRSRLVVLSTVGVPGTGKSTLLNTMFGLRFATGKSCGPRGAFMQLITVAEGFSQDLGCDHILVIDSGGLIGGALTSAGDRFELEASLATLLMGLSNVTVISLAETKDIPAAILHAFLRLEKTGHMPNYQFVYQNLHDVSVPGPRPRDKRQLLDPPGDLSRAAAQMEKQGDGFRALAGLAFCDPEKQHIWHIPGLWHGAPPMAAVSLAYSEAIFELKRCLLENIRNGLSNQNKNIQQLIELVRRL
"
     misc_feature    <1300..1458
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Protein of unknown function (DUF460); Region:
                     DUF460; pfam04312"
                     /db_xref="CDD:146773"
     misc_feature    2161..>2433
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="P-loop containing Nucleoside Triphosphate
                     Hydrolases; Region: P-loop_NTPase; cl09099"
                     /db_xref="CDD:214148"
     misc_feature    order(2161..2178,2320..2322)
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="GTP/Mg2+ binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:206648"
     misc_feature    2161..2175
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="G1 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    2242..2250
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Switch I region; other site"
                     /db_xref="CDD:206648"
     misc_feature    2311..2322
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="G3 box; other site"
                     /db_xref="CDD:206648"
     misc_feature    order(2317..2322,2404..2409)
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /note="Switch II region; other site"
                     /db_xref="CDD:206648"
     exon            72..98
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     exon            99..169
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     exon            170..220
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     exon            221..259
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     variation       258
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:17423654"
     exon            260..3618
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /inference="alignment:Splign:1.39.8"
     variation       1338
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:17172256"
     variation       1515
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232098"
     variation       1649
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232099"
     variation       1776
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2232100"
     variation       1785
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232101"
     variation       1796
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232102"
     variation       1845
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232103"
     variation       1860
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232104"
     variation       2106
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232105"
     variation       2146
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:2232106"
     variation       2337
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232107"
     variation       2392
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:2232108"
     variation       2628
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:2232109"
     variation       2981
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:1468405"
     STS             3232..3363
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="RH103374"
                     /db_xref="UniSTS:97701"
     STS             3467..3525
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="STS-Z40982"
                     /db_xref="UniSTS:64179"
     STS             3469..3593
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /standard_name="SHGC-36996"
                     /db_xref="UniSTS:13584"
     variation       3471
                     /gene="URGCP"
                     /gene_synonym="URG4"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:1043200"
     polyA_signal    3587..3592
                     /gene="URGCP"
                     /gene_synonym="URG4"
     polyA_site      3607
                     /gene="URGCP"
                     /gene_synonym="URG4"
     polyA_site      3618
                     /gene="URGCP"
                     /gene_synonym="URG4"
ORIGIN      
gagccgcggccgcgcggaggaagcgaaggaggcgggagcggagacctcgctgcgctcatggcgtcgcccgggatagaagtggaattactgggcaaagggcattcagatttgggagaagtagccccagaaataaaagcatcagagagacgaacagctgtggccattgcagatttggaatggagagaaatggaaggagatgattgcgagttccgttatggagatggtacaaatgaggctcaggacaatgattttccaacagtggagagaagcaggcttcaagaaatgctgtcacttttgggcctagagacgtaccaggtccagaaactcagcctccaggactctctgcagatcagttttgacagtatgaagaactgggcccctcaggttcccaaagacttgccctggaatttcctcaggaagttgcaggccctcaatgctgatgccaggaataccactatggtgctggacgtgctcccagacgccaggcctgtggagaaggagagccagatggaagaggagatcatctactgggacccagctgatgaccttgctgccgacatttattccttttctgagctgcccacccctgatacgccagtgaaccccttagaccttctctgtgccctgctgctctcctcagacagtttcctgcaacaagaaatagcgttgaaaatggccctctgccagtttgcactcccactcgtgttgcctgactcggagaaccactaccatacatttctgctgtgggccatgcggggcattgtgaggacatggtggtcccagcccccaaggggcatggggagcttccgggaagacagcgtggtcttgtccagggcgcccgccttcgccttcgtgcgcatggacgtcagtagcaactccaagtcccagcttctcaacgccgtcctcagcccgggccacaggcagtgggactgcttctggcatcgggacctcaacttgggcaccaatgcccgggagatttcggatgggttggtagaaatttcctggttttttcccagcggaagggaggacttggacattttcccagaacctgtggcctttctgaacctgagaggtgacatcgggtctcactggctgcagtttaagctcttgacagaaatctcctccgctgtgtttatattgactgacaatatcagtaagaaggaatacaaattgctgtactccatgaaggagtcaaccacaaaatactacttcatcctgagtccctaccgtgggaagcgcaacacaaacctgagatttctgaataagttaattcctgtgctgaaaatagaccactcacatgtcctggtaaaggtcagcagcactgacagcgacagcttcgtgaagaggatccgggccatcgttgggaatgtgctgcgggcaccctgcaggcgggtatctgtggaggacatggcgcacgcagcccgcaaactgggcctaaaggtcgacgaggactgtgaggagtgtcagaaagcgaaagaccggatggagaggattaccaggaaaatcaaagactcggatgcctacagaagggacgagctgaggctgcagggggacccctggagaaaggcagcccaagtggagaaggagttctgccagctccagtgggccgtggacccccctgagaagcacagggctgagctgaggcggcggctgctagaacttcgaatgcagcagaacggccatgatccctcctcgggggtgcaggagttcatctcggggatcagcagcccctccttgagtgagaagcagtacttcctgaggtggatggagtggggcctggcacgggtggcccagccgcgactgagacagcctccggagacgcttctcaccctgagaccaaagcatgggggcaccacagacgtgggggagccgctctggcctgagcccctaggggtggaacacttcttgcgggagatgggacagttttatgaggctgagagctgtcttgtggaggcagggaggctgccggcaggccagaggcgttttgcccacttcccaggcttggcctcggagctgctgctgacagggctgcctctggagctaatcgatgggagcacgctgagcatgcccgtccgctgggtcacagggctcctgaaggagctgcacgtccgactggagagacggtcaaggctggtggttctgtcaaccgtcggggtgccaggcacgggcaagtccacactcctcaacaccatgtttgggctgcggtttgccacagggaagagctgcggtcctcgaggggccttcatgcagctcatcacagtggctgagggcttcagccaggacctgggctgtgaccacatcctggtgatagactccgggggcttgataggtggggccttgacgtcagctggggacagatttgagctggaggcttccttggccactctgctcatgggactgagcaatgtcaccgtgatcagtctagctgaaaccaaggacattccagcagctattctgcatgcatttctgaggttagaaaaaacggggcacatgcccaactaccagtttgtataccagaaccttcatgatgtatctgttcccggccctaggcccagagacaagagacagctcctggatccacctggtgacctgagcagggctgcagcccagatggagaaacagggcgacggcttccgggcactggcaggcctggccttctgcgaccctgagaagcagcacatctggcacatcccaggcctgtggcacggagcacctcccatggccgcagtgagcttggcctacagtgaagccatatttgaattgaagagatgcctactcgaaaacatcaggaacggcttgtcgaaccaaaacaaaaacatccagcagctcattgagctggtgagacggctgtgagtgtgcagagaaacccagttcaggtgtaggaggctgctgtgggcagccctgtctgatggggcacccgtgtggggctgtgctctggtgcctgagaatggctggtgcccaatcgacatgagaagacgaggaaaagacagggtttggagtctcctcaacagtgttaaaagaggaagtgacctcacagaccagctcagagatgttaccaagaatatcacagcccccagggtagggagacaagcagcagtttgttctgtctcagctcctgtcaaggatcctgcggggtgggccctctgtatagctgctctctgtcactggcccctggagtgggagcagcgtccttagtcactgcaggcccaggcgggcaggtggtcccaggacagaggtggggaagttgtcctgaggaagcagaagtaggccttgctcccgcccaacccaagggcctccagtggaccagcattcaagatgtgagtgcccgtggtgtgcaaggcactcccatggcaccgtatttattgactgatctgtgaaggcttccctgacccctgcccaggaagagttcactggtcgctctgttgtgccccacagcactttgttatacctctgccacacacttcacgcagcgcgttgtaactcatgtgtttacatgtctgtccccccagactgtgagctccttgagggcagggactgtacattctccagctctgtgtccccagggcctggcacattgtagacgcttaataaatgtctgttaaatgaatgagtgcacaaaaaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:55665 -> Molecular function: GO:0005525 [GTP binding] evidence: IEA
            GeneID:55665 -> Biological process: GO:0007049 [cell cycle] evidence: IEA
            GeneID:55665 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
            GeneID:55665 -> Cellular component: GO:0005737 [cytoplasm] evidence: IEA

by @meso_cacase at DBCLS
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