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2024-04-20 08:41:12, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001077197 8316 bp mRNA linear PRI 17-APR-2013
DEFINITION Homo sapiens phosphodiesterase 11A (PDE11A), transcript variant 3,
mRNA.
ACCESSION NM_001077197
VERSION NM_001077197.1 GI:116536086
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8316)
AUTHORS Vezzosi,D., Libe,R., Baudry,C., Rizk-Rabin,M., Horvath,A., Levy,I.,
Rene-Corail,F., Ragazzon,B., Stratakis,C.A., Vandecasteele,G. and
Bertherat,J.
TITLE Phosphodiesterase 11A (PDE11A) gene defects in patients with
acth-independent macronodular adrenal hyperplasia (AIMAH):
functional variants may contribute to genetic susceptibility of
bilateral adrenal tumors
JOURNAL J. Clin. Endocrinol. Metab. 97 (11), E2063-E2069 (2012)
PUBMED 22996146
REMARK GeneRIF: PDE11A genetic variants may increase predisposition to
ACTH-independent macronodular adrenal hyperplasia.
REFERENCE 2 (bases 1 to 8316)
AUTHORS Uckert,S., Oelke,M., Albrecht,K., Breitmeier,D., Kuczyk,M.A. and
Hedlund,P.
TITLE Expression and distribution of key enzymes of the cyclic GMP
signaling in the human clitoris: relation to phosphodiesterase type
5 (PDE5)
JOURNAL Int. J. Impot. Res. 23 (5), 206-212 (2011)
PUBMED 21697861
REMARK GeneRIF: found in single nerve trunks in the clitoral stroma
REFERENCE 3 (bases 1 to 8316)
AUTHORS Libe,R., Horvath,A., Vezzosi,D., Fratticci,A., Coste,J.,
Perlemoine,K., Ragazzon,B., Guillaud-Bataille,M., Groussin,L.,
Clauser,E., Raffin-Sanson,M.L., Siegel,J., Moran,J.,
Drori-Herishanu,L., Faucz,F.R., Lodish,M., Nesterova,M.,
Bertagna,X., Bertherat,J. and Stratakis,C.A.
TITLE Frequent phosphodiesterase 11A gene (PDE11A) defects in patients
with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may
contribute to adrenal and testicular tumors in CNC as a modifier of
the phenotype
JOURNAL J. Clin. Endocrinol. Metab. 96 (1), E208-E214 (2011)
PUBMED 21047926
REMARK GeneRIF: We demonstrate, in a large cohort of Carney Complex
patients, a high frequency of PDE11A variants, suggesting that
PDE11A is a genetic modifying factor for the development of
testicular and adrenal tumors in patients with germline PRKAR1A
mutation.
GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 4 (bases 1 to 8316)
AUTHORS Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
TITLE Hundreds of variants clustered in genomic loci and biological
pathways affect human height
JOURNAL Nature 467 (7317), 832-838 (2010)
PUBMED 20881960
REFERENCE 5 (bases 1 to 8316)
AUTHORS DeWan,A.T., Triche,E.W., Xu,X., Hsu,L.I., Zhao,C., Belanger,K.,
Hellenbrand,K., Willis-Owen,S.A., Moffatt,M., Cookson,W.O.,
Himes,B.E., Weiss,S.T., Gauderman,W.J., Baurley,J.W., Gilliland,F.,
Wilk,J.B., O'Connor,G.T., Strachan,D.P., Hoh,J. and Bracken,M.B.
TITLE PDE11A associations with asthma: results of a genome-wide
association scan
JOURNAL J. Allergy Clin. Immunol. 126 (4), 871-873 (2010)
PUBMED 20920776
REMARK GeneRIF: PDE11A SNP assocaited with allergic asthma.
GeneRIF: Observational study and genome-wide association study of
gene-disease association. (HuGE Navigator)
REFERENCE 6 (bases 1 to 8316)
AUTHORS Hetman,J.M., Robas,N., Baxendale,R., Fidock,M., Phillips,S.C.,
Soderling,S.H. and Beavo,J.A.
TITLE Cloning and characterization of two splice variants of human
phosphodiesterase 11A
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (23), 12891-12895 (2000)
PUBMED 11050148
REFERENCE 7 (bases 1 to 8316)
AUTHORS Yuasa,K., Kotera,J., Fujishige,K., Michibata,H., Sasaki,T. and
Omori,K.
TITLE Isolation and characterization of two novel phosphodiesterase
PDE11A variants showing unique structure and tissue-specific
expression
JOURNAL J. Biol. Chem. 275 (40), 31469-31479 (2000)
PUBMED 10906126
REFERENCE 8 (bases 1 to 8316)
AUTHORS Fawcett,L., Baxendale,R., Stacey,P., McGrouther,C., Harrow,I.,
Soderling,S., Hetman,J., Beavo,J.A. and Phillips,S.C.
TITLE Molecular cloning and characterization of a distinct human
phosphodiesterase gene family: PDE11A
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 97 (7), 3702-3707 (2000)
PUBMED 10725373
REFERENCE 9 (bases 1 to 8316)
AUTHORS Loughney,K., Martins,T.J., Harris,E.A., Sadhu,K., Hicks,J.B.,
Sonnenburg,W.K., Beavo,J.A. and Ferguson,K.
TITLE Isolation and characterization of cDNAs corresponding to two human
calcium, calmodulin-regulated, 3',5'-cyclic nucleotide
phosphodiesterases
JOURNAL J. Biol. Chem. 271 (2), 796-806 (1996)
PUBMED 8557689
REFERENCE 10 (bases 1 to 8316)
AUTHORS Beavo,J.A., Conti,M. and Heaslip,R.J.
TITLE Multiple cyclic nucleotide phosphodiesterases
JOURNAL Mol. Pharmacol. 46 (3), 399-405 (1994)
PUBMED 7935318
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AB038041.1, AC073892.6,
AC073834.6 and AI919276.1.
This sequence is a reference standard in the RefSeqGene project.
Summary: The 3',5'-cyclic nucleotides cAMP and cGMP function as
second messengers in a wide variety of signal transduction
pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs)
catalyze the hydrolysis of cAMP and cGMP to the corresponding
5'-monophosphates and provide a mechanism to downregulate cAMP and
cGMP signaling. This gene encodes a member of the PDE protein
superfamily. Mutations in this gene are a cause of Cushing disease
and adrenocortical hyperplasia. Multiple transcript variants
encoding different isoforms have been found for this gene.
[provided by RefSeq, Jul 2008].
Transcript Variant: This variant (3) contains a distinct 5' UTR and
5' coding region, compared to variant 4. The resulting isoform (3)
contains a shorter and distinct N-terminus, compared to isoform 4.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AB038041.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
ERS025082, ERS025083 [ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: full length.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-611 AB038041.1 1-611
612-612 AC073892.6 35773-35773 c
613-2112 AB038041.1 613-2112
2113-2273 AB038041.1 2116-2276
2274-8005 AC073834.6 116649-122380 c
8006-8316 AI919276.1 1-311 c
FEATURES Location/Qualifiers
source 1..8316
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q31.2"
gene 1..8316
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="phosphodiesterase 11A"
/db_xref="GeneID:50940"
/db_xref="HGNC:8773"
/db_xref="MIM:604961"
exon 1..86
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
misc_feature 1
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="major transcription initiation site"
misc_feature 19..21
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="upstream in-frame stop codon"
exon 87..261
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
CDS 100..2151
/gene="PDE11A"
/gene_synonym="PPNAD2"
/EC_number="3.1.4.35"
/EC_number="3.1.4.17"
/note="isoform 3 is encoded by transcript variant 3; cAMP
and cGMP cyclic nucleotide phosphodiesterase 11A; dual
3',5'-cyclic-AMP and -GMP phosphodiesterase 11A"
/codon_start=1
/product="dual 3',5'-cyclic-AMP and -GMP phosphodiesterase
11A isoform 3"
/protein_id="NP_001070665.1"
/db_xref="GI:116536087"
/db_xref="CCDS:CCDS42785.1"
/db_xref="GeneID:50940"
/db_xref="HGNC:8773"
/db_xref="MIM:604961"
/translation="
MLKQARRPLFRNVLSATQWKKVKITRLVQISGASLAEKQEKHQDFLIQRQTKTKDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
"
misc_feature <121..495
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="FOG: GAF domain [Signal transduction mechanisms];
Region: FhlA; COG2203"
/db_xref="CDD:32385"
misc_feature <217..489
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Domain present in phytochromes and cGMP-specific
phosphodiesterases; Region: GAF; smart00065"
/db_xref="CDD:197499"
misc_feature 511..1059
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="FOG: GAF domain [Signal transduction mechanisms];
Region: FhlA; COG2203"
/db_xref="CDD:32385"
misc_feature 553..1053
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Domain present in phytochromes and cGMP-specific
phosphodiesterases; Region: GAF; smart00065"
/db_xref="CDD:197499"
misc_feature 1336..1866
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Metal dependent phosphohydrolases with conserved
'HD' motif; Region: HDc; cd00077"
/db_xref="CDD:28958"
misc_feature order(1351..1353,1459..1464,1795..1797)
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Zn2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
misc_feature 1462..1464
/gene="PDE11A"
/gene_synonym="PPNAD2"
/note="Mg2+ binding site [ion binding]; other site"
/db_xref="CDD:28958"
exon 262..420
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 265
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:76865936"
variation 394
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77477862"
exon 421..510
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 511..651
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 520
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78426895"
variation 582
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77789692"
variation 592
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:74460362"
variation 600
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76725221"
exon 652..716
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 676
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75920749"
exon 717..849
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 747
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:78731210"
variation 789
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:77896877"
exon 850..925
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 926..993
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 994..1086
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 1087..1137
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1106
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:78384547"
exon 1138..1284
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1162
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:76110544"
variation 1174
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77934668"
variation 1188
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75157857"
exon 1285..1392
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1322
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:77597060"
variation 1326
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="g"
/replace="t"
/db_xref="dbSNP:77341035"
variation 1383
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78730670"
exon 1393..1502
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1435
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74666005"
variation 1494
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:35194777"
exon 1503..1593
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1582
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:79840971"
exon 1594..1694
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1647
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:78690307"
exon 1695..1772
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1760
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:75127279"
exon 1773..1836
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
exon 1837..1911
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1846
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:75950476"
variation 1853
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="c"
/db_xref="dbSNP:75226037"
variation 1867
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/replace="t"
/db_xref="dbSNP:79903863"
exon 1912..1995
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1925
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79384192"
variation 1981
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74357545"
exon 1996..8309
/gene="PDE11A"
/gene_synonym="PPNAD2"
/inference="alignment:Splign:1.39.8"
variation 1996
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:79400048"
variation 2014
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:75437575"
variation 2071
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="t"
/db_xref="dbSNP:80129029"
variation 2112..2113
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace=""
/replace="tcc"
/db_xref="dbSNP:3830637"
variation 2128
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="a"
/replace="g"
/db_xref="dbSNP:74326729"
STS 2874..3563
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="PDE11A_V281"
/db_xref="UniSTS:277573"
polyA_signal 3447..3452
/gene="PDE11A"
/gene_synonym="PPNAD2"
polyA_site 3475
/gene="PDE11A"
/gene_synonym="PPNAD2"
STS 3956..4300
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="RH79802"
/db_xref="UniSTS:88688"
STS 6539..6704
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="L30021"
/db_xref="UniSTS:3276"
STS 7862..8022
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="RH91242"
/db_xref="UniSTS:87167"
variation 8005
/gene="PDE11A"
/gene_synonym="PPNAD2"
/replace="c"
/replace="g"
/db_xref="dbSNP:1047884"
STS 8158..8282
/gene="PDE11A"
/gene_synonym="PPNAD2"
/standard_name="SHGC-37408"
/db_xref="UniSTS:1328"
polyA_signal 8289..8294
/gene="PDE11A"
/gene_synonym="PPNAD2"
polyA_site 8309
/gene="PDE11A"
/gene_synonym="PPNAD2"
ORIGIN
cgcttgcagcccagggcgtgaggtgctctttctggatcgccagcctcgaagttgaggcgtggactctggccaggtggctgttccagagcaacatgggagatgctgaagcaggcaagaagacctttattcagaaatgtgctcagtgccacacagtggaaaaaggtgaaaatcacaagactggtccaaatctctggggcctctttggctgaaaaacaggaaaagcaccaggattttcttatacagaggcaaacaaaaacaaaggatcgacgattcaatgatgaaatcgacaagctaactggatacaagacaaaatcattattgtgcatgcctatccgaagcagtgatggtgagattattggtgtggcccaagcgataaataagattcctgaaggagctccatttactgaagatgatgaaaaagttatgcagatgtatcttccattttgtggaatcgccatatctaacgctcagctctttgctgcctcaaggaaagaatatgaaagaagcagagctttgctagaggtggttaatgacctctttgaagaacagactgacctggagaaaattgtcaagaaaataatgcatcgggcccaaactctgctgaaatgtgaacgctgttctgttttactcctagaggacatcgaatcaccagtggtgaaatttaccaaatcctttgaattgatgtccccaaagtgcagtgctgatgctgagaacagtttcaaagaaagcatggagaaatcatcatactccgactggctaataaataacagcattgctgagctggttgcttcaacaggccttccagtgaacatcagtgatgcctaccaggatccgcgctttgatgcagaggcagaccagatatctggttttcacataagatctgttctttgtgtccctatttggaatagcaaccaccaaataattggagtggctcaagtgttaaacagacttgatgggaaaccttttgatgatgcagatcaacgactttttgaggcttttgtcatcttttgtggacttggcatcaacaacacaattatgtatgatcaagtgaagaagtcctgggccaagcagtctgtggctcttgatgtgctatcataccatgcaacatgttcaaaagctgaagttgacaagtttaaggcagccaacatccctctggtgtcagaacttgccatcgatgacattcattttgatgacttttctctcgacgttgatgccatgatcacagctgctctccggatgttcatggagctggggatggtacagaaatttaaaattgactatgagacactgtgtaggtggcttttgacagtgaggaaaaactatcggatggttctataccacaactggagacatgccttcaacgtgtgtcagctgatgttcgcgatgttaaccactgctgggtttcaagacattctgaccgaggtggaaattttagcggtgattgtgggatgcctgtgtcatgacctcgaccacaggggaaccaacaatgccttccaagctaagagtggctctgccctggcccaactctatggaacctctgctaccttggagcatcaccatttcaaccacgccgtgatgatccttcaaagtgagggtcacaatatctttgctaacctgtcctccaaggaatatagtgaccttatgcagcttttgaagcagtcaatattggcaacagacctcacgctgtactttgagaggagaactgaattctttgaacttgtcagtaaaggagaatacgattggaacatcaaaaaccatcgtgatatatttcgatcaatgttaatgacagcctgtgaccttggagccgtgaccaaaccgtgggagatctccagacaggtggcagaacttgtaaccagtgagttcttcgaacaaggagatcgggagagattagagctcaaactcactccttcagcaatttttgatcggaaccggaaggatgaactgcctcggttgcaactggagtggattgatagcatctgcatgcctttgtatcaggcactggtgaaggtcaacgtgaaactgaagccgatgctagattcagtagctacaaacagaagtaagtgggaagagctacaccaaaaacgactgctggcctcaactgcctcatcctcccctgccagtgttatggtagccaaggaagacaggaactaaacctccaggtcagctgcagctgcaaaatgactacagcctgaagggccattttcagtccagcaatgtcatccttttgttcttttagctcagaaagacctaacatctcaaggatgcactgggaagcatgcctgggctttcaccttgaagcatggtcagcagcagagagagcaacgggaaggacaaagaaagaggtggggcagggagcacaccccaggaccctcacttttccctaatgaacacgcatgggctgaaatgaaggctctgggtaggggactgttttggatccaaggacctgtggacagtcggcctacttactctgagctgagggaacactgaacagtaaaagcgtcattagcgctgcttcgttttgtatagggcttttctgtttgttacaagccaaacactgcctgtctttgcttcctgtccctgaatgcctttttgtgccagactgtcccaagaatcctaatttgtattccatagaggtattttatttttaatcctagagcttcttattgatggatcctttagaattgcctacctaaaaggtaaactatactatccttataaatactgatcaatcccagttctccccctaaaaatgaatacatagtaggactatagcaaatgtgtttgatgggtaattctagactgggactatggtacccttttccagagttttaaaattcaaccttcattacagacaaagttttctcccagaaggaatggattgatagattttgattaaagtaagggtggaaggaaatctgtagctggatttaccacaagtgacatctagaaactatagttcacaggacagagcagagccatggagactaagcattgactaccttgagttctcctagtgaggagttctggtataaaatttaagattactaccagtaaccaacttaaagcaaactataggggtccctaattttggatttttccttaagtgtaagaaacaatgcttcaaatgttaagaaataacagtctgggcaaagaacgcatattctataggaagccaggtttacaataggtaagaataaactgtattaagtagatgtaatgactagaaagctgctttgctccctatattgagaaattgtggacatggtatgtgttatccaaagaacattgggctagaagatagatttctatccttagctttggcattattgactggattgacttgaacaagtcacttaacttctacaagcttgtttccttatttgtcaaattagattacactaggaaacgattctcgaacatgttttaaccttacaactctttgttcaaataaatctttcaatgaatccccaacatataaaacgtcaaaaagctgaattcctatgtgaattataagcagggtttggacatccagagcacctacaaaccttcatctctttgattacgtacatgggggtccacagggactctgaagagtttgaaaatccctggcctagattaaacctgagagccattctagctcttaaaaaaatctgaaatttacaaaccatttttcttgttattgtttttgtttctttgtttgtttgttttttgagactgagttttcactcttgttgcccaggctggagtgcaatggcgtgatctcggcttactgcaacctctgcttcctgggttcaagcaattctccagcctcaacctcctgagaagctgggattacaggtgcctgccaccacgcctggctaatttttgtacttttagtagacacagggtttcaccatgtttgccaggctgatctcaaactcctgacctcaggtgagccacccacctctgcctccgaaagtgctgggattacaggcgtgagccaccgtacccggcccttgttattgttattaatcattatcaatcattaactttacagatattaaagaaataggggccatgttctacatgcgacattgttttcctggcacacagtagacaattcaggaaatgtctgaagaaggaatgggtaaaattaagataccaaaatggaattgaggggagagcaggtaattgtagagaaaaagactctttatggcaagaaacaaagtaaaagaaatgtatagaccgggcgcggtggctcacgcctgtaatcccagcaatttggaaggccgaggcgggcggatcacgaggtcaggagatcgagaccgtcctggctaacacggtgaaaccctgtctctactaaaaaacacaaaacaaattagccaggcgcggtggcaggcgtctgtagtcccagctactggggaggctgaggcaagagaatggcgggaacccgcgaggcggagcttgcagtgagtcgagatcacgtcactgccctccagcctgggcgaccagcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaagtataaaccagactaagaggggaataaaagcaagaagaaaaagaaacgtaagaacaccagtaaaggaaagacagggaccgagacaggtggttaagggaaatgaaaaaaaaaaaaaaaaggtgaaagtcaatccaaacaaagaaaaatggcacttccaaccaaaaaaaatgaaggtgtagaaccctgtcatcaattgctcagaaaagagagacacttgagcagggaggggtttgagaaaggggagaaggaaggagtgagagccctaaaaaataatgttcctagctaccctttacagctgtctctgcagggaagactggagaaagtagagggggaaatgaatgcaggaagaaactgcctctgcagagcaggtaagaggaggttgttcagatttatggattttattaagccagttttctgtatcactctgctataaaggaaaatagcttctgcagggctgtctctcctccttcaggtggggaacaaagggtgggtggagtcagggacagagtctggtctgcgagatcgtgacgtgtctgcagctccgaagcactgcaggtgtttctgggtaatgtgccacatcatgtttatatcacgaacgggaattgaaaatcagtctgtgtgaggcagagatgagcccacatctgttatcctccccaacaataaataaataaatagcccagacaaatggatgccagtccatctacagcaacattttaaagcatgtgctttatgacaaaactggacccagggtctgacagagactgcaggctgccgtgagcactgtagctatcctgaacattgatgctacatattgctaaggggaacataatttatagcataaaccctacaagcttccactaaggttgagttttcctctcattttcttgccgttttattggcttcactgcatggttgccaatagcaacatccactggtagcaaggggagttcaacaccattgcaatctgccatacagtggagccctgacaatgtcaaccatcaatctagtagctgtttgtaattgcctccatctatttctcctgtcttgaggtatctttcctattgtgggtcaagatttagaaactgctgactaatgccatgggtctgtgtctccatgactatgaagcagtggacaggaaggtagcagcttcctggtgccaacaaccccagaggttagaggttgaactcttgcgggtttcaggcgtttttaatcccttttctaaacaatttataattttgcaagaatgtgaggcatatgcagttatccatataatctgcttttccaaaaaagagaaaggaagtttcccagtccttattattaatgtttatttcctattggagaaagacatttgaaatatgagccttcttgtaaaaactcaaactgaccagattatgtttgcttcctcaggtctcttggcattaattgttgaaataacttcatcctactttttcgatgagatgtatttttttcagacatatttattcttactagtcactatgtagctattatgtgcacaatctacaatgtagtggcaatcctggtgggtagggacagcttcacatactgcaaagggtgccattcagtgcatagcagactggaactccctcctagcttggccaccagctgaacctgtaatcttaggactctccaagtcttagaatctccatctattacataaaagcactgacttttattcagtccccacaccaaaggaccaagacgtgtttagctttaaagaaattttccagataattttcttttttattcttctcaaataaaatagcaacaaacctaaagcagtcatcttcttaataaagacataataaaacttacatatatggggtagatgtaagcacaatcatactacagatgtatcttgagcctgtctctaattatgatgaaagatgtagtcatcaatacaatttaaaaaaagatatgtcctttttttgagacagggtcttgctctgtcacccaggctggagggcagtggcacaatcacagccactgcagccttgacctctccaacttaagtgatctttcctgcctcagcctcatgagtagctgggaccacaggtgtgcaccaccacacccagctaaattttgtattgtttgtaaagacgaggcctcactatgctgaccacactggtctcgaactcctgggctcaagcaatcctcctgccttggcctcccaaagtgttagggttagagatatgaaccaccacacccaccttatatgtccttttatttcataaaaaacaattttagattatctgatatcacacatatcccataaatggtagtcattaatttagaagtgaatttataaagttaagagaagttaaaattgcacatgcattttgtttctaaaatctgagatgtctatgcatttccaggtattgtatatttgcaaatacattgggttagaaatcatctttaacattttgtgttagtgtaataacaatattatctaatattaatgctgccagaatccagttgctttttctgtgtatcaaaatttatcataactttttccacttaacactaggtaattaaacagaatctgcccaatttattctgcagtaaaattattttaaaatctatttttcctgctgactcttagaaattgcagaaagacaaaaaccagtttcatctccagtaatagtgtgaaacaatttccttccagtgggacagaaacctagacatactagggaaagatttaaatataaagaaaaatgccttggctgaaaaaaaaaaaaaccaccaaaacacaaaaaggattcattaaagcaacagaacaaaacctaatttgggaccctaaaaactctggcaatgccactgtaatgaagtttcattatctgcttcagagtaacagtctctgaaattgttattctgctacatgctgtaaagaactcccaaaactcaaatgtatcaggaaatgtaaaggttaagtctgactacaagaaggccaaaattgcaccagcttcctaagtgaagaataatagaataaaacatatagagggcagaaataaaatgaggtgtatctggagaatttcatgatgagcatttagatttagcaatgcccaatgtcatgctgacactgtttgtcatgaccttgtcttcagctagtaatttggggttgtacttttttaaatttaattttgaatgttcttgcatgtttggtacctctctcctcactgctaaagataaattgtttatctgtataacataactacaccaatgtcatttttgtatacgctagtacacaaatgtgtttttttattaagtaatgaagtatttgctgtgaaaaatgtattatttgtgccaccgtttatatctgtgttcattttctgtgtgtatatgcgtgtgtattcgaatctcaatttttcttttactctagtttagattaagacatatttagatgaaattttaaaaataacattggaaataggaggctaagttttgttgagtctcattcccttggggggaaattgcttttgccattttattttcatgtacaataacctaaaaaggatctcctactgacttccttcctaattattattgttttacacgaaagaaaggaaatacgttttcaattgagttgtttgaaatcattcactttgtgtagatttcccagactgatgtttcattgtaagaatattacattatagacaggttggccatttcacaagcaactaatccatagttttggaagcccgctttaagagacctgaatatctttgtttttaataaaatacttagagtttaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:50940 -> Molecular function: GO:0004112 [cyclic-nucleotide phosphodiesterase activity] evidence: NAS
GeneID:50940 -> Molecular function: GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] evidence: TAS
GeneID:50940 -> Molecular function: GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] evidence: IDA
GeneID:50940 -> Molecular function: GO:0030552 [cAMP binding] evidence: IEA
GeneID:50940 -> Molecular function: GO:0030553 [cGMP binding] evidence: IDA
GeneID:50940 -> Molecular function: GO:0046872 [metal ion binding] evidence: IEA
GeneID:50940 -> Molecular function: GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] evidence: IEA
GeneID:50940 -> Biological process: GO:0006198 [cAMP catabolic process] evidence: IEA
GeneID:50940 -> Biological process: GO:0007165 [signal transduction] evidence: IEA
GeneID:50940 -> Biological process: GO:0007596 [blood coagulation] evidence: TAS
GeneID:50940 -> Biological process: GO:0046069 [cGMP catabolic process] evidence: IEA
GeneID:50940 -> Cellular component: GO:0005575 [cellular_component] evidence: ND
GeneID:50940 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:50940 -> Cellular component: GO:0043204 [perikaryon] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001070665 -> EC 3.1.4.17
NP_001070665 -> EC 3.1.4.35
by
@meso_cacase at
DBCLS
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