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2024-04-17 02:34:44, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001065 2258 bp mRNA linear PRI 15-JUL-2013
DEFINITION Homo sapiens tumor necrosis factor receptor superfamily, member 1A
(TNFRSF1A), mRNA.
ACCESSION NM_001065
VERSION NM_001065.3 GI:301336149
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2258)
AUTHORS Bachetti,T., Chiesa,S., Castagnola,P., Bani,D., Di Zanni,E.,
Omenetti,A., D'Osualdo,A., Fraldi,A., Ballabio,A., Ravazzolo,R.,
Martini,A., Gattorno,M. and Ceccherini,I.
TITLE Autophagy contributes to inflammation in patients with
TNFR-associated periodic syndrome (TRAPS)
JOURNAL Ann. Rheum. Dis. 72 (6), 1044-1052 (2013)
PUBMED 23117241
REMARK GeneRIF: Mutations in TNFR1 inhibit autophagy in TNFR-associated
periodic syndrome, leading to accumulation of mutant TNFR1,
increased NF-kB activation, increased IL-1B secretion, and chronic
inflammation.
REFERENCE 2 (bases 1 to 2258)
AUTHORS Silke,J. and Strasser,A.
TITLE The FLIP Side of Life
JOURNAL Sci Signal 6 (258), PE2 (2013)
PUBMED 23322903
REMARK GeneRIF: Studies indicate that the anti-apoptotic protein c-FLIP is
an important regulator of death receptor signaling, including
TNFR1, Fas, DR4, and DR5.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 2258)
AUTHORS Mizrahi,K., Stein,J., Yaniv,I., Kaplan,O. and Askenasy,N.
TITLE TNF-alpha has tropic rather than apoptotic activity in human
hematopoietic progenitors: involvement of TNF receptor-1 and
caspase-8
JOURNAL Stem Cells 31 (1), 156-166 (2013)
PUBMED 23081800
REMARK GeneRIF: Progenitor stimulation is selectively mediated by TNF-R1
and involves activation of caspase-8, without redundant activity of
TNF-R2.
REFERENCE 4 (bases 1 to 2258)
AUTHORS Lopatnikova,J.A., Vasilyev,F.F., Alshevskaya,A.A. and Sennikov,S.V.
TITLE Quantitative flow cytometric analysis of expression of tumor
necrosis factor receptor types I and II on mononuclear cells
JOURNAL J. Recept. Signal Transduct. Res. 33 (1), 49-55 (2013)
PUBMED 23316846
REMARK GeneRIF: Application of the protocol-identified differences in the
percentage of cells that expressed TNFRs, as well as the absolute
number of receptors per cell, among different subpopulations of
PBMCs, and between PBMCs cultured with and without LPS.
REFERENCE 5 (bases 1 to 2258)
AUTHORS Agnello,E., Malfi,G., Costantino,A.M., Massarenti,P., Pugliese,M.,
Fortunati,N., Catalano,M.G. and Palmo,A.
TITLE Tumour necrosis factor alpha and oxidative stress as maintaining
factors in the evolution of anorexia nervosa
JOURNAL Eat Weight Disord 17 (3), E194-E199 (2012)
PUBMED 23086255
REMARK GeneRIF: TNF-R55 was higher in anorexia nervosa patients with
duration of disease longer than one year as compared to controls
and patients with shorter duration. TNF-R55 inversely correlated
with BMI and directly with disease duration.
REFERENCE 6 (bases 1 to 2258)
AUTHORS McDermott,M.F., Aksentijevich,I., Galon,J., McDermott,E.M.,
Ogunkolade,B.W., Centola,M., Mansfield,E., Gadina,M., Karenko,L.,
Pettersson,T., McCarthy,J., Frucht,D.M., Aringer,M., Torosyan,Y.,
Teppo,A.M., Wilson,M., Karaarslan,H.M., Wan,Y., Todd,I., Wood,G.,
Schlimgen,R., Kumarajeewa,T.R., Cooper,S.M., Vella,J.P., Amos,C.I.,
Mulley,J., Quane,K.A., Molloy,M.G., Ranki,A., Powell,R.J.,
Hitman,G.A., O'Shea,J.J. and Kastner,D.L.
TITLE Germline mutations in the extracellular domains of the 55 kDa TNF
receptor, TNFR1, define a family of dominantly inherited
autoinflammatory syndromes
JOURNAL Cell 97 (1), 133-144 (1999)
PUBMED 10199409
REFERENCE 7 (bases 1 to 2258)
AUTHORS Zhang,X.M., Weber,I. and Chen,M.J.
TITLE Site-directed mutational analysis of human tumor necrosis
factor-alpha receptor binding site and structure-functional
relationship
JOURNAL J. Biol. Chem. 267 (33), 24069-24075 (1992)
PUBMED 1331108
REFERENCE 8 (bases 1 to 2258)
AUTHORS Fuchs,P., Strehl,S., Dworzak,M., Himmler,A. and Ambros,P.F.
TITLE Structure of the human TNF receptor 1 (p60) gene (TNFR1) and
localization to chromosome 12p13 [corrected]
JOURNAL Genomics 13 (1), 219-224 (1992)
PUBMED 1315717
REMARK Erratum:[Genomics 1992 Aug;13(4):1384]
REFERENCE 9 (bases 1 to 2258)
AUTHORS Derre,J., Kemper,O., Cherif,D., Nophar,Y., Berger,R. and Wallach,D.
TITLE The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is
localized on band 12p13
JOURNAL Hum. Genet. 87 (2), 231-233 (1991)
PUBMED 1648547
REFERENCE 10 (bases 1 to 2258)
AUTHORS Belokrylov,G.A. and Zhitnukhin,Iu.L.
TITLE [Effect of antibodies to rat and human cerebral cortex and white
matter on heterologous T- and B-cells]
JOURNAL Zh. Mikrobiol. Epidemiol. Immunobiol. 9, 66-70 (1976)
PUBMED 1087798
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DA664652.1, AK315509.1,
M63121.1 and BC010140.2.
This sequence is a reference standard in the RefSeqGene project.
On Jul 27, 2010 this sequence version replaced gi:23312372.
Summary: The protein encoded by this gene is a member of the
TNF-receptor superfamily. This protein is one of the major
receptors for the tumor necrosis factor-alpha. This receptor can
activate NF-kappaB, mediate apoptosis, and function as a regulator
of inflammation. Antiapoptotic protein BCL2-associated athanogene 4
(BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to
interact with this receptor, and thus play regulatory roles in the
signal transduction mediated by the receptor. Germline mutations of
the extracellular domains of this receptor were found to be
associated with the autosomal dominant periodic fever syndrome. The
impaired receptor clearance is thought to be a mechanism of the
disease. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BC010140.2, M63121.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025084, ERS025088 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-3 DA664652.1 1-3
4-1065 AK315509.1 1-1062
1066-2209 M63121.1 969-2112
2210-2258 BC010140.2 2137-2185
FEATURES Location/Qualifiers
source 1..2258
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p13.2"
gene 1..2258
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="tumor necrosis factor receptor superfamily, member
1A"
/db_xref="GeneID:7132"
/db_xref="HGNC:11916"
/db_xref="HPRD:01861"
/db_xref="MIM:191190"
exon 1..342
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
variation 52..71
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="c"
/replace="t"
/db_xref="dbSNP:45537340"
misc_feature 292..294
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="upstream in-frame stop codon"
CDS 304..1671
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="tumor necrosis factor-alpha receptor; tumor
necrosis factor binding protein 1; tumor necrosis factor
receptor type 1; tumor necrosis factor receptor 1A isoform
beta; TNF-R1; TNF-RI; TNFR-I"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 1A precursor"
/protein_id="NP_001056.1"
/db_xref="GI:4507575"
/db_xref="CCDS:CCDS8542.1"
/db_xref="GeneID:7132"
/db_xref="HGNC:11916"
/db_xref="HPRD:01861"
/db_xref="MIM:191190"
/translation="
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWKSKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYTPGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLYAVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLELLGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
"
sig_peptide 304..366
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
mat_peptide 367..1668
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/product="tumor necrosis factor receptor superfamily
member 1A"
misc_feature 430..549
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
Region: TNFR-Cys 1"
misc_feature 433..750
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="Tumor necrosis factor receptor (TNFR) domain;
superfamily of TNF-like receptor domains. When bound to
TNF-like cytokines, TNFRs trigger multiple signal
transduction pathways, they are involved in inflammation
response, apoptosis, autoimmunity and...; Region: TNFR;
cd00185"
/db_xref="CDD:29147"
misc_feature order(433..438,568..570,601..603,634..636,700..702,
739..741)
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="antiparallel homodimerization interface
[polypeptide binding]; other site"
/db_xref="CDD:29147"
misc_feature order(445..447,481..483,493..495,499..501,541..543,
550..552,580..582)
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="parallel homodimerization interface [polypeptide
binding]; other site"
/db_xref="CDD:29147"
misc_feature order(481..510,538..552,655..663)
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="protein binding site [polypeptide binding]; other
site"
/db_xref="CDD:29147"
misc_feature 550..678
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
Region: TNFR-Cys 2"
misc_feature order(577..582,598..606)
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="50's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 679..801
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
Region: TNFR-Cys 3"
misc_feature order(700..702,739..750)
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="90's loop TNF binding site; other site"
/db_xref="CDD:29147"
misc_feature 802..891
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
Region: TNFR-Cys 4"
misc_feature 937..1005
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
transmembrane region"
misc_feature 1081..1083
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="proteolytic cleavage site; modified site"
/db_xref="HPRD:03457"
misc_feature 1123..1125
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1141..1143
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
/db_xref="HPRD:01496"
misc_feature 1315..1347
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P19438.1);
Region: N-SMase activation domain (NSD)"
misc_feature 1375..1617
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/note="Death domain of Tumor Necrosis Factor Receptor 1;
Region: Death_TNFR1; cd08313"
/db_xref="CDD:176729"
exon 343..496
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 497..625
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
variation 527
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="c"
/replace="t"
/db_xref="dbSNP:4149637"
exon 626..775
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 776..854
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 855..928
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 929..1042
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 1043..1071
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
exon 1072..1360
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
variation 1119
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="c"
/replace="t"
/db_xref="dbSNP:45562531"
variation 1216
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:1804532"
exon 1361..2226
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/inference="alignment:Splign:1.39.8"
variation 1603
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="c"
/replace="t"
/db_xref="dbSNP:1062460"
STS 1685..1924
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/standard_name="STS-M58286"
/db_xref="UniSTS:34937"
variation 1866
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="a"
/replace="g"
/db_xref="dbSNP:3202413"
variation 1923
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="a"
/replace="g"
/db_xref="dbSNP:45563431"
STS 1945..2193
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/standard_name="RH75052"
/db_xref="UniSTS:91966"
STS 1982..2119
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/standard_name="WI-18755"
/db_xref="UniSTS:57193"
STS 1988..2186
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/standard_name="G15949"
/db_xref="UniSTS:44467"
variation 2004
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="a"
/replace="g"
/db_xref="dbSNP:4149646"
variation 2044..2048
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace=""
/replace="ttttt"
/db_xref="dbSNP:36188382"
variation 2206
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
/replace="a"
/replace="t"
/db_xref="dbSNP:3180866"
polyA_site 2226
/gene="TNFRSF1A"
/gene_synonym="CD120a; FPF; MS5; p55; p55-R; p60; TBP1;
TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR1-d2; TNFR55;
TNFR60"
ORIGIN
ctcctccagctcttcctgtcccgctgttgcaacactgcctcactcttcccctcccaccttctctcccctcctctctgctttaattttctcagaattctctggactgaggctccagttctggcctttggggttcaagatcactgggaccaggccgtgatctctatgcccgagtctcaaccctcaactgtcaccccaaggcacttgggacgtcctggacagaccgagtcccgggaagccccagcactgccgctgccacactgccctgagcccaaatgggggagtgagaggccatagctgtctggcatgggcctctccaccgtgcctgacctgctgctgccactggtgctcctggagctgttggtgggaatatacccctcaggggttattggactggtccctcacctaggggacagggagaagagagatagtgtgtgtccccaaggaaaatatatccaccctcaaaataattcgatttgctgtaccaagtgccacaaaggaacctacttgtacaatgactgtccaggcccggggcaggatacggactgcagggagtgtgagagcggctccttcaccgcttcagaaaaccacctcagacactgcctcagctgctccaaatgccgaaaggaaatgggtcaggtggagatctcttcttgcacagtggaccgggacaccgtgtgtggctgcaggaagaaccagtaccggcattattggagtgaaaaccttttccagtgcttcaattgcagcctctgcctcaatgggaccgtgcacctctcctgccaggagaaacagaacaccgtgtgcacctgccatgcaggtttctttctaagagaaaacgagtgtgtctcctgtagtaactgtaagaaaagcctggagtgcacgaagttgtgcctaccccagattgagaatgttaagggcactgaggactcaggcaccacagtgctgttgcccctggtcattttctttggtctttgccttttatccctcctcttcattggtttaatgtatcgctaccaacggtggaagtccaagctctactccattgtttgtgggaaatcgacacctgaaaaagagggggagcttgaaggaactactactaagcccctggccccaaacccaagcttcagtcccactccaggcttcacccccaccctgggcttcagtcccgtgcccagttccaccttcacctccagctccacctatacccccggtgactgtcccaactttgcggctccccgcagagaggtggcaccaccctatcagggggctgaccccatccttgcgacagccctcgcctccgaccccatccccaacccccttcagaagtgggaggacagcgcccacaagccacagagcctagacactgatgaccccgcgacgctgtacgccgtggtggagaacgtgcccccgttgcgctggaaggaattcgtgcggcgcctagggctgagcgaccacgagatcgatcggctggagctgcagaacgggcgctgcctgcgcgaggcgcaatacagcatgctggcgacctggaggcggcgcacgccgcggcgcgaggccacgctggagctgctgggacgcgtgctccgcgacatggacctgctgggctgcctggaggacatcgaggaggcgctttgcggccccgccgccctcccgcccgcgcccagtcttctcagatgaggctgcgcccctgcgggcagctctaaggaccgtcctgcgagatcgccttccaaccccacttttttctggaaaggaggggtcctgcaggggcaagcaggagctagcagccgcctacttggtgctaacccctcgatgtacatagcttttctcagctgcctgcgcgccgccgacagtcagcgctgtgcgcgcggagagaggtgcgccgtgggctcaagagcctgagtgggtggtttgcgaggatgagggacgctatgcctcatgcccgttttgggtgtcctcaccagcaaggctgctcgggggcccctggttcgtccctgagcctttttcacagtgcataagcagttttttttgtttttgttttgttttgttttgtttttaaatcaatcatgttacactaatagaaacttggcactcctgtgccctctgcctggacaagcacatagcaagctgaactgtcctaaggcaggggcgagcacggaacaatggggccttcagctggagctgtggacttttgtacatacactaaaattctgaagttaaagctctgctcttggaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:7132 -> Molecular function: GO:0002020 [protease binding] evidence: IEA
GeneID:7132 -> Molecular function: GO:0005031 [tumor necrosis factor-activated receptor activity] evidence: TAS
GeneID:7132 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:7132 -> Molecular function: GO:0032403 [protein complex binding] evidence: IEA
GeneID:7132 -> Molecular function: GO:0043120 [tumor necrosis factor binding] evidence: IEA
GeneID:7132 -> Biological process: GO:0001666 [response to hypoxia] evidence: IEA
GeneID:7132 -> Biological process: GO:0006693 [prostaglandin metabolic process] evidence: IEA
GeneID:7132 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
GeneID:7132 -> Biological process: GO:0006954 [inflammatory response] evidence: ISS
GeneID:7132 -> Biological process: GO:0008625 [extrinsic apoptotic signaling pathway via death domain receptors] evidence: TAS
GeneID:7132 -> Biological process: GO:0009812 [flavonoid metabolic process] evidence: IEA
GeneID:7132 -> Biological process: GO:0010629 [negative regulation of gene expression] evidence: IEA
GeneID:7132 -> Biological process: GO:0016101 [diterpenoid metabolic process] evidence: IEA
GeneID:7132 -> Biological process: GO:0019048 [modulation by virus of host morphology or physiology] evidence: IEA
GeneID:7132 -> Biological process: GO:0019221 [cytokine-mediated signaling pathway] evidence: ISS
GeneID:7132 -> Biological process: GO:0032496 [response to lipopolysaccharide] evidence: IEA
GeneID:7132 -> Biological process: GO:0032715 [negative regulation of interleukin-6 production] evidence: IEA
GeneID:7132 -> Biological process: GO:0032760 [positive regulation of tumor necrosis factor production] evidence: IEA
GeneID:7132 -> Biological process: GO:0033013 [tetrapyrrole metabolic process] evidence: IEA
GeneID:7132 -> Biological process: GO:0033160 [positive regulation of protein import into nucleus, translocation] evidence: IEA
GeneID:7132 -> Biological process: GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein] evidence: IMP
GeneID:7132 -> Biological process: GO:0042742 [defense response to bacterium] evidence: IEA
GeneID:7132 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IEA
GeneID:7132 -> Biological process: GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB cascade] evidence: IEP
GeneID:7132 -> Biological process: GO:0043200 [response to amino acid stimulus] evidence: IEA
GeneID:7132 -> Biological process: GO:0043279 [response to alkaloid] evidence: IEA
GeneID:7132 -> Biological process: GO:0045471 [response to ethanol] evidence: IEA
GeneID:7132 -> Biological process: GO:0045766 [positive regulation of angiogenesis] evidence: IEA
GeneID:7132 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: IMP
GeneID:7132 -> Biological process: GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] evidence: ISS
GeneID:7132 -> Biological process: GO:0050728 [negative regulation of inflammatory response] evidence: IMP
GeneID:7132 -> Biological process: GO:0050729 [positive regulation of inflammatory response] evidence: ISS
GeneID:7132 -> Biological process: GO:0051291 [protein heterooligomerization] evidence: IEA
GeneID:7132 -> Biological process: GO:0071260 [cellular response to mechanical stimulus] evidence: IEP
GeneID:7132 -> Biological process: GO:0071392 [cellular response to estradiol stimulus] evidence: IEA
GeneID:7132 -> Biological process: GO:0097190 [apoptotic signaling pathway] evidence: TAS
GeneID:7132 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IDA
GeneID:7132 -> Cellular component: GO:0005576 [extracellular region] evidence: NAS
GeneID:7132 -> Cellular component: GO:0005615 [extracellular space] evidence: IDA
GeneID:7132 -> Cellular component: GO:0005634 [nucleus] evidence: IEA
GeneID:7132 -> Cellular component: GO:0005886 [plasma membrane] evidence: TAS
GeneID:7132 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
GeneID:7132 -> Cellular component: GO:0009986 [cell surface] evidence: IEA
GeneID:7132 -> Cellular component: GO:0030424 [axon] evidence: IEA
GeneID:7132 -> Cellular component: GO:0043234 [protein complex] evidence: IEA
GeneID:7132 -> Cellular component: GO:0045121 [membrane raft] evidence: IDA
by
@meso_cacase at
DBCLS
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