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2024-04-24 11:14:39, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001048200 7621 bp mRNA linear PRI 14-MAY-2013
DEFINITION Homo sapiens homeodomain interacting protein kinase 3 (HIPK3),
transcript variant 3, mRNA.
ACCESSION NM_001048200
VERSION NM_001048200.2 GI:498917228
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 7621)
AUTHORS Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
Honda,M. and Tokunaga,K.
TITLE An approach based on a genome-wide association study reveals
candidate loci for narcolepsy
JOURNAL Hum. Genet. 128 (4), 433-441 (2010)
PUBMED 20677014
REMARK GeneRIF: Observational study of gene-disease association. (HuGE
Navigator)
REFERENCE 2 (bases 1 to 7621)
AUTHORS Xu,Y., Li,F., Zhang,B., Zhang,K., Zhang,F., Huang,X., Sun,N.,
Ren,Y., Sui,M. and Liu,P.
TITLE MicroRNAs and target site screening reveals a pre-microRNA-30e
variant associated with schizophrenia
JOURNAL Schizophr. Res. 119 (1-3), 219-227 (2010)
PUBMED 20347265
REMARK GeneRIF: Observational study of gene-disease association and
gene-gene interaction. (HuGE Navigator)
REFERENCE 3 (bases 1 to 7621)
AUTHORS Lan,H.C., Li,H.J., Lin,G., Lai,P.Y. and Chung,B.C.
TITLE Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through
homeodomain-interacting protein kinase 3-mediated Jun N-terminal
kinase and c-Jun phosphorylation
JOURNAL Mol. Cell. Biol. 27 (6), 2027-2036 (2007)
PUBMED 17210646
REMARK GeneRIF: This finding has linked three common factors, HIPK3, JNK,
and c-Jun, to the cAMP signaling pathway leading to increased
steroidogenic gene expression
REFERENCE 4 (bases 1 to 7621)
AUTHORS Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
Lander,E.S. and Sakaki,Y.
TITLE Human chromosome 11 DNA sequence and analysis including novel gene
identification
JOURNAL Nature 440 (7083), 497-500 (2006)
PUBMED 16554811
REFERENCE 5 (bases 1 to 7621)
AUTHORS Venables,J.P., Bourgeois,C.F., Dalgliesh,C., Kister,L., Stevenin,J.
and Elliott,D.J.
TITLE Up-regulation of the ubiquitous alternative splicing factor
Tra2beta causes inclusion of a germ cell-specific exon
JOURNAL Hum. Mol. Genet. 14 (16), 2289-2303 (2005)
PUBMED 16000324
REFERENCE 6 (bases 1 to 7621)
AUTHORS Scaffidi,C., Volkland,J., Blomberg,I., Hoffmann,I., Krammer,P.H.
and Peter,M.E.
TITLE Phosphorylation of FADD/ MORT1 at serine 194 and association with a
70-kDa cell cycle-regulated protein kinase
JOURNAL J. Immunol. 164 (3), 1236-1242 (2000)
PUBMED 10640736
REFERENCE 7 (bases 1 to 7621)
AUTHORS Nupponen,N.N. and Visakorpi,T.
TITLE Assignment of the protein kinase homolog of YAK1 (HIPK3) to human
chromosome band 11p13 by in situ hybridization
JOURNAL Cytogenet. Cell Genet. 87 (1-2), 102-103 (1999)
PUBMED 10640824
REFERENCE 8 (bases 1 to 7621)
AUTHORS Kim,Y.H., Choi,C.Y., Lee,S.J., Conti,M.A. and Kim,Y.
TITLE Homeodomain-interacting protein kinases, a novel family of
co-repressors for homeodomain transcription factors
JOURNAL J. Biol. Chem. 273 (40), 25875-25879 (1998)
PUBMED 9748262
REFERENCE 9 (bases 1 to 7621)
AUTHORS Moilanen,A.M., Karvonen,U., Poukka,H., Janne,O.A. and Palvimo,J.J.
TITLE Activation of androgen receptor function by a novel nuclear protein
kinase
JOURNAL Mol. Biol. Cell 9 (9), 2527-2543 (1998)
PUBMED 9725910
REFERENCE 10 (bases 1 to 7621)
AUTHORS Begley,D.A., Berkenpas,M.B., Sampson,K.E. and Abraham,I.
TITLE Identification and sequence of human PKY, a putative kinase with
increased expression in multidrug-resistant cells, with homology to
yeast protein kinase Yak1
JOURNAL Gene 200 (1-2), 35-43 (1997)
PUBMED 9373137
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
HY053621.1, DR000092.1, AK315277.1, AL122015.17 and BX117467.1.
On May 14, 2013 this sequence version replaced gi:114796629.
Transcript Variant: This variant (3) lacks an in-frame exon in the
central region, compared to variant 1. The resulting isoform (2)
lacks an internal segment, compared to isoform 1. Variants 2, 3 and
4 encode the same isoform 2.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AF305239.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
ERS025081, ERS025082 [ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-300 HY053621.1 1-300
301-738 DR000092.1 1-438
739-4155 AK315277.1 252-3668
4156-7305 AL122015.17 31791-34940 c
7306-7621 BX117467.1 1-316 c
FEATURES Location/Qualifiers
source 1..7621
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="11"
/map="11p13"
gene 1..7621
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="homeodomain interacting protein kinase 3"
/db_xref="GeneID:10114"
/db_xref="HGNC:4915"
/db_xref="MIM:604424"
exon 1..568
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 15
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370483960"
variation 120
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:373895171"
variation 194
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:192080128"
variation 223
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:111729659"
variation 248
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:114828426"
variation 343..345
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="cag"
/db_xref="dbSNP:201412692"
variation 492
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376181419"
misc_feature 562..564
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="upstream in-frame stop codon"
exon 569..1667
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
CDS 571..4155
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/EC_number="2.7.11.1"
/note="isoform 2 is encoded by transcript variant 3;
homeodomain-interacting protein kinase 3; ANPK; FIST;
homolog of protein kinase YAK1; fas-interacting
serine/threonine-protein kinase; androgen
receptor-interacting nuclear protein kinase"
/codon_start=1
/product="homeodomain-interacting protein kinase 3 isoform
2"
/protein_id="NP_001041665.1"
/db_xref="GI:114796630"
/db_xref="CCDS:CCDS41634.1"
/db_xref="GeneID:10114"
/db_xref="HGNC:4915"
/db_xref="MIM:604424"
/translation="
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
"
misc_feature 1159..2145
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="Protein kinase domain; Region: Pkinase; pfam00069"
/db_xref="CDD:215690"
misc_feature 1159..>1833
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="Protein Kinases, catalytic domain; Region:
PKc_like; cl09925"
/db_xref="CDD:245201"
misc_feature order(1177..1191,1201..1203,1240..1242,1246..1248,
1345..1347,1393..1404,1411..1413,1417..1419,1534..1536,
1540..1542,1546..1551,1555..1557,1600..1602,1609..1611,
1651..1662)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="active site"
/db_xref="CDD:173623"
misc_feature order(1177..1191,1201..1203,1240..1242,1246..1248,
1345..1347,1393..1404,1411..1413,1534..1536,1540..1542,
1546..1551,1555..1557,1600..1602)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:173623"
misc_feature order(1189..1191,1411..1413,1417..1419,1534..1536,
1540..1542,1546..1548,1609..1611,1651..1662)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="substrate binding site [chemical binding]; other
site"
/db_xref="CDD:173623"
misc_feature order(1597..1617,1651..1662)
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/note="activation loop (A-loop); other site"
/db_xref="CDD:173623"
misc_feature 1645..1647
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 1645..1647
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 2893..3180
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Interaction with FAS (By similarity)"
misc_feature 3070..3540
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Required for localization to nuclear speckles (By
similarity)"
misc_feature 3103..3261
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: SUMO interaction motifs (SIM), required for
nuclear localization and kinase activity (By similarity)"
misc_feature 3115..3147
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="non-experimental evidence, no additional
details recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H422.1);
Region: Interaction with UBL1 (Probable)"
variation 574
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144688161"
variation 632
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372642188"
variation 687
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374944934"
variation 689
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200300898"
variation 691
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:371285073"
variation 694
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148530680"
variation 701
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:145481182"
variation 748
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147614894"
variation 770
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144644881"
variation 800
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:144410310"
variation 812
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151214053"
variation 826
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140400527"
variation 879
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:150292649"
variation 899
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144907072"
variation 902
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:375017758"
variation 908
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187022690"
variation 941
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368850984"
variation 963
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140900571"
variation 995
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34193811"
variation 1002
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144714786"
variation 1077
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138597548"
variation 1078
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:374084636"
variation 1079
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:34698015"
variation 1113
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369151270"
variation 1123
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148715569"
variation 1140
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201202256"
variation 1141
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35689361"
variation 1161
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:372051248"
variation 1169
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:141595291"
variation 1190
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:376339186"
variation 1203
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:55650492"
variation 1204
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:369914142"
variation 1224
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:376935843"
variation 1236
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:374098516"
variation 1311
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:150819399"
variation 1372
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:376939727"
variation 1373
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139279668"
variation 1382
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200282854"
variation 1446
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200073641"
variation 1489
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368956023"
variation 1573
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142299107"
variation 1574
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143910249"
variation 1621
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147258823"
variation 1642
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/replace="g"
/db_xref="dbSNP:199856578"
variation 1644
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201805414"
variation 1664
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140836901"
exon 1668..1791
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1761
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:370526633"
variation 1770
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144371900"
exon 1792..1911
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1797
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:377260169"
variation 1855
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:144565971"
variation 1883
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:370787117"
variation 1898
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:148475804"
exon 1912..1998
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 1990
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:266472"
exon 1999..2183
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2011
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373644583"
variation 2021
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368066220"
variation 2069
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:11032229"
variation 2081
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201753105"
variation 2098
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200260579"
variation 2099
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:201133345"
variation 2126
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371957082"
variation 2146
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:188152932"
exon 2184..2343
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
STS 2273..2442
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="MARC_16007-16008:1017070197:5"
/db_xref="UniSTS:267932"
variation 2326
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140757794"
exon 2344..2467
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2347
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:143169582"
exon 2468..2589
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2502
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:146687175"
variation 2508
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140297828"
variation 2509
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:112993351"
variation 2519
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:113037552"
variation 2529
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371306723"
variation 2542
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77834200"
variation 2587
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:374207916"
exon 2590..2714
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2591
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:367997325"
variation 2603
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372518927"
variation 2636
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:199603859"
variation 2644
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:181305871"
exon 2715..2876
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2749
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189153633"
variation 2756
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:55807239"
variation 2762
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:138907505"
variation 2789
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:547809"
variation 2807
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:149006860"
variation 2832
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="g"
/db_xref="dbSNP:5790928"
variation 2838
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:77998863"
variation 2870
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:143841994"
exon 2877..3173
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 2889
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:111773781"
variation 2900
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:143804053"
variation 2909
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:147249051"
variation 2914
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373565743"
variation 2952
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:139123780"
variation 2982
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141483565"
variation 2986
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:150770633"
variation 3017
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:370501263"
variation 3041
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:187124851"
variation 3068
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139168123"
variation 3087
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:149933512"
variation 3104
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144093715"
variation 3172
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373619155"
exon 3174..3314
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3183
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:201916597"
variation 3268
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368393624"
variation 3269
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:372352323"
variation 3270
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:139983826"
variation 3305
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:143130710"
variation 3309
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:147557040"
exon 3315..3550
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3318
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140277514"
variation 3323
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:371101353"
variation 3362
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:371278906"
variation 3366
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:189975516"
variation 3377
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142589533"
variation 3381
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200853149"
variation 3386
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369147055"
variation 3418
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371973544"
variation 3424
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375435479"
variation 3435
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:370104100"
variation 3436
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200063110"
variation 3444
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:151298583"
variation 3455
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:140531306"
variation 3476
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201934152"
variation 3487
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:373543551"
variation 3499
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:368948226"
variation 3529
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200039689"
variation 3544
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:201982369"
exon 3551..3678
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3556
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:150461240"
variation 3657
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:138517447"
exon 3679..7610
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/inference="alignment:Splign:1.39.8"
variation 3679
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:374715839"
variation 3680
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:148327404"
STS 3734..4267
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="HIPK3__6530"
/db_xref="UniSTS:463980"
variation 3735
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146323020"
variation 3738
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139085464"
variation 3777
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:200186370"
variation 3787
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:141714879"
variation 3800
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:200223965"
variation 3802
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:199898293"
variation 3806..3807
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="c"
/db_xref="dbSNP:34253010"
variation 3818
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:149374485"
variation 3841
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:373637582"
variation 3859
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:186297123"
variation 3886
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:368061213"
variation 3888
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:144710455"
variation 3892
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:371485212"
variation 3958
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:148114408"
variation 3991..3993
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="cac"
/db_xref="dbSNP:141782878"
variation 4013..4014
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="a"
/db_xref="dbSNP:34629163"
variation 4029
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:141503633"
variation 4047
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:201569128"
variation 4063
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146004527"
variation 4075
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:139964400"
variation 4083
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:141882893"
variation 4093
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:200574738"
variation 4107
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:369816213"
variation 4109
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373299730"
variation 4126
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:146182417"
variation 4127
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:76323203"
variation 4157
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:139062945"
variation 4170
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:190940410"
variation 4186
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="c"
/db_xref="dbSNP:150884070"
variation 4321
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:183354813"
variation 4343
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:140114380"
variation 4353
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:187999224"
variation 4387
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:115163947"
variation 4445
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:144080192"
variation 4698
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:147337267"
variation 4754
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:192087334"
variation 4794
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:183081083"
variation 5125
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:202123118"
variation 5136
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:4755571"
variation 5255
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:187860214"
variation 5287..5288
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:200851825"
variation 5287
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:370250777"
variation 5288..5289
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:11429812"
variation 5359
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375339434"
variation 5366
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:375418698"
variation 5425
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032233"
variation 5431
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:368071186"
variation 5442
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032234"
variation 5443
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:11032235"
variation 5598
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:373082522"
variation 5781
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:192913092"
variation 5920
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184157642"
variation 5977
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:79556626"
STS 6168..6237
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="D11S2229E"
/db_xref="UniSTS:25085"
variation 6368
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:140296161"
variation 6385..6386
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="t"
/db_xref="dbSNP:35464888"
variation 6433
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:189429278"
variation 6522
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:191474583"
variation 6591
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="g"
/db_xref="dbSNP:16924206"
variation 6657
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="g"
/replace="t"
/db_xref="dbSNP:78602081"
variation 6727
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:73489287"
variation 6925
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:5021318"
variation 6985
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="c"
/replace="t"
/db_xref="dbSNP:142600026"
STS 7214..7388
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/standard_name="RH98961"
/db_xref="UniSTS:91554"
variation 7235
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:184628276"
variation 7250
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:10600"
variation 7388
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:189463875"
variation 7397
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:146479622"
variation 7408..7409
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace=""
/replace="g"
/db_xref="dbSNP:35645257"
variation 7524
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:369088368"
variation 7572
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="t"
/db_xref="dbSNP:141043933"
variation 7596
/gene="HIPK3"
/gene_synonym="DYRK6; FIST3; PKY; YAK1"
/replace="a"
/replace="g"
/db_xref="dbSNP:181421671"
ORIGIN
tgcggaggcggtggccgaggccgacgagcgcggaggaggggcccgaggctggggcggctggtggcagctgcctcagtgacgactgccggcatcgcggcgacctgaggagatcaagccgcaggccccgccgtcgccaccactcccgccagtcttccttctccgctcccggccggggcgtcaggaatgggccccaatcgccgtgggccccgcaccctgcgtcgcccgtaggccccagtagccggaggccgaccggcctcccactacccctcgccctagccaagccgtccccaccccaaatccccgggaaggaagatgagggagacgggcccggcgcttagcagccagagcagcagcagcagcagcagcggtcgggggagggtgtttcgccgtttcctctcagccgccaggacaagatggcagcggccgcggagaggggctgagcccgggctgggtggtgccgcctgctgaagcgcctggctcccggtccccggcacggccctgcgccccaccccggacatgctcagggctgcggccgcccgaagaggagagagcgcgggcctctaggaaggtatggcctcacaagtcttggtctacccaccatatgtttatcaaactcagtcaagtgccttttgtagtgtgaagaaactcaaagtagagccaagcagttgtgtattccaggaaagaaactatccacggacctatgtgaatggtagaaactttggaaattctcatcctcccactaagggtagtgcttttcagacaaagataccatttaatagacctcgaggacacaacttttcattgcagacaagtgctgttgttttgaaaaacactgcaggtgctacaaaggtcatagcagctcaggcacagcaagctcacgtgcaggcacctcagattggggcgtggcgaaacagattgcatttcctagaaggcccccagcgatgtggattgaagcgcaagagtgaggagttggataatcatagcagcgcaatgcagattgtcgatgaattgtccatacttcctgcaatgttgcaaaccaacatgggaaatccagtgacagttgtgacagctaccacaggatcaaaacagaattgtaccactggagaaggtgactatcagttagtacagcatgaagtcttatgctccatgaaaaatacttacgaagtccttgattttcttggtcgaggcacgtttggccaggtagttaaatgctggaaaagagggacaaatgaaattgtagcaatcaaaattttgaagaatcatccttcttatgcccgtcaaggtcaaatagaagtgagcatattagcaaggctcagtactgaaaatgctgatgaatataactttgtacgagcttatgaatgctttcagcaccgtaaccatacttgtttagtctttgagatgctggaacaaaacttgtatgactttctgaaacaaaataaatttagtcccctgccactaaaagtgattcggcccattcttcaacaagtggccactgcactgaaaaaattgaaaagtcttggtttaattcatgctgatctcaagccagagaatattatgttggtggatcctgttcggcagccttacagggttaaagtaatagactttgggtcggccagtcatgtatcaaagactgtttgttcaacatatctacaatctcggtactacagagctccagagattatattggggttgccattttgtgaagccatagacatgtggtcattgggatgtgtgattgcagaattatttcttggatggccgctctacccaggagccttggagtatgatcagattcgatacatttctcagactcaaggtttgccaggagaacagttgttaaatgtgggtactaaatccacaagatttttttgcaaagaaacagatatgtctcattctggttggagattaaagacattggaagagcatgaggcagagacaggaatgaagtctaaagaagccagaaaatacattttcaacagtctggatgatgtagcgcatgtgaacacagtgatggatttggaaggaagtgatcttttggctgagaaagctgatagaagagaatttgttagtctgttgaagaaaatgttgctgattgatgcagatttaagaattactccagctgagaccctgaaccatccttttgttaatatgaaacatcttctagatttccctcatagcaaccatgtaaagtcctgttttcatattatggatatttgtaagtcccacctaaattcatgtgacacaaataatcacaacaaaacttcacttttaagaccagttgcttcaagcagtactgctacactgactgcaaattttactaaaatcggaacattaagaagtcaggcattgaccacatctgctcattcagttgtgcaccatggaatacctctgcaggcaggaactgctcagtttggttgtggtgatgcttttcagcagacattgattatctgtcccccagctattcaaggtattcctgcaacacatggtaaacccaccagttattcaataagggtagataatacagttccacttgtaactcaggccccagctgtgcagccactacagatccgaccaggagttctttctcagacgtggtctggtagaacacagcagatgctggtgcctgcctggcaacaggtgacacccctggctcctgctactactacactaacttctgagagtgtggctggttcacacaggcttggagactgggggaagatgatttcatgcagcaatcattataactcagtgatgccgcagcctcttctgaccaatcagataactttatctgcccctcagccagttagtgtggggattgcacatgttgtctggcctcagcctgccactaccaagaaaaataaacagtgccagaacaggagtaattcattacagaataccaatatcccacattcagcatttatttctccaaagataattaatgggaaagatgtcgaggaagtaagttgtatagaaacacaggacaatcagaactcagaaggagaggcaagaaattgctgtgaaacatctatcagacaggactctgattcatcagtttcagacaaacagcggcaaaccatcattattgccgactccccgagtcctgcagtgagtgtcatcactatcagcagtgacactgatgaggaagagacttcccagagacattcactcagagaatgtaaaggtagtctagattgtgaagcttgccagagcactttgaatattgatcggatgtgttcattaagtagtcctgatagtactctgagtaccagctcctcagggcagtccagcccatccccctgcaagagaccgaatagtatgtcagatgaagagcaagaaagtagttgtgatacggtggatggctctccgacatctgactcttccgggcatgacagtccatttgcagagagcacttttgtggaggacactcatgaaaacacagaattggtatcctctgctgacacagaaaccaagccagctgtctgttctgttgtggtgccaccagtggaactagaaaatggcttaaatgccgatgagcatatggcaaacacagattctatatgccagccattaataaaaggacgatctgcccctggaagattaaaccagccttctgcagtgggtactcgtcagcaaaaattgacatcagcattccagcagcagcatttgaacttcagtcaggttcagcactttggatctgggcatcaagagtggaatggaaactttgggcacagaagacagcaagcttatattcctactagtgttaccagtaatccattcactctttctcatggaagtcccaatcacacagcagtgcatgcccacctggctggaaatacacacctcggaggacagcctactctacttccatacccatcatcagccaccctcagtagtgctgcaccagtggcccacctgttagcctctccgtgtacctcaagacctatgttacagcatccaacttataatatctcccatcccagtggcatagttcaccaagtcccagtgggcttaaatccccgtctgttaccatccccaaccattcatcagactcagtacaaaccaatcttcccaccacattcttacattgcagcatcacctgcatatactggatttccactgagtccaacaaaactcagccagtatccatatatgtgaaaaacagtatattggggaagctcaatgatacaaacatttgattaaaaataaaaacatggtatttaatattagccatggcacaagaaaattatttttgaatcatgtagacttgggtgcaatttaaacaactttgagctttaaaaactcacttttgatgtgttttgcacatttggtataacttgtctttggtcatgttatcttcttatgtagtaactctagacaggtgacttatgggagcagaagtccagttttgctcctgctattttttataaattgccttctaactagtgcaagacacgtctacatttgggaagccattctgtgtacagacttagagcaacagatgcacatatgtcagaattacagcatacaagtgaattgtattatccgtgtcttagtgtataaatgttgggtcacttacctaagaaattgagctattgttctttacatttgcatgtgtcttttgcatgggcaaaatgttgcctagactttgctcttaaatgttgttctaataatctcagctgcattgtaaaccgttcctacacatagtgccttaaatatttgaggttgttaatgttattacctatatataaatgttgaggactgcagcacttaaaattcagacctactatttagtttccttttgatagcgtaatgttcatttttgtttttgtgtggtatgatttcaggtagtagctgtttttttccttattaagagggcagcatgtttgctatagctgaattctgctgtctgatttttcagaatgatctagcttcaagaaaagcaagcagttagtagtgcttaagaaaaattgattcagtatctaatggatagttgataactgtcacagcacagcattttatatactgttaagtgaaactgcaatacaatctaagtttattttgagagtgtttgctgtataattggacttaataaaatgtttagaggtacagtaggcatgactttgggtagataataaaatgcaaaatgctcattgattcatgatgtggttttatcttagcttgggcaaaccatgcagtatttaataaatagtagcagaacttttactattgaagcttgaaaagatgtgagttctttgtgtgcaatttttgatttatgcatgtgagagggttttttttttttttaagtatttttacattgcagtacttgttttgcttgttggtgatgtttgcttatttaatacattccgtcagggacagaaattacatgcttttttttctttctaggaagtgtgttgagttccccccttccccgacatttttttcttttttgggtggtggtgatggtagtggttatgtctgtttaaatgaagttgcttttacagcaccaaagacttaatcatccatttcctatataaaggtagctactttttgcatagacctcaagtatattgtagtgtaaaggtggaatttaaggaaaggtattaaattgaggctgtgttttagcttacaggcaagtaataaattgtatcatttatcttgaatgtatcatagataagctgctatataacgattgccacttcagatagctgtgaaattaggtgattaactagttgttatttagccttctaatttctgtataagtctaattacatgaatagaaattggggttttgattttttactttgcttttctgtttggagtgtcattgtaactactgtattgtaaatggtggaaaataattgcatttgttactttggggtgtgttatttgcatcagtattttatctctattaatgtttgtgctcatcactgcatattaaaaaaacttggatgtatcagtgtaacttaattttttattttcatactggcattgtagacacttgagaaagctgtatcttgcaggcttgacttaacttttttccttaaaaatctggaatataatcttacagcatttactggaataaacagtacaaagcattggagtgtaaaactctagatgttttggatttacagcgtttctttgataaatgaattgtataccactagtacagctctagtacagcgttcacaataagctaataatggataagttttcttcactccattaacacaagcagtgttttatttaataatcatcaatgaaataaatgtgcctgaaattgattttaaaaattacagtattagatcataaagtaaaaaccagcagtacatttttagtcacactgaaaatgaaggacttaattttccccacaagtttcagtgtttttagtaattaattctatgcattttatacaaatagaaatatatatatataaaaaattaaatgtttaaaaaggagtagcctaagattaatttaaaagattatttacagatgacacatttatggggtcactatttaagtaaatttgctgccctccacagccttctaattttatttatatgttccagcagattattaggatctgcttacttcttaggaaagaatcaatgctggcaacacattgtttcagaaacaccaagtgcaaaggattgattgtatcacaacaggtacaaaactgacagagttttctttttgtttagggccatgtttactaccctgaaatgttgtattttttgtctttaatttccaagacttaaagcagtcttgttaaattgacataaatggtaaacttcaacattttcataatacagtattaatgtttgataaaggtatatcccagttaactacactgctctttaattgcaatcatgggcattttaatgtattttaaaataaatttcaaaattctgctaaattcttaatttagcatattgacaaagtaatctggatttataccttttaaaaaccattttgaccagttttcttcggttttaatgctttcttaaataaaacactgcatgatttccaagttgcatatttgcatactattttaatttgcaaaatgttttttaaatcaaatatcctgatatttagttgttttttttttcctccagcgtgtttaattaaatatgttactgtattagcaaaacattttcatttttaaaatctgctaattttaaacttggactgtgttaagtaaaagttaaatcatacactgcaaggtgtaggaagatttgttttaatgaatccaatgatacagatttgattactaagtttgaactgttaattgtttaacaattttagacttgtggctttctttctttggtttatttgtttttgcttttactcctatgctacactagtttgccatgtagcaattgcactgtgcaatattacaataaggactgggaaaattttatggatgtaatgtctattacggtttgcgatagtatttctctctagttctcagtgatttaaatgtgaccaagccttctgtactttgtcacaaaaagcgggttttccaggtgactattttggtgagtgtcaaaataagaatttatggtgtattactgtcgattcactttgaattaaaatatatatattgcagcaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:10114 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
GeneID:10114 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IDA
GeneID:10114 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: ISS
GeneID:10114 -> Molecular function: GO:0005524 [ATP binding] evidence: NAS
GeneID:10114 -> Biological process: GO:0006355 [regulation of transcription, DNA-dependent] evidence: IEA
GeneID:10114 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
GeneID:10114 -> Biological process: GO:0006915 [apoptotic process] evidence: IEA
GeneID:10114 -> Biological process: GO:0009299 [mRNA transcription] evidence: IDA
GeneID:10114 -> Biological process: GO:0018105 [peptidyl-serine phosphorylation] evidence: ISS
GeneID:10114 -> Biological process: GO:0018107 [peptidyl-threonine phosphorylation] evidence: ISS
GeneID:10114 -> Biological process: GO:0043066 [negative regulation of apoptotic process] evidence: IMP
GeneID:10114 -> Biological process: GO:0043508 [negative regulation of JUN kinase activity] evidence: ISS
GeneID:10114 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:10114 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:10114 -> Cellular component: GO:0016605 [PML body] evidence: IEA
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001041665 -> EC 2.7.11.1
by
@meso_cacase at
DBCLS
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