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2024-04-26 05:56:43, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001042604 10053 bp mRNA linear PRI 05-MAY-2013
DEFINITION Homo sapiens 5'-3' exoribonuclease 1 (XRN1), transcript variant 2,
mRNA.
ACCESSION NM_001042604
VERSION NM_001042604.1 GI:110624786
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10053)
AUTHORS Li,Y., Masaki,T., Yamane,D., McGivern,D.R. and Lemon,S.M.
TITLE Competing and noncompeting activities of miR-122 and the 5'
exonuclease Xrn1 in regulation of hepatitis C virus replication
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (5), 1881-1886 (2013)
PUBMED 23248316
REMARK GeneRIF: Data show that 5' exonuclease Xrn1 knockdown and miR-122
supplementation have equal, redundant, and nonadditive effects on
the rate of viral RNA decay, indicating that miR-122 protects HCV
RNA from 5' decay.
REFERENCE 2 (bases 1 to 10053)
AUTHORS Braun,J.E., Truffault,V., Boland,A., Huntzinger,E., Chang,C.T.,
Haas,G., Weichenrieder,O., Coles,M. and Izaurralde,E.
TITLE A direct interaction between DCP1 and XRN1 couples mRNA decapping
to 5' exonucleolytic degradation
JOURNAL Nat. Struct. Mol. Biol. 19 (12), 1324-1331 (2012)
PUBMED 23142987
REMARK GeneRIF: findings reveal a role for XRN1 in decapping and provide a
molecular basis for the coupling of decapping to 5'-->3' mRNA
degrada
REFERENCE 3 (bases 1 to 10053)
AUTHORS Mullen,T.E. and Marzluff,W.F.
TITLE Degradation of histone mRNA requires oligouridylation followed by
decapping and simultaneous degradation of the mRNA both 5' to 3'
and 3' to 5'
JOURNAL Genes Dev. 22 (1), 50-65 (2008)
PUBMED 18172165
REFERENCE 4 (bases 1 to 10053)
AUTHORS van Dijk,E.L., Schilders,G. and Pruijn,G.J.
TITLE Human cell growth requires a functional cytoplasmic exosome, which
is involved in various mRNA decay pathways
JOURNAL RNA 13 (7), 1027-1035 (2007)
PUBMED 17545563
REFERENCE 5 (bases 1 to 10053)
AUTHORS Lehner,B. and Sanderson,C.M.
TITLE A protein interaction framework for human mRNA degradation
JOURNAL Genome Res. 14 (7), 1315-1323 (2004)
PUBMED 15231747
REFERENCE 6 (bases 1 to 10053)
AUTHORS Ingelfinger,D., Arndt-Jovin,D.J., Luhrmann,R. and Achsel,T.
TITLE The human LSm1-7 proteins colocalize with the mRNA-degrading
enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
JOURNAL RNA 8 (12), 1489-1501 (2002)
PUBMED 12515382
REMARK GeneRIF: LSm1-7 proteins colocalize with DCP1,DCP2 and Xrn1 in
cytoplasmic foci
REFERENCE 7 (bases 1 to 10053)
AUTHORS Zhang,K., Dion,N., Fuchs,B., Damron,T., Gitelis,S., Irwin,R.,
O'Connor,M., Schwartz,H., Scully,S.P., Rock,M.G., Bolander,M.E. and
Sarkar,G.
TITLE The human homolog of yeast SEP1 is a novel candidate tumor
suppressor gene in osteogenic sarcoma
JOURNAL Gene 298 (2), 121-127 (2002)
PUBMED 12426100
REFERENCE 8 (bases 1 to 10053)
AUTHORS Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
Offenbacher,J., Danzig,J. and Ducar,M.
TITLE Creation of genome-wide protein expression libraries using random
activation of gene expression
JOURNAL Nat. Biotechnol. 19 (5), 440-445 (2001)
PUBMED 11329013
REFERENCE 9 (bases 1 to 10053)
AUTHORS Sato,Y., Shimamoto,A., Shobuike,T., Sugimoto,M., Ikeda,H.,
Kuroda,S. and Furuichi,Y.
TITLE Cloning and characterization of human Sep1 (hSEP1) gene and
cytoplasmic localization of its product
JOURNAL DNA Res. 5 (4), 241-246 (1998)
PUBMED 9802570
REFERENCE 10 (bases 1 to 10053)
AUTHORS Bashkirov,V.I., Scherthan,H., Solinger,J.A., Buerstedde,J.M. and
Heyer,W.D.
TITLE A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4
tetraplex substrates
JOURNAL J. Cell Biol. 136 (4), 761-773 (1997)
PUBMED 9049243
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BX640905.1, AY137776.1, BG197321.1 and AC023508.16.
Summary: SEP1 localizes to cytoplasmic foci containing a complex of
mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1
has been implicated in a variety of nuclear and cytoplasmic
functions, including homologous recombination, meiosis, telomere
maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-67 BX640905.1 1-67
68-4685 AY137776.1 1-4618
4686-5149 AY137776.1 4658-5121
5150-5230 BG197321.1 308-388
5231-10053 AC023508.16 31718-36540 c
FEATURES Location/Qualifiers
source 1..10053
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="3"
/map="3q23"
gene 1..10053
/gene="XRN1"
/gene_synonym="SEP1"
/note="5'-3' exoribonuclease 1"
/db_xref="GeneID:54464"
/db_xref="HGNC:30654"
/db_xref="MIM:607994"
exon 1..142
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
STS 32..160
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="18494"
misc_feature 41..43
/gene="XRN1"
/gene_synonym="SEP1"
/note="upstream in-frame stop codon"
CDS 68..5149
/gene="XRN1"
/gene_synonym="SEP1"
/note="isoform b is encoded by transcript variant 2;
strand-exchange protein 1 homolog"
/codon_start=1
/product="5'-3' exoribonuclease 1 isoform b"
/protein_id="NP_001036069.1"
/db_xref="GI:110624787"
/db_xref="GeneID:54464"
/db_xref="HGNC:30654"
/db_xref="MIM:607994"
/translation="
MGVPKFYRWISERYPCLSEVVKEHQIPEFDNLYLDMNGIIHQCSHPNDDDVHFRISDDKIFTDIFHYLEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAKEAEDKIKKAIEKGETLPTEARFDSNCITPGTEFMARLHEHLKYFVNMKISTDKSWQGVTIYFSGHETPGEGEHKIMEFIRSEKAKPDHDPNTRHCLYGLDADLIMLGLTSHEAHFSLLREEVRFGGKKTQRVCAPEETTFHLLHLSLMREYIDYEFSVLKEKITFKYDIERIIDDWILMGFLVGNDFIPHLPHLHINHDALPLLYGTYVTILPELGGYINESGHLNLPRFEKYLVKLSDFDREHFSEVFVDLKWFESKVGNKYLNEAAGVAAEEARNYKEKKKLKGQENSLCWTALDKNEGEMITSKDNLEDETEDDDLFETEFRQYKRTYYMTKMGVDVVSDDFLADQAACYVQAIQWILHYYYHGVQSWSWYYPYHYAPFLSDIHNISTLKIHFELGKPFKPFEQLLAVLPAASKNLLPACYQHLMTNEDSPIIEYYPPDFKTDLNGKQQEWEAVVLIPFIDEKRLLEAMETCNHSLKKEERKRNQHSECLMCWYDRDTEFIYPSPWPEKFPAIERCCTRYKIISLDAWRVDINKNKITRIDQKALYFCGFPTLKHIRHKFFLKKSGVQVFQQSSRGENMMLEILVDAESDELTVENVASSVLGKSVFVNWPHLEEARVVAVSDGETKFYLEEPPGTQKLYSGRTAPPSKVVHLGDKEQSNWAKEVQGISEHYLRRKGIIINETSAVVYAQLLTGRKYQINQNGEVRLEKQWSKQVVPFVYQTIVKDIRAFDSRFSNIKTLDDLFPLRSMVFMLGTPYYGCTGEVQDSGDVITEGRIRVIFSIPCEPNLDALIQNQHKYSIKYNPGYVLASRLGVSGYLVSRFTGSIFIGRGSRRNPHGDHKANVGLNLKFNKKNEEVPGYTKKVGSEWMYSSAAEQLLAEYLERAPELFSYIAKNSQEDVFYEDDIWPGENENGAEKVQEIITWLKGHPVSTLSRSSCDLQILDAAIVEKIEEEVEKCKQRKNNKKVRVTVKPHLLYRPLEQQHGVIPDRDAEFCLFDRVVNVRENFSVPVGLRGTIIGIKGANREADVLFEVLFDEEFPGGLTIRCSPGRGYRLPTSALVNLSHGSRSETGNQKLTAIVKPQPAVHQHSSSSSVSSGHLGALNHSPQSLFVPTQVPTKDDDEFCNIWQSLQGSGKMQYFQPTIQEKGAVLPQEISQVNQHHKSGFNDNSVKYQQRKHDPHRKFKEECKSPKAECWSQKMSNKQPNSGIENFLASLNISKENEVQSSHHGEPPSEEHLSPQSFAMGTRMLKEILKIDGSNTVDHKNEIKQIANEIPVSSNRRDEYGLPSQPKQNKKLASYMNKPHSANEYHNVQSMDNMCWPAPSQIPPVSTPVTELSRICSLVGMPQPDFSFLRMPQTMTVCQVKLSNGLLVHGPQCHSENEAKEKAALFALQQLGSLGMNFPLPSQVFANYPSAVPPGTIPPAFPPPTANIMPSSSHLFGSMPWGPSVPVPGKPFHHTLYSGTMPMAGGIPGGVHNQFIPLQVTKKRVANKKNFENKEAQSSQATPVQTSQPDSSNIVKVSPRESSSASLKSSPIAQPASSFQVETASQGHSISHHKSTPISSSRRKSRKLAVNFGVSKPSE
"
misc_feature 68..751
/gene="XRN1"
/gene_synonym="SEP1"
/note="XRN 5'-3' exonuclease N-terminus; Region: XRN_N;
pfam03159"
/db_xref="CDD:202558"
exon 143..375
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 376..473
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
STS 440..567
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="16STS01"
/db_xref="UniSTS:505254"
exon 474..583
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 584..694
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 695..777
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 778..865
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 866..1034
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
variation 962
/gene="XRN1"
/gene_synonym="SEP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35351308"
exon 1035..1102
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1103..1240
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1241..1307
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1308..1413
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1414..1503
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1504..1660
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1661..1780
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1781..1950
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 1951..2071
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2072..2170
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
variation 2087
/gene="XRN1"
/gene_synonym="SEP1"
/replace="a"
/replace="g"
/db_xref="dbSNP:35214510"
exon 2171..2274
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2275..2406
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2407..2569
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2570..2683
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2684..2782
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2783..2898
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 2899..3045
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3046..3135
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3136..3271
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3272..3328
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3329..3461
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3462..3531
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3532..3739
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 3740..3835
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
STS 3746..3845
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="72487"
STS 3750..3933
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="47073"
exon 3836..3944
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
variation 3843
/gene="XRN1"
/gene_synonym="SEP1"
/replace="c"
/replace="t"
/db_xref="dbSNP:35902661"
exon 3945..4006
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4007..4129
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4130..4286
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4287..4468
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4469..4582
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4583..4685
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
exon 4686..4846
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
STS 4687..4767
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="6621"
exon 4847..10053
/gene="XRN1"
/gene_synonym="SEP1"
/inference="alignment:Splign:1.39.8"
STS 5287..5367
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="STS-T66948"
/db_xref="UniSTS:6621"
STS 6121..6304
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="RH46274"
/db_xref="UniSTS:47073"
STS 6209..6308
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="SHGC-56571"
/db_xref="UniSTS:72487"
variation 8594..8597
/gene="XRN1"
/gene_synonym="SEP1"
/replace=""
/replace="agtt"
/db_xref="dbSNP:67083822"
STS 9782..9953
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="AB048929"
/db_xref="UniSTS:479818"
STS 9894..10022
/gene="XRN1"
/gene_synonym="SEP1"
/standard_name="WI-13749"
/db_xref="UniSTS:18494"
variation 9978
/gene="XRN1"
/gene_synonym="SEP1"
/replace="a"
/replace="c"
/db_xref="dbSNP:3191463"
ORIGIN
cggcggagccccggcggggcgtttggtttcggtttggccctgactgggattagtgttgacgatcgaaatgggagtccccaagttttacagatggatctcagagcggtatccctgtctcagcgaagtggtgaaagagcatcagattcctgaatttgacaacttgtacctggatatgaatggaattatacatcagtgctcccatcctaatgatgatgatgttcactttagaatttcagatgataaaatctttactgatatttttcactacctggaggtgttgtttcgcattattaaacccaggaaagtgttctttatggctgtagatggtgtggctcctcgagcaaaaatgaaccagcagcgtgggaggcgttttaggtcagcaaaggaggcagaagacaaaattaaaaaggcaatagagaagggagaaactcttcctacagaggccagatttgattccaactgtatcacaccaggaactgaatttatggccaggttacatgaacatctgaagtattttgtaaatatgaaaatttccacagacaagtcatggcaaggagttaccatctacttctcaggccatgagactcctggagaaggagagcataaaatcatggaatttatcagatccgagaaagcaaagccagatcatgatccaaacaccagacactgtctttatggtttagatgctgacttgattatgcttggattaacaagtcatgaggcacatttttctctcttaagagaagaagttcgatttggtggcaaaaaaacacaacgggtatgtgctccagaagaaactacatttcaccttctacacttgtctttaatgagagagtatattgactatgagttttcagtattaaaagaaaagatcacatttaaatatgatattgaaaggataatagatgattggattttgatggggtttcttgttggtaatgattttatccctcatctacctcatttacatattaatcatgatgcactgcctcttctttatggaacatatgttaccatcctgccagaacttgggggttatattaatgaaagtgggcacctcaacttacctcgatttgagaaataccttgtgaaactatcagattttgatcgggagcacttcagtgaagtttttgtggacctaaaatggtttgaaagcaaagttggtaacaagtacctcaatgaagcagcaggtgtcgcagcagaagaagccaggaactacaaggaaaagaaaaagttaaagggccaggaaaattctctgtgttggactgctttagacaaaaatgaaggcgaaatgataacttctaaggataatttagaagatgagactgaagatgatgacctatttgaaactgagtttagacaatataaaagaacatattacatgacgaagatgggggttgacgtagtatctgatgactttctggctgatcaagctgcatgttatgttcaggcaatacagtggattttgcactattactatcatggagttcagtcctggagctggtattatccttatcattatgcacctttcctgtctgatatacacaacatcagtacactcaaaatccattttgaactaggaaaaccttttaagccatttgaacagcttcttgctgtacttccagcagccagcaaaaatttacttcctgcatgctaccagcatttgatgaccaatgaagactcaccaattatagaatattacccacctgattttaaaactgacctaaatgggaaacaacaggaatgggaagctgtggtgttaatcccttttattgatgagaagcgattattggaagccatggagacatgtaaccactccctcaaaaaggaagagaggaaaagaaaccaacatagtgagtgcctaatgtgctggtatgatagagacacagagtttatctatccttctccatggccagaaaagttccctgccatagaacgatgttgtacaaggtataaaataatatccttagatgcttggcgtgtagacataaacaaaaacaaaataaccagaattgaccagaaagcattatatttctgtggatttcctactctgaaacacatcagacacaaattttttttgaagaaaagtggtgttcaagtattccagcaaagcagtcgtggagaaaacatgatgttggaaatcttagtggatgcagaatcagatgaacttaccgtagaaaatgtagcttcatcagtgcttggaaaatctgtctttgttaattggcctcaccttgaggaagctagagtcgtggctgtatcagatggagaaactaagttttacttggaagaacctccaggaacacagaagctttattcaggaagaactgccccaccatctaaagtggttcatcttggagataaagaacaatctaactgggcaaaagaagtacaaggaatttcagaacactacctgagaagaaaaggaataataataaatgaaacatctgcagttgtgtatgctcagttactcacaggtcgtaaatatcaaataaatcaaaatggtgaagttcgtctagagaaacagtggtcaaaacaagttgttccttttgtttatcaaactattgtcaaggacatccgagctttcgactcccgtttctccaatatcaaaacattggatgatttgtttcctctgagaagtatggtctttatgctgggaactccctattatggctgcactggagaagttcaggattcaggtgatgtgattacagaaggtaggattcgtgtgattttcagcattccatgtgaacccaatcttgatgctttaatacagaaccagcataaatattctataaagtacaacccaggatatgtgttggccagtcgccttggagtgagtggataccttgtttcaaggtttacaggaagtatttttattggaagaggatctaggagaaaccctcatggagaccataaagcaaatgtgggtttaaatctcaaattcaacaagaaaaatgaggaggtacctggatatactaagaaagttggaagtgaatggatgtattcatctgcagcagaacaacttctggcagagtacttagagagagctccagaactatttagttatatagccaaaaatagccaagaggatgtgttctatgaagatgacatttggcctggagaaaatgagaatggtgctgaaaaagttcaagaaattattacttggctaaaaggacatcctgtcagtactttatctcgttcttcttgtgatttacaaattctggatgcagctattgttgagaaaattgaggaagaagtcgaaaagtgcaagcaaagaaagaataataagaaggtgcgagtaacagtgaaaccccatttgctatacagacctttagaacagcaacatggagtcattcctgatcgggatgcagaattttgtctttttgaccgtgttgtaaatgtgagagaaaacttctcagttccagttggccttcgaggcaccatcataggaataaaaggagctaatagagaagccgatgtactatttgaagtattatttgatgaagaatttcctggagggttaacaataagatgctcacctggtagaggttatcgactgccaacaagtgccttggtgaacctttctcatgggagtcgctctgaaactggaaatcagaagttgacagccatcgtaaaaccacaaccagctgtacatcaacatagctcaagttcatcagtttcctctgggcatttgggagccctcaaccattcccctcaatcactttttgttcctactcaagtacctactaaagatgatgatgaattctgcaacatttggcagtccttacagggatctggaaagatgcaatactttcagccaactatacaagagaagggtgcagttctacctcaagaaataagccaagtaaatcaacatcataaatctggctttaatgacaacagtgttaaatatcagcaaagaaaacatgaccctcacagaaaatttaaagaagagtgtaagagtcctaaagctgagtgttggtcccaaaaaatgtccaataagcagcctaactctggaattgagaactttttagcatctttgaatatctccaaagaaaatgaagtacagtcatctcatcatggggagcctccaagtgaagagcatttgtcaccacagtcatttgccatgggaacacggatgcttaaagaaattctaaaaattgatggctctaacactgtggaccataagaatgaaatcaaacagattgctaatgaaatccctgtttcctctaacagaagagatgaatatggattaccctctcagcctaaacaaaataagaaattagcatcttatatgaacaagcctcacagtgctaatgagtaccataatgttcagtctatggacaatatgtgttggcctgcccccagccagatccctcctgtatccacaccagtaactgaactttctcgaatttgttcccttgttggaatgccacaacctgatttctcctttcttaggatgccacagacaatgaccgtttgccaagtaaaattatctaatggcttactggtacatgggccacagtgccactctgaaaatgaagccaaagagaaagctgcactttttgctttacaacagttgggctccttaggcatgaatttccctttgccttcacaagtatttgcaaattatccttcagctgtaccacctggaaccattcctccagcctttcccccacctactgctaatataatgccttcgtcgtctcatctctttggctcaatgccatggggaccatcggtgccagttcctgggaagcccttccatcatactttatattctgggaccatgcccatggctgggggaataccagggggtgtgcacaatcagtttatacctctgcaggttactaaaaaaagggttgcaaacaaaaagaactttgagaataaggaagcccagagttctcaagccactccagttcagactagccagccagattcttccaacattgtcaaagtaagtccacgggagagctcatcagcttctttgaagtcctctccgattgctcaacctgcatcttcttttcaagttgaaactgcctctcaaggccatagtatatctcaccataagtcaacaccaatctcttcttcaagaagaaaatcaagaaaactggctgttaattttggtgtttctaaaccttctgagtaaatttggctcttagaattaagttaatttcttctctttccatctacctttttataaatacatatctatgtctcataaaaattagaatgtactattttaaaataatatgtgtaaattgaaatttttttcatttttaagttatcaggcacttttcatgctgtttaaaagactgtgtatcaaattgtgcactttaagtatgtgcagtttgttgtatgtcaattatacctcaataaatctgtaataaaaaactaaattaaaccttgcattaaaataatatcacagtatcagtggactaaacattaaaatgtaccactctaatcattggcctcatgattgaagcatcctgaactatgaattagacatcagttagcaataataagcattttttacactatcattgaggaataattacatggagcatgaaatttgggcctccagtataacttactgaatgtggattttatttctctttttaatgatgtaagaaaattgtcaggagaatggctcttatttatgtgtgttttaacttatgctttgttgcctctgagggtctttagacctgctgtgaaaggatcacatttgttgtggtgctgccagttttgctttattctaaattttgtaccaaagcaactttagaataatcagaatatttcatctaactgcttagaactataaatagcattctaaatttgagtaaatacaattttttaggttactcaagaaccagcattagtaatttctagtaaaattgtttcaaaatctacagggtacaatgattacaaattaatcttctaacaaaataaaatatgaaatattagtcatgttaattaataaactgtattattttgtatagctttttatttgcttacctgacattttatgagagcttcatagttggtcggtatgtagtgcttcttgggactgaagaaattctaattgttgtttaagttccaaggtgtgctacaatataggaggcacagtcatcagtttgtgacatacattatttactgcctatttcattctgattctatatttttagctttatgctgaactgttcaatgatgctgggattctctctttgcatgtcatatgtgaatgtgtggttcaagctgtaactgttgaaattattttagaatttatgacgatttctcagcagggcctatgtttatatatatatatatatttattctttagtttttgtgatatgcttatatttttaaggaagtaagttatagcatacttttttaaaagtaggaaccacaatctttatatggagcagcttgttatatctgattttcatgtaactcattggaaactctgccatgactcttaaagtagtcttacttgttttttaaaatgctggtattaaactaaatggactcctttcactaactgctgatttcagagtttaaatgttagcaggatatttgtgtattagcagtgccttcagtataagagagaaatattcattatctgtcatttatcatagtcgtataagtttccatgattttattttctgttattttcataagttcagatgtttatcagttcccaacattgtttctttatctgtagtgggatcttgagtaatgaggctcaagtaaatcctcaatgtgtataattattgcctcataaactctctctttgtttttaaaggaaacatctattatggtaatacaaagaaaagttaaattgtgacagtaatgttatattaacctcttcctactttaaagtgtgaaatgtttcacctcagctgtacaaactccagcattgagaatttgcctcactcattactcctgtgtgacagttatataaatagcatgcagctcacatctgttttagagcatagaagaagcggcacctgccatcttctgaaaactccaaagggaaatttcagtagacatagtgcactaaacccataaggatacttgaccaatatttgagcacagcaagctgacagttctatacagataggcagtgaaagagttttattttccagccaggcgcagtggctcaaatcccagcacttcgggaggctaaggcaggcggatcacttgaggtccggagttccagacaagcctggccaacatgatgaagccctgtctctactaaaaatacaaaaattagccgggcgtgatggcacatgcctttagtcccagctactcgggaggctgaggcatgagaatcatttgaacccgcgaggcagagtctgcagtgagccgagattgcaccactgcactccagcctggagagcagagcaagactctgtctcaaaaaaaagaaaaaagttttattatccttactttttttttaacattattattctaaaggtcaaaactgagaagagattaagataggagagagctccataatggctggatagtggtcaggcattctctattcttttccccctgtagacccattctaaatgtgggcctgaggtcaatgggagatgtgccctccctatggaggatgtaagaagcagaggccatttctgccccatgttgaggaaacaatctgttgatagacctggaatttagagtatatctgaaaagcagttggacttcaagaaatttaaaattctctctttgagatggggtggactaagaccacccccaaagtttaaaaatatgctcattcaacttgaatcttctgaggactttttgtgaaaatggtggactgtttagggcataggacagattccccaaattgctttatgcttccacataactagagcacttcaatctatttaagcctttgtctcctaactgaaacattatttctaaatatttctattcaataagttttttcttttttgagcaacttaagtgaattttgaagattgctccttccagtctcgttccttttcacattttcctgcattacctaataattacctcagcgttagaatttgaatgtattaattgatttaaacatcatgtagactaaagtcttaaacatctaagactcagttgtagttgcagaaaaaaattaaagtcacctctactgaaccttggtttcaatttaagatttttcttgcttttcaaaggggtaactaataaagattgaagggtttttttcccgattggtggaggaatgaagaactattgatgcaagtttttttattgtttctttctatgatcaggtacctgctttcattttagactgctacttccaaactaagctagattcttggttttaatgagaggaggcagagagagggaggcagatggaagaagaaaaacagttaaataagacatacccagtcactgcatttttggactataccgtatctttctagcacaaggaaatagataaactgtaaggtcttttttactcactttttatttatgtgttctatttgtgttagtcataactgtttatagtggttgtctaatttttacttttattatatgagatagagctgtgcagatcttcactcaagttagttctgtcacgcttcttcccattatttagagcacagttttttaaagcaactgtacaatttctcagccttatgagcttgctgtatttcttggtatcatgttgcttccaaattttgtttttactgtagaagacaattaatttattgtagagaagtggctgtgaaagtcgttctctgtctttaaaaatcaattgcagaagttcatttgtcatttttctagagataaattatagtactcaaactggcagtgctcagtatatacattttgtaagctttgtcagtgaaaccatcagttttgcaggagcttcctttcctagtcaagataaagcttaaaattccagaaattaatgtcgttcggactgactttattcatatttccatcaaacttctccaatacagtaagagatagtgttgaaccagcatcaagtctccagaaacatggcagagcagacaggccgttaagtttcacagacatcatagatccttttcttaaagaagaaaaacatgtataaaatagttttagtagtccaaaatgtcaactatctgtagctgcttttgtgtgtgtgtcagtgaacaaataataatgccttgctcaatcaatgcattcagccatctcaagtgcaatttgtgaaggagactatggtttccaaaagatacatttttttacaaagttaaacctgtaaaaagtctttttttttttccctccagccgtacaccaactgcacttggttgtttcagcagttggtatactattaaattgtccaggccaaataggtttctgtagctgttttagtaatttgaagccaaattctcatgctgtttctcattaaaaagaatgagaatttggtccatagttagctttaagttctctcttcctttctttcccttacagttaagggtttggtgggggatggggaggttgttttcgttttttggatttttttgtcttttggctttaagtatcatattttcttttgcctgtatccaactgcttctttgagtattttcatctagtttaatgtgagtaatagatgctgtgctgtcattgaagtgttcaacattttgttcatttaaacaaaagtgtaattcatacatatatagatacatatcttaattgatttctcaactattttataagtaactggaatttttcattagatcttatacagagaagtattttattaaaaattcaaaagggaagacttttatgtgctcattttgtaatttttgattttaaatatctttacattgtctgccaattaaagtgttttaaacttgcattggaatggactccgaatgtatttttgtggtgttacgttatccgtagatttctagcatgaagttagcctcacgatgctgtgcaaaggattttaaaatatgagagtcactgaaagagtttaaacatctgttcatgttaaatgctctatggattttaattaaagacttgagaatgattttataa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:54464 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:54464 -> Molecular function: GO:0003723 [RNA binding] evidence: IEA
GeneID:54464 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:54464 -> Molecular function: GO:0008409 [5'-3' exonuclease activity] evidence: IEA
GeneID:54464 -> Biological process: GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] evidence: TAS
GeneID:54464 -> Biological process: GO:0000956 [nuclear-transcribed mRNA catabolic process] evidence: IMP
GeneID:54464 -> Biological process: GO:0010467 [gene expression] evidence: TAS
GeneID:54464 -> Biological process: GO:0016070 [RNA metabolic process] evidence: TAS
GeneID:54464 -> Biological process: GO:0016071 [mRNA metabolic process] evidence: TAS
GeneID:54464 -> Biological process: GO:0016075 [rRNA catabolic process] evidence: IMP
GeneID:54464 -> Biological process: GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay] evidence: TAS
GeneID:54464 -> Biological process: GO:0071028 [nuclear mRNA surveillance] evidence: IMP
GeneID:54464 -> Biological process: GO:0071044 [histone mRNA catabolic process] evidence: IMP
GeneID:54464 -> Cellular component: GO:0000932 [cytoplasmic mRNA processing body] evidence: IEA
GeneID:54464 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:54464 -> Cellular component: GO:0005794 [Golgi apparatus] evidence: IDA
GeneID:54464 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
GeneID:54464 -> Cellular component: GO:0005886 [plasma membrane] evidence: IDA
GeneID:54464 -> Cellular component: GO:0045111 [intermediate filament cytoskeleton] evidence: IDA
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