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2024-04-25 13:17:28, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001042603 10835 bp mRNA linear PRI 09-FEB-2013
DEFINITION Homo sapiens lysine (K)-specific demethylase 5A (KDM5A), mRNA.
ACCESSION NM_001042603
VERSION NM_001042603.1 GI:110618243
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 10835)
AUTHORS Beshiri,M.L., Holmes,K.B., Richter,W.F., Hess,S., Islam,A.B.,
Yan,Q., Plante,L., Litovchick,L., Gevry,N., Lopez-Bigas,N.,
Kaelin,W.G. Jr. and Benevolenskaya,E.V.
TITLE Coordinated repression of cell cycle genes by KDM5A and E2F4 during
differentiation
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (45), 18499-18504 (2012)
PUBMED 23093672
REMARK GeneRIF: In terminally differentiated cells, common KDM5A and E2F4
gene targets were bound by the pRB-related protein p130, a DREAM
complex component.
REFERENCE 2 (bases 1 to 10835)
AUTHORS Chicas,A., Kapoor,A., Wang,X., Aksoy,O., Evertts,A.G., Zhang,M.Q.,
Garcia,B.A., Bernstein,E. and Lowe,S.W.
TITLE H3K4 demethylation by Jarid1a and Jarid1b contributes to
retinoblastoma-mediated gene silencing during cellular senescence
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (23), 8971-8976 (2012)
PUBMED 22615382
REMARK GeneRIF: Jarid1a/b-mediated H3K4 demethylation contributes to
silencing of retinoblastoma target genes in senescent cells,
suggesting a mechanism by which retinoblastoma triggers gene
silencing.
REFERENCE 3 (bases 1 to 10835)
AUTHORS Pointon,J.J., Harvey,D., Karaderi,T., Appleton,L.H., Farrar,C. and
Wordsworth,B.P.
TITLE The histone demethylase JARID1A is associated with susceptibility
to ankylosing spondylitis
JOURNAL Genes Immun. 12 (5), 395-398 (2011)
PUBMED 21562575
REMARK GeneRIF: JARID1A or a locus in strong linkage disequilibrium with
it is a positional candidate for susceptibility to AS.
REFERENCE 4 (bases 1 to 10835)
AUTHORS Stratmann,A. and Haendler,B.
TITLE The histone demethylase JARID1A regulates progesterone receptor
expression
JOURNAL FEBS J. 278 (9), 1458-1469 (2011)
PUBMED 21348942
REMARK GeneRIF: that H3K4 tri- and dimethylation play an important role
and JARID1A is the histone-demethylating enzyme responsible for
removal of this mark
REFERENCE 5 (bases 1 to 10835)
AUTHORS Yan,H., Chen,X., Zhang,Q., Qin,J., Li,H., Liu,C., Calhoun-Davis,T.,
Coletta,L.D., Klostergaard,J., Fokt,I., Skora,S., Priebe,W., Bi,Y.
and Tang,D.G.
TITLE Drug-tolerant cancer cells show reduced tumor-initiating capacity:
depletion of CD44 cells and evidence for epigenetic mechanisms
JOURNAL PLoS ONE 6 (9), E24397 (2011)
PUBMED 21935404
REMARK GeneRIF: Evidence was provided that chronic drug exposure generated
drug-tolerant cells via epigenetic mechanisms involving molecules
such as CD44 and KDM5A.
REFERENCE 6 (bases 1 to 10835)
AUTHORS Mao,S., Neale,G.A. and Goorha,R.M.
TITLE T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding
protein 2
JOURNAL Oncogene 14 (13), 1531-1539 (1997)
PUBMED 9129143
REFERENCE 7 (bases 1 to 10835)
AUTHORS Baens,M., Aerssens,J., van Zand,K., Van den Berghe,H. and
Marynen,P.
TITLE Isolation and regional assignment of human chromosome 12p cDNAs
JOURNAL Genomics 29 (1), 44-52 (1995)
PUBMED 8530100
REFERENCE 8 (bases 1 to 10835)
AUTHORS Kim,Y.W., Otterson,G.A., Kratzke,R.A., Coxon,A.B. and Kaye,F.J.
TITLE Differential specificity for binding of retinoblastoma binding
protein 2 to RB, p107, and TATA-binding protein
JOURNAL Mol. Cell. Biol. 14 (11), 7256-7264 (1994)
PUBMED 7935440
REFERENCE 9 (bases 1 to 10835)
AUTHORS Fattaey,A.R., Helin,K., Dembski,M.S., Dyson,N., Harlow,E.,
Vuocolo,G.A., Hanobik,M.G., Haskell,K.M., Oliff,A., Defeo-Jones,D.
et al.
TITLE Characterization of the retinoblastoma binding proteins RBP1 and
RBP2
JOURNAL Oncogene 8 (11), 3149-3156 (1993)
PUBMED 8414517
REFERENCE 10 (bases 1 to 10835)
AUTHORS Defeo-Jones,D., Huang,P.S., Jones,R.E., Haskell,K.M., Vuocolo,G.A.,
Hanobik,M.G., Huber,H.E. and Oliff,A.
TITLE Cloning of cDNAs for cellular proteins that bind to the
retinoblastoma gene product
JOURNAL Nature 352 (6332), 251-254 (1991)
PUBMED 1857421
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC053893.1, DB079061.1,
AB209999.1 and AC007406.1.
Summary: The protein encoded by this gene is a ubiquitously
expressed nuclear protein. It binds directly, with several other
proteins, to retinoblastoma protein which regulates cell
proliferation. This protein also interacts with rhombotin-2 which
functions distinctly in erythropoiesis and in T-cell
leukemogenesis. Rhombotin-2 is thought to either directly affect
the activity of the encoded protein or may indirectly modulate the
functions of the retinoblastoma protein by binding to this protein.
[provided by RefSeq, Mar 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##RefSeq-Attributes-START##
Transcript_exon_combination_evidence :: AB209999.1 [ECO:0000332]
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-352 BC053893.1 1-352
353-863 DB079061.1 44-554
864-6568 AB209999.1 711-6415
6569-10835 AC007406.1 106980-111246 c
FEATURES Location/Qualifiers
source 1..10835
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="12"
/map="12p11"
gene 1..10835
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="lysine (K)-specific demethylase 5A"
/db_xref="GeneID:5927"
/db_xref="HGNC:9886"
/db_xref="MIM:180202"
exon 1..528
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
misc_feature 63..613
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="Region: Similar to Unigene cluster containing
AI017036 and W16898"
variation 92
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:11552171"
misc_feature 295..297
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="upstream in-frame stop codon"
CDS 364..5436
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="retinoblastoma-binding protein 2; retinoblastoma
binding protein 2; Jumonji, AT rich interactive domain 1A
(RBP2-like); Jumonji, AT rich interactive domain 1A
(RBBP2-like); histone demethylase JARID1A; jumonji/ARID
domain-containing protein 1A"
/codon_start=1
/product="lysine-specific demethylase 5A"
/protein_id="NP_001036068.1"
/db_xref="GI:110618244"
/db_xref="CCDS:CCDS41736.1"
/db_xref="GeneID:5927"
/db_xref="HGNC:9886"
/db_xref="MIM:180202"
/translation="
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKREKKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSFIMSYKLPMEDLKETS
"
misc_feature 436..540
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="Small domain found in the jumonji family of
transcription factors; Region: JmjN; smart00545"
/db_xref="CDD:128818"
misc_feature 610..873
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="ARID/BRIGHT DNA binding domain; Region: ARID;
pfam01388"
/db_xref="CDD:201763"
misc_feature 1246..1392
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="PHD-finger; Region: PHD; pfam00628"
/db_xref="CDD:201356"
misc_feature 1618..1632
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P29375.3);
Region: GSGFP motif"
misc_feature 1771..2121
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="JmjC domain, hydroxylase; Region: JmjC; pfam02373"
/db_xref="CDD:202224"
misc_feature 2389..2550
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="C5HC2 zinc finger; Region: zf-C5HC2; pfam02928"
/db_xref="CDD:190479"
misc_feature 2581..3579
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="PLU-1-like protein; Region: PLU-1; pfam08429"
/db_xref="CDD:203940"
misc_feature 3694..3696
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
misc_feature 3694..3696
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 3853..4008
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="PHD zinc finger; Region: PHD; smart00249"
/db_xref="CDD:197604"
misc_feature 4354..4356
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
misc_feature 4390..4392
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphothreonine; propagated from
UniProtKB/Swiss-Prot (P29375.3); phosphorylation site"
misc_feature 4396..4398
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
misc_feature 5155..5157
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
misc_feature 5155..5157
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 5170..5172
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
misc_feature 5170..5172
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="phosphorylation site"
misc_feature 5206..5337
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="PHD-finger; Region: PHD; pfam00628"
/db_xref="CDD:201356"
misc_feature 5230..5433
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (P29375.3);
Region: Interaction with LMO2"
misc_feature 5359..5361
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/experiment="experimental evidence, no additional details
recorded"
/note="Phosphoserine; propagated from UniProtKB/Swiss-Prot
(P29375.3); phosphorylation site"
exon 529..606
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 607..729
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 730..900
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
misc_feature 828..1192
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="Region: tg85f09.x1 Homo sapiens cDNA AI493397"
STS 839..951
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="G26350"
exon 901..1035
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 1036..1141
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 1142..1233
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 1234..1392
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
misc_feature 1248..1388
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="Region: yi91f11.r1 Homo sapiens cDNA R81128"
variation 1386
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2229352"
exon 1393..1512
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 1513..1671
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
misc_feature 1554..2720
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/note="Region: Similar to Unigene cluster containing
Z44246, AA053435, and AA703247"
exon 1672..1853
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 1854..2016
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2017..2136
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2137..2331
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2332..2513
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 2346
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:2229349"
exon 2514..2638
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2639..2789
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2790..2904
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 2905..3260
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 2957
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:11062385"
exon 3261..3399
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
STS 3396..3529
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH44598"
/db_xref="UniSTS:59193"
exon 3400..3579
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 3558
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:2229350"
exon 3580..3741
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 3742..4293
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 3931
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="g"
/db_xref="dbSNP:2229353"
exon 4294..4437
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 4438..4597
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 4512
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="g"
/replace="t"
/db_xref="dbSNP:2229351"
exon 4598..4818
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
exon 4819..5229
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
STS 4878..5002
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH70148"
/db_xref="UniSTS:34151"
exon 5230..10835
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/inference="alignment:Splign:1.39.8"
variation 5276
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="a"
/replace="g"
/db_xref="dbSNP:1049953"
variation 5534
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049954"
STS 5584..5718
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="D12S1897"
/db_xref="UniSTS:71658"
variation 5661
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="c"
/replace="t"
/db_xref="dbSNP:1049956"
STS 5795..6614
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="JARID1A_2177"
/db_xref="UniSTS:280794"
STS 6414..6504
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="D12S1914"
/db_xref="UniSTS:18654"
STS 7917..8077
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH68615"
/db_xref="UniSTS:74082"
variation 8607
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/replace="a"
/replace="c"
/db_xref="dbSNP:1043599"
STS 9015..9192
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH47587"
/db_xref="UniSTS:71747"
STS 9827..9952
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH11182"
/db_xref="UniSTS:40953"
STS 9885..9997
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="A003M44"
/db_xref="UniSTS:53263"
STS 10341..10564
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH70779"
/db_xref="UniSTS:40357"
STS 10498..10710
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="RH75356"
/db_xref="UniSTS:91513"
STS 10589..10754
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
/standard_name="STS-R65684"
/db_xref="UniSTS:69464"
polyA_signal 10727..10732
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
polyA_site 10763
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
polyA_site 10835
/gene="KDM5A"
/gene_synonym="JARID1A; RBBP-2; RBBP2; RBP2"
ORIGIN
gcagaactttggcgggcaaggagacaaacagccacactgtgctgccggggaagagaagaagaaggaaaggccagacacacaggcgtcgtgcagctgcggaaggattccgtttcctgcagggggcggagggatttgacagcacggtaacttccggaaaagtcctgaacctcagtggaaaagccttgcaagaaacaataacaaacgggaggaggaagcgattctggggtttctgtgttgaacggttcttgtccgcgaagatgcgcttcggcctctgtcaggggacttgaacgggcttagtgggcttcagccagcttttctccaccggttccccacggggacccccccccccccccggccgttgcaatggcgggcgtggggccggggggctacgcggcggagttcgtgccaccgccagagtgccccgtctttgagccgagttgggaggagttcacagatccgctcagctttatcggccgcatccggcctttggcggagaaaaccggcatctgcaaaattcggccgcccaaggactggcagcctccatttgcctgtgaagtaaaaagctttcgtttcactccaagagtccagcgcctgaatgaacttgaggcaatgaccagagtgagattggatttcttggatcaactagcaaaattttgggaacttcaaggatctactctgaagatccctgtggtagagagaaaaatcctggatctgtatgctttgagcaagattgttgccagcaaaggaggttttgaaatggtcaccaaagagaagaaatggtctaaagtgggtagtcgcttgggatatctgccaggaaaaggaactgggtctcttttgaagtcacattatgaaagaattctctacccatatgagcttttccagtctggtgtgagccttatgggtgtgcagatgcctaatttagatcttaaagaaaaagtggagcctgaggttctcagcactgatacccaaacttccccagagccaggcacaaggatgaacattctgccgaagagaacaagacgtgtgaagactcagtcagaatctggagatgtgagtagaaacacggaactgaagaaacttcagatttttggggctgggcccaaggttgtgggcttggcaatgggaacaaaagataaagaagatgaggtcacccgaagacgaaaagttaccaacaggtcagacgcatttaacatgcaaatgagacaacggaaaggcactctctctgttaactttgttgatctctatgtttgtatgttttgtggtcggggaaacaatgaagataaattgcttttgtgtgatggatgtgatgacagctatcatacattttgtctaattcctccactacctgatgtgcccaaaggagactggaggtgtcctaaatgtgtcgccgaggaatgtagcaaacctcgagaagcctttggatttgaacaagctgtacgagagtatacacttcagagctttggagagatggcagataattttaagtctgattattttaatatgccagtccatatggttcccacagaactagtagaaaaggaattttggcggctggtaagcagcattgaagaagatgttattgtggaatatggagcagatatctcctcaaaagactttggaagtggatttccggtgaaggatgggcggagaaagattctgccagaagaagaggaatatgcactttctggttggaatttgaataacatgcctgtcctggaacagtctgttcttgcacatattaatgtggacatctctggtatgaaagtgccgtggctctatgtgggaatgtgcttctcttctttttgctggcacattgaggatcactggagttattccatcaactacttgcactggggggagccaaagacatggtatggtgtgccatctcatgctgcagagcaactggaggaggtgatgagagagctggcccccgagttatttgaatcccagcctgatcttctgcatcagttagttaccatcatgaaccccaacgtgctaatggagcatggtgtgcctgtgtacaggaccaatcagtgtgctggcgagtttgttgtgacatttcctcgtgcctatcactctggatttaaccagggctacaactttgctgaagctgtgaacttctgtactgctgactggttgcccattggacgtcaatgtgtaaatcattaccgacgcctaaggcgccactgtgtcttttcacacgaggaactaattttcaagatggcagcagatccagaatgcttagatgtggggctggctgccatggtctgcaaagaattgactctcatgactgaagaagaaacacgattaagagagtctgttgtacagatgggtgtcctgatgtcagaagaagaagtgtttgaacttgttcctgatgatgagcggcagtgttcagcatgcagaaccacatgttttctctctgctctcacatgttcctgtaatcctgagcggcttgtatgtctctaccatccaactgatctgtgcccctgccccatgcagaagaaatgtcttagatatcgctacccattagaagacctcccttctctgctatatggtgtaaaagtcagggcacagtcctatgacacttgggtcagtcgtgttacagaagcattgtctgctaacttcaaccacaaaaaagatttgattgaattgcgagtaatgctggaagatgctgaggataggaaatacccagagaatgatctctttcgaaaactcagggatgctgtaaaagaagctgagacctgtgcttctgtggctcagctgcttctgagcaaaaagcagaaacacagacagagcccagatagtgggaggactcggaccaaactgacagtggaagaattgaaggcctttgtccaacaactttttagtcttccgtgtgtcatcagccaagctcggcaagtaaagaatctgctagatgatgtggaagagtttcatgaacgtgctcaggaggccatgatggatgaaaccccagattcttccaaactccagatgttgatagatatgggctctagtctctatgtggaactccctgaattaccacgactgaagcaagagctacaacaggctcggtggttggacgaagtaagactgaccttatcagatccgcaacaagtcactttggatgtcatgaagaagctgatagactctggggtagggttggcaccccaccatgctgtggagaaagcaatggctgaactacaggagctccttacagtctctgaacgatgggaagaaaaggctaaggtctgcctacaggcaagaccgaggcacagtgtggcaagtttagaaagcattgtgaatgaagccaagaacattccagcctttctacccaatgtgttgtccttgaaagaagccttacaaaaggctcgagaatggaccgctaaagtggaagctattcagagtggcagcaattacgcttatttggagcagcttgagagcttgtctgcgaaaggacgccctattcctgtgcgtcttgaagcactgccgcaagtggaatcacaggtagcagcagcacgggcatggagagaacggactgggcggacgtttcttaagaagaattctagccatacattgttacaggtgctgagcccccggaccgacattggtgtatatgggagtggcaaaaataggaggaaaaaagtaaaagaactaatagaaaaagaaaaagaaaaggatctggacctggagcctctgagtgatctggaggaaggattggaggaaaccagagatacagccatggtggtggcagttttcaaagaacgggagcaaaaagagattgaagccatgcattctctcagagcagccaacctagccaagatgacaatggtggaccgcatagaagaagtaaaattttgcatttgccgcaagacagccagtgggtttatgctacagtgtgagctctgcaaagactggttccataacagctgtgttcctcttcctaaatcaagttcccaaaaaaaaggatccagctggcaagctaaagaagtaaaattcctttgccctctttgtatgcggtctcgaaggcccaggctagagactattctgtcactcctggtatcccttcagaagttgcccgtacggttgcctgaaggagaggccctgcagtgtttgacagaacgtgctatgagttggcaagatagagcgcggcaggctctagccacagatgaactatcctctgccctggccaaactatctgtgttgagccagcgtatggtggaacaggcggctcgagaaaaaactgaaaagatcatcagtgcagaactccaaaaagcagctgccaatccagacttacagggacacttacctagtttccagcagtctgcttttaaccgggtggtgagcagtgtgtcatcttctcctcgacaaacaatggactatgatgatgaagaaacagactctgatgaagacattcgagagacatatggctacgacatgaaggacacagccagtgtgaagtcctctagtagtcttgaacccaatcttttttgtgatgaagagattcccatcaaatccgaggaggtggtgacccacatgtggacagcaccttcattttgtgcagagcatgcttattcttctgcttctaagagttgttctcaaggttctagcaccccaaggaaacaacctcggaagagccctttggtgccccgaagtttggaacctccagtgctggagttgtcacctggagctaaggcacaactggaagaacttatgatggttggagatctcctggaagtatctctggacgagactcaacacatatggcggattttgcaggccacacacccaccctctgaagacagattcttgcatatcatggaggatgacagcatggaagagaaaccactaaaagtgaaaggaaaggactcttcagagaagaaacggaaacggaagctagaaaaggtagagcaactttttggagaaggaaaacagaagtccaaggagttaaagaaaatggacaaacctagaaagaagaaattaaaattaggtgcagacaaatcaaaggagctgaataaactggccaagaaactagcaaaagaagaagagagaaagaaaaagaaggagaaggctgctgcagccaaagttgaacttgtgaaagagagcactgaaaagaaaagagagaaaaaggtgctggacatcccctcaaagtatgactggtcaggagcagaggagtctgatgatgagaatgctgtgtgcgcagcacagaactgccaaaggccctgcaaggacaaggtagactgggtacaatgtgatggtggctgtgatgagtggtttcatcaagtttgtgtgggtgtatctccagaaatggctgaaaatgaagattacatctgtataaactgtgcaaagaagcaggggccagttagcccaggtccagcaccacctccttccttcataatgagctacaaactaccaatggaggatcttaaagagaccagttagcagatgcttggttagtttgggacatggggggacatggaccacattgagaccttagtcatcaagtagagtggtttatatccacttggaatgttgcttccaaagatgaatggccttcagagaaagtccccttagtgctggcttcctctttgcatggactctgtgggttacattctctatcaacatatctatgcagagggtgtcttctttggtacaacagccaatatttcatgtctcctttgagtgtggtttactgcattaaggccagatgcttaattgagctctagggtggctggttagtattaatacattggtgtgctaacagggcatataggatgtggcttttgtccagctgatagtagttagaggcttacaacttaggagcagcaccaactgaaggtgctaattgcttggatctccttcattgggatagttggagagggattggagtaccactttccttccactgttacctggtacttaatgccctaaagatacaactaggagtaacagggccaaagttatttctgttagacgtcaaggaatggtatcacagtctattgacctcagcgatttgtgcttgtttgtgctagaagaacatcccaaataggagaacctctcacaagctggggcaggtcaccttatctttgtaagatgaggatatcatctagatcagaaatctgactagattggattctgaggagaagaacctactacaaggcaaggagccgttttttggctttgaaaagtcttgctgtcttgggtctacattttagggaagagcaggtacatggatccaggcttctgccaaaaaaaaaaagagaagaagatgacgatgatgaccagtcgtactatcttactgagccacagtgatgcatgcttttcggggaaaacttcattcacaagtattccagacaccaggcttcaggcatggccatgagcaagaccagcaaataacagctttttgccttgcagccctgaccccaatgtctgctgtttccaacactggtgatttctaactacggcccacagcagatgctgttgaataacaccatggcttcatcagaggatgtggggttgtagtacctctgggtgatgaagttgttttagtaaatccatttttaaaaaaaaaaaaggacttgtttttacttttttctaaatgtctctgactactgactgttctatacatagattatttttccttttttaatatacatatatgaatatataaatatatatatttactgttaccagcagcatatgacagagtttcaacatcaaaaatccatttgggggcttgctttttcttttttgctttaaaaaaaaaaatcccattccttctttgtagtacaaggagttagcactccctcctccatcccagcctgaccagatcttccattttgcttttgttcatatagataattatatgtcctttgtgtgttgggacttgtccctgtctgttgggaaacttggtctcactctagtctgtgctggctcttttttcttttgtgtgtgaatgtttgaaactatggtgctgtgtcctcttccctcctgttgtgttctctgttcttcttaaggtattaggtaagctgtatgtaaactcttattagaaggggactaatttttttttaaaggacaaaaaaaaaaatgactaaaaatagtgttttgtcatcactgtctggtgtctttattttggtttaaaaaaatctgtggtttgacttaaattcatcagttttccttttaaaggggggattggggtggacctagcaacagcttatagtttcctcttccctttttgccccagtctcttttaaagaactgtcttctagtaactagaagtgaaatgtactgtccagttacagtttgagtgggtatgagatttaactcaaaaggaatcttacaaaaaaaaagatgttttcttataaaatccaatttctgtaaatgttttctctgaagttcatactacctactttttattcattcttaatactgtataacattttgagtgttttgacttgttcagaggtttgttagtgttgctgtgcatatgtcttgaggtctcatctgaagtaagtttgtgtatgatcgaagatttcaatggatattgcaaggtaactaattaactgatttcataagttttcgttttgccaagctaacgattatcaattaagaatttcctctggttgatgttatacaagaaagcacaatattttttgcctgttgatcttctttgtaacagtcttcagatatttgtgggttaaaaattgaatgtaattttaagtgacagatgcctggaatacatttaaaatttttatttttccttcctaatcatccattaactattccactatcagtggagagtcatgaggatgctgagaaagtatgaatagcttcctgtcaccttctgacgttttgaaacttaaatatgtcttttcgttgatactgtgggattttctgtatttacttgacagtcatggaggatttggtatgacttgaccacaggtttagaccaaggctgagaagaacagaagggagaaattaatggcaaaacaaaaaatacacaaatctgcggttttggaattaatgaaacaagattcatctatttaaagaaatgttggtgttctaatacaaagcattattttcacttagagaaaattacttacttgctcccttctgtattgtaatattttgtattaagacatgatttaaaatgtctttctacccttatctcctctaaactgcaactgaagttgcaattcttcatcattagtattttaactctggcaaaggttatagaaagaaaaatggaaatatggtaggcctgtggtattcttaaaagctaagtcattagaactatgcagatccccaagtttaaaagtacaaatacagcaccagtagttagctttctagctgggggagaagacaggagatttttcttccacagatgtttattttgcttcctgataggtactgcagcaaagccatgttgatgtgtagatgcatgacttcctcactaagctgctgcacaccagctttgcctgcatgattcaaatttgtgcctcagtaaaattataaattattgcatgtcataccttgaataatggaaacggcaaacattaaacctgtgattacccataatgtactttaataataaaaaacatggcagccaggtgcagtagagtgcacctgtggtcaggaggctgaagtgggaagattgcttcaacctgtgagtttgagtcccgcctggtcaacagcgagaccccatgtgtctgtctgtctctctctttttttaaaggacagaggctaagctgtaaggttagcatggttctgcctgggctttgcttctgtgcttctgtgcaggctgagctgtaaggttagcatggttctgcctgggctttgcttctgcgcttctgtgcaggctgagctgtaaggttagcatggttctgcctgggctttgcttctgcgcttctgtgcaggctgagctgtaaggttagcatggttctgcctgggctttgcttctgcgcttctgtgctagcaggtgcccacaaaatgtctttttgaatttcttaatttttgggttctggatgcaattcgtgcacgccaagaaactacttgcttgtcagtattttaattctgtagtacatgtgtgtgaatatcagccagtacttacagtaggaggatgaacagaaaaactgagaagacctgtctttcaaaagatgggtttatccactttttaagggaaaaagtgacagtttggcatgggatttgaaaagtggaaattgtggaaaaattgagctgttgaagtcccacatataaccagatttaataaagcttcacatgtgaattagctccatatgtgtgtagaaggttgcttttatagcaggtccttaagtactccttttgaaattcctcctttttttttaagtcataccattacttctttggatatgaatgtcccaagtggtatctcctactgtagtatgaggaagaatggctgttaatgtattttttgaattttggtcttgtcttggcctggatcatatccagtcaccactatgcaacaaatgatgtgcactgggcaaggatatgatgggttatgaaagctgtatcttgtttgttttttcttttgcagtactccaagtggtctaaacaggaatgtcttgtaaaacctcaagactccctattgattattcccttacatatttatttacaatttatcagggtaattggtggtgccttatgaaaagtataactcgatttcttgatctttgagcatgttttgtgtttcttgtgttttctaaaagaatattagatatggttaattgcattacatctaaaagatttaaaaaattgtgtgtatgctcaggttccccacacccatacccaccctaacccctgtcatttacattggtggcaactttaaatggtaaccaagcaaaagtacattttgataatgagtattgataatcctgaggaaaactagtgagtatatgggagccacctttgacctgtgccaaagcagtttctaatttcatttgctaactataaaataaagaactgagccaaaataatttgatcagtggtgtgattagcctattatcattgctgagaatagtgtttttggagtgtgaagtgattcctgaagatttcacctgccttctgtttccagcaagaatccagtgatgaccaacacatttcctcacttttggttcttgagaagtttatccctttgcaacaaaccattaatagggaaaacaaggaaatgctttccctttctctttggcttcttaaagctcacaaccaattcagaccccaagttacttcagagaagcaaatggcaccttttccccattgccaaggatcccagcttatgcagatatgaaggacggatcatttctgaaaatgttaagactctgcttgcagtggacttggcctcagtttcatgaaatgtgtaactctgtatgtgtatgttaggaggagggttggttgaaagagcgggggcagggaggggaatctgattacctcttgggaaataattttcttgccaacaaaaagatacacttgaagtttcttaaggtggcaagtccattaaaaaaaaaaattgtgttggaccctcccagtttagatcaagtatttcttgggggtcttgctattgtggttgataccaataaatggaagatccagaatattttcatttaaagctcaaccattaattggaacatggtgaaacattgtacacattgtaaaagtagggaacagtacaaaagaatggaatcaaatactatattatgtgaataaactagagtgattttggaatttcactctcttcaccccttctcacttgtatgttctgtaaagtgtatttctactttggtaggaagaaagacttgatttaatatttc
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5927 -> Molecular function: GO:0003677 [DNA binding] evidence: IEA
GeneID:5927 -> Molecular function: GO:0003682 [chromatin binding] evidence: IEA
GeneID:5927 -> Molecular function: GO:0003700 [sequence-specific DNA binding transcription factor activity] evidence: TAS
GeneID:5927 -> Molecular function: GO:0008270 [zinc ion binding] evidence: IEA
GeneID:5927 -> Molecular function: GO:0016702 [oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] evidence: IEA
GeneID:5927 -> Molecular function: GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] evidence: IEA
GeneID:5927 -> Biological process: GO:0006366 [transcription from RNA polymerase II promoter] evidence: TAS
GeneID:5927 -> Biological process: GO:0007275 [multicellular organismal development] evidence: IEA
GeneID:5927 -> Biological process: GO:0016568 [chromatin modification] evidence: IEA
GeneID:5927 -> Biological process: GO:0045893 [positive regulation of transcription, DNA-dependent] evidence: IDA
GeneID:5927 -> Cellular component: GO:0005634 [nucleus] evidence: IDA
GeneID:5927 -> Cellular component: GO:0005730 [nucleolus] evidence: IEA
GeneID:5927 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
GeneID:5927 -> Cellular component: GO:0019907 [cyclin-dependent protein kinase activating kinase holoenzyme complex] evidence: IDA
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