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2019-03-25 08:19:30, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001042482            2302 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens thiamin pyrophosphokinase 1 (TPK1), transcript variant
            2, mRNA.
ACCESSION   NM_001042482
VERSION     NM_001042482.1  GI:110227856
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Mayr,J.A., Freisinger,P., Schlachter,K., Rolinski,B.,
            Zimmermann,F.A., Scheffner,T., Haack,T.B., Koch,J., Ahting,U.,
            Prokisch,H. and Sperl,W.
  TITLE     Thiamine pyrophosphokinase deficiency in encephalopathic children
            with defects in the pyruvate oxidation pathway
  JOURNAL   Am. J. Hum. Genet. 89 (6), 806-812 (2011)
   PUBMED   22152682
  REMARK    GeneRIF: Mutation analysis of TPK1 uncovered three missense, one
            splice-site, and one frameshift mutation resulting in decreased TPK
            protein levels
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Fradin,D. and Bougneres,P.
  TITLE     Three common intronic variants in the maternal and fetal thiamine
            pyrophosphokinase gene (TPK1) are associated with birth weight
  JOURNAL   Ann. Hum. Genet. 71 (PT 5), 578-585 (2007)
   PUBMED   17295612
  REMARK    GeneRIF: Genomic variations in either the fetal or maternal TPK1
            gene could contribute to variability of birth weight in normal
            humans.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Onozuka,M., Konno,H., Akaji,K., Nishino,H. and Nosaka,K.
  TITLE     Molecular cloning and analysis of the 5'-flanking region of the
            human thiamin pyrophosphokinase gene
  JOURNAL   J. Nutr. Sci. Vitaminol. 51 (4), 274-277 (2005)
   PUBMED   16262001
  REMARK    GeneRIF: findings indicate the importance of the Sp1 transcription
            factor cis-element in regulating the human thiamin
            pyrophosphokinase gene (hTPK1) gene expression
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Toyoshima,M., Oka,A., Egi,Y., Yamamoto,T., Onozuka,M., Nosaka,K.,
            Naito,E. and Yamada,K.
  TITLE     Thiamine-responsive congenital lactic acidosis: clinical and
            biochemical studies
  JOURNAL   Pediatr. Neurol. 33 (2), 98-104 (2005)
   PUBMED   16087053
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Bellyei,S., Szigeti,A., Boronkai,A., Szabo,Z., Bene,J., Janaky,T.,
            Barna,L., Sipos,K., Minik,O., Kravjak,A., Ohmacht,R., Melegh,B.,
            Zavodszky,P., Than,G.N., Sumegi,B., Bohn,H. and Than,N.G.
  TITLE     Cloning, sequencing, structural and molecular biological
            characterization of placental protein 20 (PP20)/human thiamin
            pyrophosphokinase (hTPK)
  JOURNAL   Placenta 26 (1), 34-46 (2005)
   PUBMED   15664409
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Nosaka,K., Onozuka,M., Nishino,H., Nishimura,H., Kawasaki,Y. and
            Ueyama,H.
  TITLE     Molecular cloning and expression of a mouse thiamin
            pyrophosphokinase cDNA
  JOURNAL   J. Biol. Chem. 274 (48), 34129-34133 (1999)
   PUBMED   10567383
  REMARK    GeneRIF: This is the first report on the primary sequence for
            mammalian thiamin pyrophosphokinase, a protein that catalyzes the
            pyrophosphorylation of thiamin with adenosine 5'-triphosphate to
            form thiamin pyrophosphate.
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Egi,Y., Koyama,S., Shioda,T., Yamada,K. and Kawasaki,T.
  TITLE     Identification, purification and reconstitution of thiamin
            metabolizing enzymes in human red blood cells
  JOURNAL   Biochim. Biophys. Acta 1160 (2), 171-178 (1992)
   PUBMED   1332781
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Haas,R.H.
  TITLE     Thiamin and the brain
  JOURNAL   Annu. Rev. Nutr. 8, 483-515 (1988)
   PUBMED   3060175
  REMARK    Review article
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Bohn,H. and Winckler,W.
  TITLE     Isolation and characterization of four new placental tissue
            proteins (PP18, PP19, PP20, PP21)
  JOURNAL   Arch. Gynecol. 236 (4), 235-242 (1985)
   PUBMED   3896163
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Iwashima,A., Kinugasa,A. and Nose,Y.
  TITLE     Radiometric assay for thiamine pyrophosphokinase activity in human
            leukocytes
  JOURNAL   Acta Vitaminol. Enzymol. 5 (1), 41-45 (1983)
   PUBMED   6303095
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA135998.1, BX446289.2,
            BI770816.1, AC004534.1 and BC040555.1.
            
            Summary: This gene encodes a protein, that exists as a homodimer,
            which catalyzes the conversion of thiamine to thiamine
            pyrophosphate. Alternate transcriptional splice variants, encoding
            different isoforms, have been characterized. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform b), compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX446289.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           ERS025084, ERS025088 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DA135998.1         1-18
            19-235              BX446289.2         1-217
            236-293             BI770816.1         152-209
            294-354             BX446289.2         275-335
            355-519             BI770816.1         269-433
            520-933             BX446289.2         501-914
            934-2074            AC004534.1         107534-108674       c
            2075-2302           BC040555.1         2598-2825
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34-q35"
     gene            1..2302
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="thiamin pyrophosphokinase 1"
                     /db_xref="GeneID:27010"
                     /db_xref="HGNC:17358"
                     /db_xref="MIM:606370"
     exon            1..87
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(8)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:189728006"
     variation       complement(30..31)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="at"
                     /replace="ga"
                     /db_xref="dbSNP:34581809"
     variation       complement(37)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185802456"
     variation       complement(68)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:181214483"
     exon            88..146
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     misc_feature    95..97
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="upstream in-frame stop codon"
     CDS             104..688
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /EC_number="2.7.6.2"
                     /note="isoform b is encoded by transcript variant 2;
                     placental protein 20; thiamine kinase; thiamine
                     diphosphokinase"
                     /codon_start=1
                     /product="thiamin pyrophosphokinase 1 isoform b"
                     /protein_id="NP_001035947.1"
                     /db_xref="GI:110227857"
                     /db_xref="CCDS:CCDS55178.1"
                     /db_xref="GeneID:27010"
                     /db_xref="HGNC:17358"
                     /db_xref="MIM:606370"
                     /translation="
MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS
"
     misc_feature    161..673
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="Thiamine pyrophosphokinase; Region: TPK; cd07995"
                     /db_xref="CDD:153431"
     misc_feature    164..679
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="thiamin pyrophosphokinase; Region: PLN02714"
                     /db_xref="CDD:178316"
     misc_feature    order(173..181,236..244,314..316,320..325,389..406,
                     560..562,566..568,602..613)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="active site"
                     /db_xref="CDD:153431"
     misc_feature    order(242..244,254..256,263..265,389..397,407..409,
                     449..451,500..502,506..508,512..514,518..523,599..601,
                     605..610,668..670)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:153431"
     misc_feature    order(314..316,389..400,560..562,566..568,602..613)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /note="thiamine binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:153431"
     variation       complement(124)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:201567119"
     exon            147..218
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(191)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:150306900"
     variation       complement(200)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368467309"
     variation       complement(201)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77358162"
     variation       complement(211)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375142717"
     exon            219..288
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       222
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:387906936"
     variation       complement(224)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:199780530"
     variation       complement(241)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:138773679"
     variation       251
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:387906935"
     variation       complement(255)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:202038293"
     variation       complement(260)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201086987"
     variation       complement(267)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:373745325"
     variation       complement(271)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:370527936"
     variation       complement(272)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:200717734"
     exon            289..361
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(331)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190902373"
     variation       complement(333)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145863885"
     variation       complement(334)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142178442"
     exon            362..457
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(429)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:186564802"
     exon            458..569
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(466)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:371701702"
     variation       complement(569)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367833269"
     exon            570..2292
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /inference="alignment:Splign:1.39.8"
     variation       complement(612)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:371271054"
     variation       complement(619)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:113536847"
     variation       complement(620)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:368458768"
     variation       complement(625)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:113056357"
     variation       complement(720)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375718551"
     variation       complement(777)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:113719353"
     variation       complement(792)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:115576202"
     variation       complement(803)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146756933"
     variation       complement(1149)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:142197214"
     variation       complement(1151)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193069601"
     variation       complement(1316..1317)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace=""
                     /replace="gaaatgatgtgaaaga"
                     /db_xref="dbSNP:140880403"
     variation       complement(1317)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:200480908"
     variation       complement(1339)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:372934267"
     variation       complement(1347)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149043256"
     variation       complement(1379)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144891862"
     variation       complement(1452)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:61594332"
     variation       complement(1502)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:190747119"
     variation       complement(1517)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149912480"
     variation       complement(1597)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373133137"
     variation       complement(1662)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139543062"
     variation       complement(1663)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:114826691"
     variation       complement(1835)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369414591"
     variation       complement(1866)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:147369616"
     variation       complement(1874)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:185049418"
     variation       complement(1877)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:369853323"
     STS             1974..2084
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /standard_name="SHGC-52409"
                     /db_xref="UniSTS:19055"
     variation       complement(2028)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:117837628"
     variation       complement(2033)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:111378541"
     variation       complement(2053)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145581947"
     STS             2092..2242
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /standard_name="RH103305"
                     /db_xref="UniSTS:97636"
     variation       complement(2129..2130)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace=""
                     /replace="gaat"
                     /db_xref="dbSNP:374194467"
     variation       complement(2155..2156)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:35199404"
     variation       complement(2180)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:376632615"
     variation       complement(2246)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193167794"
     variation       complement(2253)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:1024482"
     variation       complement(2263)
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:77542038"
     polyA_signal    2266..2271
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
     polyA_site      2292
                     /gene="TPK1"
                     /gene_synonym="HTPK1; PP20; THMD5"
ORIGIN      
aaggctcctcagccgagcgccgagcggtcgatcgccgtagctcccgcagcctgcgatctccagtctgtggctcctaccagccattgtaggccaataatccgttatggagcatgcctttaccccgttggagcccctgctttccactgggaatttgaagtactgccttgtaattcttaatcagcctttggacaactattttcgtcatctttggaacaaagctcttttaagagcctgtgccgatggaggtgccaaccgcttatatgatatcaccgaaggagagagagaaagctttttgcctgaattcatcaatggagactttgattctattaggcctgaagtcagagaatactatgctactaagggatgtgagctcatttcaactcctgatcaagaccacactgactttactaagtgccttaaaatgctccaaaagaagatagaagaaaaagacttaaagggaaagcacaggttgcatgtagacactggaatggagggtgattggtgtggccttattcctgttggacagccttgtatgcaggttacaaccacaggcctcaagtggaacctcacaaatgatgtgcttgcttttggaacattggtcagtacttccaatacctacgacgggtctggtgttgtgactgtggaaactgaccacccactcctctggaccatggccatcaaaagctaacctgttgactggcatccataagtgtgcctctgccttatctcatttctcaacagttcattgctcaacaagaacgattcacctgggtttgcaagaatctaaacctctctaggggaagcccactgggtttaaagatgttagtgtttagataatacaggtaacattataaatgacagatctcaattttatagtagtgggaaagatacatgctaagaaagcaaataagctctattatattcggttggaacctaatgggaatcattccactatacaattcagtactgattattcttcttacattattaatcattccatttatcctagaaaattgtttttaatttgaatcagagaaaactgttgaggttcctcttggagtctagaacatccttaaatgtctaacaacaagggctacctctgagtaccttttagtattagttttctgtatatgatatatattatcttatactgaaaaaaaattcctttcagattggggtgttagaagtgcaccaggtcactctgaccttattactgtctttggtattgtcttaaataaatcaagaatcattgacctaattgttaaatttaaaaataggtagttagcaataggtggaaagagaaatgatgtgaaagataaatgatgattcgtggagccctactcacacattaacccccaaattcaaaagtaagaatgcaaaagtctagagggggtaacagtctgcatcatcatcacaacctaaatggagaaagctgtgcagaggaaacttaagcataaaaattgaattcgtttctgacataccttagactgaaaaactgttggttcatccagaagtgtattcatattaccagaaaatgagtttgtctatggggatacatgaacttcatatactaaggagcctaactccaaagcctgcgttctcatcccagtctgatattcacctaagtttccggacccttttccttagctgtaaaatggaagcggttggactgatggtgtctgaggttctttcccacactgaaattctaaatattgacacttagcagtcatagggctgataatacacacagttactgacttagcctaaacaacctggtgcatcgaaatgtattcacctttcttttgtaaagagaccatcttctatcttctttccacctttctctgttttatgaaaccaactgttgacatacaaaccatgattgaaggagaacctgtccaacatgttttatgtacacaaatccctatgttgctataagaaaagtgaaagtaactgttttcttcttggtgctatgacagtgtgagactcaggttgtctgtagagaatgaaaggagcagtggcccgcgtgattgtggcatttaaggagcagtggcccatgtgactgtggcattttcggcacttttcattactttctgcttgaccggaagttgaggcttagctatgtttccatcttcagtttctgaagactagttatatattccttactagaaatatattcataatatataaaagaaatatatctgtgattttaaaattttgctaccaaagaatgcatgttctgtgtgccctgaaaatgttaccagtgttaataaatggatacttatcaaaaaagaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:27010 -> Molecular function: GO:0004788 [thiamine diphosphokinase activity] evidence: TAS
            GeneID:27010 -> Molecular function: GO:0005524 [ATP binding] evidence: IEA
            GeneID:27010 -> Molecular function: GO:0016301 [kinase activity] evidence: IEA
            GeneID:27010 -> Biological process: GO:0006766 [vitamin metabolic process] evidence: TAS
            GeneID:27010 -> Biological process: GO:0006767 [water-soluble vitamin metabolic process] evidence: TAS
            GeneID:27010 -> Biological process: GO:0006772 [thiamine metabolic process] evidence: IEA
            GeneID:27010 -> Biological process: GO:0009229 [thiamine diphosphate biosynthetic process] evidence: IEA
            GeneID:27010 -> Biological process: GO:0042723 [thiamine-containing compound metabolic process] evidence: TAS
            GeneID:27010 -> Biological process: GO:0044281 [small molecule metabolic process] evidence: TAS
            GeneID:27010 -> Cellular component: GO:0005737 [cytoplasm] evidence: IDA
            GeneID:27010 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001035947 -> EC 2.7.6.2

by @meso_cacase at DBCLS
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