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2024-03-29 16:47:59, GGRNA : RefSeq release 60 (20130726)

LOCUS       NM_001042452            2875 bp    mRNA    linear   PRI 17-APR-2013
DEFINITION  Homo sapiens serine/threonine protein kinase MST4 (MST4),
            transcript variant 3, mRNA.
ACCESSION   NM_001042452
VERSION     NM_001042452.1  GI:109633025
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2875)
  AUTHORS   Xu,X., Wang,X., Ding,J. and Wang,D.C.
  TITLE     Crystallization and preliminary crystallographic studies of CCM3 in
            complex with the C-terminal domain of MST4
  JOURNAL   Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68 (PT 7),
            760-763 (2012)
   PUBMED   22750858
  REMARK    GeneRIF: crystal of the CCM3-MST4 C-terminal domain complex
            belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell
            parameters a = 69.10, b = 69.10, c = 117.57 A
REFERENCE   2  (bases 1 to 2875)
  AUTHORS   ten Klooster,J.P., Jansen,M., Yuan,J., Oorschot,V., Begthel,H., Di
            Giacomo,V., Colland,F., de Koning,J., Maurice,M.M., Hornbeck,P. and
            Clevers,H.
  TITLE     Mst4 and Ezrin induce brush borders downstream of the
            Lkb1/Strad/Mo25 polarization complex
  JOURNAL   Dev. Cell 16 (4), 551-562 (2009)
   PUBMED   19386264
  REMARK    GeneRIF: These data define a brush border induction pathway
            downstream of the Lkb1/Strad/Mo25 polarization complex, yet
            separate from other polarity events.
REFERENCE   3  (bases 1 to 2875)
  AUTHORS   Goudreault,M., D'Ambrosio,L.M., Kean,M.J., Mullin,M.J.,
            Larsen,B.G., Sanchez,A., Chaudhry,S., Chen,G.I., Sicheri,F.,
            Nesvizhskii,A.I., Aebersold,R., Raught,B. and Gingras,A.C.
  TITLE     A PP2A phosphatase high density interaction network identifies a
            novel striatin-interacting phosphatase and kinase complex linked to
            the cerebral cavernous malformation 3 (CCM3) protein
  JOURNAL   Mol. Cell Proteomics 8 (1), 157-171 (2009)
   PUBMED   18782753
REFERENCE   4  (bases 1 to 2875)
  AUTHORS   Ma,X., Zhao,H., Shan,J., Long,F., Chen,Y., Chen,Y., Zhang,Y.,
            Han,X. and Ma,D.
  TITLE     PDCD10 interacts with Ste20-related kinase MST4 to promote cell
            growth and transformation via modulation of the ERK pathway
  JOURNAL   Mol. Biol. Cell 18 (6), 1965-1978 (2007)
   PUBMED   17360971
  REMARK    GeneRIF: Results show that PDCD10 modulation of ERK signaling is
            mediated by MST4, and that PDCD10 may be a regulatory adaptor
            necessary for MST4 function, suggesting a link between cerebral
            cavernous malformation and the ERK-MAPK cascade via PDCD10/MST4.
REFERENCE   5  (bases 1 to 2875)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   6  (bases 1 to 2875)
  AUTHORS   Dan,I., Ong,S.E., Watanabe,N.M., Blagoev,B., Nielsen,M.M.,
            Kajikawa,E., Kristiansen,T.Z., Mann,M. and Pandey,A.
  TITLE     Cloning of MASK, a novel member of the mammalian germinal center
            kinase III subfamily, with apoptosis-inducing properties
  JOURNAL   J. Biol. Chem. 277 (8), 5929-5939 (2002)
   PUBMED   11741893
  REMARK    GeneRIF: cloning of a germinal center iii kinase that induces
            apoptosis
REFERENCE   7  (bases 1 to 2875)
  AUTHORS   Lin,J.L., Chen,H.C., Fang,H.I., Robinson,D., Kung,H.J. and
            Shih,H.M.
  TITLE     MST4, a new Ste20-related kinase that mediates cell growth and
            transformation via modulating ERK pathway
  JOURNAL   Oncogene 20 (45), 6559-6569 (2001)
   PUBMED   11641781
REFERENCE   8  (bases 1 to 2875)
  AUTHORS   Qian,Z., Lin,C., Espinosa,R., LeBeau,M. and Rosner,M.R.
  TITLE     Cloning and characterization of MST4, a novel Ste20-like kinase
  JOURNAL   J. Biol. Chem. 276 (25), 22439-22445 (2001)
   PUBMED   11306563
REFERENCE   9  (bases 1 to 2875)
  AUTHORS   Dan,I., Watanabe,N.M. and Kusumi,A.
  TITLE     The Ste20 group kinases as regulators of MAP kinase cascades
  JOURNAL   Trends Cell Biol. 11 (5), 220-230 (2001)
   PUBMED   11316611
REFERENCE   10 (bases 1 to 2875)
  AUTHORS   Liu,K.C. and Wang,D.
  TITLE     [Synthesis of n-substituted beta-methyl DL-aspartates as potential
            hypocholesteremics (author's transl)]
  JOURNAL   Arch. Pharm. (Weinheim) 308 (7), 564-570 (1975)
   PUBMED   1164178
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF344883.1 and BC070056.1.
            
            Summary: The product of this gene is a member of the GCK group III
            family of kinases, which are a subset of the Ste20-like kinases.
            The encoded protein contains an amino-terminal kinase domain, and a
            carboxy-terminal regulatory domain that mediates homodimerization.
            The protein kinase localizes to the Golgi apparatus and is
            specifically activated by binding to the Golgi matrix protein
            GM130. It is also cleaved by caspase-3 in vitro, and may function
            in the apoptotic pathway. Several alternatively spliced transcript
            variants of this gene have been described, but the full-length
            nature of some of these variants has not been determined. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon, compared to variant 1. The resulting isoform (3) is shorter
            compared to isoform 1, and lacks kinase activity.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF344883.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           ERS025084, ERS025085 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1186              AF344883.1         1-1186
            1187-2359           BC070056.1         1579-2751
            2360-2875           BC070056.1         2753-3268
FEATURES             Location/Qualifiers
     source          1..2875
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..2875
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="serine/threonine protein kinase MST4"
                     /db_xref="GeneID:51765"
                     /db_xref="MIM:300547"
     exon            1..52
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     CDS             11..1075
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     STE20-like kinase MST4; Mst3 and SOK1-related kinase;
                     mammalian Ste20-like protein kinase 4; mammalian sterile
                     20-like 4; serine/threonine-protein kinase MASK"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MST4 isoform 3"
                     /protein_id="NP_001035917.1"
                     /db_xref="GI:109633026"
                     /db_xref="CCDS:CCDS43995.1"
                     /db_xref="GeneID:51765"
                     /db_xref="MIM:300547"
                     /translation="
MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHSDDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPAFAELKQQDENNASRNQAIEELEKSIAVAEAACPGITDKMVKKLIEKFQKCSADESP
"
     misc_feature    74..709
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="Protein Kinases, catalytic domain; Region:
                     PKc_like; cl09925"
                     /db_xref="CDD:213116"
     misc_feature    80..>607
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="Serine/Threonine protein kinases, catalytic domain;
                     Region: S_TKc; smart00220"
                     /db_xref="CDD:197582"
     misc_feature    order(98..112,122..124,161..163,167..169,257..259,
                     305..316,326..328,332..334,440..442,446..448,452..457,
                     461..463,494..496,503..505,551..562)
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="active site"
                     /db_xref="CDD:173623"
     misc_feature    order(98..112,122..124,161..163,167..169,257..259,
                     305..316,326..328,440..442,446..448,452..457,461..463,
                     494..496)
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:173623"
     misc_feature    order(110..112,326..328,332..334,440..442,446..448,
                     452..454,503..505,551..562)
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:173623"
     misc_feature    order(491..511,551..562)
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:173623"
     misc_feature    542..544
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="phosphorylation site"
                     /db_xref="HPRD:06663"
     variation       36
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:56035648"
     variation       37
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:369364323"
     exon            53..283
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       67
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:11555984"
     variation       73
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:146889914"
     variation       95
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:375587063"
     variation       143
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56044451"
     variation       189
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:193206254"
     variation       211
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:141788407"
     variation       265
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:150155667"
     variation       267
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:138637956"
     exon            284..340
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     exon            341..449
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       374
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:146294919"
     variation       387
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:375206609"
     variation       436
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:139634080"
     variation       437
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:369853762"
     exon            450..607
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       541
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:142833022"
     variation       603
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201522308"
     exon            608..756
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       610
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:150917439"
     variation       658
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:139399862"
     variation       693
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:144238597"
     STS             696..825
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /standard_name="RH65695"
                     /db_xref="UniSTS:65096"
     variation       739
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:3210621"
     variation       742
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:56021439"
     variation       746
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:141248916"
     exon            757..850
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       791
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:3210622"
     variation       832
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:370089311"
     variation       846
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:145082590"
     exon            851..913
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       886
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:145005460"
     exon            914..1050
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       937
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:371247497"
     variation       967
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:34419165"
     variation       981
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:201251228"
     variation       994
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:374158091"
     variation       999
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:141969228"
     exon            1051..2859
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /inference="alignment:Splign:1.39.8"
     variation       1066
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:367783889"
     variation       1070
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:149095600"
     variation       1088
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:368300222"
     STS             1217..1342
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /standard_name="RH16585"
                     /db_xref="UniSTS:53890"
     variation       1475
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace=""
                     /replace="t"
                     /db_xref="dbSNP:373523628"
     variation       1483..1484
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:200019710"
     variation       1483
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:5933061"
     variation       1484..1485
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace=""
                     /replace="a"
                     /db_xref="dbSNP:201033420"
     variation       1484
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:995246"
     variation       1485
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:190158958"
     variation       1552
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="c"
                     /db_xref="dbSNP:370760997"
     variation       1559
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:182430156"
     variation       1563
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:186750291"
     variation       1628
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="t"
                     /db_xref="dbSNP:191219104"
     variation       1772
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:185717782"
     variation       2038
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="g"
                     /replace="t"
                     /db_xref="dbSNP:111875905"
     variation       2115..2117
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace=""
                     /replace="gat"
                     /db_xref="dbSNP:376484357"
     STS             2317..2440
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /standard_name="WI-16556"
                     /db_xref="UniSTS:45781"
     variation       2462
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="g"
                     /db_xref="dbSNP:373630576"
     variation       2607
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="a"
                     /replace="t"
                     /db_xref="dbSNP:189045844"
     STS             2715..2842
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /standard_name="WI-11835"
                     /db_xref="UniSTS:21460"
     variation       2728
                     /gene="MST4"
                     /gene_synonym="MASK"
                     /replace="c"
                     /replace="g"
                     /db_xref="dbSNP:193010445"
     polyA_signal    2836..2841
                     /gene="MST4"
                     /gene_synonym="MASK"
     polyA_site      2859
                     /gene="MST4"
                     /gene_synonym="MASK"
ORIGIN      
attcgcctccatggcccactcgccggtggctgtccaagtgcctgggatgcagaataacatagctgatccagaagaactgttcacaaaattagagcgcattgggaaaggctcatttggggaagttttcaaaggaattgataaccgtacccagcaagtcgttgctattaaaatcatagaccttgaggaagccgaagatgaaatagaagacattcagcaagaaataactgtcttgagtcaatgtgacagctcatatgtaacaaaatactatgggtcatatttaaaggggtctaaattatggataataatggaatacctgggcggtggttcagcactggatcttcttcgagctggtccatttgatgagttccagattgctaccatgctaaaggaaattttaaaaggtctggactatctgcattcagaaaagaaaattcaccgagacataaaagctgccaatgtcttgctctcagaacaaggagatgttaaacttgctgattttggagttgctggtcagctgacagatacacagattaaaagaaatacctttgtgggaactccattttggatggctcctgaagttattcaacagtcagcttatgactcaaaacgtcctacagcaaaagaacttctgaaacacaaattcattgtaaaaaattcaaagaagacttcttatctgactgaactgatagatcgttttaagagatggaaggcagaaggacacagtgatgatgaatctgattccgagggctctgattcggaatctaccagcagggaaaacaatactcatcctgaatggagctttaccaccgtacgaaagaagcctgatccaaagaaagtacagaatggggcagagcaagatcttgtgcaaaccctgagttgtttgtctatgataatcacacctgcatttgctgaacttaaacagcaggacgagaataacgctagcaggaatcaggcgattgaagaactcgagaaaagtattgctgtggctgaagccgcctgtcccggcatcacagataaaatggtgaagaaactaattgaaaaatttcaaaagtgttcagcagacgaatccccctaagaaacttattattggcttctgtttcatatggacccagagagccccaccaaacctacgtcaagattaacaatgcttaacccatgagctccatgtgccttttggatctttgcaacactgaagatttggaagaagctattaaactattttgtgatggcgtttatcattttatattttgaaaggattattttgtaaggaataacttttaatactatagtttcacctgtattctagtaaatgttgagacaccgttttgcttttaagtatccctatttcttaagttacgaggatgaatacctttcacattttgatctttagttgactctacagtcatgaaacatacaggtctttcaaagtcattctcaatattcagcttttgtaaattatcaagcttcaaaaagcttttttttttaaaaaaaaacatgcatattctaaaaatgactattggtggggaggtgtaaataagtcataccttcttaaaacagaaaatttaagtaaagtcttttaaatgaaacctgtaaaagtattgactcttctaccaagttggtatgatattccaggcagctcaatgattatcacatttgagaccctgtgtttgaagcatttacaggcaatgtacagcaacagaggtacctcttggtgtatagtatttacattctcttttaggtagaagaggcaattttacccttatttcacatggttagaaatttaaagcaagatcatttacccaaggataggtgtttggtaatgttgaaggagttagtctggcttcatgttttacatcttcaactaaaatcccatactatctgcttggatttggagagccaaaaaataaagctgattgtcatgtgattaaatatctgatcaacaggtatgaatataacttaaatcagcatatttttgccatggtaataaattgtcctataaactatttatatatttttgttcttcataattatcactaataagcatcagtttgttgtttttaaaaggatatttaagtgagcattttctagttcatatgaaaataaccatagtacaggatgatttctgtccacacaaaggttaaattagattgcacagttaattttcacttatatttatggtactattatgtgggtgatgcctttttcttttaagcccagtacatatattatgcctgcctaagttctgaactggggctgtatttcagtagttgtagaattattgatatttagttttgatagctaatgtttaattgtttggatctgcacagtttggtttttgcacaaaagtcatttaaaaaaatctgagtaattgtcaaatattaaaagaaagatattcttcctgtaaggaatacagtttttagtcaaagtggccattacatcctctttttaatttacataatacagatacttgagaaagttgttgtggtgttgtatgccaagaaaattctttttattggtgcctatattgtaacaattatttttaatgcattgtattttgaagtaacggttcagttaaatttttcacctgctgtgtaactgaaacacaattacagtttataatcatctgtagaagtctggagataattttgcaactcatgttatgggttaaatgaatatttttgtaaaagtaaaagcaacaaatttataaattgattatttgaaactttacaacacaattgcatcccaaatacaaattgtattgcttattcattatagctattcgtcctgtaatctgtttctaggtgaagcatactccagtgttttaggggttttgaaaataaatatttaaatttcacagtcaaaaaaaaaaaaaaaa
//

Annotations:

ANNOTATIONS from NCBI Entrez Gene (20130726):
            GeneID:51765 -> Molecular function: GO:0000287 [magnesium ion binding] evidence: IDA
            GeneID:51765 -> Molecular function: GO:0004672 [protein kinase activity] evidence: IDA
            GeneID:51765 -> Molecular function: GO:0004674 [protein serine/threonine kinase activity] evidence: IEA
            GeneID:51765 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
            GeneID:51765 -> Molecular function: GO:0005524 [ATP binding] evidence: IDA
            GeneID:51765 -> Molecular function: GO:0042802 [identical protein binding] evidence: IPI
            GeneID:51765 -> Biological process: GO:0006468 [protein phosphorylation] evidence: IDA
            GeneID:51765 -> Biological process: GO:0006915 [apoptotic process] evidence: TAS
            GeneID:51765 -> Biological process: GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] evidence: TAS
            GeneID:51765 -> Biological process: GO:0042981 [regulation of apoptotic process] evidence: IDA
            GeneID:51765 -> Cellular component: GO:0000139 [Golgi membrane] evidence: IEA
            GeneID:51765 -> Cellular component: GO:0005829 [cytosol] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
            NP_001035917 -> EC 2.7.11.1

by @meso_cacase at DBCLS
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