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2024-04-20 12:30:33, GGRNA : RefSeq release 60 (20130726)
LOCUS NM_001040712 8257 bp mRNA linear PRI 15-JUN-2013
DEFINITION Homo sapiens protein tyrosine phosphatase, receptor type, D
(PTPRD), transcript variant 5, mRNA.
ACCESSION NM_001040712
VERSION NM_001040712.2 GI:283484018
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 8257)
AUTHORS Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
Ferrucci,L., Fornage,M. and Mozaffarian,D.
TITLE Genome-wide association study identifies novel loci associated with
concentrations of four plasma phospholipid fatty acids in the de
novo lipogenesis pathway: results from the Cohorts for Heart and
Aging Research in Genomic Epidemiology (CHARGE) consortium
JOURNAL Circ Cardiovasc Genet 6 (2), 171-183 (2013)
PUBMED 23362303
REFERENCE 2 (bases 1 to 8257)
AUTHORS Du,Y., Su,T., Tan,X., Li,X., Xie,J., Wang,G., Shen,J., Hou,J. and
Cao,G.
TITLE Polymorphism in protein tyrosine phosphatase receptor delta is
associated with the risk of clear cell renal cell carcinoma
JOURNAL Gene 512 (1), 64-69 (2013)
PUBMED 23069849
REMARK GeneRIF: Polymorphism in protein tyrosine phosphatase receptor
delta is associated with the risk of clear cell renal cell
carcinoma.
REFERENCE 3 (bases 1 to 8257)
AUTHORS Meng,W., Butterworth,J., Bradley,D.T., Hughes,A.E., Soler,V.,
Calvas,P. and Malecaze,F.
TITLE A genome-wide association study provides evidence for association
of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in
the French Population
JOURNAL Invest. Ophthalmol. Vis. Sci. 53 (13), 7983-7988 (2012)
PUBMED 23049088
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 8257)
AUTHORS Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
Rotter,J.I., Artigas,M.S., Starr,J.M., Uitterlinden,A.G.,
Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
and Stricker,B.H.
TITLE Genome-wide association studies identify CHRNA5/3 and HTR4 in the
development of airflow obstruction
JOURNAL Am. J. Respir. Crit. Care Med. 186 (7), 622-632 (2012)
PUBMED 22837378
REFERENCE 5 (bases 1 to 8257)
AUTHORS Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
Gibbs,R.A. and Butte,N.F.
TITLE Novel genetic loci identified for the pathophysiology of childhood
obesity in the Hispanic population
JOURNAL PLoS ONE 7 (12), E51954 (2012)
PUBMED 23251661
REFERENCE 6 (bases 1 to 8257)
AUTHORS Blanchetot,C., Tertoolen,L.G., Overvoorde,J. and den Hertog,J.
TITLE Intra- and intermolecular interactions between intracellular
domains of receptor protein-tyrosine phosphatases
JOURNAL J. Biol. Chem. 277 (49), 47263-47269 (2002)
PUBMED 12376545
REMARK GeneRIF: interactions between RPTP-domain1s and RPTP-domain 2s are
a common but specific mechanism that is likely to be regulated-
domain2s and the wedge structures are crucial determinants of
binding specificity, thus regulating cross-talk between RPTPs
REFERENCE 7 (bases 1 to 8257)
AUTHORS Wallace,M.J., Fladd,C., Batt,J. and Rotin,D.
TITLE The second catalytic domain of protein tyrosine phosphatase delta
(PTP delta) binds to and inhibits the first catalytic domain of PTP
sigma
JOURNAL Mol. Cell. Biol. 18 (5), 2608-2616 (1998)
PUBMED 9566880
REFERENCE 8 (bases 1 to 8257)
AUTHORS Pulido,R., Serra-Pages,C., Tang,M. and Streuli,M.
TITLE The LAR/PTP delta/PTP sigma subfamily of transmembrane
protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and
PTP sigma isoforms are expressed in a tissue-specific manner and
associate with the LAR-interacting protein LIP.1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (25), 11686-11690 (1995)
PUBMED 8524829
REFERENCE 9 (bases 1 to 8257)
AUTHORS Pulido,R., Krueger,N.X., Serra-Pages,C., Saito,H. and Streuli,M.
TITLE Molecular characterization of the human transmembrane
protein-tyrosine phosphatase delta. Evidence for tissue-specific
expression of alternative human transmembrane protein-tyrosine
phosphatase delta isoforms
JOURNAL J. Biol. Chem. 270 (12), 6722-6728 (1995)
PUBMED 7896816
REFERENCE 10 (bases 1 to 8257)
AUTHORS Krueger,N.X., Streuli,M. and Saito,H.
TITLE Structural diversity and evolution of human receptor-like protein
tyrosine phosphatases
JOURNAL EMBO J. 9 (10), 3241-3252 (1990)
PUBMED 2170109
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DR001889.1, AB208869.1,
AL356584.21, AL590397.7, AL445926.5 and BM680342.1.
On Jan 8, 2010 this sequence version replaced gi:104487001.
Summary: The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an extracellular
region, a single transmembrane segment and two tandem
intracytoplasmic catalytic domains, and thus represents a
receptor-type PTP. The extracellular region of this protein is
composed of three Ig-like and eight fibronectin type III-like
domains. Studies of the similar genes in chicken and fly suggest
the role of this PTP is in promoting neurite growth, and regulating
neurons axon guidance. Multiple alternatively spliced transcript
variants of this gene have been reported. A related pseudogene has
been identified on chromosome 5. [provided by RefSeq, Jan 2010].
Transcript Variant: This variant (5) has multiple differences in
the coding region, compared to variant 1, resulting in an isoform
(5) that is shorter than isoform 1. The 5' UTR of this variant is
incomplete because no 5' complete transcripts representing this
variant exist, and there are alternate splicing choices in the
upstream region.
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
RNAseq introns :: mixed/partial sample support ERS025081, ERS025082
[ECO:0000350]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-174 DR001889.1 76-249
175-1341 AB208869.1 1-1167
1342-1342 AL356584.21 17258-17258 c
1343-3126 AB208869.1 1169-2952
3127-3127 AL590397.7 136670-136670 c
3128-5562 AB208869.1 2954-5388
5563-7601 AL445926.5 119217-121255 c
7602-8257 BM680342.1 1-656 c
FEATURES Location/Qualifiers
source 1..8257
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="9"
/map="9p23-p24.3"
gene 1..8257
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="protein tyrosine phosphatase, receptor type, D"
/db_xref="GeneID:5789"
/db_xref="HGNC:9668"
/db_xref="MIM:601598"
exon 1..167
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
misc_feature 20..22
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="upstream in-frame stop codon"
CDS 104..4612
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/EC_number="3.1.3.48"
/note="isoform 5 precursor is encoded by transcript
variant 5; protein tyrosine phosphatase, receptor type,
delta polypeptide; receptor-type tyrosine-protein
phosphatase delta; R-PTP-delta; protein-tyrosine
phosphatase delta"
/codon_start=1
/product="receptor-type tyrosine-protein phosphatase delta
isoform 5 precursor"
/protein_id="NP_001035802.1"
/db_xref="GI:104487002"
/db_xref="CCDS:CCDS55288.1"
/db_xref="GeneID:5789"
/db_xref="HGNC:9668"
/db_xref="MIM:601598"
/translation="
MVHVARLLLLLLTFFLRTDAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT
"
sig_peptide 104..163
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
mat_peptide 164..4609
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/product="receptor-type tyrosine-protein phosphatase delta
isoform 5"
misc_feature 173..448
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 191..448
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin; Region: IG; smart00409"
/db_xref="CDD:197707"
misc_feature 530..766
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Second immunoglobulin (Ig)-like domain of the
receptor protein tyrosine phosphatase (RPTP)-F, also known
as LAR; Region: Ig2_RPTP_IIa_LAR_like; cd05738"
/db_xref="CDD:143215"
misc_feature 806..1051
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Immunoglobulin I-set domain; Region: I-set;
pfam07679"
/db_xref="CDD:191810"
misc_feature 842..1048
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Third immunoglobulin (Ig)-like domain of the
receptor protein tyrosine phosphatase (RPTP)-F, also known
as LAR; Region: Ig3_RPTP_IIa_LAR_like; cd05739"
/db_xref="CDD:143216"
misc_feature 1061..1330
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1061..1063,1247..1249,1292..1294)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1295..1300,1304..1309)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1349..1627
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1544..1546,1589..1591)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1592..1597,1601..1606)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1640..1906
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature order(1640..1642,1823..1825,1868..1870)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Interdomain contacts; other site"
/db_xref="CDD:28945"
misc_feature order(1871..1876,1880..1885)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Cytokine receptor motif; other site"
/db_xref="CDD:28945"
misc_feature 1925..>2119
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Fibronectin type 3 domain; One of three types of
internal repeats found in the plasma protein fibronectin.
Its tenth fibronectin type III repeat contains an RGD cell
recognition sequence in a flexible loop between 2 strands.
Approximately 2% of all...; Region: FN3; cd00063"
/db_xref="CDD:28945"
misc_feature 2939..3706
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 3017..3706
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(3434..3436,3527..3532,3539..3541,3548..3553)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="active site"
/db_xref="CDD:28929"
misc_feature 3800..4579
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatase, catalytic domain;
Region: PTPc; smart00194"
/db_xref="CDD:197567"
misc_feature 3887..4579
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="Protein tyrosine phosphatases (PTP) catalyze the
dephosphorylation of phosphotyrosine peptides; they
regulate phosphotyrosine levels in signal transduction
pathways. The depth of the active site cleft renders the
enzyme specific for phosphorylated Tyr; Region: PTPc;
cd00047"
/db_xref="CDD:28929"
misc_feature order(4301..4303,4400..4405,4412..4414,4421..4426)
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/note="active site"
/db_xref="CDD:28929"
exon 168..313
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 314..455
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 456..644
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 612..874
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="GDB:582179"
/db_xref="UniSTS:157878"
exon 645..662
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 663..773
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 774..785
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 786..1055
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1056..1637
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
variation 1090
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:3763653"
STS 1622..1987
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="GDB:582186"
/db_xref="UniSTS:157880"
exon 1638..1771
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1772..1916
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 1917..2014
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2015..2274
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2275..2365
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2366..2575
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2576..2736
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2737..2748
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2749..2861
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2862..2959
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 2960..3083
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3084..3259
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3260..3379
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3380..3534
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3535..3820
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 3821..3999
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 3893..4111
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="PTPRD"
/db_xref="UniSTS:512659"
exon 4000..4126
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 4087..4592
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="Ptprd"
/db_xref="UniSTS:545976"
exon 4127..4252
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4253..4407
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4408..4543
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
exon 4544..8240
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/inference="alignment:Splign:1.39.8"
STS 4623..5063
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="SGC35386"
/db_xref="UniSTS:31522"
variation 5513
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="c"
/replace="t"
/db_xref="dbSNP:1051863"
STS 5577..5595
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/db_xref="UniSTS:98954"
variation 6208
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:11542527"
polyA_signal 6228..6233
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
polyA_site 6252
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
STS 6550..6730
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="D9S1044E"
/db_xref="UniSTS:151264"
STS 6585..6757
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="RH47322"
/db_xref="UniSTS:12791"
variation 6826
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="g"
/db_xref="dbSNP:1065682"
STS 7186..7303
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="A003M12"
/db_xref="UniSTS:64813"
STS 7249..7390
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/standard_name="G31002"
/db_xref="UniSTS:79310"
variation 7498
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
/replace="a"
/replace="c"
/db_xref="dbSNP:3739579"
polyA_signal 8218..8223
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
polyA_site 8240
/gene="PTPRD"
/gene_synonym="HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA"
ORIGIN
gctctgaaagtgttccagctgaaatttcagatcggacagactcgctgcggctccggaggcagtgattccaagctgctcgcgcacgctgctgccaagctgcaggatggtgcacgtagccaggctgctgctgctgctcctcactttcttcctccgcacggatgctgagacacctccaaggtttacacgaacacccgttgatcagacaggggtctctggcggagttgcctctttcatctgccaagctacgggagacccaagacctaaaattgtctggaacaaaaaaggaaagaaagtcagcaatcagagatttgaggtaatagagtttgacgatgggtctggatcagttctcagaatacaacccttacggactccgagggatgaggccatttatgaatgtgtggcctcaaataatgtgggagaaataagtgtatccaccagactcacagttttgcgggaagatcaaattcccaggggcttccctaccattgacatgggcccacagttgaaggtggttgagcgtactcgcacggccaccatgctttgtgcagccagtggtaatccggatccagaaatcacttggtttaaagatttcttacctgtggacacaagcaacaacaatggtcgtattaagcagttacgatcaggtggtacaccaataagaggagcccttcagattgagcagagtgaagagtctgaccaaggaaaatatgagtgtgttgccaccaacagcgcgggcactcgctattccgctcctgccaatttatatgtcagagagctgcgagaagttcgccgtgtcccaccaagattctctatcccacccactaatcatgaaatcatgccaggcggaagcgttaatatcacctgtgtggccgtggggtcaccaatgccttatgtaaagtggatgttgggggcagaagatctgacacctgaagatgatatgccaataggaagaaatgtgctagaactgaatgatgtaagacagtcagcaaattacacctgtgttgctatgtcaacactgggtgtcattgaagcaatagcacagatcactgtcaaagccttacccaaacctccaggaactcctgtagtgaccgagagcacagctacaagcatcacactgacgtgggactctgggaaccctgagcctgtttcttattacataattcagcataaacctaaaaactctgaggaactttacaaagaaattgatggggtggcgaccacacgctacagtgtcgctggactaagtccctactcggattatgaattcagggttgttgctgtcaataacattgggcgggggcctcccagcgaacctgtgctaacacaaacctcagagcaagcaccatccagtgccccgagggatgtccaggcacgaatgttgagttcgaccaccattttggtacagtggaaggaacctgaagagccaaatggacagatccaaggatatagagtttattatacaatggatcccactcaacatgtcaacaactggatgaaacacaatgtagctgacagccaaatcactactattggcaacttagtgccccagaaaacatattctgtcaaagtcctggcttttacctcaattggagatggtcccctttcaagtgacatacaagtcatcactcagacaggagtaccagggcagccactaaacttcaaagcagaacctgagtctgaaacaagtattttgctctcttggacacctccacgttcagataccattgccaactatgaactggtctacaaagatggggagcatggagaggagcaacgaattaccattgagccagggacatcatataggctgcaaggactgaaaccaaacagcttatactatttccgtctggctgcacgctcccctcaaggcctgggtgcttctactgcagaaatatcagctagaaccatgcagtcaatgtttgcaaaaaattttcatgtcaaagcagtaatgaagacttccgtgttgctgtcttgggagattccagagaattataactccgccatgcctttcaaaattctttatgatgatgggaaaatggtagaagaagtggatggccgagccacacagaagttaattgtcaacctgaagcctgagaaatcatattcatttgtgctgacaaatcgtggaaacagtgctggtgggctgcagcacagggtcacggcaaagactgcaccagatgtattacgtaccaagcctgccttcattgggaagaccaacttggatggcatgattactgtgcaactgcctgaagtacctgcaaatgagaatataaaaggttactacataataattgtgcctttgaagaaatctcgcgggaaatttatcaagccatgggagagtccagatgaaatggaattagatgagctgcttaaggagatatctaggaagcgcagaagcatccgttatgggagagaagttgaattaaagccatatattgccgctcactttgatgtccttcccactgagttcaccctgggggatgacaagcattatggtggatttacaaacaagcaactccaaagtggtcaagaatatgtcttctttgtgttagcagtaatggaacatgcagagtctaagatgtatgcaaccagcccttactccgaccccgtggtgtcaatggatctggatccgcagccaatcacggatgaagaagaaggcttgatctgggttgtaggtcctgtccttgcagtggtctttatcatctgcattgtcattgctattcttctttataaaagtaaacccgacaggaagagggcagagtccgactctagaaaaagcagcataccgaacaataaggagatcccttcacaccacccaacagaccctgtagaactgaggcgccttaactttcaaacaccgggtatggctagccatcctccaatacccatcttggaacttgcagaccacattgaaagattgaaagcaaatgacaacttgaagttttcccaggaatatgagtcaattgaccctggccagcagttcacttgggaacattcaaacttggaagtaaacaaaccaaagaatagatacgcgaatgtaatcgcatatgatcattcccgggttctcctatcagctatagaagggatcccaggaagtgactatgtgaatgccaactacatagatgggtataggaagcaaaatgcctatattgcaacacagggatctctccccgaaacatttggggacttttggagaatgatatgggaacaacggagtgccacagttgtcatgatgacaaaactagaagaaagatcaagggtgaagtgtgaccagtattggcctagcagaggcacagaaacccacggactcgttcaagtaacgctgcttgatactgtggagctggccacatattgtgttcgaacatttgcactttacaagaatggttcaagtgagaagagagaagtgagacaattccagttcaccgcctggcctgatcatggtgttccagaacaccctacaccttttctagctttcttacgtagagtcaaaacctgtaaccctcccgatgctggtccgatggttgtgcactgcagtgcgggagttggccggactggttgcttcatcgtcatagatgccatgttagaaagaataaagcatgaaaaaactgtagatatttatggccatgtaactttaatgagagcccagaggaactatatggttcaaacagaagaccaatacatctttatccatgatgcactgttagaagcagtgacttgtggaaataccgaagtgccagctagaaacttgtatgcctacattcagaagctgacacaaatagaaacgggagagaatgtcacaggaatggagctcgaatttaagcgtctagccagctcaaaagctcacacctcaaggtttatcagtgccaatcttccatgtaataaattcaaaaatcgccttgttaatattatgccatatgaatccacaagggtatgcctgcagcctatccgtggagtagaaggatctgattacatcaatgccagttttattgatggatacagacaacagaaagcctacatcgctacccaggggcccttggcagagaccactgaagacttctggcggatgctctgggaacacaattccaccatagttgtgatgctcaccaagctgcgtgaaatgggcagagagaaatgtcaccaatactggccagcagaacggtctgcaagataccagtactttgttgtagatcccatggctgagtacaacatgccacagtatatcctaagggaattcaaggtcacagatgccagggacggccagtcccgaacagtaaggcagttccagttcactgactggccagagcaaggagtgccaaagtccggagaaggatttattgacttcatcggccaagtccataaaacaaaagaacagtttggccaagatggacccatttcagtccattgcagcgcgggcgttggaagaactggagtcttcataacgctaagcattgttttggaaagaatgagatatgaaggagttgtagatatcttccagactgtcaaaatgttaagaacacaacgaccagctatggtacagacagaggatcaatatcagttttcctatcgtgccgcactagagtacctgggcagctttgaccactatgcaacgtagaaacccctgacccattctggatttttactacaggcccttcaatatccatggagtctcttctgagccatacagggcacttgagaagtccttcttaacttctagctaacaactacttagtgggactattacacacaaaacaaattaaaaacaaattattccaggtggaccaagaattcacagtttaataatctaacctgaaaaataatgaagagaatcctgactgatgaggcatctgaaggattttatttacagatacctcaaggattcaaaatcaagggaagaagaaatcacagcaaagaaccaccatcttattcaggattgcttgaaaggtgcaaggagaaattgccagaatgctgcagttcagcacaagatatgtgctggtgtggcttctcacaatgaaacggactctgctttgacatcgccccttcccaccatactgctcataataacattttagggggaaaggggagggaatgtttaaaaagaaagtccttgatttagttttttagtattgtaaagatactgctgacctgtgcttcatttctaactgtgtaaacttttttttaacaaaatgtatcattcgataaagtgaattttaaaaaagttacataactcttcatttttttatttccaaatcgtaggtttttttaagctgtagaactgttatctgtaatatcttgctgtagaaatatcaaatcatttgaaaatttgcacatttttgtgcaaaactcaatctacagtatcagtctcgtcagatatattaattttacacttcagttttgattggtgagaaagtacccattctcttcaaataatcaaagataattattattttgttttgtttttggaatcaacagggaggcgcaaagtataaagttgctgctaacatatatacatatatatccatattttataagggtgtctatgtatatatagacagtgtgtccacacaaaaaatagatacagttatcagtcagtcagttcttccatgatttagtttttttaaacgtagaaaagctattgtaaacatctctttccatttattcttaattttttgacatattggtatttctttaaagggaaatgaggaatgcacatcagtgattgattgtcaaacctcaccccctgatttcctacctaatctacccccacctaaccaatcaatcacatccacaaattgttttgtttgtttgttagtcaggcttccaacaaagttcaatatttctaacactctagtgcaataaaaattattattaaatagctaagaggtgtgcatgtgggaaaggtcagtgcatatccctttaggaggggagaatgttgtaatatatcagctatcgagttgtttaaaaaaagtgtattcaatcgtatattgtctatagtatgtgctatgaaatttgcatttatgatatgtaacaggggcaaagccaaattcatgttactctgttcagtcagaaacattttgtggcatacagcattcctgggaagtgctgtactttgtttcgttttggttttagttttgcatttagagtgccttataattgatgcctattttaatagcatttctttttagcttttggttcgtatttccattcactgttcgtatctgttactttctattaaagcattatctgtttaccacatgtacaaaaactctttgaataatatgcattcctagttttcagccaagtcggggatgttagtgattgtaccagcccaaagcacttggataatcagggcccttcttccttttataatcaatcatcaacatcagaaaaagctacttgttttatttatattcccttccaaatccgctctggaacatgcagtaactgcaccaaacttattttagtaacaaatatcattggcaactttggaatatatttgatattccattaggatttttctaaaaggggaaataaactatatatatatatgtatcttacccccaattcttccaacagaatttctataggaagccatggatgatggcataagtttgccacatattacatgattttaaataatcctcaaaatacccaaggaactcttaaagagttttggtatgagtatactactttggtttaattttagcttcatggatgttctgcatggaaggatttttgttttccacattttcccattgctagcagagtgaaatccaagagaccaaacatttgcaagcattgtatttgagcacttttgtaaaaaacaaagaaaaagaaaaaaaagaaaatatatataatactaaaaaaaagtatctagaaggctacctcagaatgagactctctaacctacatcagaaccagagaagaatgtgcactatgtgggtctgttatcattattttcttttagtttgtatctttttggagatttatccaagtgccagattactcagtgctataattttcttttagttaaacaaagggggtcagacagacattgcatcatccagacatgccttgttggacatgtagaatccgatggagcactgcacaccagaatgattggccaatgagcagcttctctccctgaaacaataactgcccatttggcaaagggaaagatgacaataatcagaagaagaaaatgaatgggatgcataccatagacgaacgaggcggagactattgcgggaatcttactgttcaggagctgttcctagaactaactcccttactgtcattgatgtgcattccactctgtgcttttctgtacaaccattcaagttttaatttcccaggtgaaccatctttatctgccattaccacaagctttcaagtttccagttattttcatcatcataaccagtacggtgctattatttacctatgtacgtgtagttatgtataattttgtaattagttacaatggtaaaaaaaatcaaaatatataaaaagtgatttgtacagaactttattttagctcttttttaaaaatgatttgcatggttagaaaacggcgaggacagccaggggagggaagggcctctagggaactttgcactttctatacctttgtactatgcactgccctattgattctacacccaataatgatattacttgaacccatctgtaagaaactgcttcggaaattcatttgtgtgtatgtaaataacacaacatagaaacaggaagggaaaaaagtctgcagtaatgcacgtattttttttctttcctgtttattttcggttttgctttaagtccttttatttttaattccctttttgtttttctttttgggttttggttccttttgggtttatgggtgccctgatactccagcagagatcagaaggctacagatccattctatccatccgttatgtggctttgccatcccagcttggagtgtctttacaaagataataacagttgtgttctttgctctcgttttggatgcatagactgaaaaattaaaacaaataacttgtaaaatggcttgttaaaaaatacaattacctctaattagtagtacgcgtaaatgttttacagaatgaaaggcgtgctttttattttcttacttcgttacattggtggcgaaagaagtctgtatgaaaatcagttctttgctgacacaagttccatttgttacaaatgaattctaataaaaatgtcagtgttatgcaaaaaaaaaaaaaaaaaa
//
ANNOTATIONS from NCBI Entrez Gene (20130726):
GeneID:5789 -> Molecular function: GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity] evidence: TAS
GeneID:5789 -> Molecular function: GO:0005102 [receptor binding] evidence: ISS
GeneID:5789 -> Molecular function: GO:0005515 [protein binding] evidence: IPI
GeneID:5789 -> Molecular function: GO:0050839 [cell adhesion molecule binding] evidence: ISS
GeneID:5789 -> Biological process: GO:0006470 [protein dephosphorylation] evidence: TAS
GeneID:5789 -> Biological process: GO:0006796 [phosphate-containing compound metabolic process] evidence: NAS
GeneID:5789 -> Biological process: GO:0007157 [heterophilic cell-cell adhesion] evidence: ISS
GeneID:5789 -> Biological process: GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway] evidence: TAS
GeneID:5789 -> Biological process: GO:0030182 [neuron differentiation] evidence: ISS
GeneID:5789 -> Biological process: GO:0050775 [positive regulation of dendrite morphogenesis] evidence: ISS
GeneID:5789 -> Biological process: GO:0097105 [presynaptic membrane assembly] evidence: ISS
GeneID:5789 -> Cellular component: GO:0005887 [integral to plasma membrane] evidence: TAS
ANNOTATIONS from NCBI Entrez Gene (20130726):
NP_001035802 -> EC 3.1.3.48
by
@meso_cacase at
DBCLS
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